ID   A0A075B7C0_HUMAN        Unreviewed;       197 AA.
AC   A0A075B7C0;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 35.
DE   SubName: Full=Calpain small subunit 1 {ECO:0000313|Ensembl:ENSP00000474036};
DE   Flags: Fragment;
GN   Name=CAPNS1 {ECO:0000313|Ensembl:ENSP00000474036};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000474036, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000474036, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000213|PubMed:19608861}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA   Walther T.C., Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [3] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000313|Ensembl:ENSP00000474036}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2014) to UniProtKB.
RN   [6] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AD001527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A075B7C0; -.
DR   SMR; A0A075B7C0; -.
DR   jPOST; A0A075B7C0; -.
DR   PeptideAtlas; A0A075B7C0; -.
DR   PRIDE; A0A075B7C0; -.
DR   Ensembl; ENST00000590049; ENSP00000474036; ENSG00000126247.
DR   UCSC; uc060xno.1; human.
DR   EuPathDB; HostDB:ENSG00000126247.10; -.
DR   HGNC; HGNC:1481; CAPNS1.
DR   OpenTargets; ENSG00000126247; -.
DR   eggNOG; KOG0037; Eukaryota.
DR   eggNOG; ENOG410YKQK; LUCA.
DR   GeneTree; ENSGT00940000155478; -.
DR   ChiTaRS; CAPNS1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000126247; Expressed in 235 organ(s), highest expression level in adult mammalian kidney.
DR   ExpressionAtlas; A0A075B7C0; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR029642; CAPN4.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR44408:SF3; PTHR44408:SF3; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A075B7C0,
KW   ECO:0000213|MaxQB:A0A075B7C0, ECO:0000213|PeptideAtlas:A0A075B7C0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    197       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001705786.
FT   DOMAIN       90    118       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      120    155       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      170    190       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND     103    114       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND     133    144       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000474036}.
SQ   SEQUENCE   197 AA;  21912 MW;  EB4F64DE30CE097E CRC64;
     GGGGGGGTAM RILGGVISAI SEAAAQYNPE PPPPRTHYSN IEANESEEVR QFRRLFAQLA
     GDDMEVSATE LMNILNKVVT RHPDLKTDGF GIDTCRSMVA VMDSDTTGKL GFEEFKYLWN
     NIKRWQAIYK QFDTDRSGTI CSSELPGAFE AAGFHLNEHL YNMIIRRYSD ESGNMDFDNF
     ISCLAQEEIN MPQLLIS
//