{"accession":"Q60996","id":"2A5G_MOUSE","proteinExistence":"Evidence at protein level","info":{"type":"Swiss-Prot","created":"2000-05-30","modified":"2017-09-27","version":146},"organism":{"taxonomy":10090,"names":[{"type":"scientific","value":"Mus musculus"},{"type":"common","value":"Mouse"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"secondaryAccession":["O35708","Q6TQF7","Q99KW8","Q99N67","Q99N68"],"protein":{"recommendedName":{"fullName":{"value":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform"}},"alternativeName":[{"fullName":{"value":"PP2A B subunit isoform B'-alpha-3"}},{"fullName":{"value":"PP2A B subunit isoform B'-gamma"}},{"fullName":{"value":"PP2A B subunit isoform B56-gamma"}},{"fullName":{"value":"PP2A B subunit isoform PR61-gamma"}},{"fullName":{"value":"PP2A B subunit isoform R5-gamma"}}]},"gene":[{"name":{"value":"Ppp2r5c"}}],"comments":[{"type":"FUNCTION","text":[{"value":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation","evidences":[{"code":"ECO:0000250"}]}]},{"type":"SUBUNIT","text":[{"value":"PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Interacts with SGO1; the interaction is direct. May interact with TP53 (By similarity). Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation","evidences":[{"code":"ECO:0000250"}]}]},{"type":"INTERACTION","interactions":[{"interactionType":"XENO","id":"P30153","gene":"PPP2R1A","interactor1":"EBI-1369292","interactor2":"EBI-302388","experiments":2}]},{"type":"SUBCELLULAR_LOCATION","locations":[{"location":{"value":"Nucleus","evidences":[{"code":"ECO:0000250"}]}},{"location":{"value":"Chromosome, centromere","evidences":[{"code":"ECO:0000250"}]}}]},{"type":"ALTERNATIVE_PRODUCTS","event":["Alternative splicing"],"isoforms":[{"ids":["Q60996-1"],"name":{"value":"2"},"synonyms":[{"value":"Gamma-2"}],"sequenceStatus":"displayed"},{"ids":["Q60996-2"],"name":{"value":"1"},"synonyms":[{"value":"Gamma-1"}],"text":[{"value":"No experimental confirmation available."}],"sequenceStatus":"described","sequence":["VSP_014719","VSP_014720"]},{"ids":["Q60996-3"],"name":{"value":"3"},"synonyms":[{"value":"Gamma-3"}],"sequenceStatus":"described","sequence":["VSP_014718"]},{"ids":["Q60996-4"],"name":{"value":"4"},"synonyms":[{"value":"Gamma-4"}],"sequenceStatus":"described","sequence":["VSP_038641","VSP_038642"]}]},{"type":"TISSUE_SPECIFICITY","text":[{"value":"Highest levels in heart, liver and brain. Lower levels in skeletal muscle, spleen, kidney and lung. Isoform 4 is testis-specific","evidences":[{"code":"ECO:0000269","source":{"name":"PubMed","id":"15051958","url":"http://www.ncbi.nlm.nih.gov/pubmed/15051958","alternativeUrl":"http://europepmc.org/abstract/MED/15051958"}}]}]},{"type":"SIMILARITY","text":[{"value":"Belongs to the phosphatase 2A regulatory subunit B56 family","evidences":[{"code":"ECO:0000305"}]}]}],"features":[{"type":"CHAIN","category":"MOLECULE_PROCESSING","ftId":"PRO_0000071458","description":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma 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