{"accession":"P04278","id":"SHBG_HUMAN","proteinExistence":"Evidence at protein level","info":{"type":"Swiss-Prot","created":"1987-03-20","modified":"2017-09-27","version":178},"organism":{"taxonomy":9606,"names":[{"type":"scientific","value":"Homo sapiens"},{"type":"common","value":"Human"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"secondaryAccession":["B0FWH4","E9PGW1","F5H5Z8","I3L1N7","P14689","Q16616","Q3MIL0","Q6ISD2"],"protein":{"recommendedName":{"fullName":{"value":"Sex hormone-binding globulin"},"shortName":[{"value":"SHBG"}]},"alternativeName":[{"fullName":{"value":"Sex steroid-binding protein"},"shortName":[{"value":"SBP"}]},{"fullName":{"value":"Testis-specific androgen-binding protein"},"shortName":[{"value":"ABP"}]},{"fullName":{"value":"Testosterone-estradiol-binding globulin"},"shortName":[{"value":"TeBG"}]},{"fullName":{"value":"Testosterone-estrogen-binding globulin"}}]},"gene":[{"name":{"value":"SHBG"}}],"comments":[{"type":"FUNCTION","text":[{"value":"Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration"}]},{"type":"SUBUNIT","text":[{"value":"Homodimer"}]},{"type":"SUBCELLULAR_LOCATION","locations":[{"location":{"value":"Secreted","evidences":[{"code":"ECO:0000250"}]}}],"text":[{"value":"In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis","evidences":[{"code":"ECO:0000250"}]}]},{"type":"ALTERNATIVE_PRODUCTS","comment":[{"value":"Additional isoforms seem to exist."}],"event":["Alternative splicing"],"isoforms":[{"ids":["P04278-1"],"name":{"value":"1"},"synonyms":[{"value":"SHBG"},{"value":"SHBGr-1"}],"sequenceStatus":"displayed"},{"ids":["P04278-2"],"name":{"value":"2"},"synonyms":[{"value":"Sex hormone binding globulin-gene-related protein (SHBGgrp)"},{"value":"SHBGr-2"}],"text":[{"value":"Incomplete sequence."}],"sequenceStatus":"described","sequence":["VSP_006090","VSP_006091","VSP_006092"]},{"ids":["P04278-3"],"name":{"value":"3"},"text":[{"value":"No experimental confirmation available."}],"sequenceStatus":"described","sequence":["VSP_006091","VSP_006092"]},{"ids":["P04278-4"],"name":{"value":"4"},"sequenceStatus":"described","sequence":["VSP_045358"]},{"ids":["P04278-5"],"name":{"value":"5"},"sequenceStatus":"described","sequence":["VSP_045376"]}]},{"type":"TISSUE_SPECIFICITY","text":[{"value":"Isoform 1 and isoform 2 are present in liver and testis"}]},{"type":"PTM","text":[{"value":"Variant Asn-356 contains one N-linked (GlcNAc...) at position 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