ID   A0A075B783_HUMAN        Unreviewed;       576 AA.
AC   A0A075B783;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Laminin subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000468316};
GN   Name=LAMA3 {ECO:0000313|Ensembl:ENSP00000468316};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468316, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000468316, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000468316}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR   EMBL; AC010754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC067796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A075B783; -.
DR   jPOST; A0A075B783; -.
DR   PeptideAtlas; A0A075B783; -.
DR   Ensembl; ENST00000585600; ENSP00000468316; ENSG00000053747.
DR   UCSC; uc060nzc.1; human.
DR   EuPathDB; HostDB:ENSG00000053747.15; -.
DR   HGNC; HGNC:6483; LAMA3.
DR   OpenTargets; ENSG00000053747; -.
DR   eggNOG; KOG1836; Eukaryota.
DR   eggNOG; ENOG410XRDC; LUCA.
DR   GeneTree; ENSGT00940000155638; -.
DR   ChiTaRS; LAMA3; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000053747; Expressed in 173 organ(s), highest expression level in ectocervix.
DR   ExpressionAtlas; A0A075B783; baseline and differential.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00053; Laminin_EGF; 4.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00180; EGF_Lam; 4.
DR   SMART; SM00136; LamNT; 1.
DR   PROSITE; PS01248; EGF_LAM_1; 2.
DR   PROSITE; PS50027; EGF_LAM_2; 4.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00966286};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A075B783,
KW   ECO:0000213|PeptideAtlas:A0A075B783};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00580781};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37    576       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001705229.
FT   DOMAIN       43    298       Laminin N-terminal.
FT                                {ECO:0000259|PROSITE:PS51117}.
FT   DOMAIN      299    355       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      356    425       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      426    469       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      491    535       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DISULFID    321    330       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    393    402       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    445    454       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    491    503       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    511    520       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   576 AA;  63335 MW;  0E9464296C3664EC CRC64;
     MAAAARPRGR ALGPVLPPTP LLLLVLRVLP ACGATARDPG AAAGLSLHPT YFNLAEAARI
     WATATCGERG PGEGRPQPEL YCKLVGGPTA PGSGHTIQGQ FCDYCNSEDP RKAHPVTNAI
     DGSERWWQSP PLSSGTQYNR VNLTLDLGQL FHVAYILIKF ANSPRPDLWV LERSVDFGST
     YSPWQYFAHS KVDCLKEFGR EANMAVTRDD DVLCVTEYSR IVPLENGEVV VSLINGRPGA
     KNFTFSHTLR EFTKATNIRL RFLRTNTLLG HLISKAQRDP TVTRRYYYSI KDISIGGQCV
     CNGHAEVCNI NNPEKLFRCE CQHHTCGETC DRCCTGYNQR RWRPAAWEQS HECEACNCHG
     HASNCYYDPD VERQQASLNT QGIYAGGGVC INCQHNTAGV NCEQCAKGYY RPYGVPVDAP
     DGCIPCSCDP EHADGCEQGS GRCHCKPNFH GDNCEKCAIG YYNFPFCLRI PIFPVSTPSS
     EDPVAGDIKG CDCNLEGVLP EICDAHGRCL CRPGVEGPRC DTCRSGFYSF PICQGPSEKV
     AIYKPESRPS AETEPASTWI LDFPASRTGE INFYCL
//