{"accession":"P97497","id":"SHBG_MOUSE","proteinExistence":"Evidence at transcript level","info":{"type":"Swiss-Prot","created":"1998-12-15","modified":"2017-05-10","version":121},"organism":{"taxonomy":10090,"names":[{"type":"scientific","value":"Mus musculus"},{"type":"common","value":"Mouse"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"secondaryAccession":["Q0VB52"],"protein":{"recommendedName":{"fullName":{"value":"Sex hormone-binding globulin"},"shortName":[{"value":"SHBG"}]},"alternativeName":[{"fullName":{"value":"Sex steroid-binding protein"},"shortName":[{"value":"SBP"}]},{"fullName":{"value":"Testis-specific androgen-binding protein"},"shortName":[{"value":"ABP"}]}]},"gene":[{"name":{"value":"Shbg"}}],"comments":[{"type":"FUNCTION","text":[{"value":"Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration","evidences":[{"code":"ECO:0000250"}]}]},{"type":"SUBUNIT","text":[{"value":"Homodimer","evidences":[{"code":"ECO:0000250"}]}]},{"type":"SUBCELLULAR_LOCATION","locations":[{"location":{"value":"Secreted","evidences":[{"code":"ECO:0000250"}]}}],"text":[{"value":"In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis","evidences":[{"code":"ECO:0000250"}]}]}],"features":[{"type":"SIGNAL","category":"MOLECULE_PROCESSING","description":"","begin":"1","end":"30","evidences":[{"code":"ECO:0000250"}]},{"type":"CHAIN","category":"MOLECULE_PROCESSING","ftId":"PRO_0000032558","description":"Sex hormone-binding globulin","begin":"31","end":"403"},{"type":"DOMAIN","category":"DOMAINS_AND_SITES","description":"Laminin G-like 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Cell. Endocrinol."},"location":{"volume":"63","firstPage":"85","lastPage":"92"},"dbReferences":[{"type":"PubMed","id":"2753230"},{"type":"DOI","id":"10.1016/0303-7207(89)90084-1"}]},"source":{"strain":[{"value":"CD-1"}],"tissue":[{"value":"Testis"}]},"scope":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"citation":{"type":"journal article","publicationDate":"2004","title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","consortiums":["The MGC Project Team"],"publication":{"journalName":"Genome Res."},"location":{"volume":"14","firstPage":"2121","lastPage":"2127"},"dbReferences":[{"type":"PubMed","id":"15489334"},{"type":"DOI","id":"10.1101/gr.2596504"}]},"source":{"tissue":[{"value":"Testis"}]},"scope":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]}],"sequence":{"version":1,"length":403,"mass":44816,"modified":"1997-05-01","sequence":"MEKRDSVALHWRLLLLLLLLMPPPTHQGRALRHIDPIQSAQDPPAKYLSNGPGQEPVMVMTIDLTKISKPHSSFEFRTWDPEGVIFYGDTNTEDDWFLLGLRAGQLEIQLHNAWARLTVGFGPRLDDGRWHPVELKMNGDSLLLWVDGKEMLCLRQISASLADHSQRSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSASPRTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHADPWTFSLELGFKLVDGSGQLLALGTGTNSSWLNIHLQNQSVVLSSEAEPKVVLPLDVGLPLQLTLDRVKVVLSQGPKMEVLSMSLLRPASLWRLWSHPQGHLSLGALPGESSSASFCLSDFWVQGQRLDIDQALSRSQDIWTHSCPQRPSNDTRTSH"}}