{"accession":"Q8WV41","id":"SNX33_HUMAN","proteinExistence":"Evidence at protein level","info":{"type":"Swiss-Prot","created":"2007-12-04","modified":"2017-10-25","version":141},"organism":{"taxonomy":9606,"names":[{"type":"scientific","value":"Homo sapiens"},{"type":"common","value":"Human"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"secondaryAccession":["B1NM17"],"protein":{"recommendedName":{"fullName":{"value":"Sorting nexin-33"}},"alternativeName":[{"fullName":{"value":"SH3 and PX domain-containing protein 3"}}]},"gene":[{"name":{"value":"SNX33"},"synonyms":[{"value":"SH3PX3"},{"value":"SH3PXD3C"},{"value":"SNX30"}]}],"comments":[{"type":"FUNCTION","text":[{"value":"Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"18353773","url":"http://www.ncbi.nlm.nih.gov/pubmed/18353773","alternativeUrl":"http://europepmc.org/abstract/MED/18353773"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"18419754","url":"http://www.ncbi.nlm.nih.gov/pubmed/18419754","alternativeUrl":"http://europepmc.org/abstract/MED/18419754"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"19487689","url":"http://www.ncbi.nlm.nih.gov/pubmed/19487689","alternativeUrl":"http://europepmc.org/abstract/MED/19487689"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"20964629","url":"http://www.ncbi.nlm.nih.gov/pubmed/20964629","alternativeUrl":"http://europepmc.org/abstract/MED/20964629"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"21048941","url":"http://www.ncbi.nlm.nih.gov/pubmed/21048941","alternativeUrl":"http://europepmc.org/abstract/MED/21048941"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"22718350","url":"http://www.ncbi.nlm.nih.gov/pubmed/22718350","alternativeUrl":"http://europepmc.org/abstract/MED/22718350"}}]}]},{"type":"SUBUNIT","text":[{"value":"Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"16374509","url":"http://www.ncbi.nlm.nih.gov/pubmed/16374509","alternativeUrl":"http://europepmc.org/abstract/MED/16374509"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"18353773","url":"http://www.ncbi.nlm.nih.gov/pubmed/18353773","alternativeUrl":"http://europepmc.org/abstract/MED/18353773"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"19487689","url":"http://www.ncbi.nlm.nih.gov/pubmed/19487689","alternativeUrl":"http://europepmc.org/abstract/MED/19487689"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"19718658","url":"http://www.ncbi.nlm.nih.gov/pubmed/19718658","alternativeUrl":"http://europepmc.org/abstract/MED/19718658"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"19807924","url":"http://www.ncbi.nlm.nih.gov/pubmed/19807924","alternativeUrl":"http://europepmc.org/abstract/MED/19807924"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"20964629","url":"http://www.ncbi.nlm.nih.gov/pubmed/20964629","alternativeUrl":"http://europepmc.org/abstract/MED/20964629"}}]}]},{"type":"INTERACTION","interactions":[{"interactionType":"SELF","interactor1":"EBI-2481535","interactor2":"EBI-2481535","experiments":2},{"interactionType":"BINARY","id":"Q13444","gene":"ADAM15","interactor1":"EBI-2481535","interactor2":"EBI-77818","experiments":2},{"interactionType":"BINARY","id":"Q05193","gene":"DNM1","interactor1":"EBI-2481535","interactor2":"EBI-713135","experiments":2},{"interactionType":"BINARY","id":"Q7L190","gene":"DPPA4","interactor1":"EBI-2481535","interactor2":"EBI-710457","experiments":4},{"interactionType":"BINARY","id":"P48023","gene":"FASLG","interactor1":"EBI-2481535","interactor2":"EBI-495538","experiments":2},{"interactionType":"BINARY","id":"Q96HR8","gene":"NAF1","interactor1":"EBI-2481535","interactor2":"EBI-2515597","experiments":3},{"interactionType":"BINARY","id":"Q9Y5X1","gene":"SNX9","interactor1":"EBI-2481535","interactor2":"EBI-77848","experiments":2},{"interactionType":"BINARY","id":"P42768","gene":"WAS","interactor1":"EBI-2481535","interactor2":"EBI-346375","experiments":3}]},{"type":"SUBCELLULAR_LOCATION","locations":[{"location":{"value":"Cytoplasm, cytosol"}},{"location":{"value":"Membrane"},"topology":{"value":"Peripheral membrane protein"},"orientation":{"value":"Cytoplasmic side"}},{"location":{"value":"Cytoplasmic vesicle membrane"},"topology":{"value":"Peripheral membrane protein"},"orientation":{"value":"Cytoplasmic side"}}],"text":[{"value":"Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941)","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"18353773","url":"http://www.ncbi.nlm.nih.gov/pubmed/18353773","alternativeUrl":"http://europepmc.org/abstract/MED/18353773"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"21048941","url":"http://www.ncbi.nlm.nih.gov/pubmed/21048941","alternativeUrl":"http://europepmc.org/abstract/MED/21048941"}}]}]},{"type":"TISSUE_SPECIFICITY","text":[{"value":"Detected in heart and pancreas","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"18353773","url":"http://www.ncbi.nlm.nih.gov/pubmed/18353773","alternativeUrl":"http://europepmc.org/abstract/MED/18353773"}}]}]},{"type":"DOMAIN","text":[{"value":"The PX and BAR domains mediate association with membranes and are required for membrane tubulation","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"20964629","url":"http://www.ncbi.nlm.nih.gov/pubmed/20964629","alternativeUrl":"http://europepmc.org/abstract/MED/20964629"}}]}]},{"type":"PTM","text":[{"value":"Phosphorylated","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"18353773","url":"http://www.ncbi.nlm.nih.gov/pubmed/18353773","alternativeUrl":"http://europepmc.org/abstract/MED/18353773"}}]}]},{"type":"SIMILARITY","text":[{"value":"Belongs to the sorting nexin family","evidences":[{"code":"ECO:0000305"}]}]}],"features":[{"type":"CHAIN","category":"MOLECULE_PROCESSING","ftId":"PRO_0000311948","description":"Sorting nexin-33","begin":"1","end":"574"},{"type":"DOMAIN","category":"DOMAINS_AND_SITES","description":"SH3","begin":"1","end":"61","evidences":[{"code":"ECO:0000255","source":{"name":"PROSITE-ProRule","id":"PRU00192","url":"http://prosite.expasy.org/unirule/PRU00192"}}]},{"type":"DOMAIN","category":"DOMAINS_AND_SITES","description":"PX","begin":"230","end":"340","evidences":[{"code":"ECO:0000255","source":{"name":"PROSITE-ProRule","id":"PRU00147","url":"http://prosite.expasy.org/unirule/PRU00147"}}]},{"type":"DOMAIN","category":"DOMAINS_AND_SITES","description":"BAR","begin":"371","end":"574"},{"type":"COMPBIAS","category":"SEQUENCE_INFORMATION","description":"Poly-Asp","begin":"112","end":"122"},{"type":"MOD_RES","category":"PTM","description":"Phosphoserine","begin":"77","end":"77","evidences":[{"code":"ECO:0000244","source":{"name":"PubMed","id":"18669648","url":"http://www.ncbi.nlm.nih.gov/pubmed/18669648","alternativeUrl":"http://europepmc.org/abstract/MED/18669648"}},{"code":"ECO:0000244","source":{"name":"PubMed","id":"23186163","url":"http://www.ncbi.nlm.nih.gov/pubmed/23186163","alternativeUrl":"http://europepmc.org/abstract/MED/23186163"}}]},{"type":"MOD_RES","category":"PTM","description":"Phosphoserine","begin":"92","end":"92","evidences":[{"code":"ECO:0000244","source":{"name":"PubMed","id":"23186163","url":"http://www.ncbi.nlm.nih.gov/pubmed/23186163","alternativeUrl":"http://europepmc.org/abstract/MED/23186163"}}]},{"type":"STRAND","category":"STRUCTURAL","begin":"213","end":"215","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"STRAND","category":"STRUCTURAL","begin":"220","end":"223","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"STRAND","category":"STRUCTURAL","begin":"232","end":"235","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"STRAND","category":"STRUCTURAL","begin":"252","end":"256","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"STRAND","category":"STRUCTURAL","begin":"259","end":"261","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"STRAND","category":"STRUCTURAL","begin":"263","end":"265","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"267","end":"280","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"STRAND","category":"STRUCTURAL","begin":"282","end":"284","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"TURN","category":"STRUCTURAL","begin":"302","end":"304","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"305","end":"318","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"323","end":"325","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"327","end":"333","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"339","end":"349","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"355","end":"360","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"371","end":"407","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"409","end":"427","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"432","end":"434","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"437","end":"459","evidences":[{"code":"ECO:0000244","source":{"name":"PDB","id":"4AKV","url":"http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKV"}}]},{"type":"HELIX","category":"STRUCTURAL","begin":"460"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