ID   A0A075B788_HUMAN        Unreviewed;       753 AA.
AC   A0A075B788;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase C {ECO:0000313|Ensembl:ENSP00000469141};
GN   Name=PTPRC {ECO:0000313|Ensembl:ENSP00000469141};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000469141, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000469141, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000469141}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2014) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00160}.
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DR   EMBL; AL157402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A075B788; -.
DR   jPOST; A0A075B788; -.
DR   PeptideAtlas; A0A075B788; -.
DR   Ensembl; ENST00000529828; ENSP00000469141; ENSG00000081237.
DR   UCSC; uc021pgy.3; human.
DR   EuPathDB; HostDB:ENSG00000081237.18; -.
DR   HGNC; HGNC:9666; PTPRC.
DR   OpenTargets; ENSG00000081237; -.
DR   GeneTree; ENSGT00940000159457; -.
DR   ChiTaRS; PTPRC; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000081237; Expressed in 219 organ(s), highest expression level in blood.
DR   ExpressionAtlas; A0A075B788; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR024739; PTP_recept_N.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016335; Ptprc.
DR   Pfam; PF12567; CD45; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF12453; PTP_N; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00194; PTPc; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A075B788,
KW   ECO:0000213|MaxQB:A0A075B788, ECO:0000213|PeptideAtlas:A0A075B788};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    753       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001705782.
FT   TRANSMEM    530    551       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      343    435       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      436    528       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      605    753       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
SQ   SEQUENCE   753 AA;  85023 MW;  EA52BABC2DB9916D CRC64;
     MTMYLWLKLL AFGFAFLDTE VFVTGQSPTP SPTGLTTAKM PSVPLSSDPL PTHTTAFSPA
     STFERENDFS ETTTSLSPDN TSTQVSPDSL DNASAFNTTG VSSVQTPHLP THADSQTPSA
     GTDTQTFSGS AANAKLNPTP GSNAISDAYL NASETTTLSP SGSAVISTTT IATTPSKPTC
     DEKYANITVD YLYNKETKLF TAKLNVNENV ECGNNTCTNN EVHNLTECKN ASVSISHNSC
     TAPDKTLILD VPPGVEKFQL HDCTQVEKAD TTICLKWKNI ETFTCDTQNI TYRFQCGNMI
     FDNKEIKLEN LEPEHEYKCD SEILYNNHKF TNASKIIKTD FGSPGEPQII FCRSEAAHQG
     VITWNPPQRS FHNFTLCYIK ETEKDCLNLD KNLIKYDLQN LKPYTKYVLS LHAYIIAKVQ
     RNGSAAMCHF TTKSAPPSQV WNMTVSMTSD NSMHVKCRPP RDRNGPHERY HLEVEAGNTL
     VRNESHKNCD FRVKDLQYST DYTFKAYFHN GDYPGEPFIL HHSTSYNSKA LIAFLAFLII
     VTSIALLVVL YKIYDLHKKR SCNLDEQQEL VERDDEKQLM NVEPIHADIL LETYKRKIAD
     EGRLFLAEFQ SIPRVFSKFP IKEARKPFNQ NKNRYVDILP YDYNRVELSE INGDAGSNYI
     NASYIDGFKE PRKYIAAQGP RDETVDDFWR MIWEQKATVI VMVTRCEEGN RNKCAEYWPS
     MEEGTRAFGD VVVKINQHKR CPDYIIQKLN IVN
//