{"accession":"Q8K209","id":"AGRG1_MOUSE","proteinExistence":"Evidence at protein level","info":{"type":"Swiss-Prot","created":"2004-03-15","modified":"2017-10-25","version":132},"organism":{"taxonomy":10090,"names":[{"type":"scientific","value":"Mus musculus"},{"type":"common","value":"Mouse"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"secondaryAccession":["Q3UR17","Q9QZT2"],"protein":{"recommendedName":{"fullName":{"value":"Adhesion G-protein coupled receptor G1"}},"alternativeName":[{"fullName":{"value":"G-protein coupled receptor 56"}},{"fullName":{"value":"Serpentine receptor cyt28"}}],"component":[{"recommendedName":{"fullName":{"value":"ADGRG1 N-terminal fragment"},"shortName":[{"value":"ADGRG1 NT"}]},"alternativeName":[{"fullName":{"value":"GPR56 N-terminal fragment"},"shortName":[{"value":"GPR56 NT"},{"value":"GPR56(N)"}]},{"fullName":{"value":"GPR56 extracellular subunit"}},{"fullName":{"value":"GPR56 subunit alpha"}}]},{"recommendedName":{"fullName":{"value":"ADGRG1 C-terminal fragment"},"shortName":[{"value":"ADGRG1-CT"}]},"alternativeName":[{"fullName":{"value":"GPR56 C-terminal fragment"},"shortName":[{"value":"GPR56 CT"},{"value":"GPR56(C)"}]},{"fullName":{"value":"GPR56 seven-transmembrane subunit"},"shortName":[{"value":"GPR56 7TM"}]},{"fullName":{"value":"GPR56 subunit beta"}}]}]},"gene":[{"name":{"value":"Adgrg1","evidences":[{"code":"ECO:0000312","source":{"name":"MGI","id":"MGI:1340051","url":"http://www.informatics.jax.org/marker/MGI:1340051"}}]},"synonyms":[{"value":"Cyt28"},{"value":"Gpr56"}]}],"comments":[{"type":"FUNCTION","text":[{"value":"Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665). Plays a critical role in tumourigenesis (By similarity). Plays essential role in testis development (PubMed:20981830)","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"18378689","url":"http://www.ncbi.nlm.nih.gov/pubmed/18378689","alternativeUrl":"http://europepmc.org/abstract/MED/18378689"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"18509043","url":"http://www.ncbi.nlm.nih.gov/pubmed/18509043","alternativeUrl":"http://europepmc.org/abstract/MED/18509043"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"19515912","url":"http://www.ncbi.nlm.nih.gov/pubmed/19515912","alternativeUrl":"http://europepmc.org/abstract/MED/19515912"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"20981830","url":"http://www.ncbi.nlm.nih.gov/pubmed/20981830","alternativeUrl":"http://europepmc.org/abstract/MED/20981830"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"21768377","url":"http://www.ncbi.nlm.nih.gov/pubmed/21768377","alternativeUrl":"http://europepmc.org/abstract/MED/21768377"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"23478665","url":"http://www.ncbi.nlm.nih.gov/pubmed/23478665","alternativeUrl":"http://europepmc.org/abstract/MED/23478665"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"24531968","url":"http://www.ncbi.nlm.nih.gov/pubmed/24531968","alternativeUrl":"http://europepmc.org/abstract/MED/24531968"}}]}]},{"type":"ENZYME_REGULATION","text":[{"value":"ADGRG1 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands and /or homophilic ADGRG1 NT interactions may relieve the inhibition. Following ligand binding to the N-terminal fragment, the N-terminal fragment is released from the seven-transmembrane C-terminal fragment to unveil a new N-terminal stalk, which then stimulates G-protein-dependent signaling activity. The N-terminal stalk has also been shown to be dispensable for at least some G-protein-dependent signaling","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}}]}]},{"type":"SUBUNIT","text":[{"value":"Predominantly non-covalently linked heterodimer of the N-terminal and the C-terminal fragment. ADGRG1 NT self-associates in a trans-trans manner; the homophilic interaction enhances receptor signaling. ADGRG1 CT interacts with ARRB2; the interaction is impaired by ADGRG1 NT. Part of a GPCR-tetraspanin complex at least consisting of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11 (By similarity). Interacts with heparin; leading to the reduction of ADGRG1 shedding (PubMed:27068534)","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"27068534","url":"http://www.ncbi.nlm.nih.gov/pubmed/27068534","alternativeUrl":"http://europepmc.org/abstract/MED/27068534"}}]}]},{"type":"SUBCELLULAR_LOCATION","locations":[{"location":{"value":"Cell membrane","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"17576745","url":"http://www.ncbi.nlm.nih.gov/pubmed/17576745","alternativeUrl":"http://europepmc.org/abstract/MED/17576745"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"22238662","url":"http://www.ncbi.nlm.nih.gov/pubmed/22238662","alternativeUrl":"http://europepmc.org/abstract/MED/22238662"}}]},"topology":{"value":"Multi-pass membrane protein","evidences":[{"code":"ECO:0000255"}]}}]},{"type":"SUBCELLULAR_LOCATION","molecule":"ADGRG1 N-terminal fragment","locations":[{"location":{"value":"Secreted","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}}]}}]},{"type":"SUBCELLULAR_LOCATION","molecule":"ADGRG1 C-terminal fragment","locations":[{"location":{"value":"Membrane raft","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}}]}}],"text":[{"value":"Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}}]}]},{"type":"TISSUE_SPECIFICITY","text":[{"value":"Expressed in neural progenitor cells in fetal forbrain. Expressed in migrating neurons. Expressed in radial glial endfeet (at protein level) (PubMed:21768377). Expressed in peritubular myoid cells, Sertoli cells, and germ cells of the testis (PubMed:20981830)","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"20981830","url":"http://www.ncbi.nlm.nih.gov/pubmed/20981830","alternativeUrl":"http://europepmc.org/abstract/MED/20981830"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"21768377","url":"http://www.ncbi.nlm.nih.gov/pubmed/21768377","alternativeUrl":"http://europepmc.org/abstract/MED/21768377"}}]}]},{"type":"PTM","text":[{"value":"Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment and the membroune-bound C-terminal fragment predominantly remain associated and non-covalently linked","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"22238662","url":"http://www.ncbi.nlm.nih.gov/pubmed/22238662","alternativeUrl":"http://europepmc.org/abstract/MED/22238662"}}]}]},{"type":"PTM","text":[{"value":"N-glycosylated. The secreted ADGRG1 N-terminal fragment is heavily glycosylated","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"17576745","url":"http://www.ncbi.nlm.nih.gov/pubmed/17576745","alternativeUrl":"http://europepmc.org/abstract/MED/17576745"}}]}]},{"type":"PTM","text":[{"value":"Ubiquitinated. Undergoes polyubiquitination upon activation","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}}]}]},{"type":"DISRUPTION_PHENOTYPE","text":[{"value":"Cobblestone-like cortical malformation with defective pial basement membrane (BM), abnormal anchorage of radial glial endfeet, mislocalized Cajal-Retzius cells and neuronal overmigration. Severe malformation of the rostral cerebellum that develops perinatally. Granule cells from the rostral region show loss of adhesion to extracellular matrix molecules of the pial basement membrane. In ADGRG1 knockout mice, neurons overmigrate through breached pial basement membrane or undermigrate forming irregular cortical layers. Deficient mice shown disruption of seminiferous tubule formation and increased sterility (PubMed:20981830)","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"18509043","url":"http://www.ncbi.nlm.nih.gov/pubmed/18509043","alternativeUrl":"http://europepmc.org/abstract/MED/18509043"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"20981830","url":"http://www.ncbi.nlm.nih.gov/pubmed/20981830","alternativeUrl":"http://europepmc.org/abstract/MED/20981830"}},{"code":"ECO:0000269","source":{"name":"PubMed","id":"24531968","url":"http://www.ncbi.nlm.nih.gov/pubmed/24531968","alternativeUrl":"http://europepmc.org/abstract/MED/24531968"}}]}]},{"type":"SIMILARITY","text":[{"value":"Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily","evidences":[{"code":"ECO:0000305"}]}]}],"features":[{"type":"SIGNAL","category":"MOLECULE_PROCESSING","description":"","begin":"1","end":"25","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}}]},{"type":"CHAIN","category":"MOLECULE_PROCESSING","ftId":"PRO_0000012882","description":"Adhesion G-protein coupled receptor G1","begin":"26","end":"687"},{"type":"CHAIN","category":"MOLECULE_PROCESSING","ftId":"PRO_0000436505","description":"ADGRG1 N-terminal fragment","begin":"26","end":"unsure","evidences":[{"code":"ECO:0000250","source":{"name":"UniProtKB","id":"Q9Y653","url":"http://www.uniprot.org/uniprot/Q9Y653"}}]},{"type":"CHAIN","category":"MOLECULE_PROCESSING","ftId":"PRO_0000436506","description":"ADGRG1 C-terminal 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