INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2834138 2834138 2689922 skin mucosal female_genital_tract_(site_indeterminate) NS malignant_melanoma NS NS NS y COSV104623170 COSM9341102 118750620 c.17C>A p.P6H Substitution - Missense 38 17:1513469-1513469 - - PATHOGENIC .98931 Variant of unknown origin 28296713 surgery - NOS primary 76 ENSP00000385177.4:p.Pro6His ENST00000406424.8:c.17C>A 17:g.1513469G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK036_C01 1918829 1806150 liver NS NS NS carcinoma NS NS NS y COSV57439762 COSN1714041 118752972 c.548+1278G>A p.? Unknown het 38 17:1505702-1505702 - - NEUTRAL .0172 Variant of unknown origin 322 fresh/frozen - NOS primary ENST00000406424.8:c.548+1278G>A 17:g.1505702C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SNU-175 2302007 2167290 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441485 COSM2738174 118750526 c.601C>T p.R201W Substitution - Missense het 38 17:1498070-1498070 - - PATHOGENIC .83124 Variant of unknown origin 24755471 cell-line NS ENSP00000385177.4:p.Arg201Trp ENST00000406424.8:c.601C>T 17:g.1498070G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV57442436 COSM178157 118751587 c.691G>A p.G231S Substitution - Missense het 38 17:1497980-1497980 - - NEUTRAL .01795 Variant of unknown origin 30545397 cell-line primary ENSP00000385177.4:p.Gly231Ser ENST00000406424.8:c.691G>A 17:g.1497980C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 ESO-1096 1890882 1780251 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57439838 COSM1254855 118752934 c.-102C>T p.? Unknown 38 17:1513897-1513897 - - NEUTRAL .13365 Variant of unknown origin 23525077 surgery fresh/frozen primary 73 ENST00000406424.8:c.-102C>T 17:g.1513897G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC1438 2776294 2634430 lung NS NS NS carcinoma large_cell_carcinoma NS NS y COSV99052630 COSM7372286 118752473 c.638C>T p.P213L Substitution - Missense 38 17:1498033-1498033 - - NEUTRAL .05806 Variant of unknown origin 29681454 NS NS 43 ENSP00000385177.4:p.Pro213Leu ENST00000406424.8:c.638C>T 17:g.1498033G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440852 COSM975658 118753164 c.72C>T p.V24= Substitution - coding silent het 38 17:1509761-1509761 - - PATHOGENIC .80498 Variant of unknown origin 419 fresh/frozen - NOS primary 33 ENSP00000385177.4:p.Val24= ENST00000406424.8:c.72C>T 17:g.1509761G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57442400 COSM975652 118750864 c.636G>A p.P212= Substitution - coding silent het 38 17:1498035-1498035 - - NEUTRAL .02365 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000385177.4:p.Pro212= ENST00000406424.8:c.636G>A 17:g.1498035C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LUAD-CHTN-3090346 1765232 1669552 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV57440835 COSM356825 118753492 c.467T>C p.L156P Substitution - Missense 38 17:1507061-1507061 - - PATHOGENIC .92333 Variant of unknown origin 22980975 surgery - NOS primary 78 ENSP00000385177.4:p.Leu156Pro ENST00000406424.8:c.467T>C 17:g.1507061A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 NCI-H929 2809759 2666429 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV57441243 COSM2738184 118750970 c.502C>T p.P168S Substitution - Missense het 38 17:1507026-1507026 - - .52576 Variant of unknown origin 30545397 cell-line NS ENSP00000385177.4:p.Pro168Ser ENST00000406424.8:c.502C>T 17:g.1507026G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440600 COSM975655 118753178 c.504G>A p.P168= Substitution - coding silent het 38 17:1507024-1507024 - - NEUTRAL .04613 Variant of unknown origin 419 fresh/frozen - NOS primary 53 ENSP00000385177.4:p.Pro168= ENST00000406424.8:c.504G>A 17:g.1507024C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SNU-C2B 2302010 2167293 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV57440138 COSM2738166 118752548 c.864A>G p.G288= Substitution - coding silent het 38 17:1496675-1496675 - - PATHOGENIC .72859 Variant of unknown origin 24755471 cell-line NS ENSP00000385177.4:p.Gly288= ENST00000406424.8:c.864A>G 17:g.1496675T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 H157 2776238 2634374 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99052630 COSM7372286 118752473 c.638C>T p.P213L Substitution - Missense 38 17:1498033-1498033 - - NEUTRAL .05806 Variant of unknown origin 29681454 NS NS 59 ENSP00000385177.4:p.Pro213Leu ENST00000406424.8:c.638C>T 17:g.1498033G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC1T 1566773 1488580 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS n COSV57440954 COSN1193215 118751898 c.-575+96A>G p.? Unknown het 38 17:1516360-1516360 - - NEUTRAL .01043 Variant of unknown origin 323 surgery fresh/frozen primary 55 ENST00000406424.8:c.-575+96A>G 17:g.1516360T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GBC_22 2907868 2762051 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV57443533 COSM2738244 118752223 c.-184-5C>T p.? Unknown 38 17:1513984-1513984 - - NEUTRAL .0451 Variant of unknown origin 33563892 surgery-fixed NS 62 ENST00000406424.8:c.-184-5C>T 17:g.1513984G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SW1222 2302013 2167296 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439938 COSM4654771 118753788 c.-116T>C p.? Unknown het 38 17:1513911-1513911 - - PATHOGENIC .98734 Variant of unknown origin 24755471 cell-line NS ENST00000406424.8:c.-116T>C 17:g.1513911A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC123T 1919182 1806503 liver NS NS NS carcinoma NS NS NS y COSV57443268 COSN1193197 118750757 c.*787C>T p.? Unknown het 38 17:1495036-1495036 - - NEUTRAL .04496 Variant of unknown origin 323 fresh/frozen - NOS primary ENST00000406424.8:c.*787C>T 17:g.1495036G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK126_C01 1918880 1806201 liver NS NS NS carcinoma NS NS NS y COSV57441297 COSN1714053 118751820 c.-397C>T p.? Unknown hom 38 17:1515941-1515941 - - NEUTRAL .02907 Variant of unknown origin 322 fresh/frozen - NOS primary ENST00000406424.8:c.-397C>T 17:g.1515941G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SW1222 2302013 2167296 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439923 COSM4654769 118753779 c.502C>G p.P168A Substitution - Missense het 38 17:1507026-1507026 - - .59826 Variant of unknown origin 24755471 cell-line NS ENSP00000385177.4:p.Pro168Ala ENST00000406424.8:c.502C>G 17:g.1507026G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHEWS002 2294515 2160542 bone pelvis NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV57440707 COSM4579451 118752652 c.196T>C p.Y66H Substitution - Missense 38 17:1509308-1509308 - - PATHOGENIC .7629 Variant of unknown origin 25186949 NS NS 10 ENSP00000385177.4:p.Tyr66His ENST00000406424.8:c.196T>C 17:g.1509308A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LIM2405 2301994 2167277 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV57441800 COSM4642073 118753598 c.984T>C p.P328= Substitution - coding silent het 38 17:1496138-1496138 - - NEUTRAL .02457 Variant of unknown origin 24755471 cell-line NS ENSP00000385177.4:p.Pro328= ENST00000406424.8:c.984T>C 17:g.1496138A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 587284 1766769 1671089 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV57440902 COSM1210737 118751694 c.-184-1G>T p.? Unknown 38 17:1513980-1513980 - - PATHOGENIC .99647 Variant of unknown origin 22895193 surgery fresh/frozen primary ENST00000406424.8:c.-184-1G>T 17:g.1513980C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK042_C01 1918833 1806154 liver NS NS NS carcinoma NS NS NS y COSV57441764 COSN1714034 118750732 c.549-4020G>C p.? Unknown het 38 17:1502142-1502142 - - NEUTRAL .00011 Reported in another cancer sample as somatic 322 fresh/frozen - NOS primary ENST00000406424.8:c.549-4020G>C 17:g.1502142C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK042_C01 1918833 1806154 liver NS NS NS carcinoma NS NS NS y COSV57441768 COSN1714035 118750738 c.549-4023C>G p.? Unknown het 38 17:1502145-1502145 - - NEUTRAL .00026 Reported in another cancer sample as somatic 322 fresh/frozen - NOS primary ENST00000406424.8:c.549-4023C>G 17:g.1502145G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC142T 1919196 1806517 liver NS NS NS carcinoma NS NS NS y COSV57440930 COSN1193209 118751830 c.326+56_326+65del p.? Unknown het 38 17:1509124-1509133 - - Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000406424.8:c.326+56_326+65del 17:g.1509124_1509133del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 DLD1 2301972 2167255 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439847 COSM2150351 118750924 c.-175C>T p.? Unknown het 38 17:1513970-1513970 - - NEUTRAL .02048 Reported in another cancer sample as somatic 24755471 cell-line NS ENST00000406424.8:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 BN06T 1919137 1806458 liver NS NS NS carcinoma NS NS NS y COSV57442850 COSN1193203 118751765 c.735+37T>A p.? Unknown het 38 17:1497899-1497899 - - NEUTRAL .02871 Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000406424.8:c.735+37T>A 17:g.1497899A>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440057 COSM975648 118750851 c.1030C>T p.R344C Substitution - Missense het 38 17:1496092-1496092 - - NEUTRAL .09246 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 69 ENSP00000385177.4:p.Arg344Cys ENST00000406424.8:c.1030C>T 17:g.1496092G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 tumor_4137230 2634554 2494950 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441087 COSN23438524 118751550 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 440 NS primary 50 ENST00000406424.8:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 S00827 1759193 1663941 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV57441520 COSM312000 118751503 c.124A>T p.T42S Substitution - Missense 38 17:1509709-1509709 - - PATHOGENIC .95918 Reported in another cancer sample as somatic 22941188 fresh/frozen - NOS NS 73 ENSP00000385177.4:p.Thr42Ser ENST00000406424.8:c.124A>T 17:g.1509709T>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC132T 1919188 1806509 liver NS NS NS carcinoma NS NS NS y COSV57440930 COSN1193209 118751830 c.326+56_326+65del p.? Unknown het 38 17:1509124-1509133 - - Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000406424.8:c.326+56_326+65del 17:g.1509124_1509133del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 22T 2745864 2604567 liver NS NS NS other neoplasm NS NS y COSV57443437 COSN29899782 118754128 c.549-2614G>A p.? Unknown 38 17:1500736-1500736 - - NEUTRAL .00211 Confirmed somatic variant 660 NS primary 67 ENST00000406424.8:c.549-2614G>A 17:g.1500736C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC361TB 2340446 2205429 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57439946 COSN25044683 118751146 c.549-2149G>A p.? Unknown 38 17:1500271-1500271 - - NEUTRAL .0428 Confirmed somatic variant 647 NS primary 67 ENST00000406424.8:c.549-2149G>A 17:g.1500271C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHG-15-00821T 2634340 2494736 liver NS NS NS other neoplasm NS NS y COSV57441898 COSN26577197 118753408 c.33+50C>A p.? Unknown 38 17:1513403-1513403 - - NEUTRAL .18705 Confirmed somatic variant 660 NS primary 53 ENST00000406424.8:c.33+50C>A 17:g.1513403G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6008269-DNA_E01 2688150 2547132 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57443507 COSN27046300 118752766 c.548+3483T>A p.? Unknown 38 17:1503497-1503497 - - NEUTRAL .00478 Confirmed somatic variant 535 NS primary 77 ENST00000406424.8:c.548+3483T>A 17:g.1503497A>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2748840 2748840 2607543 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV57441547 COSM7324773 118751649 c.957+2T>C p.? Unknown 38 17:1496317-1496317 - - .53901 Confirmed somatic variant 29360550 surgery fresh/frozen NS 78 ENST00000406424.8:c.957+2T>C 17:g.1496317A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 DA16007 2635112 2495508 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV57440471 COSM6437186 118752416 c.735G>A p.E245= Substitution - coding silent 38 17:1497936-1497936 - - PATHOGENIC .98858 Confirmed somatic variant 677 NS primary 62 ENSP00000385177.4:p.Glu245= ENST00000406424.8:c.735G>A 17:g.1497936C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EE-A2GH-06 2121658 1995894 skin NS NS NS malignant_melanoma NS NS NS y COSV100233689 COSM7983353 118751173 c.1082G>T p.R361M Substitution - Missense 38 17:1495860-1495860 - - NEUTRAL .02005 Confirmed somatic variant 540 NS NS 34 ENSP00000385177.4:p.Arg361Met ENST00000406424.8:c.1082G>T 17:g.1495860C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV100233979 COSM9174724 118751334 c.778G>A p.E260K Substitution - Missense 38 17:1496761-1496761 - - PATHOGENIC .96769 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000385177.4:p.Glu260Lys ENST00000406424.8:c.778G>A 17:g.1496761C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV57439902 COSM6686175 118751345 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000385177.4:p.Arg130Trp ENST00000406424.8:c.388C>T 17:g.1508165G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-CD-8529-01 2198058 2066336 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57443033 COSM4064066 118750694 c.-29C>A p.? Unknown 38 17:1513514-1513514 - - PATHOGENIC .95385 Confirmed somatic variant 541 NS NS 65 ENST00000406424.8:c.-29C>A 17:g.1513514G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EE-A2MH-06 2121679 1995915 skin NS NS NS malignant_melanoma NS NS NS y COSV57441603 COSM3514448 118751137 c.1066C>T p.P356S Substitution - Missense 38 17:1495876-1495876 - - NEUTRAL .15283 Confirmed somatic variant 540 NS NS 66 ENSP00000385177.4:p.Pro356Ser ENST00000406424.8:c.1066C>T 17:g.1495876G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CN-AML-CR-21-Dx 2340285 2205268 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57442223 COSN19628996 118753119 c.326+113G>A p.? Unknown 38 17:1509065-1509065 - - NEUTRAL .00192 Confirmed somatic variant 544 blood-bone marrow primary 28 ENST00000406424.8:c.326+113G>A 17:g.1509065C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-BK-A6W3-01 2263446 2130430 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440002 COSM266711 118751075 c.1031G>A p.R344H Substitution - Missense 38 17:1496091-1496091 - - NEUTRAL .0033 Confirmed somatic variant 419 NS primary 34 ENSP00000385177.4:p.Arg344His ENST00000406424.8:c.1031G>A 17:g.1496091C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2785970 2785970 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 118751756 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000385177.4:p.Tyr230= ENST00000406424.8:c.690C>T 17:g.1497981G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 C0100T 2197804 2066082 kidney NS NS NS NS NS NS NS y COSV57440805 COSN15570238 118751904 c.549-3151A>T p.? Unknown 38 17:1501273-1501273 - - NEUTRAL .14618 Confirmed somatic variant 588 NS NS ENST00000406424.8:c.549-3151A>T 17:g.1501273T>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-A5-A0VP-01 1783327 1687326 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233618 COSM8819723 118751275 c.525G>A p.R175= Substitution - coding silent 38 17:1507003-1507003 - - NEUTRAL .06188 Confirmed somatic variant 419 fresh/frozen - NOS primary 74 ENSP00000385177.4:p.Arg175= ENST00000406424.8:c.525G>A 17:g.1507003C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 DN15007 2633582 2493978 breast NS NS NS carcinoma HER-positive_carcinoma NS NS y COSV57441312 COSM6349374 118751100 c.-175C>A p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .04999 Confirmed somatic variant 668 NS primary 46 ENST00000406424.8:c.-175C>A 17:g.1513970G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC361TA 2120615 1994851 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57439946 COSN25044683 118751146 c.549-2149G>A p.? Unknown 38 17:1500271-1500271 - - NEUTRAL .0428 Confirmed somatic variant 381 NS NS ENST00000406424.8:c.549-2149G>A 17:g.1500271C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6007594 2262933 2129917 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57441794 COSN15055521 118752991 c.326+263C>T p.? Unknown 38 17:1508915-1508915 - - NEUTRAL .00143 Confirmed somatic variant 535 NS primary ENST00000406424.8:c.326+263C>T 17:g.1508915G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-06-0171-02 2120251 1994487 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 118750924 c.-175C>T p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 329 NS NS 65 ENST00000406424.8:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-06-0171-01 2339818 2204801 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 118750924 c.-175C>T p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 329 NS primary 65 ENST00000406424.8:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-W3-AA1W-06 2339958 2204941 skin NS NS NS malignant_melanoma NS NS NS y COSV100233883 COSM8026356 118752037 c.341T>A p.F114Y Substitution - Missense 38 17:1508212-1508212 - - PATHOGENIC .99149 Confirmed somatic variant 540 NS NS 64 ENSP00000385177.4:p.Phe114Tyr ENST00000406424.8:c.341T>A 17:g.1508212A>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK176_C01 2194707 2062985 liver NS NS NS carcinoma NS NS NS y COSV57442289 COSN6099335 118753401 c.548+1383G>C p.? Unknown 38 17:1505597-1505597 - - NEUTRAL .02961 Confirmed somatic variant 322 NS NS ENST00000406424.8:c.548+1383G>C 17:g.1505597C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GCTK_444_T 2747468 2606171 stomach NS NS NS carcinoma NS NS NS y COSV100233770 COSM8558056 118753250 c.489C>T p.G163= Substitution - coding silent 38 17:1507039-1507039 - - NEUTRAL .15391 Confirmed somatic variant 683 NS primary ENSP00000385177.4:p.Gly163= ENST00000406424.8:c.489C>T 17:g.1507039G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 YURUB 2013679 1896311 skin NS NS NS malignant_melanoma NS NS NS y COSV57443209 COSM1709542 118753504 c.113C>T p.S38F Substitution - Missense het 38 17:1509720-1509720 - - PATHOGENIC .74112 Confirmed somatic variant 22842228 NS NS ENSP00000385177.4:p.Ser38Phe ENST00000406424.8:c.113C>T 17:g.1509720G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2293782 2293782 2159833 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma functioning NS NS y COSV57443083 COSM4608647 118753209 c.910G>T p.A304S Substitution - Missense 38 17:1496366-1496366 - - PATHOGENIC .85582 Confirmed somatic variant 24747642 surgery-fixed NS 44.5 ENSP00000385177.4:p.Ala304Ser ENST00000406424.8:c.910G>T 17:g.1496366C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 0187_CRUK_PC_0187_T1_DNA 2634990 2495386 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57441725 COSN26361667 118752025 c.548+4050G>A p.? Unknown 38 17:1502930-1502930 - - NEUTRAL .00259 Confirmed somatic variant 538 NS primary 62 ENST00000406424.8:c.548+4050G>A 17:g.1502930C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV57440779 COSM6398503 118751449 c.448G>A p.A150T Substitution - Missense 38 17:1507080-1507080 - - .61456 Confirmed somatic variant 676 NS primary 40 ENSP00000385177.4:p.Ala150Thr ENST00000406424.8:c.448G>A 17:g.1507080C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV57440757 COSM6399895 118751437 c.1049G>T p.S350I Substitution - Missense 38 17:1496073-1496073 - - PATHOGENIC .91364 Confirmed somatic variant 676 NS primary 40 ENSP00000385177.4:p.Ser350Ile ENST00000406424.8:c.1049G>T 17:g.1496073C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 Pat_53_B 2492893 2355507 NS NS NS NS malignant_melanoma NS NS NS y COSV57440676 COSM5851850 118751857 c.718G>A p.G240S Substitution - Missense 38 17:1497953-1497953 - - NEUTRAL .10276 Confirmed somatic variant 24265153 surgery-fixed NS 53 ENSP00000385177.4:p.Gly240Ser ENST00000406424.8:c.718G>A 17:g.1497953C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-BH-A0HA-01 1899939 1788623 breast NS NS NS carcinoma NS NS NS y COSV100233635 COSM7691643 118750515 c.686C>T p.T229M Substitution - Missense 38 17:1497985-1497985 - - NEUTRAL .00988 Confirmed somatic variant 414 fresh/frozen - NOS primary 31 ENSP00000385177.4:p.Thr229Met ENST00000406424.8:c.686C>T 17:g.1497985G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 AOCS-108-1-7 2196304 2064582 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441425 COSN8831789 118752647 c.327-216C>G p.? Unknown 38 17:1508442-1508442 - - NEUTRAL .14437 Confirmed somatic variant 585 NS NS ENST00000406424.8:c.327-216C>G 17:g.1508442G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-ZF-AA4X-01 2385833 2248665 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57440964 COSM7180871 118752046 c.824C>T p.S275L Substitution - Missense 38 17:1496715-1496715 - - NEUTRAL .01467 Confirmed somatic variant 413 NS primary 56 ENSP00000385177.4:p.Ser275Leu ENST00000406424.8:c.824C>T 17:g.1496715G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHG-95T 2634277 2494673 liver NS NS NS other neoplasm NS NS y COSV57443045 COSN26671163 118752761 c.*415C>A p.? Unknown 38 17:1495408-1495408 - - PATHOGENIC .76068 Confirmed somatic variant 660 NS primary 49 ENST00000406424.8:c.*415C>A 17:g.1495408G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EOPC-014_tumor_01 2633793 2494189 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 118751550 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 45 ENST00000406424.8:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AG-3885-01 1651560 1566347 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV100233650 COSM7526312 118753443 c.-28C>T p.? Unknown 38 17:1513513-1513513 - - PATHOGENIC .75567 Confirmed somatic variant 375 NS primary 71 ENST00000406424.8:c.-28C>T 17:g.1513513G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 sysucc-1024T 2504582 2366914 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442104 COSM5763189 118751668 c.186T>G p.L62= Substitution - coding silent 38 17:1509318-1509318 - - NEUTRAL .49978 Confirmed somatic variant 646 NS primary 71 ENSP00000385177.4:p.Leu62= ENST00000406424.8:c.186T>G 17:g.1509318A>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 ML_124_T_01 2688384 2547366 skin NS NS NS carcinoma NS NS NS y COSV57441732 COSN27612453 118751961 c.34-1069A>G p.? Unknown 38 17:1510868-1510868 - - NEUTRAL .00068 Confirmed somatic variant 656 NS primary 74 ENST00000406424.8:c.34-1069A>G 17:g.1510868T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 DA16008 2635113 2495509 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV57440471 COSM6437186 118752416 c.735G>A p.E245= Substitution - coding silent 38 17:1497936-1497936 - - PATHOGENIC .98858 Confirmed somatic variant 677 NS primary 62 ENSP00000385177.4:p.Glu245= ENST00000406424.8:c.735G>A 17:g.1497936C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC2157 1235084 1146870 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV57443001 COSM33344 118751244 c.716C>T p.S239F Substitution - Missense het 38 17:1497955-1497955 - - .65418 Confirmed somatic variant 16959974 cell-line primary 48 ENSP00000385177.4:p.Ser239Phe ENST00000406424.8:c.716C>T 17:g.1497955G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 ESOSCC162T 1860018 1750959 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440993 COSM1172380 118751609 c.122C>T p.S41F Substitution - Missense 38 17:1509711-1509711 - - PATHOGENIC .81311 Confirmed somatic variant 22877736 fresh/frozen - NOS primary 82 ENSP00000385177.4:p.Ser41Phe ENST00000406424.8:c.122C>T 17:g.1509711G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CRC-27T 2456797 2319634 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440751 COSN19718001 118752278 c.326+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 646 NS primary 69 ENST00000406424.8:c.326+396G>C 17:g.1508782C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D9-A4Z6-01 2121566 1995802 skin NS NS NS malignant_melanoma NS NS NS y COSV57442416 COSM3514457 118750812 c.-19C>T p.? Unknown 38 17:1513504-1513504 - - PATHOGENIC .8518 Confirmed somatic variant 540 NS NS 54 ENST00000406424.8:c.-19C>T 17:g.1513504G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PCSI_0476_Pa_P_526 2385500 2248332 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57440553 COSN17208512 118753586 c.549-3101C>A p.? Unknown 38 17:1501223-1501223 - - NEUTRAL .00218 Confirmed somatic variant 382 NS primary 43 ENST00000406424.8:c.549-3101C>A 17:g.1501223G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EB-A44O-01 2121602 1995838 skin NS NS NS malignant_melanoma NS NS NS y COSV100233746 COSM8129790 118752676 c.838C>A p.P280T Substitution - Missense 38 17:1496701-1496701 - - PATHOGENIC .85982 Confirmed somatic variant 540 NS NS 69 ENSP00000385177.4:p.Pro280Thr ENST00000406424.8:c.838C>A 17:g.1496701G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EB-A44O-01 2121602 1995838 skin NS NS NS malignant_melanoma NS NS NS y COSV100233745 COSM8129799 118752666 c.839C>T p.P280L Substitution - Missense 38 17:1496700-1496700 - - NEUTRAL .39106 Confirmed somatic variant 540 NS NS 69 ENSP00000385177.4:p.Pro280Leu ENST00000406424.8:c.839C>T 17:g.1496700G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 275 2748247 2606950 stomach NS NS NS carcinoma NS NS NS y COSV100233669 COSN30566516 118752466 c.548+96del p.? Unknown 38 17:1506890-1506890 - - Confirmed somatic variant 683 NS primary ENST00000406424.8:c.548+96del 17:g.1506890del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 ICGC_GBM85_tumor 2634877 2495273 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV57439887 COSN23285747 118751115 c.549-3738_549-3737del p.? Unknown 38 17:1501882-1501883 - - Confirmed somatic variant 379 NS primary ENST00000406424.8:c.549-3738_549-3737del 17:g.1501882_1501883del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 WGC067123 2549396 2410851 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440072 COSN28860754 118750941 c.439-117G>A p.? Unknown 38 17:1507206-1507206 - - NEUTRAL .06517 Confirmed somatic variant 646 NS primary 73 ENST00000406424.8:c.439-117G>A 17:g.1507206C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 WGC067123 2549396 2410851 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440057 COSM975648 118750851 c.1030C>T p.R344C Substitution - Missense 38 17:1496092-1496092 - - NEUTRAL .09246 Confirmed somatic variant 646 NS primary 73 ENSP00000385177.4:p.Arg344Cys ENST00000406424.8:c.1030C>T 17:g.1496092G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CPCG_0184_Pr_P_P2 2121453 1995689 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440490 COSN4905499 118752058 c.-185+418G>T p.? Unknown 38 17:1515009-1515009 - - NEUTRAL .0047 Confirmed somatic variant 537 NS NS ENST00000406424.8:c.-185+418G>T 17:g.1515009C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC2157 749715 668686 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57443014 COSM30714 118751254 c.651C>T p.F217= Substitution - coding silent het 38 17:1498020-1498020 - - PATHOGENIC .83995 Confirmed somatic variant 678 cell-line primary 48 ENSP00000385177.4:p.Phe217= ENST00000406424.8:c.651C>T 17:g.1498020G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T112 2658324 2518483 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441957 COSM6686173 118751756 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000385177.4:p.Tyr230= ENST00000406424.8:c.690C>T 17:g.1497981G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 345973 2144505 2013723 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441128 COSN5852672 118753112 c.735+12G>A p.? Unknown 38 17:1497924-1497924 - - NEUTRAL .00646 Confirmed somatic variant 22696596 NS NS 52 ENST00000406424.8:c.735+12G>A 17:g.1497924C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV100233793 COSM8151450 118751017 c.128C>A p.P43H Substitution - Missense 38 17:1509705-1509705 - - PATHOGENIC .88297 Confirmed somatic variant 540 NS NS 37 ENSP00000385177.4:p.Pro43His ENST00000406424.8:c.128C>A 17:g.1509705G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV100233872 COSM8146683 118752312 c.839C>A p.P280H Substitution - Missense 38 17:1496700-1496700 - - PATHOGENIC .73316 Confirmed somatic variant 540 NS NS 37 ENSP00000385177.4:p.Pro280His ENST00000406424.8:c.839C>A 17:g.1496700G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PCSI_0161_Pa_P_526 2339921 2204904 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441186 COSN16098920 118753395 c.438+186G>C p.? Unknown 38 17:1507929-1507929 - - NEUTRAL .00946 Confirmed somatic variant 382 NS primary 81 ENST00000406424.8:c.438+186G>C 17:g.1507929C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-XK-AAIW-01 2339713 2204696 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 118750878 c.581G>A p.R194H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 435 NS primary 78 ENSP00000385177.4:p.Arg194His ENST00000406424.8:c.581G>A 17:g.1498090C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6007546-DNA_A01 2549449 2410904 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442857 COSN23559361 118751748 c.34-1679C>G p.? Unknown 38 17:1511478-1511478 - - NEUTRAL .04212 Confirmed somatic variant 535 NS primary ENST00000406424.8:c.34-1679C>G 17:g.1511478G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2014_Lung_sq_66_T 2744937 2603640 lung NS NS NS carcinoma NS NS NS y COSV57440812 COSN13701328 118750767 c.34-25G>A p.? Unknown 38 17:1509824-1509824 - - NEUTRAL .16185 Confirmed somatic variant 583 NS primary 53 ENST00000406424.8:c.34-25G>A 17:g.1509824C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6007438-DNA_A01 2263456 2130440 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442932 COSN14857961 118751329 c.549-3471C>T p.? Unknown 38 17:1501593-1501593 - - NEUTRAL .01431 Confirmed somatic variant 535 NS primary ENST00000406424.8:c.549-3471C>T 17:g.1501593G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHG-12-09247T 2634292 2494688 liver NS NS NS other neoplasm NS NS y COSV57441538 COSN30040156 118753099 c.549-34C>T p.? Unknown 38 17:1498156-1498156 - - NEUTRAL .02254 Confirmed somatic variant 660 NS primary 48 ENST00000406424.8:c.549-34C>T 17:g.1498156G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV57440779 COSM6398503 118751449 c.448G>A p.A150T Substitution - Missense 38 17:1507080-1507080 - - .61456 Confirmed somatic variant 676 NS primary 40 ENSP00000385177.4:p.Ala150Thr ENST00000406424.8:c.448G>A 17:g.1507080C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV57440757 COSM6399895 118751437 c.1049G>T p.S350I Substitution - Missense 38 17:1496073-1496073 - - PATHOGENIC .91364 Confirmed somatic variant 676 NS primary 40 ENSP00000385177.4:p.Ser350Ile ENST00000406424.8:c.1049G>T 17:g.1496073C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV57442083 COSM5364466 118751917 c.-151A>G p.? Unknown het 38 17:1513946-1513946 - - NEUTRAL .29067 Confirmed somatic variant 25957691 NS NS 81 ENST00000406424.8:c.-151A>G 17:g.1513946T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV57442068 COSM5364464 118751910 c.560G>A p.R187H Substitution - Missense het 38 17:1498111-1498111 - - PATHOGENIC .97388 Confirmed somatic variant 25957691 NS NS 81 ENSP00000385177.4:p.Arg187His ENST00000406424.8:c.560G>A 17:g.1498111C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D1-A16N-01 1783513 1687512 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57439815 COSM975660 118751293 c.47G>A p.R16H Substitution - Missense 38 17:1509786-1509786 - - PATHOGENIC .95481 Confirmed somatic variant 419 fresh/frozen - NOS primary 51 ENSP00000385177.4:p.Arg16His ENST00000406424.8:c.47G>A 17:g.1509786C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 551 2478463 2341233 adrenal_gland adrenal_gland NS NS adrenal_cortical_adenoma NS NS NS y COSV57442792 COSM5613049 118751162 c.72C>G p.V24= Substitution - coding silent 38 17:1509761-1509761 - - PATHOGENIC .8448 Confirmed somatic variant 25490274 fixed - NOS primary 68 ENSP00000385177.4:p.Val24= ENST00000406424.8:c.72C>G 17:g.1509761G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-ER-A42K-06 2340113 2205096 skin NS NS NS malignant_melanoma NS NS NS y COSV57443110 COSM4894813 118751399 c.653C>T p.S218F Substitution - Missense 38 17:1498018-1498018 - - NEUTRAL .04612 Confirmed somatic variant 540 NS NS 40 ENSP00000385177.4:p.Ser218Phe ENST00000406424.8:c.653C>T 17:g.1498018G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 YUPAER 2439354 2302195 skin NS NS NS malignant_melanoma NS NS NS y COSV57440177 COSM5385733 118753070 c.351G>A p.M117I Substitution - Missense het 38 17:1508202-1508202 - - PATHOGENIC .75407 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 70 ENSP00000385177.4:p.Met117Ile ENST00000406424.8:c.351G>A 17:g.1508202C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-GM-A2DH-01 2187734 2056012 breast NS NS NS carcinoma NS NS NS y COSV100233735 COSM7700391 118751736 c.738G>A p.L246= Substitution - coding silent 38 17:1496801-1496801 - - PATHOGENIC .83189 Confirmed somatic variant 414 NS NS 58 ENSP00000385177.4:p.Leu246= ENST00000406424.8:c.738G>A 17:g.1496801C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 MSU2-c 2809979 2666641 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV100233979 COSM9174724 118751334 c.778G>A p.E260K Substitution - Missense 38 17:1496761-1496761 - - PATHOGENIC .96769 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000385177.4:p.Glu260Lys ENST00000406424.8:c.778G>A 17:g.1496761C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2932 2296135 2161738 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441581 COSM4692622 118750667 c.688T>C p.Y230H Substitution - Missense 38 17:1497983-1497983 - - PATHOGENIC .9847 Confirmed somatic variant 25344691 NS NS 78.08 ENSP00000385177.4:p.Tyr230His ENST00000406424.8:c.688T>C 17:g.1497983A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 MSU2-c 2809979 2666641 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 118751345 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000385177.4:p.Arg130Trp ENST00000406424.8:c.388C>T 17:g.1508165G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 364 2131821 2005885 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441008 COSM3722171 118751312 c.295G>A p.G99R Substitution - Missense 38 17:1509209-1509209 - - NEUTRAL .07332 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 74 ENSP00000385177.4:p.Gly99Arg ENST00000406424.8:c.295G>A 17:g.1509209C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-A5-A2K7-01 2198265 2066543 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233685 COSN31545877 118753362 c.*288C>A p.? Unknown 38 17:1495535-1495535 - - NEUTRAL .03426 Confirmed somatic variant 419 NS NS 41 ENST00000406424.8:c.*288C>A 17:g.1495535G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV57439973 COSM5851852 118752457 c.391G>A p.E131K Substitution - Missense 38 17:1508162-1508162 - - .54001 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000385177.4:p.Glu131Lys ENST00000406424.8:c.391G>A 17:g.1508162C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2857095 2857095 2712395 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105203823 COSM9525077 118753727 c.830C>T p.S277L Substitution - Missense 38 17:1496709-1496709 - - PATHOGENIC .74004 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000385177.4:p.Ser277Leu ENST00000406424.8:c.830C>T 17:g.1496709G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV57439956 COSM5851848 118752448 c.1025G>A p.S342N Substitution - Missense 38 17:1496097-1496097 - - NEUTRAL .01037 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000385177.4:p.Ser342Asn ENST00000406424.8:c.1025G>A 17:g.1496097C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 19 2747991 2606694 stomach NS NS NS carcinoma NS NS NS y COSV100233839 COSN30565011 118752077 c.1062+74G>T p.? Unknown 38 17:1495986-1495986 - - NEUTRAL .01269 Confirmed somatic variant 683 NS primary ENST00000406424.8:c.1062+74G>T 17:g.1495986C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 H2347 2776270 2634406 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99052641 COSM7372284 118751282 c.285G>C p.Q95H Substitution - Missense 38 17:1509219-1509219 - - PATHOGENIC .91716 Confirmed somatic variant 29681454 NS NS 54 ENSP00000385177.4:p.Gln95His ENST00000406424.8:c.285G>C 17:g.1509219C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CPCG0211-F1 2340573 2205556 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57442127 COSN29616394 118751891 c.735+465_735+466dup p.? Unknown 38 17:1497485-1497486 - - Confirmed somatic variant 537 NS primary ENST00000406424.8:c.735+465_735+466dup 17:g.1497484_1497485dup INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 61 2497169 2359521 small_intestine duodenum NS NS adenoma NS NS NS y COSV57441337 COSM5740783 118750805 c.-125T>C p.? Unknown 38 17:1513920-1513920 - - PATHOGENIC .99507 Confirmed somatic variant 26806338 fresh/frozen - NOS primary ENST00000406424.8:c.-125T>C 17:g.1513920A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-06-2566-01 2178226 2046524 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233679 COSM7489154 118752018 c.-603C>A p.? Unknown 38 17:1516484-1516484 - - NEUTRAL .13026 Confirmed somatic variant 329 NS NS 23 ENST00000406424.8:c.-603C>A 17:g.1516484G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PCSI_0048_Pa_P 1653156 1567943 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441452 COSN8240383 118750722 c.34-230A>G p.? Unknown 38 17:1510029-1510029 - - NEUTRAL .04077 Confirmed somatic variant 382 fresh/frozen - NOS primary ENST00000406424.8:c.34-230A>G 17:g.1510029T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PD9000a 1613700 1532748 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441286 COSN22701850 118753651 c.33+1485C>G p.? Unknown 38 17:1511968-1511968 - - .68966 Confirmed somatic variant 652 NS NS ENST00000406424.8:c.33+1485C>G 17:g.1511968G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2932 2658347 2518506 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441581 COSM4692622 118750667 c.688T>C p.Y230H Substitution - Missense 38 17:1497983-1497983 - - PATHOGENIC .9847 Confirmed somatic variant 27149842 NS NS 78.08 ENSP00000385177.4:p.Tyr230His ENST00000406424.8:c.688T>C 17:g.1497983A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC139T 1919194 1806515 liver NS NS NS carcinoma NS NS NS y COSV57440912 COSN6414831 118754094 c.326+146T>C p.? Unknown 38 17:1509032-1509032 - - NEUTRAL .00699 Confirmed somatic variant 323 fresh/frozen - NOS primary ENST00000406424.8:c.326+146T>C 17:g.1509032A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HCC139T 1919194 1806515 liver NS NS NS carcinoma NS NS NS y COSV57440917 COSN6414832 118754098 c.326+144T>C p.? Unknown 38 17:1509034-1509034 - - NEUTRAL .00818 Confirmed somatic variant 323 fresh/frozen - NOS primary ENST00000406424.8:c.326+144T>C 17:g.1509034A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-85-A4CL-01 2195132 2063410 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233961 COSM8679772 118752065 c.1116C>G p.I372M Substitution - Missense 38 17:1495826-1495826 - - PATHOGENIC .73673 Confirmed somatic variant 418 NS NS 65 ENSP00000385177.4:p.Ile372Met ENST00000406424.8:c.1116C>G 17:g.1495826G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2843839 2843839 2699247 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS y COSV105883442 COSM9973989 118752351 c.1049del p.S350Tfs*11 Deletion - Frameshift 38 17:1496073-1496073 - - Confirmed somatic variant 27655895 blood-bone marrow recurrent 6 ENSP00000385177.4:p.Ser350ThrfsTer11 ENST00000406424.8:c.1049del 17:g.1496073del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 8058339 2121213 1995449 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441419 COSN7160500 118752542 c.-225T>G p.? Unknown 38 17:1515467-1515467 - - NEUTRAL .0841 Confirmed somatic variant 328 NS NS ENST00000406424.8:c.-225T>G 17:g.1515467A>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CSCC-27-T 2292469 2158533 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441071 COSM4488765 118751629 c.109C>T p.L37= Substitution - coding silent het 38 17:1509724-1509724 - - PATHOGENIC .75042 Confirmed somatic variant 25303977 surgery fresh/frozen primary 72 ENSP00000385177.4:p.Leu37= ENST00000406424.8:c.109C>T 17:g.1509724G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T1222 2658242 2518401 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 118751345 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 71.91 ENSP00000385177.4:p.Arg130Trp ENST00000406424.8:c.388C>T 17:g.1508165G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D9-A6EC-06 2262880 2129864 skin NS NS NS malignant_melanoma NS NS NS y COSV100233657 COSM8115635 118750787 c.395C>T p.S132F Substitution - Missense 38 17:1508158-1508158 - - PATHOGENIC .94511 Confirmed somatic variant 540 NS NS 56 ENSP00000385177.4:p.Ser132Phe ENST00000406424.8:c.395C>T 17:g.1508158G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PCSI_0048_Pa_P_526 2197258 2065536 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441452 COSN8240383 118750722 c.34-230A>G p.? Unknown 38 17:1510029-1510029 - - NEUTRAL .04077 Confirmed somatic variant 382 NS NS ENST00000406424.8:c.34-230A>G 17:g.1510029T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CPCG0217-F1 2340498 2205481 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440046 COSN16288830 118752695 c.548+2259T>A p.? Unknown 38 17:1504721-1504721 - - NEUTRAL .03225 Confirmed somatic variant 537 NS primary ENST00000406424.8:c.548+2259T>A 17:g.1504721A>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-F1-6177-01 2198156 2066434 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233696 COSN30497832 118753064 c.-640C>T p.? Unknown 38 17:1516521-1516521 - - NEUTRAL .14094 Confirmed somatic variant 541 NS NS 90 ENST00000406424.8:c.-640C>T 17:g.1516521G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 I2L-P24Tb-Tumor-Biopsy 2433484 2296365 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV57441627 COSM5364256 118750560 c.727G>A p.D243N Substitution - Missense het 38 17:1497944-1497944 - - PATHOGENIC .70948 Confirmed somatic variant 25957691 NS NS 60 ENSP00000385177.4:p.Asp243Asn ENST00000406424.8:c.727G>A 17:g.1497944C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LICA-CN-HCC_WGS_016T 2634223 2494619 liver NS NS NS other neoplasm NS NS y COSV57440981 COSN26616313 118751030 c.-184-173C>T p.? Unknown 38 17:1514152-1514152 - - NEUTRAL .00383 Confirmed somatic variant 660 NS primary 48 ENST00000406424.8:c.-184-173C>T 17:g.1514152G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6005500-DNA_A01 2262738 2129722 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57441040 COSN17309196 118750991 c.327-355C>T p.? Unknown 38 17:1508581-1508581 - - NEUTRAL .05546 Confirmed somatic variant 535 NS primary ENST00000406424.8:c.327-355C>T 17:g.1508581G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-GN-A8LK-06 2340243 2205226 skin NS NS NS malignant_melanoma NS NS NS y COSV100233562 COSM7958046 118753543 c.279G>A p.E93= Substitution - coding silent 38 17:1509225-1509225 - - PATHOGENIC .7441 Confirmed somatic variant 540 NS NS 70 ENSP00000385177.4:p.Glu93= ENST00000406424.8:c.279G>A 17:g.1509225C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 4-2 2746099 2604802 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441758 COSN28835429 118751215 c.549-85G>A p.? Unknown 38 17:1498207-1498207 - - NEUTRAL .00964 Confirmed somatic variant 646 NS primary 46 ENST00000406424.8:c.549-85G>A 17:g.1498207C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D9-A6EC-06 2262880 2129864 skin NS NS NS malignant_melanoma NS NS NS y COSV100233656 COSM8115268 118750774 c.396C>T p.S132= Substitution - coding silent 38 17:1508157-1508157 - - PATHOGENIC .89222 Confirmed somatic variant 540 NS NS 56 ENSP00000385177.4:p.Ser132= ENST00000406424.8:c.396C>T 17:g.1508157G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2785969 2785969 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 118751756 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000385177.4:p.Tyr230= ENST00000406424.8:c.690C>T 17:g.1497981G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 4-2 2746099 2604802 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441742 COSM3701153 118751204 c.915G>T p.W305C Substitution - Missense 38 17:1496361-1496361 - - PATHOGENIC .95169 Confirmed somatic variant 646 NS primary 46 ENSP00000385177.4:p.Trp305Cys ENST00000406424.8:c.915G>T 17:g.1496361C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2785971 2785971 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 118751756 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000385177.4:p.Tyr230= ENST00000406424.8:c.690C>T 17:g.1497981G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CN-AML-NR-08-Dx 2456284 2319121 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 118750660 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 blood-bone marrow primary ENST00000406424.8:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK298_C01 2120999 1995235 liver NS NS NS carcinoma NS NS NS y COSV57441742 COSM3701153 118751204 c.915G>T p.W305C Substitution - Missense 38 17:1496361-1496361 - - PATHOGENIC .95169 Confirmed somatic variant 322 NS NS ENSP00000385177.4:p.Trp305Cys ENST00000406424.8:c.915G>T 17:g.1496361C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T_CCA_SG_4 2688136 2547118 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57442188 COSN27227981 118752507 c.548+1837dup p.? Unknown 38 17:1505153-1505154 - - Confirmed somatic variant 653 NS primary 61 ENST00000406424.8:c.548+1837dup 17:g.1505153dup INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6005500-DNA_C01 2549483 2410938 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442243 COSN23565574 118753269 c.548+3134G>A p.? Unknown 38 17:1503846-1503846 - - NEUTRAL .0167 Confirmed somatic variant 535 NS primary ENST00000406424.8:c.548+3134G>A 17:g.1503846C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 A001-T-S01 2757354 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV100233671 COSM7411841 118752236 c.466C>A p.L156M Substitution - Missense 38 17:1507062-1507062 - - .59764 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000385177.4:p.Leu156Met ENST00000406424.8:c.466C>A 17:g.1507062G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 38T 2745883 2604586 liver NS NS NS other neoplasm NS NS y COSV57442315 COSN29975831 118751497 c.-185+521dup p.? Unknown 38 17:1514924-1514925 - - Confirmed somatic variant 660 NS primary 62 ENST00000406424.8:c.-185+521dup 17:g.1514924dup INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PD_01 2688657 2547639 skin shoulder NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440218 COSM6867459 118753349 c.507C>A p.P169= Substitution - coding silent het 38 17:1507021-1507021 - - .63631 Confirmed somatic variant 24662767 surgery fresh/frozen NS 71 ENSP00000385177.4:p.Pro169= ENST00000406424.8:c.507C>A 17:g.1507021G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T306558 2658252 2518411 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441669 COSM6686185 118751572 c.809T>C p.M270T Substitution - Missense 38 17:1496730-1496730 - - .64209 Confirmed somatic variant 27149842 NS NS 80.41 ENSP00000385177.4:p.Met270Thr ENST00000406424.8:c.809T>C 17:g.1496730A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-DA-A960-01 2380407 2243239 skin NS NS NS malignant_melanoma NS NS NS y COSV100233581 COSM8029324 118751408 c.-77+1dup p.? Unknown 38 17:1513873-1513874 - - Confirmed somatic variant 540 NS primary 73 ENST00000406424.8:c.-77+1dup 17:g.1513873dup INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-LP-A4AX-01 2193354 2061632 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441157 COSM4829770 118751185 c.-30G>A p.? Unknown 38 17:1513515-1513515 - - PATHOGENIC .84408 Confirmed somatic variant 415 NS NS 45 ENST00000406424.8:c.-30G>A 17:g.1513515C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 AOCS-139-12-5 2185820 2054117 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441924 COSM3983266 118751884 c.-38C>G p.? Unknown 38 17:1513523-1513523 - - PATHOGENIC .9676 Confirmed somatic variant 585 NS NS ENST00000406424.8:c.-38C>G 17:g.1513523G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T691 2658541 2518700 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 118751345 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 65.58 ENSP00000385177.4:p.Arg130Trp ENST00000406424.8:c.388C>T 17:g.1508165G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GCTK_16444_T 2747525 2606228 stomach NS NS NS carcinoma NS NS NS y COSV100233973 COSM8588882 118750606 c.327-7del p.? Unknown 38 17:1508239-1508239 - - Confirmed somatic variant 683 NS primary ENST00000406424.8:c.327-7del 17:g.1508239del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CSCC-20-T 2292468 2158532 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441169 COSM4508387 118753002 c.545C>T p.T182I Substitution - Missense het 38 17:1506983-1506983 - - PATHOGENIC .87428 Confirmed somatic variant 25303977 surgery fresh/frozen primary 93 ENSP00000385177.4:p.Thr182Ile ENST00000406424.8:c.545C>T 17:g.1506983G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HUB-02-B2-006 2607081 2466795 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442265 COSM6053586 118750952 c.1087G>C p.D363H Substitution - Missense 38 17:1495855-1495855 - - NEUTRAL .0652 Confirmed somatic variant 670 organoid culture NS ENSP00000385177.4:p.Asp363His ENST00000406424.8:c.1087G>C 17:g.1495855C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LICA-CN-HCC_WGS_009T 2634216 2494612 liver NS NS NS other neoplasm NS NS y COSV57440248 COSN26517209 118751793 c.33+1573A>C p.? Unknown 38 17:1511880-1511880 - - NEUTRAL .00604 Confirmed somatic variant 660 NS primary 52 ENST00000406424.8:c.33+1573A>C 17:g.1511880T>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T1224 2658634 2518793 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440352 COSM5642741 118750821 c.635C>T p.P212L Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .00382 Confirmed somatic variant 27149842 NS NS 57.75 ENSP00000385177.4:p.Pro212Leu ENST00000406424.8:c.635C>T 17:g.1498036G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EOPC-139_tumor_01 2549437 2410892 prostate NS NS NS carcinoma NS NS NS y COSV57440751 COSN19718001 118752278 c.326+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 534 NS primary 47 ENST00000406424.8:c.326+396G>C 17:g.1508782C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 tumor_4176133 2121030 1995266 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441778 COSN4768428 118752409 c.151-151G>A p.? Unknown 38 17:1509504-1509504 - - NEUTRAL .16975 Confirmed somatic variant 440 NS NS ENST00000406424.8:c.151-151G>A 17:g.1509504C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AP-A1DM-01 2198333 2066611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233687 COSM8955248 118753366 c.719G>A p.G240D Substitution - Missense 38 17:1497952-1497952 - - NEUTRAL .35784 Confirmed somatic variant 419 NS NS 60 ENSP00000385177.4:p.Gly240Asp ENST00000406424.8:c.719G>A 17:g.1497952C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 A001-T-S02 2757355 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV100233671 COSM7411841 118752236 c.466C>A p.L156M Substitution - Missense 38 17:1507062-1507062 - - .59764 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000385177.4:p.Leu156Met ENST00000406424.8:c.466C>A 17:g.1507062G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-19-1787-01 2178217 2046515 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233576 COSM7466631 118750748 c.621C>T p.P207= Substitution - coding silent 38 17:1498050-1498050 - - NEUTRAL .06315 Confirmed somatic variant 329 NS NS 48 ENSP00000385177.4:p.Pro207= ENST00000406424.8:c.621C>T 17:g.1498050G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 8016470 1842414 1735679 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441913 COSN7160484 118752299 c.548+327G>C p.? Unknown 38 17:1506653-1506653 - - NEUTRAL .03287 Confirmed somatic variant 328 cell-line NS ENST00000406424.8:c.548+327G>C 17:g.1506653C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 cSCCP2 1604870 1524189 skin hand NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440547 COSM137654 118751222 c.-123C>T p.? Unknown 38 17:1513918-1513918 - - PATHOGENIC .98532 Confirmed somatic variant 21984974 surgery - NOS primary 84 ENST00000406424.8:c.-123C>T 17:g.1513918G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AA-A010-01 1651109 1565896 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57439795 COSM178159 118752490 c.559C>T p.R187C Substitution - Missense 38 17:1498112-1498112 - - PATHOGENIC .91324 Confirmed somatic variant 22810696 376 NS NS 46 ENSP00000385177.4:p.Arg187Cys ENST00000406424.8:c.559C>T 17:g.1498112G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D1-A1NS-01 2198290 2066568 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233692 COSM8852950 118754121 c.607C>T p.P203S Substitution - Missense 38 17:1498064-1498064 - - NEUTRAL .10371 Confirmed somatic variant 419 NS NS 53 ENSP00000385177.4:p.Pro203Ser ENST00000406424.8:c.607C>T 17:g.1498064G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 118751923 c.326+388_326+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 60 ENST00000406424.8:c.326+388_326+389insC 17:g.1508789_1508790insG INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T189255 2658275 2518434 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57443168 COSM6686179 118751682 c.674G>A p.S225N Substitution - Missense 38 17:1497997-1497997 - - NEUTRAL .02559 Confirmed somatic variant 27149842 NS NS 77.16 ENSP00000385177.4:p.Ser225Asn ENST00000406424.8:c.674G>A 17:g.1497997C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2275_T 2194907 2063185 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441332 COSN8602376 118751326 c.34-25G>T p.? Unknown 38 17:1509824-1509824 - - NEUTRAL .2918 Confirmed somatic variant 583 NS NS ENST00000406424.8:c.34-25G>T 17:g.1509824C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AA-3672-01 1651015 1565802 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57440002 COSM266711 118751075 c.1031G>A p.R344H Substitution - Missense 38 17:1496091-1496091 - - NEUTRAL .0033 Confirmed somatic variant 22810696 376 NS NS 90 ENSP00000385177.4:p.Arg344His ENST00000406424.8:c.1031G>A 17:g.1496091C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PD40845k_lo0005 2875098 2729864 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma non_papillary_transitional_cell_carcinoma_non_invasive NS y COSV105203812 COSN32152386 118751805 c.549-4279G>A p.? Unknown 38 17:1502401-1502401 - - NEUTRAL .03905 Confirmed somatic variant 33004514 surgery-fixed NS 67 ENST00000406424.8:c.549-4279G>A 17:g.1502401C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 APGI-AMP-3734 2866052 2721129 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105203794 COSM9623940 118750649 c.359G>A p.R120Q Substitution - Missense 38 17:1508194-1508194 - - PATHOGENIC .98657 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000385177.4:p.Arg120Gln ENST00000406424.8:c.359G>A 17:g.1508194C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 C91 2293724 2159788 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439873 COSM4444568 118751389 c.362T>C p.I121T Substitution - Missense het 38 17:1508191-1508191 - - PATHOGENIC .99126 Confirmed somatic variant 24211491 NS NS ENSP00000385177.4:p.Ile121Thr ENST00000406424.8:c.362T>C 17:g.1508191A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 12 2747984 2606687 stomach NS NS NS carcinoma NS NS NS y COSV57440057 COSM975648 118750851 c.1030C>T p.R344C Substitution - Missense 38 17:1496092-1496092 - - NEUTRAL .09246 Confirmed somatic variant 683 NS primary ENSP00000385177.4:p.Arg344Cys ENST00000406424.8:c.1030C>T 17:g.1496092G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T3611 2658318 2518477 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442475 COSM6686187 118750841 c.403A>C p.N135H Substitution - Missense 38 17:1508150-1508150 - - PATHOGENIC .81961 Confirmed somatic variant 27149842 NS NS 69.08 ENSP00000385177.4:p.Asn135His ENST00000406424.8:c.403A>C 17:g.1508150T>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SS6003320 2193473 2061751 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442833 COSN8674007 118751515 c.-574-51G>C p.? Unknown 38 17:1516169-1516169 - - NEUTRAL .09524 Confirmed somatic variant 535 NS NS ENST00000406424.8:c.-574-51G>C 17:g.1516169C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T207 2658316 2518475 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442201 COSM4692620 118751865 c.805A>G p.M269V Substitution - Missense 38 17:1496734-1496734 - - NEUTRAL .14185 Confirmed somatic variant 27149842 NS NS 72.83 ENSP00000385177.4:p.Met269Val ENST00000406424.8:c.805A>G 17:g.1496734T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233829 COSM7472155 118753144 c.-67A>C p.? Unknown 38 17:1513552-1513552 - - PATHOGENIC .93138 Confirmed somatic variant 329 NS NS 53 ENST00000406424.8:c.-67A>C 17:g.1513552T>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 0129_CRUK_PC_0129_T1_DNA 2634968 2495364 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440086 COSN26093849 118751107 c.549-617G>A p.? Unknown 38 17:1498739-1498739 - - NEUTRAL .0021 Confirmed somatic variant 538 NS primary 55 ENST00000406424.8:c.549-617G>A 17:g.1498739C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442897 COSM6225141 118752714 c.758C>T p.P253L Substitution - Missense 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 646 NS primary 45 ENSP00000385177.4:p.Pro253Leu ENST00000406424.8:c.758C>T 17:g.1496781G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442916 COSN26437000 118752724 c.439-87G>A p.? Unknown 38 17:1507176-1507176 - - NEUTRAL .11296 Confirmed somatic variant 646 NS primary 45 ENST00000406424.8:c.439-87G>A 17:g.1507176C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 Patient_1 2443644 2306483 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV57442180 COSN18837027 118751664 c.549-1426G>T p.? Unknown 38 17:1499548-1499548 - - NEUTRAL .03782 Confirmed somatic variant 26082451 surgery fresh/frozen NS 70 ENST00000406424.8:c.549-1426G>T 17:g.1499548C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SDC5 2564866 2426260 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV57439731 COSM5987990 118752436 c.1008_1009del p.C337Lfs*30 Deletion - Frameshift 38 17:1496115-1496116 - - Confirmed somatic variant 27103403 surgery fresh/frozen NS ENSP00000385177.4:p.Cys337LeufsTer30 ENST00000406424.8:c.1008_1009del 17:g.1496115_1496116del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-VQ-A8P2-01 2339964 2204947 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233726 COSM8162258 118751087 c.741G>T p.K247N Substitution - Missense 38 17:1496798-1496798 - - PATHOGENIC .91255 Confirmed somatic variant 541 NS primary 68 ENSP00000385177.4:p.Lys247Asn ENST00000406424.8:c.741G>T 17:g.1496798C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EOPC-171_tumor_01 2633752 2494148 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 118751550 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 50 ENST00000406424.8:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 WGC002974 2785035 2645151 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV100233732 COSM7425448 118753837 c.626C>G p.T209S Substitution - Missense 38 17:1498045-1498045 - - NEUTRAL .0814 Confirmed somatic variant 25526346 surgery fresh/frozen primary 45 ENSP00000385177.4:p.Thr209Ser ENST00000406424.8:c.626C>G 17:g.1498045G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 tumor_4144951 2385475 2248307 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57439887 COSN23285747 118751115 c.549-3738_549-3737del p.? Unknown 38 17:1501882-1501883 - - Confirmed somatic variant 440 NS primary 62 ENST00000406424.8:c.549-3738_549-3737del 17:g.1501882_1501883del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442923 COSN26436233 118752731 c.327-162T>C p.? Unknown 38 17:1508388-1508388 - - NEUTRAL .06716 Confirmed somatic variant 646 NS primary 45 ENST00000406424.8:c.327-162T>C 17:g.1508388A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-3M-AB46-01 2457336 2320173 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233619 COSM8193053 118753877 c.1068G>A p.P356= Substitution - coding silent 38 17:1495874-1495874 - - NEUTRAL .00578 Confirmed somatic variant 541 NS primary 70 ENSP00000385177.4:p.Pro356= ENST00000406424.8:c.1068G>A 17:g.1495874C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EC-A24G-01 2198318 2066596 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233972 COSM8814445 118753192 c.324C>T p.H108= Substitution - coding silent 38 17:1509180-1509180 - - .56858 Confirmed somatic variant 419 NS NS 57 ENSP00000385177.4:p.His108= ENST00000406424.8:c.324C>T 17:g.1509180G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 BD49T 2459910 2322747 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57441395 COSN20046519 118753832 c.*115G>A p.? Unknown 38 17:1495708-1495708 - - NEUTRAL .07967 Confirmed somatic variant 658 NS primary 50 ENST00000406424.8:c.*115G>A 17:g.1495708C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AX-A3FT-01 2198367 2066645 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233984 COSM9040758 118752485 c.-107G>A p.? Unknown 38 17:1513902-1513902 - - NEUTRAL .01064 Confirmed somatic variant 419 NS NS 64 ENST00000406424.8:c.-107G>A 17:g.1513902C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 8068611 2197319 2065597 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57439861 COSN9222116 118752745 c.549-2531G>A p.? Unknown 38 17:1500653-1500653 - - NEUTRAL .00011 Confirmed somatic variant 586 NS NS ENST00000406424.8:c.549-2531G>A 17:g.1500653C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 8016470 1842414 1735679 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441905 COSN7160476 118752292 c.548+4086A>T p.? Unknown 38 17:1502894-1502894 - - NEUTRAL .00239 Confirmed somatic variant 328 cell-line NS ENST00000406424.8:c.548+4086A>T 17:g.1502894T>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 J31_T 2194998 2063276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441106 COSN8602377 118752608 c.-76-24A>T p.? Unknown 38 17:1513585-1513585 - - NEUTRAL .01819 Confirmed somatic variant 583 NS NS ENST00000406424.8:c.-76-24A>T 17:g.1513585T>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GCYC_414_T 2747633 2606336 stomach NS NS NS carcinoma NS NS NS y COSV57442897 COSM6225141 118752714 c.758C>T p.P253L Substitution - Missense 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 683 NS primary ENSP00000385177.4:p.Pro253Leu ENST00000406424.8:c.758C>T 17:g.1496781G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-HU-A4GN-01 2198035 2066313 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440664 COSM4064059 118750507 c.461A>G p.D154G Substitution - Missense 38 17:1507067-1507067 - - PATHOGENIC .86353 Confirmed somatic variant 541 NS NS 61 ENSP00000385177.4:p.Asp154Gly ENST00000406424.8:c.461A>G 17:g.1507067T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233827 COSM7468116 118753132 c.577G>A p.D193N Substitution - Missense 38 17:1498094-1498094 - - PATHOGENIC .97388 Confirmed somatic variant 329 NS NS 53 ENSP00000385177.4:p.Asp193Asn ENST00000406424.8:c.577G>A 17:g.1498094C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EXTERN_MELA_20140526_033 2839346 2695112 skin trunk NS NS malignant_melanoma NS NS NS y COSV57441603 COSM3514448 118751137 c.1066C>T p.P356S Substitution - Missense 38 17:1495876-1495876 - - NEUTRAL .15283 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000385177.4:p.Pro356Ser ENST00000406424.8:c.1066C>T 17:g.1495876G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D1-A2G0-01 2198422 2066700 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233799 COSM8816674 118752116 c.1063-1G>A p.? Unknown 38 17:1495880-1495880 - - PATHOGENIC .91507 Confirmed somatic variant 419 NS NS 70 ENST00000406424.8:c.1063-1G>A 17:g.1495880C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233824 COSM7469318 118753123 c.651C>A p.F217L Substitution - Missense 38 17:1498020-1498020 - - PATHOGENIC .9186 Confirmed somatic variant 329 NS NS 53 ENSP00000385177.4:p.Phe217Leu ENST00000406424.8:c.651C>A 17:g.1498020G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2014_Lung_sq_23_T 2744894 2603597 lung NS NS NS carcinoma NS NS NS y COSV57441227 COSN28674085 118751363 c.439-74C>G p.? Unknown 38 17:1507163-1507163 - - NEUTRAL .08275 Confirmed somatic variant 583 NS primary 74 ENST00000406424.8:c.439-74C>G 17:g.1507163G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC197T 1652970 1567757 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442094 COSN19368247 118753422 c.549-2837del p.? Unknown 38 17:1500978-1500978 - - Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.549-2837del 17:g.1500978del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 tumor_4170844 2634759 2495155 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57442780 COSN25365884 118750586 c.-184-376G>A p.? Unknown 38 17:1514355-1514355 - - NEUTRAL .01295 Confirmed somatic variant 440 NS primary 5 ENST00000406424.8:c.-184-376G>A 17:g.1514355C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 ccRCC-55 1980791 1867037 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV57440030 COSN2470106 118751476 c.34-1705C>A p.? Unknown 38 17:1511504-1511504 - - PATHOGENIC .79646 Confirmed somatic variant 23797736 NS NS ENST00000406424.8:c.34-1705C>A 17:g.1511504G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T_CCA_SG_20 2688092 2547074 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 118751923 c.326+388_326+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 56 ENST00000406424.8:c.326+388_326+389insC 17:g.1508789_1508790insG INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 0198_CRUK_PC_0198_T1_DNA 2634978 2495374 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57442458 COSN26174651 118750591 c.548+1435G>C p.? Unknown 38 17:1505545-1505545 - - NEUTRAL .02245 Confirmed somatic variant 538 NS primary 57 ENST00000406424.8:c.548+1435G>C 17:g.1505545C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHG-2015-31289T 2634363 2494759 liver NS NS NS other neoplasm NS NS y COSV57440322 COSM6237841 118750715 c.-96C>A p.? Unknown 38 17:1513891-1513891 - - NEUTRAL .148 Confirmed somatic variant 660 NS primary 45 ENST00000406424.8:c.-96C>A 17:g.1513891G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-C5-A3HF-01 2193301 2061579 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233649 COSM8649284 118752702 c.19C>T p.L7= Substitution - coding silent 38 17:1513467-1513467 - - PATHOGENIC .80721 Confirmed somatic variant 415 NS NS 24 ENSP00000385177.4:p.Leu7= ENST00000406424.8:c.19C>T 17:g.1513467G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-D9-A4Z6-06 2263151 2130135 skin NS NS NS malignant_melanoma NS NS NS y COSV57442416 COSM3514457 118750812 c.-19C>T p.? Unknown 38 17:1513504-1513504 - - PATHOGENIC .8518 Confirmed somatic variant 540 NS NS 54 ENST00000406424.8:c.-19C>T 17:g.1513504G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233844 COSM9192840 118752084 c.-20A>G p.? Unknown 38 17:1513505-1513505 - - PATHOGENIC .98841 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENST00000406424.8:c.-20A>G 17:g.1513505T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 NYZ-1200985T 2633889 2494285 stomach NS NS NS carcinoma NS NS NS y COSV57442167 COSN24444054 118752229 c.549-1313C>T p.? Unknown 38 17:1499435-1499435 - - NEUTRAL .01503 Confirmed somatic variant 371 NS primary 45 ENST00000406424.8:c.549-1313C>T 17:g.1499435G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 C0021T 2197771 2066049 kidney NS NS NS NS NS NS NS y COSV57443321 COSN9655907 118752805 c.548+341C>G p.? Unknown 38 17:1506639-1506639 - - NEUTRAL .04687 Confirmed somatic variant 588 NS NS ENST00000406424.8:c.548+341C>G 17:g.1506639G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6007520-DNA_A01 2263452 2130436 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57440165 COSN15262548 118753795 c.549-3161C>T p.? Unknown 38 17:1501283-1501283 - - NEUTRAL .00032 Confirmed somatic variant 535 NS primary ENST00000406424.8:c.549-3161C>T 17:g.1501283G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PASLZM 2367612 2230450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV57442137 COSM5006535 118750538 c.1060C>T p.Q354* Substitution - Nonsense 38 17:1496062-1496062 - - PATHOGENIC .82826 Confirmed somatic variant 25790293 NS NS ENSP00000385177.4:p.Gln354Ter ENST00000406424.8:c.1060C>T 17:g.1496062G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PASLZM 2367612 2230450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV57442156 COSM5006193 118750549 c.793G>A p.V265M Substitution - Missense 38 17:1496746-1496746 - - NEUTRAL .01467 Confirmed somatic variant 25790293 NS NS ENSP00000385177.4:p.Val265Met ENST00000406424.8:c.793G>A 17:g.1496746C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCG-Testes_DFCI_24-Tumor-SM-4PDEI 2806613 2663330 testis NS NS NS germ_cell_tumour non_seminoma NS NS y COSV100233840 COSM9116897 118752213 c.828C>T p.T276= Substitution - coding silent het 38 17:1496711-1496711 - - NEUTRAL .02659 Confirmed somatic variant 27905446 fixed - NOS primary ENSP00000385177.4:p.Thr276= ENST00000406424.8:c.828C>T 17:g.1496711G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-CG-4442-01 2198151 2066429 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233635 COSM7691643 118750515 c.686C>T p.T229M Substitution - Missense 38 17:1497985-1497985 - - NEUTRAL .00988 Confirmed somatic variant 541 NS NS 85 ENSP00000385177.4:p.Thr229Met ENST00000406424.8:c.686C>T 17:g.1497985G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EXTERN_MELA_20140924_107 2839322 2695088 skin upper_leg NS NS malignant_melanoma NS NS NS y COSV104626978 COSM9370470 118753641 c.886G>A p.D296N Substitution - Missense 38 17:1496390-1496390 - - .58709 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000385177.4:p.Asp296Asn ENST00000406424.8:c.886G>A 17:g.1496390C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 5-VS034-T1 2869858 2724855 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV57443110 COSM4894813 118751399 c.653C>T p.S218F Substitution - Missense 38 17:1498018-1498018 - - NEUTRAL .04612 Confirmed somatic variant 26950094 surgery fresh/frozen NS 75 ENSP00000385177.4:p.Ser218Phe ENST00000406424.8:c.653C>T 17:g.1498018G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SJBALL021373_D1 2364176 2227090 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia Ph-like NS y COSV57442939 COSN17079618 118750800 c.326+337G>A p.? Unknown 38 17:1508841-1508841 - - NEUTRAL .0859 Confirmed somatic variant 25207766 blood-bone marrow NS ENST00000406424.8:c.326+337G>A 17:g.1508841C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-BR-8372-01 2198045 2066323 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440510 COSM2738170 118751485 c.722C>T p.T241M Substitution - Missense 38 17:1497949-1497949 - - PATHOGENIC .84124 Confirmed somatic variant 541 NS NS 63 ENSP00000385177.4:p.Thr241Met ENST00000406424.8:c.722C>T 17:g.1497949G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2014_Lung_sq_22_T 2744893 2603596 lung NS NS NS carcinoma NS NS NS y COSV57441227 COSN28674085 118751363 c.439-74C>G p.? Unknown 38 17:1507163-1507163 - - NEUTRAL .08275 Confirmed somatic variant 583 NS primary 69 ENST00000406424.8:c.439-74C>G 17:g.1507163G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 Thyroid-CN-WZ044T 2635105 2495501 thyroid NS NS NS carcinoma NS NS NS y COSV57440258 COSM6420326 118751039 c.532A>G p.N178D Substitution - Missense 38 17:1506996-1506996 - - NEUTRAL .40772 Confirmed somatic variant 676 NS primary 27 ENSP00000385177.4:p.Asn178Asp ENST00000406424.8:c.532A>G 17:g.1506996T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PT33 2521290 2383633 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV57443040 COSM5909589 118750702 c.958-7C>T p.? Unknown 38 17:1496171-1496171 - - NEUTRAL .07984 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENST00000406424.8:c.958-7C>T 17:g.1496171G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 S00827_1 2480817 2343562 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV57441520 COSM312000 118751503 c.124A>T p.T42S Substitution - Missense 38 17:1509709-1509709 - - PATHOGENIC .95918 Confirmed somatic variant 26168399 surgery fresh/frozen primary 73 ENSP00000385177.4:p.Thr42Ser ENST00000406424.8:c.124A>T 17:g.1509709T>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SJDOSTEOS005 2502772 2365122 bone NS NS NS osteosarcoma NS NS NS y COSV57440930 COSN1193209 118751830 c.326+56_326+65del p.? Unknown 38 17:1509124-1509133 - - Confirmed somatic variant 25512523 NS NS ENST00000406424.8:c.326+56_326+65del 17:g.1509124_1509133del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 77 2748049 2606752 stomach NS NS NS carcinoma NS NS NS y COSV100233990 COSM8575061 118750577 c.549-8C>G p.? Unknown 38 17:1498130-1498130 - - NEUTRAL .09199 Confirmed somatic variant 683 NS primary ENST00000406424.8:c.549-8C>G 17:g.1498130G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 FFPE-13 2818008 2674307 pancreas NS NS NS carcinoma acinar_carcinoma NS NS y COSV57442897 COSM6225141 118752714 c.758C>T p.P253L Substitution - Missense het 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 29109526 surgery-fixed primary ENSP00000385177.4:p.Pro253Leu ENST00000406424.8:c.758C>T 17:g.1496781G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-55-8301-01 2194837 2063115 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV100233820 COSM7743401 118753235 c.-148G>T p.? Unknown 38 17:1513943-1513943 - - NEUTRAL .17092 Confirmed somatic variant 417 NS NS 58 ENST00000406424.8:c.-148G>T 17:g.1513943C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2014_Lung_sq_27_T 2744898 2603601 lung NS NS NS carcinoma NS NS NS y COSV57441106 COSN8602377 118752608 c.-76-24A>T p.? Unknown 38 17:1513585-1513585 - - NEUTRAL .01819 Confirmed somatic variant 583 NS primary 76 ENST00000406424.8:c.-76-24A>T 17:g.1513585T>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AF-6672-01 1651524 1566311 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV57441061 COSM1563397 118753799 c.-117C>A p.? Unknown 38 17:1513912-1513912 - - PATHOGENIC .9876 Confirmed somatic variant 375 NS primary 43 ENST00000406424.8:c.-117C>A 17:g.1513912G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 tumor_4179894 2634671 2495067 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57440372 COSN6651475 118752132 c.*817G>T p.? Unknown 38 17:1495006-1495006 - - NEUTRAL .01546 Confirmed somatic variant 440 NS primary 72 ENST00000406424.8:c.*817G>T 17:g.1495006C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2014_Lung_sq_102_T 2744869 2603572 lung NS NS NS carcinoma NS NS NS y COSV57443380 COSM7249097 118751929 c.439-10T>G p.? Unknown 38 17:1507099-1507099 - - NEUTRAL .07942 Confirmed somatic variant 583 NS primary 74 ENST00000406424.8:c.439-10T>G 17:g.1507099A>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 BN06 2120643 1994879 liver NS NS NS carcinoma NS NS NS y COSV57442850 COSN1193203 118751765 c.735+37T>A p.? Unknown 38 17:1497899-1497899 - - NEUTRAL .02871 Confirmed somatic variant 323 NS NS ENST00000406424.8:c.735+37T>A 17:g.1497899A>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T207 2296102 2161705 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57442201 COSM4692620 118751865 c.805A>G p.M269V Substitution - Missense 38 17:1496734-1496734 - - NEUTRAL .14185 Confirmed somatic variant 25344691 NS NS 72.83 ENSP00000385177.4:p.Met269Val ENST00000406424.8:c.805A>G 17:g.1496734T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EY-A549-01 2198465 2066743 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57442068 COSM5364464 118751910 c.560G>A p.R187H Substitution - Missense 38 17:1498111-1498111 - - PATHOGENIC .97388 Confirmed somatic variant 419 NS NS 78 ENSP00000385177.4:p.Arg187His ENST00000406424.8:c.560G>A 17:g.1498111C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 ESCC_134 2479627 2342387 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440352 COSM5642741 118750821 c.635C>T p.P212L Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .00382 Confirmed somatic variant 26873401 NS NS 68 ENSP00000385177.4:p.Pro212Leu ENST00000406424.8:c.635C>T 17:g.1498036G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK042_C 2120949 1995185 liver NS NS NS carcinoma NS NS NS y COSV57441764 COSN1714034 118750732 c.549-4020G>C p.? Unknown 38 17:1502142-1502142 - - NEUTRAL .00011 Confirmed somatic variant 322 NS NS ENST00000406424.8:c.549-4020G>C 17:g.1502142C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-MA-AA42-01 2386190 2249022 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233848 COSM8652710 118753556 c.642G>A p.A214= Substitution - coding silent 38 17:1498029-1498029 - - NEUTRAL .06811 Confirmed somatic variant 415 NS primary 75 ENSP00000385177.4:p.Ala214= ENST00000406424.8:c.642G>A 17:g.1498029C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T368 2296243 2161846 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441404 COSM4692626 118752613 c.635C>A p.P212Q Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .01179 Confirmed somatic variant 25344691 NS NS 63.75 ENSP00000385177.4:p.Pro212Gln ENST00000406424.8:c.635C>A 17:g.1498036G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-06-1801-01 2178194 2046492 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233717 COSM7481424 118751008 c.811G>C p.V271L Substitution - Missense 38 17:1496728-1496728 - - NEUTRAL .21698 Confirmed somatic variant 329 NS NS 56 ENSP00000385177.4:p.Val271Leu ENST00000406424.8:c.811G>C 17:g.1496728C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 1323-01-02TD 2456400 2319237 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV57440745 COSN19146962 118752928 c.439-287G>C p.? Unknown 38 17:1507376-1507376 - - NEUTRAL .1053 Confirmed somatic variant 340 blood primary 63 ENST00000406424.8:c.439-287G>C 17:g.1507376C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EB-A299-01 2121587 1995823 skin NS NS NS malignant_melanoma NS NS NS y COSV100233592 COSM8129016 118751836 c.256G>T p.E86* Substitution - Nonsense 38 17:1509248-1509248 - - PATHOGENIC .96263 Confirmed somatic variant 540 NS NS 63 ENSP00000385177.4:p.Glu86Ter ENST00000406424.8:c.256G>T 17:g.1509248C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 5-VS015-T1 2869836 2724833 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV105203833 COSM9691176 118750631 c.60C>T p.I20= Substitution - coding silent 38 17:1509773-1509773 - - .56592 Confirmed somatic variant 26950094 surgery fresh/frozen NS 90 ENSP00000385177.4:p.Ile20= ENST00000406424.8:c.60C>T 17:g.1509773G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2279 2658733 2518892 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441317 COSM6686181 118751946 c.576C>T p.T192= Substitution - coding silent 38 17:1498095-1498095 - - NEUTRAL .05249 Confirmed somatic variant 27149842 NS NS 65.41 ENSP00000385177.4:p.Thr192= ENST00000406424.8:c.576C>T 17:g.1498095G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-BR-8372-01 2198045 2066323 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440526 COSM4064067 118752591 c.-156T>C p.? Unknown 38 17:1513951-1513951 - - PATHOGENIC .96702 Confirmed somatic variant 541 NS NS 63 ENST00000406424.8:c.-156T>C 17:g.1513951A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 tumor_4179894 2634671 2495067 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441100 COSN25650645 118753287 c.549-4412T>G p.? Unknown 38 17:1502534-1502534 - - NEUTRAL .01333 Confirmed somatic variant 440 NS primary 72 ENST00000406424.8:c.549-4412T>G 17:g.1502534A>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHCOSK001 2779625 2637645 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV100233753 COSM9103745 118753149 c.863G>T p.G288V Substitution - Missense 38 17:1496676-1496676 - - PATHOGENIC .99025 Confirmed somatic variant 27267998 surgery-fixed NS 40 ENSP00000385177.4:p.Gly288Val ENST00000406424.8:c.863G>T 17:g.1496676C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T368 2658284 2518443 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441404 COSM4692626 118752613 c.635C>A p.P212Q Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .01179 Confirmed somatic variant 27149842 NS NS 63.75 ENSP00000385177.4:p.Pro212Gln ENST00000406424.8:c.635C>A 17:g.1498036G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK042_C 2120949 1995185 liver NS NS NS carcinoma NS NS NS y COSV57441768 COSN1714035 118750738 c.549-4023C>G p.? Unknown 38 17:1502145-1502145 - - NEUTRAL .00026 Confirmed somatic variant 322 NS NS ENST00000406424.8:c.549-4023C>G 17:g.1502145G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 C0021T 2197771 2066049 kidney NS NS NS NS NS NS NS y COSV57443329 COSN9655913 118752813 c.34-508G>T p.? Unknown 38 17:1510307-1510307 - - NEUTRAL .01852 Confirmed somatic variant 588 NS NS ENST00000406424.8:c.34-508G>T 17:g.1510307C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T1762 2658285 2518444 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440363 COSM6686177 118751122 c.558dup p.R187Tfs*82 Insertion - Frameshift 38 17:1498118-1498119 - - Confirmed somatic variant 27149842 NS NS 69.58 ENSP00000385177.4:p.Arg187ThrfsTer82 ENST00000406424.8:c.558dup 17:g.1498118dup INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV57442051 COSM3514454 118750898 c.260A>G p.H87R Substitution - Missense 38 17:1509244-1509244 - - PATHOGENIC .97324 Confirmed somatic variant 540 NS NS 30 ENSP00000385177.4:p.His87Arg ENST00000406424.8:c.260A>G 17:g.1509244T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AA-3877-01 1651067 1565854 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441118 COSM178164 118751419 c.-148G>A p.? Unknown 38 17:1513943-1513943 - - NEUTRAL .06284 Confirmed somatic variant 376 NS NS 83 ENST00000406424.8:c.-148G>A 17:g.1513943C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233889 COSM8978199 118752391 c.549-1G>A p.? Unknown 38 17:1498123-1498123 - - PATHOGENIC .97388 Confirmed somatic variant 419 NS NS 59 ENST00000406424.8:c.549-1G>A 17:g.1498123C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233845 COSM9192841 118752089 c.-149C>T p.? Unknown 38 17:1513944-1513944 - - PATHOGENIC .79904 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENST00000406424.8:c.-149C>T 17:g.1513944G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-CM-4746-01 1651207 1565994 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV100233908 COSM7605863 118751598 c.852G>A p.W284* Substitution - Nonsense 38 17:1496687-1496687 - - PATHOGENIC .98938 Confirmed somatic variant 376 NS NS 61 ENSP00000385177.4:p.Trp284Ter ENST00000406424.8:c.852G>A 17:g.1496687C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SM-4B295 2262938 2129922 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442007 COSM5032397 118750908 c.874-6T>C p.? Unknown 38 17:1496408-1496408 - - NEUTRAL .00676 Confirmed somatic variant 535 NS primary ENST00000406424.8:c.874-6T>C 17:g.1496408A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440119 COSM4692618 118751702 c.849G>A p.P283= Substitution - coding silent 38 17:1496690-1496690 - - PATHOGENIC .80915 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000385177.4:p.Pro283= ENST00000406424.8:c.849G>A 17:g.1496690C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6008336-DNA_A02 2789419 2646642 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV100234014 COSN30406679 118751956 c.548+748G>A p.? Unknown 38 17:1506232-1506232 - - NEUTRAL .01419 Confirmed somatic variant 535 NS primary 81 ENST00000406424.8:c.548+748G>A 17:g.1506232C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-18-3407-01 1780257 1684256 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233793 COSM8151450 118751017 c.128C>A p.P43H Substitution - Missense 38 17:1509705-1509705 - - PATHOGENIC .88297 Confirmed somatic variant 418 fresh/frozen - NOS primary 72 ENSP00000385177.4:p.Pro43His ENST00000406424.8:c.128C>A 17:g.1509705G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2448 2658241 2518400 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442156 COSM5006193 118750549 c.793G>A p.V265M Substitution - Missense 38 17:1496746-1496746 - - NEUTRAL .01467 Confirmed somatic variant 27149842 NS NS 68.58 ENSP00000385177.4:p.Val265Met ENST00000406424.8:c.793G>A 17:g.1496746C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 C0037T 2197815 2066093 kidney NS NS NS NS NS NS NS y COSV57440692 COSN9655895 118752687 c.736-41G>A p.? Unknown 38 17:1496844-1496844 - - NEUTRAL .05199 Confirmed somatic variant 588 NS NS ENST00000406424.8:c.736-41G>A 17:g.1496844C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 LP6008141-DNA_H01 2789459 2646682 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV100233580 COSN30207599 118753263 c.34-1668C>T p.? Unknown 38 17:1511467-1511467 - - NEUTRAL .48243 Confirmed somatic variant 535 NS primary 82 ENST00000406424.8:c.34-1668C>T 17:g.1511467G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CLL129 1897564 1786248 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV57441713 COSM1290634 118753448 c.1095G>T p.L365= Substitution - coding silent 38 17:1495847-1495847 - - NEUTRAL .05649 Confirmed somatic variant 23415222 blood-bone marrow NS ENSP00000385177.4:p.Leu365= ENST00000406424.8:c.1095G>T 17:g.1495847C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-F4-6856-01 1651313 1566100 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 118750878 c.581G>A p.R194H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 376 NS NS 45 ENSP00000385177.4:p.Arg194His ENST00000406424.8:c.581G>A 17:g.1498090C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PD24314a 2241668 2109199 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441374 COSN21484822 118751522 c.549-2538C>T p.? Unknown 38 17:1500660-1500660 - - NEUTRAL .00082 Confirmed somatic variant 652 NS NS ENST00000406424.8:c.549-2538C>T 17:g.1500660G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440412 COSN6651553 118752171 c.548+15G>C p.? Unknown 38 17:1506965-1506965 - - NEUTRAL .01662 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.548+15G>C 17:g.1506965C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 FFPE-K1 2818021 2674320 pancreas NS NS NS carcinoma acinar_carcinoma NS NS y COSV104401286 COSM9274306 118753326 c.-76-10G>A p.? Unknown het 38 17:1513571-1513571 - - PATHOGENIC .89312 Confirmed somatic variant 29109526 surgery-fixed primary ENST00000406424.8:c.-76-10G>A 17:g.1513571C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440420 COSN6651554 118752177 c.439-58G>A p.? Unknown 38 17:1507147-1507147 - - NEUTRAL .06908 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.439-58G>A 17:g.1507147C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-A4-7288-01 2193982 2062260 kidney NS NS NS carcinoma papillary_renal_cell_carcinoma NS NS y COSV57441934 COSM3988780 118752978 c.828C>G p.T276= Substitution - coding silent 38 17:1496711-1496711 - - NEUTRAL .06148 Confirmed somatic variant 543 NS NS 71 ENSP00000385177.4:p.Thr276= ENST00000406424.8:c.828C>G 17:g.1496711G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GCYC_051_T 2747641 2606344 stomach NS NS NS carcinoma NS NS NS y COSV100233803 COSN30697867 118752781 c.327-76C>T p.? Unknown 38 17:1508302-1508302 - - NEUTRAL .12541 Confirmed somatic variant 683 NS primary ENST00000406424.8:c.327-76C>T 17:g.1508302G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2763 2658548 2518707 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441317 COSM6686181 118751946 c.576C>T p.T192= Substitution - coding silent 38 17:1498095-1498095 - - NEUTRAL .05249 Confirmed somatic variant 27149842 NS NS 57.25 ENSP00000385177.4:p.Thr192= ENST00000406424.8:c.576C>T 17:g.1498095G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440408 COSN6651539 118752164 c.548+1673C>T p.? Unknown 38 17:1505307-1505307 - - NEUTRAL .00583 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.548+1673C>T 17:g.1505307G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PD23577a 2214453 2082577 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441999 COSN21680810 118750829 c.735+354G>C p.? Unknown 38 17:1497582-1497582 - - NEUTRAL .31399 Confirmed somatic variant 652 NS NS ENST00000406424.8:c.735+354G>C 17:g.1497582C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 p6low 2812886 2669300 large_intestine colon left NS adenoma tubular NS NS y COSV104411988 COSN31779190 118751460 c.*238G>A p.? Unknown 38 17:1495585-1495585 - - NEUTRAL .03835 Confirmed somatic variant 31336886 surgery-fixed NS 64 ENST00000406424.8:c.*238G>A 17:g.1495585C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T3046 2658722 2518881 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 118750878 c.581G>A p.R194H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 27149842 NS NS 60.16 ENSP00000385177.4:p.Arg194His ENST00000406424.8:c.581G>A 17:g.1498090C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T4506 2658677 2518836 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441145 COSM6686189 118750679 c.256G>A p.E86K Substitution - Missense 38 17:1509248-1509248 - - PATHOGENIC .94307 Confirmed somatic variant 27149842 NS NS 81.25 ENSP00000385177.4:p.Glu86Lys ENST00000406424.8:c.256G>A 17:g.1509248C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 GCTK_341_T 2747450 2606153 stomach NS NS NS carcinoma NS NS NS y COSV100233887 COSN30729867 118753635 c.327-13T>G p.? Unknown 38 17:1508239-1508239 - - .60195 Confirmed somatic variant 683 NS primary ENST00000406424.8:c.327-13T>G 17:g.1508239A>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CN-AML-08-T 2506791 2369127 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 118750660 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 blood-bone marrow primary ENST00000406424.8:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441432 COSM4692624 118752656 c.640G>A p.A214T Substitution - Missense 38 17:1498031-1498031 - - NEUTRAL .0531 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000385177.4:p.Ala214Thr ENST00000406424.8:c.640G>A 17:g.1498031C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440380 COSN6651502 118752140 c.549-3999C>T p.? Unknown 38 17:1502121-1502121 - - NEUTRAL .00323 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.549-3999C>T 17:g.1502121G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 SNUH_G16_S1 2120552 1994788 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 118750660 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 NS NS ENST00000406424.8:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57440119 COSM4692618 118751702 c.849G>A p.P283= Substitution - coding silent 38 17:1496690-1496690 - - PATHOGENIC .80915 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000385177.4:p.Pro283= ENST00000406424.8:c.849G>A 17:g.1496690C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-39-5022-01 1781520 1685519 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57442536 COSM704958 118750890 c.-1C>G p.? Unknown 38 17:1513486-1513486 - - PATHOGENIC .95856 Confirmed somatic variant 418 fresh/frozen - NOS primary 76 ENST00000406424.8:c.-1C>G 17:g.1513486G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-33-4587-01 2195029 2063307 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233721 COSM8709016 118751063 c.34G>A p.V12I Substitution - Missense 38 17:1509799-1509799 - - PATHOGENIC .71204 Confirmed somatic variant 418 NS NS 63 ENSP00000385177.4:p.Val12Ile ENST00000406424.8:c.34G>A 17:g.1509799C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2441 2658483 2518642 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 118751345 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 75 ENSP00000385177.4:p.Arg130Trp ENST00000406424.8:c.388C>T 17:g.1508165G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442334 COSN6651504 118751974 c.549-4045C>T p.? Unknown 38 17:1502167-1502167 - - NEUTRAL .00319 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.549-4045C>T 17:g.1502167G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T603 2658711 2518870 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440611 COSM6686191 118750599 c.389G>A p.R130Q Substitution - Missense 38 17:1508164-1508164 - - NEUTRAL .06264 Confirmed somatic variant 27149842 NS NS 69.75 ENSP00000385177.4:p.Arg130Gln ENST00000406424.8:c.389G>A 17:g.1508164C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442362 COSN6651584 118751996 c.34-1497G>C p.? Unknown 38 17:1511296-1511296 - - NEUTRAL .05338 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.34-1497G>C 17:g.1511296C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440431 COSN6651564 118752183 c.438+251A>C p.? Unknown 38 17:1507864-1507864 - - NEUTRAL .00637 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.438+251A>C 17:g.1507864T>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2394 2658590 2518749 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442954 COSM6686183 118754134 c.406C>T p.R136W Substitution - Missense 38 17:1508147-1508147 - - NEUTRAL .10513 Confirmed somatic variant 27149842 NS NS 71 ENSP00000385177.4:p.Arg136Trp ENST00000406424.8:c.406C>T 17:g.1508147G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-24-2030-01 1474934 1398633 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV100233576 COSM7466631 118750748 c.621C>T p.P207= Substitution - coding silent 38 17:1498050-1498050 - - NEUTRAL .06315 Confirmed somatic variant 331 NS primary 87 ENSP00000385177.4:p.Pro207= ENST00000406424.8:c.621C>T 17:g.1498050G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440446 COSN6651579 118752191 c.34-1050G>A p.? Unknown 38 17:1510849-1510849 - - NEUTRAL .00457 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.34-1050G>A 17:g.1510849C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 S00640 2864328 2719489 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS y COSV105203822 COSM9584085 118753566 c.640del p.A214Rfs*8 Deletion - Frameshift 38 17:1498032-1498032 - - Confirmed somatic variant 29535388 surgery fresh/frozen NS 53 ENSP00000385177.4:p.Ala214ArgfsTer8 ENST00000406424.8:c.640del 17:g.1498032del INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EL-A3CY-01 2121967 1996203 thyroid NS NS NS carcinoma NS NS NS y COSV57442823 COSM3370619 118750980 c.777C>G p.P259= Substitution - coding silent 38 17:1496762-1496762 - - NEUTRAL .02304 Confirmed somatic variant 542 NS NS 28 ENSP00000385177.4:p.Pro259= ENST00000406424.8:c.777C>G 17:g.1496762G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHG-29T 2634259 2494655 liver NS NS NS other neoplasm NS NS y COSV57441087 COSN23438524 118751550 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 660 NS primary 48 ENST00000406424.8:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440387 COSN6651505 118752146 c.549-4117G>A p.? Unknown 38 17:1502239-1502239 - - NEUTRAL .00196 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.549-4117G>A 17:g.1502239C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440372 COSN6651475 118752132 c.*817G>T p.? Unknown 38 17:1495006-1495006 - - NEUTRAL .01546 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.*817G>T 17:g.1495006C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T_CCA_JP_6 2688122 2547104 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 118751923 c.326+388_326+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 65 ENST00000406424.8:c.326+388_326+389insC 17:g.1508789_1508790insG INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 W30T 2745054 2603757 thyroid NS NS NS carcinoma NS NS NS y COSV57440258 COSM6420326 118751039 c.532A>G p.N178D Substitution - Missense 38 17:1506996-1506996 - - NEUTRAL .40772 Confirmed somatic variant 676 NS primary 27 ENSP00000385177.4:p.Asn178Asp ENST00000406424.8:c.532A>G 17:g.1506996T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 ESCC_156 2479644 2342404 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441047 COSM5645997 118752499 c.1080G>C p.L360F Substitution - Missense 38 17:1495862-1495862 - - NEUTRAL .09067 Confirmed somatic variant 26873401 NS NS 84 ENSP00000385177.4:p.Leu360Phe ENST00000406424.8:c.1080G>C 17:g.1495862C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HX27T 2120921 1995157 liver NS NS NS carcinoma NS NS NS y COSV57442880 COSN5838392 118751305 c.-344+116G>A p.? Unknown 38 17:1515772-1515772 - - NEUTRAL .25514 Confirmed somatic variant 323 NS NS ENST00000406424.8:c.-344+116G>A 17:g.1515772C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-26-5134 2108058 1985919 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57441362 COSM2157002 118752336 c.-592G>C p.? Unknown 38 17:1516473-1516473 - - NEUTRAL .15234 Confirmed somatic variant 23917401 NS NS ENST00000406424.8:c.-592G>C 17:g.1516473C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHG-14-15016T 2634332 2494728 liver NS NS NS other neoplasm NS NS y COSV57442117 COSN26562181 118752204 c.873+13C>A p.? Unknown 38 17:1496653-1496653 - - NEUTRAL .02666 Confirmed somatic variant 660 NS primary 70 ENST00000406424.8:c.873+13C>A 17:g.1496653G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442373 COSN6651596 118752004 c.33+289C>T p.? Unknown 38 17:1513164-1513164 - - NEUTRAL .00811 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.33+289C>T 17:g.1513164G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440313 COSN6651567 118750660 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 AOCS-139-19-0 2186425 2054722 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441562 COSM3983264 118753200 c.465G>T p.P155= Substitution - coding silent 38 17:1507063-1507063 - - NEUTRAL .03466 Confirmed somatic variant 585 NS NS ENSP00000385177.4:p.Pro155= ENST00000406424.8:c.465G>T 17:g.1507063C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-39-5037-01 1781591 1685590 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440018 COSM704961 118752574 c.999G>A p.E333= Substitution - coding silent 38 17:1496123-1496123 - - .64376 Confirmed somatic variant 418 fresh/frozen - NOS primary 65 ENSP00000385177.4:p.Glu333= ENST00000406424.8:c.999G>A 17:g.1496123C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440392 COSN6651506 118752152 c.549-4130C>T p.? Unknown 38 17:1502252-1502252 - - NEUTRAL .00299 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.549-4130C>T 17:g.1502252G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-EJ-7125-01 2121457 1995693 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440295 COSM3672354 118752751 c.389G>T p.R130L Substitution - Missense 38 17:1508164-1508164 - - NEUTRAL .18864 Confirmed somatic variant 435 NS NS 44 ENSP00000385177.4:p.Arg130Leu ENST00000406424.8:c.389G>T 17:g.1508164C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57443185 COSM4795479 118752258 c.733G>A p.E245K Substitution - Missense 38 17:1497938-1497938 - - PATHOGENIC .91208 Confirmed somatic variant 381 NS primary 72 ENSP00000385177.4:p.Glu245Lys ENST00000406424.8:c.733G>A 17:g.1497938C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442343 COSN6651570 118751981 c.327-328T>G p.? Unknown 38 17:1508554-1508554 - - NEUTRAL .11115 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.327-328T>G 17:g.1508554A>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 AML_14y_08_DX 2549541 2410996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440211 COSN23974391 118750964 c.326+117C>G p.? Unknown 38 17:1509061-1509061 - - NEUTRAL .00587 Confirmed somatic variant 544 blood-bone marrow primary 32 ENST00000406424.8:c.326+117C>G 17:g.1509061G>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 OSCC-GB_01060111 2341032 2206015 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV57441385 COSM4882615 118751526 c.815G>A p.S272N Substitution - Missense 38 17:1496724-1496724 - - PATHOGENIC .77196 Confirmed somatic variant 539 NS primary 60 ENSP00000385177.4:p.Ser272Asn ENST00000406424.8:c.815G>A 17:g.1496724C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-26-5134-01 2120324 1994560 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57441362 COSM2157002 118752336 c.-592G>C p.? Unknown 38 17:1516473-1516473 - - NEUTRAL .15234 Confirmed somatic variant 329 NS NS 74 ENST00000406424.8:c.-592G>C 17:g.1516473C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440401 COSN19320948 118752157 c.549-4238G>T p.? Unknown 38 17:1502360-1502360 - - NEUTRAL .00142 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.549-4238G>T 17:g.1502360C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442352 COSN6651577 118751988 c.34-449C>T p.? Unknown 38 17:1510248-1510248 - - NEUTRAL .00134 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.34-449C>T 17:g.1510248G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T2769 2296131 2161734 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57442024 COSM4692628 118753470 c.503C>T p.P168L Substitution - Missense 38 17:1507025-1507025 - - .61387 Confirmed somatic variant 25344691 NS NS 67.41 ENSP00000385177.4:p.Pro168Leu ENST00000406424.8:c.503C>T 17:g.1507025G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 273 2748245 2606948 stomach NS NS NS carcinoma NS NS NS y COSV100233936 COSN30549824 118751000 c.874-32C>A p.? Unknown 38 17:1496434-1496434 - - NEUTRAL .04855 Confirmed somatic variant 683 NS primary ENST00000406424.8:c.874-32C>A 17:g.1496434G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 sysucc-882T 2456760 2319597 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442228 COSN19666228 118753106 c.549-92G>T p.? Unknown 38 17:1498214-1498214 - - NEUTRAL .11173 Confirmed somatic variant 646 NS primary 61 ENST00000406424.8:c.549-92G>T 17:g.1498214C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442328 COSN6651503 118751970 c.549-4043A>G p.? Unknown 38 17:1502165-1502165 - - NEUTRAL .00034 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000406424.8:c.549-4043A>G 17:g.1502165T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-AZ-4315-01 1651162 1565949 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57440687 COSM1380994 118752382 c.-17C>T p.? Unknown 38 17:1513502-1513502 - - PATHOGENIC .93935 Confirmed somatic variant 376 NS NS 61 ENST00000406424.8:c.-17C>T 17:g.1513502G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-E7-A7DV-01 2193219 2061497 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57441614 COSM7110439 118751779 c.388C>A p.R130= Substitution - coding silent 38 17:1508165-1508165 - - NEUTRAL .16927 Confirmed somatic variant 413 NS NS 44 ENSP00000385177.4:p.Arg130= ENST00000406424.8:c.388C>A 17:g.1508165G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-CD-A486-01 2198066 2066344 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57443071 COSM4064063 118751050 c.358C>T p.R120W Substitution - Missense 38 17:1508195-1508195 - - PATHOGENIC .99184 Confirmed somatic variant 541 NS NS 68 ENSP00000385177.4:p.Arg120Trp ENST00000406424.8:c.358C>T 17:g.1508195G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 J32_T 2195006 2063284 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441017 COSN20301572 118753376 c.439-469C>A p.? Unknown 38 17:1507558-1507558 - - NEUTRAL .01033 Confirmed somatic variant 583 NS NS ENST00000406424.8:c.439-469C>A 17:g.1507558G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 HUB-02-B2-087 2607141 2466853 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440866 COSN24393345 118754083 c.327-474G>A p.? Unknown 38 17:1508700-1508700 - - NEUTRAL .00908 Confirmed somatic variant 670 organoid culture NS ENST00000406424.8:c.327-474G>A 17:g.1508700C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV57443304 COSN6099345 118753331 c.34-239G>A p.? Unknown 38 17:1510038-1510038 - - NEUTRAL .012 Confirmed somatic variant 322 NS NS ENST00000406424.8:c.34-239G>A 17:g.1510038C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EOPC-133_tumor_01 2549444 2410899 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 118751550 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 49 ENST00000406424.8:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 2014_Lung_sq_41_T 2744912 2603615 lung NS NS NS carcinoma NS NS NS y COSV57440751 COSN19718001 118752278 c.326+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 583 NS primary 63 ENST00000406424.8:c.326+396G>C 17:g.1508782C>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-FD-A6TC-01 2262697 2129681 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57441022 COSM7120771 118752938 c.1059C>T p.F353= Substitution - coding silent 38 17:1496063-1496063 - - PATHOGENIC .823 Confirmed somatic variant 413 NS primary 79 ENSP00000385177.4:p.Phe353= ENST00000406424.8:c.1059C>T 17:g.1496063G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441884 COSN25825941 118753086 c.549-3679T>C p.? Unknown 38 17:1501801-1501801 - - NEUTRAL .01231 Confirmed somatic variant 534 NS primary 44 ENST00000406424.8:c.549-3679T>C 17:g.1501801A>G INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441890 COSN25825863 118753093 c.326+47A>G p.? Unknown 38 17:1509131-1509131 - - NEUTRAL .00149 Confirmed somatic variant 534 NS primary 44 ENST00000406424.8:c.326+47A>G 17:g.1509131T>C INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 T604 2658649 2518808 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 118751345 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000385177.4:p.Arg130Trp ENST00000406424.8:c.388C>T 17:g.1508165G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 AOCS-119-3-9 2186509 2054806 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441447 COSN8831797 118751431 c.33+232G>A p.? Unknown 38 17:1513221-1513221 - - NEUTRAL .02029 Confirmed somatic variant 585 NS NS ENST00000406424.8:c.33+232G>A 17:g.1513221C>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 TCGA-06-0171 2107961 1985822 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 118750924 c.-175C>T p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 23917401 NS NS ENST00000406424.8:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PET124T 2507124 2369460 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57441203 COSN22987696 118751196 c.34-153G>T p.? Unknown 38 17:1509952-1509952 - - NEUTRAL .11989 Confirmed somatic variant 661 NS primary 46 ENST00000406424.8:c.34-153G>T 17:g.1509952C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441875 COSN25827061 118753079 c.549-3653C>A p.? Unknown 38 17:1501775-1501775 - - NEUTRAL .0002 Confirmed somatic variant 534 NS primary 44 ENST00000406424.8:c.549-3653C>A 17:g.1501775G>T INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 PET124T 2507124 2369460 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57441198 COSN22982472 118751191 c.549-3324G>T p.? Unknown 38 17:1501446-1501446 - - NEUTRAL .18617 Confirmed somatic variant 661 NS primary 46 ENST00000406424.8:c.549-3324G>T 17:g.1501446C>A INPP5K_ENST00000406424 ENST00000406424.8 1119 33882 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV57443312 COSN6099353 118753335 c.-184-118G>A p.? Unknown 38 17:1514097-1514097 - - NEUTRAL .01454 Confirmed somatic variant 322 NS NS ENST00000406424.8:c.-184-118G>A 17:g.1514097C>T INPP5K ENST00000421807.6 1347 33882 2834138 2834138 2689922 skin mucosal female_genital_tract_(site_indeterminate) NS malignant_melanoma NS NS NS y COSV104623170 COSM9341102 124162473 c.245C>A p.P82H Substitution - Missense 38 17:1513469-1513469 - - PATHOGENIC .98931 Variant of unknown origin 28296713 surgery - NOS primary 76 ENSP00000413937.2:p.Pro82His ENST00000421807.6:c.245C>A 17:g.1513469G>T INPP5K ENST00000421807.6 1347 33882 RK036_C01 1918829 1806150 liver NS NS NS carcinoma NS NS NS y COSV57439762 COSN1714041 124164714 c.776+1278G>A p.? Unknown het 38 17:1505702-1505702 - - NEUTRAL .0172 Variant of unknown origin 322 fresh/frozen - NOS primary ENST00000421807.6:c.776+1278G>A 17:g.1505702C>T INPP5K ENST00000421807.6 1347 33882 SNU-175 2302007 2167290 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441485 COSM2738174 124162390 c.829C>T p.R277W Substitution - Missense het 38 17:1498070-1498070 - - PATHOGENIC .83124 Variant of unknown origin 24755471 cell-line NS ENSP00000413937.2:p.Arg277Trp ENST00000421807.6:c.829C>T 17:g.1498070G>A INPP5K ENST00000421807.6 1347 33882 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV57442436 COSM178157 124163416 c.919G>A p.G307S Substitution - Missense het 38 17:1497980-1497980 - - NEUTRAL .01795 Variant of unknown origin 30545397 cell-line primary ENSP00000413937.2:p.Gly307Ser ENST00000421807.6:c.919G>A 17:g.1497980C>T INPP5K ENST00000421807.6 1347 33882 ESO-1096 1890882 1780251 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57439838 COSM1254855 124164674 c.127C>T p.L43F Substitution - Missense 38 17:1513897-1513897 - - NEUTRAL .13365 Variant of unknown origin 23525077 surgery fresh/frozen primary 73 ENSP00000413937.2:p.Leu43Phe ENST00000421807.6:c.127C>T 17:g.1513897G>A INPP5K ENST00000421807.6 1347 33882 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440852 COSM975658 124164942 c.300C>T p.V100= Substitution - coding silent het 38 17:1509761-1509761 - - PATHOGENIC .80498 Variant of unknown origin 419 fresh/frozen - NOS primary 33 ENSP00000413937.2:p.Val100= ENST00000421807.6:c.300C>T 17:g.1509761G>A INPP5K ENST00000421807.6 1347 33882 LUAD-CHTN-3090346 1765232 1669552 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV57440835 COSM356825 124165289 c.695T>C p.L232P Substitution - Missense 38 17:1507061-1507061 - - PATHOGENIC .92333 Variant of unknown origin 22980975 surgery - NOS primary 78 ENSP00000413937.2:p.Leu232Pro ENST00000421807.6:c.695T>C 17:g.1507061A>G INPP5K ENST00000421807.6 1347 33882 HCC1438 2776294 2634430 lung NS NS NS carcinoma large_cell_carcinoma NS NS y COSV99052630 COSM7372286 124164319 c.866C>T p.P289L Substitution - Missense 38 17:1498033-1498033 - - NEUTRAL .05806 Variant of unknown origin 29681454 NS NS 43 ENSP00000413937.2:p.Pro289Leu ENST00000421807.6:c.866C>T 17:g.1498033G>A INPP5K ENST00000421807.6 1347 33882 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440600 COSM975655 124164966 c.732G>A p.P244= Substitution - coding silent het 38 17:1507024-1507024 - - NEUTRAL .04613 Variant of unknown origin 419 fresh/frozen - NOS primary 53 ENSP00000413937.2:p.Pro244= ENST00000421807.6:c.732G>A 17:g.1507024C>T INPP5K ENST00000421807.6 1347 33882 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57442400 COSM975652 124162687 c.864G>A p.P288= Substitution - coding silent het 38 17:1498035-1498035 - - NEUTRAL .02365 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000413937.2:p.Pro288= ENST00000421807.6:c.864G>A 17:g.1498035C>T INPP5K ENST00000421807.6 1347 33882 NCI-H929 2809759 2666429 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV57441243 COSM2738184 124162793 c.730C>T p.P244S Substitution - Missense het 38 17:1507026-1507026 - - .52576 Variant of unknown origin 30545397 cell-line NS ENSP00000413937.2:p.Pro244Ser ENST00000421807.6:c.730C>T 17:g.1507026G>A INPP5K ENST00000421807.6 1347 33882 HCC1T 1566773 1488580 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS n COSV57440954 COSN1193215 124163780 c.44+96A>G p.? Unknown het 38 17:1516360-1516360 - - NEUTRAL .01043 Variant of unknown origin 323 surgery fresh/frozen primary 55 ENST00000421807.6:c.44+96A>G 17:g.1516360T>C INPP5K ENST00000421807.6 1347 33882 SNU-C2B 2302010 2167293 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV57440138 COSM2738166 124164399 c.1092A>G p.G364= Substitution - coding silent het 38 17:1496675-1496675 - - PATHOGENIC .72859 Variant of unknown origin 24755471 cell-line NS ENSP00000413937.2:p.Gly364= ENST00000421807.6:c.1092A>G 17:g.1496675T>C INPP5K ENST00000421807.6 1347 33882 GBC_22 2907868 2762051 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV57443533 COSM2738244 124164090 c.45-5C>T p.? Unknown 38 17:1513984-1513984 - - NEUTRAL .0451 Variant of unknown origin 33563892 surgery-fixed NS 62 ENST00000421807.6:c.45-5C>T 17:g.1513984G>A INPP5K ENST00000421807.6 1347 33882 H157 2776238 2634374 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99052630 COSM7372286 124164319 c.866C>T p.P289L Substitution - Missense 38 17:1498033-1498033 - - NEUTRAL .05806 Variant of unknown origin 29681454 NS NS 59 ENSP00000413937.2:p.Pro289Leu ENST00000421807.6:c.866C>T 17:g.1498033G>A INPP5K ENST00000421807.6 1347 33882 HCC123T 1919182 1806503 liver NS NS NS carcinoma NS NS NS y COSV57443268 COSN1193197 124162592 c.*787C>T p.? Unknown het 38 17:1495036-1495036 - - NEUTRAL .04496 Variant of unknown origin 323 fresh/frozen - NOS primary ENST00000421807.6:c.*787C>T 17:g.1495036G>A INPP5K ENST00000421807.6 1347 33882 SW1222 2302013 2167296 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439923 COSM4654769 124165544 c.730C>G p.P244A Substitution - Missense het 38 17:1507026-1507026 - - .59826 Variant of unknown origin 24755471 cell-line NS ENSP00000413937.2:p.Pro244Ala ENST00000421807.6:c.730C>G 17:g.1507026G>C INPP5K ENST00000421807.6 1347 33882 RK126_C01 1918880 1806201 liver NS NS NS carcinoma NS NS NS y COSV57441297 COSN1714053 124163687 c.44+515C>T p.? Unknown hom 38 17:1515941-1515941 - - NEUTRAL .02907 Variant of unknown origin 322 fresh/frozen - NOS primary ENST00000421807.6:c.44+515C>T 17:g.1515941G>A INPP5K ENST00000421807.6 1347 33882 SW1222 2302013 2167296 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439938 COSM4654771 124165557 c.113T>C p.L38P Substitution - Missense het 38 17:1513911-1513911 - - PATHOGENIC .98734 Variant of unknown origin 24755471 cell-line NS ENSP00000413937.2:p.Leu38Pro ENST00000421807.6:c.113T>C 17:g.1513911A>G INPP5K ENST00000421807.6 1347 33882 CHEWS002 2294515 2160542 bone pelvis NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV57440707 COSM4579451 124164513 c.424T>C p.Y142H Substitution - Missense 38 17:1509308-1509308 - - PATHOGENIC .7629 Variant of unknown origin 25186949 NS NS 10 ENSP00000413937.2:p.Tyr142His ENST00000421807.6:c.424T>C 17:g.1509308A>G INPP5K ENST00000421807.6 1347 33882 LIM2405 2301994 2167277 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV57441800 COSM4642073 124165378 c.1212T>C p.P404= Substitution - coding silent het 38 17:1496138-1496138 - - NEUTRAL .02457 Variant of unknown origin 24755471 cell-line NS ENSP00000413937.2:p.Pro404= ENST00000421807.6:c.1212T>C 17:g.1496138A>G INPP5K ENST00000421807.6 1347 33882 RK042_C01 1918833 1806154 liver NS NS NS carcinoma NS NS NS y COSV57441768 COSN1714035 124162575 c.777-4023C>G p.? Unknown het 38 17:1502145-1502145 - - NEUTRAL .00026 Reported in another cancer sample as somatic 322 fresh/frozen - NOS primary ENST00000421807.6:c.777-4023C>G 17:g.1502145G>C INPP5K ENST00000421807.6 1347 33882 RK042_C01 1918833 1806154 liver NS NS NS carcinoma NS NS NS y COSV57441764 COSN1714034 124162570 c.777-4020G>C p.? Unknown het 38 17:1502142-1502142 - - NEUTRAL .00011 Reported in another cancer sample as somatic 322 fresh/frozen - NOS primary ENST00000421807.6:c.777-4020G>C 17:g.1502142C>G INPP5K ENST00000421807.6 1347 33882 HCC142T 1919196 1806517 liver NS NS NS carcinoma NS NS NS y COSV57440930 COSN1193209 124163697 c.554+56_554+65del p.? Unknown het 38 17:1509124-1509133 - - Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000421807.6:c.554+56_554+65del 17:g.1509124_1509133del INPP5K ENST00000421807.6 1347 33882 587284 1766769 1671089 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV57440902 COSM1210737 124163529 c.45-1G>T p.? Unknown 38 17:1513980-1513980 - - PATHOGENIC .99647 Variant of unknown origin 22895193 surgery fresh/frozen primary ENST00000421807.6:c.45-1G>T 17:g.1513980C>A INPP5K ENST00000421807.6 1347 33882 DLD1 2301972 2167255 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439847 COSM2150351 124162735 c.54C>T p.V18= Substitution - coding silent het 38 17:1513970-1513970 - - NEUTRAL .02048 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000413937.2:p.Val18= ENST00000421807.6:c.54C>T 17:g.1513970G>A INPP5K ENST00000421807.6 1347 33882 BN06T 1919137 1806458 liver NS NS NS carcinoma NS NS NS y COSV57442850 COSN1193203 124163615 c.963+37T>A p.? Unknown het 38 17:1497899-1497899 - - NEUTRAL .02871 Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000421807.6:c.963+37T>A 17:g.1497899A>T INPP5K ENST00000421807.6 1347 33882 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440057 COSM975648 124162677 c.1258C>T p.R420C Substitution - Missense het 38 17:1496092-1496092 - - NEUTRAL .09246 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 69 ENSP00000413937.2:p.Arg420Cys ENST00000421807.6:c.1258C>T 17:g.1496092G>A INPP5K ENST00000421807.6 1347 33882 S00827 1759193 1663941 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV57441520 COSM312000 124163333 c.352A>T p.T118S Substitution - Missense 38 17:1509709-1509709 - - PATHOGENIC .95918 Reported in another cancer sample as somatic 22941188 fresh/frozen - NOS NS 73 ENSP00000413937.2:p.Thr118Ser ENST00000421807.6:c.352A>T 17:g.1509709T>A INPP5K ENST00000421807.6 1347 33882 tumor_4137230 2634554 2494950 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441087 COSN23438524 124163381 c.554+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 440 NS primary 50 ENST00000421807.6:c.554+22C>T 17:g.1509156G>A INPP5K ENST00000421807.6 1347 33882 HCC132T 1919188 1806509 liver NS NS NS carcinoma NS NS NS y COSV57440930 COSN1193209 124163697 c.554+56_554+65del p.? Unknown het 38 17:1509124-1509133 - - Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000421807.6:c.554+56_554+65del 17:g.1509124_1509133del INPP5K ENST00000421807.6 1347 33882 22T 2745864 2604567 liver NS NS NS other neoplasm NS NS y COSV57443437 COSN29899782 124165848 c.777-2614G>A p.? Unknown 38 17:1500736-1500736 - - NEUTRAL .00211 Confirmed somatic variant 660 NS primary 67 ENST00000421807.6:c.777-2614G>A 17:g.1500736C>T INPP5K ENST00000421807.6 1347 33882 CHC361TB 2340446 2205429 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57439946 COSN25044683 124162964 c.777-2149G>A p.? Unknown 38 17:1500271-1500271 - - NEUTRAL .0428 Confirmed somatic variant 647 NS primary 67 ENST00000421807.6:c.777-2149G>A 17:g.1500271C>T INPP5K ENST00000421807.6 1347 33882 LP6008269-DNA_E01 2688150 2547132 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57443507 COSN27046300 124164619 c.776+3483T>A p.? Unknown 38 17:1503497-1503497 - - NEUTRAL .00478 Confirmed somatic variant 535 NS primary 77 ENST00000421807.6:c.776+3483T>A 17:g.1503497A>T INPP5K ENST00000421807.6 1347 33882 CHG-15-00821T 2634340 2494736 liver NS NS NS other neoplasm NS NS y COSV57441898 COSN26577197 124165208 c.261+50C>A p.? Unknown 38 17:1513403-1513403 - - NEUTRAL .18705 Confirmed somatic variant 660 NS primary 53 ENST00000421807.6:c.261+50C>A 17:g.1513403G>T INPP5K ENST00000421807.6 1347 33882 2748840 2748840 2607543 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV57441547 COSM7324773 124163478 c.1185+2T>C p.? Unknown 38 17:1496317-1496317 - - .53901 Confirmed somatic variant 29360550 surgery fresh/frozen NS 78 ENST00000421807.6:c.1185+2T>C 17:g.1496317A>G INPP5K ENST00000421807.6 1347 33882 DA16007 2635112 2495508 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV57440471 COSM6437186 124164264 c.963G>A p.E321= Substitution - coding silent 38 17:1497936-1497936 - - PATHOGENIC .98858 Confirmed somatic variant 677 NS primary 62 ENSP00000413937.2:p.Glu321= ENST00000421807.6:c.963G>A 17:g.1497936C>T INPP5K ENST00000421807.6 1347 33882 TCGA-EE-A2GH-06 2121658 1995894 skin NS NS NS malignant_melanoma NS NS NS y COSV100233689 COSM7983353 124162988 c.1310G>T p.R437M Substitution - Missense 38 17:1495860-1495860 - - NEUTRAL .02005 Confirmed somatic variant 540 NS NS 34 ENSP00000413937.2:p.Arg437Met ENST00000421807.6:c.1310G>T 17:g.1495860C>A INPP5K ENST00000421807.6 1347 33882 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV57439902 COSM6686175 124163172 c.616C>T p.R206W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000413937.2:p.Arg206Trp ENST00000421807.6:c.616C>T 17:g.1508165G>A INPP5K ENST00000421807.6 1347 33882 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV100233979 COSM9174724 124163161 c.1006G>A p.E336K Substitution - Missense 38 17:1496761-1496761 - - PATHOGENIC .96769 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000413937.2:p.Glu336Lys ENST00000421807.6:c.1006G>A 17:g.1496761C>T INPP5K ENST00000421807.6 1347 33882 TCGA-CD-8529-01 2198058 2066336 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57443033 COSM4064066 124162540 c.200C>A p.A67D Substitution - Missense 38 17:1513514-1513514 - - PATHOGENIC .95385 Confirmed somatic variant 541 NS NS 65 ENSP00000413937.2:p.Ala67Asp ENST00000421807.6:c.200C>A 17:g.1513514G>T INPP5K ENST00000421807.6 1347 33882 TCGA-EE-A2MH-06 2121679 1995915 skin NS NS NS malignant_melanoma NS NS NS y COSV57441603 COSM3514448 124162945 c.1294C>T p.P432S Substitution - Missense 38 17:1495876-1495876 - - NEUTRAL .15283 Confirmed somatic variant 540 NS NS 66 ENSP00000413937.2:p.Pro432Ser ENST00000421807.6:c.1294C>T 17:g.1495876G>A INPP5K ENST00000421807.6 1347 33882 CN-AML-CR-21-Dx 2340285 2205268 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57442223 COSN19628996 124164893 c.554+113G>A p.? Unknown 38 17:1509065-1509065 - - NEUTRAL .00192 Confirmed somatic variant 544 blood-bone marrow primary 28 ENST00000421807.6:c.554+113G>A 17:g.1509065C>T INPP5K ENST00000421807.6 1347 33882 TCGA-BK-A6W3-01 2263446 2130430 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440002 COSM266711 124162895 c.1259G>A p.R420H Substitution - Missense 38 17:1496091-1496091 - - NEUTRAL .0033 Confirmed somatic variant 419 NS primary 34 ENSP00000413937.2:p.Arg420His ENST00000421807.6:c.1259G>A 17:g.1496091C>T INPP5K ENST00000421807.6 1347 33882 2785970 2785970 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 124163600 c.918C>T p.Y306= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000413937.2:p.Tyr306= ENST00000421807.6:c.918C>T 17:g.1497981G>A INPP5K ENST00000421807.6 1347 33882 C0100T 2197804 2066082 kidney NS NS NS NS NS NS NS y COSV57440805 COSN15570238 124163785 c.777-3151A>T p.? Unknown 38 17:1501273-1501273 - - NEUTRAL .14618 Confirmed somatic variant 588 NS NS ENST00000421807.6:c.777-3151A>T 17:g.1501273T>A INPP5K ENST00000421807.6 1347 33882 TCGA-A5-A0VP-01 1783327 1687326 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233618 COSM8819723 124163097 c.753G>A p.R251= Substitution - coding silent 38 17:1507003-1507003 - - NEUTRAL .06188 Confirmed somatic variant 419 fresh/frozen - NOS primary 74 ENSP00000413937.2:p.Arg251= ENST00000421807.6:c.753G>A 17:g.1507003C>T INPP5K ENST00000421807.6 1347 33882 DN15007 2633582 2493978 breast NS NS NS carcinoma HER-positive_carcinoma NS NS y COSV57441312 COSM6349374 124162914 c.54C>A p.V18= Substitution - coding silent 38 17:1513970-1513970 - - NEUTRAL .04999 Confirmed somatic variant 668 NS primary 46 ENSP00000413937.2:p.Val18= ENST00000421807.6:c.54C>A 17:g.1513970G>T INPP5K ENST00000421807.6 1347 33882 CHC361TA 2120615 1994851 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57439946 COSN25044683 124162964 c.777-2149G>A p.? Unknown 38 17:1500271-1500271 - - NEUTRAL .0428 Confirmed somatic variant 381 NS NS ENST00000421807.6:c.777-2149G>A 17:g.1500271C>T INPP5K ENST00000421807.6 1347 33882 LP6007594 2262933 2129917 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57441794 COSN15055521 124164740 c.554+263C>T p.? Unknown 38 17:1508915-1508915 - - NEUTRAL .00143 Confirmed somatic variant 535 NS primary ENST00000421807.6:c.554+263C>T 17:g.1508915G>A INPP5K ENST00000421807.6 1347 33882 TCGA-06-0171-02 2120251 1994487 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 124162735 c.54C>T p.V18= Substitution - coding silent 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 329 NS NS 65 ENSP00000413937.2:p.Val18= ENST00000421807.6:c.54C>T 17:g.1513970G>A INPP5K ENST00000421807.6 1347 33882 TCGA-06-0171-01 2339818 2204801 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 124162735 c.54C>T p.V18= Substitution - coding silent 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 329 NS primary 65 ENSP00000413937.2:p.Val18= ENST00000421807.6:c.54C>T 17:g.1513970G>A INPP5K ENST00000421807.6 1347 33882 TCGA-W3-AA1W-06 2339958 2204941 skin NS NS NS malignant_melanoma NS NS NS y COSV100233883 COSM8026356 124163927 c.569T>A p.F190Y Substitution - Missense 38 17:1508212-1508212 - - PATHOGENIC .99149 Confirmed somatic variant 540 NS NS 64 ENSP00000413937.2:p.Phe190Tyr ENST00000421807.6:c.569T>A 17:g.1508212A>T INPP5K ENST00000421807.6 1347 33882 RK176_C01 2194707 2062985 liver NS NS NS carcinoma NS NS NS y COSV57442289 COSN6099335 124165201 c.776+1383G>C p.? Unknown 38 17:1505597-1505597 - - NEUTRAL .02961 Confirmed somatic variant 322 NS NS ENST00000421807.6:c.776+1383G>C 17:g.1505597C>G INPP5K ENST00000421807.6 1347 33882 GCTK_444_T 2747468 2606171 stomach NS NS NS carcinoma NS NS NS y COSV100233770 COSM8558056 124165039 c.717C>T p.G239= Substitution - coding silent 38 17:1507039-1507039 - - NEUTRAL .15391 Confirmed somatic variant 683 NS primary ENSP00000413937.2:p.Gly239= ENST00000421807.6:c.717C>T 17:g.1507039G>A INPP5K ENST00000421807.6 1347 33882 YURUB 2013679 1896311 skin NS NS NS malignant_melanoma NS NS NS y COSV57443209 COSM1709542 124165297 c.341C>T p.S114F Substitution - Missense het 38 17:1509720-1509720 - - PATHOGENIC .74112 Confirmed somatic variant 22842228 NS NS ENSP00000413937.2:p.Ser114Phe ENST00000421807.6:c.341C>T 17:g.1509720G>A INPP5K ENST00000421807.6 1347 33882 2293782 2293782 2159833 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma functioning NS NS y COSV57443083 COSM4608647 124165000 c.1138G>T p.A380S Substitution - Missense 38 17:1496366-1496366 - - PATHOGENIC .85582 Confirmed somatic variant 24747642 surgery-fixed NS 44.5 ENSP00000413937.2:p.Ala380Ser ENST00000421807.6:c.1138G>T 17:g.1496366C>A INPP5K ENST00000421807.6 1347 33882 0187_CRUK_PC_0187_T1_DNA 2634990 2495386 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57441725 COSN26361667 124163913 c.776+4050G>A p.? Unknown 38 17:1502930-1502930 - - NEUTRAL .00259 Confirmed somatic variant 538 NS primary 62 ENST00000421807.6:c.776+4050G>A 17:g.1502930C>T INPP5K ENST00000421807.6 1347 33882 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV57440757 COSM6399895 124163275 c.1277G>T p.S426I Substitution - Missense 38 17:1496073-1496073 - - PATHOGENIC .91364 Confirmed somatic variant 676 NS primary 40 ENSP00000413937.2:p.Ser426Ile ENST00000421807.6:c.1277G>T 17:g.1496073C>A INPP5K ENST00000421807.6 1347 33882 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV57440779 COSM6398503 124163283 c.676G>A p.A226T Substitution - Missense 38 17:1507080-1507080 - - .61456 Confirmed somatic variant 676 NS primary 40 ENSP00000413937.2:p.Ala226Thr ENST00000421807.6:c.676G>A 17:g.1507080C>T INPP5K ENST00000421807.6 1347 33882 AOCS-108-1-7 2196304 2064582 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441425 COSN8831789 124164509 c.555-216C>G p.? Unknown 38 17:1508442-1508442 - - NEUTRAL .14437 Confirmed somatic variant 585 NS NS ENST00000421807.6:c.555-216C>G 17:g.1508442G>C INPP5K ENST00000421807.6 1347 33882 Pat_53_B 2492893 2355507 NS NS NS NS malignant_melanoma NS NS NS y COSV57440676 COSM5851850 124163730 c.946G>A p.G316S Substitution - Missense 38 17:1497953-1497953 - - NEUTRAL .10276 Confirmed somatic variant 24265153 surgery-fixed NS 53 ENSP00000413937.2:p.Gly316Ser ENST00000421807.6:c.946G>A 17:g.1497953C>T INPP5K ENST00000421807.6 1347 33882 TCGA-BH-A0HA-01 1899939 1788623 breast NS NS NS carcinoma NS NS NS y COSV100233635 COSM7691643 124162380 c.914C>T p.T305M Substitution - Missense 38 17:1497985-1497985 - - NEUTRAL .00988 Confirmed somatic variant 414 fresh/frozen - NOS primary 31 ENSP00000413937.2:p.Thr305Met ENST00000421807.6:c.914C>T 17:g.1497985G>A INPP5K ENST00000421807.6 1347 33882 TCGA-ZF-AA4X-01 2385833 2248665 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57440964 COSM7180871 124163938 c.1052C>T p.S351L Substitution - Missense 38 17:1496715-1496715 - - NEUTRAL .01467 Confirmed somatic variant 413 NS primary 56 ENSP00000413937.2:p.Ser351Leu ENST00000421807.6:c.1052C>T 17:g.1496715G>A INPP5K ENST00000421807.6 1347 33882 CHG-95T 2634277 2494673 liver NS NS NS other neoplasm NS NS y COSV57443045 COSN26671163 124164611 c.*415C>A p.? Unknown 38 17:1495408-1495408 - - PATHOGENIC .76068 Confirmed somatic variant 660 NS primary 49 ENST00000421807.6:c.*415C>A 17:g.1495408G>T INPP5K ENST00000421807.6 1347 33882 EOPC-014_tumor_01 2633793 2494189 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 124163381 c.554+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 45 ENST00000421807.6:c.554+22C>T 17:g.1509156G>A INPP5K ENST00000421807.6 1347 33882 TCGA-AG-3885-01 1651560 1566347 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV100233650 COSM7526312 124165239 c.201C>T p.A67= Substitution - coding silent 38 17:1513513-1513513 - - PATHOGENIC .75567 Confirmed somatic variant 375 NS primary 71 ENSP00000413937.2:p.Ala67= ENST00000421807.6:c.201C>T 17:g.1513513G>A INPP5K ENST00000421807.6 1347 33882 ML_124_T_01 2688384 2547366 skin NS NS NS carcinoma NS NS NS y COSV57441732 COSN27612453 124163854 c.262-1069A>G p.? Unknown 38 17:1510868-1510868 - - NEUTRAL .00068 Confirmed somatic variant 656 NS primary 74 ENST00000421807.6:c.262-1069A>G 17:g.1510868T>C INPP5K ENST00000421807.6 1347 33882 sysucc-1024T 2504582 2366914 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442104 COSM5763189 124163500 c.414T>G p.L138= Substitution - coding silent 38 17:1509318-1509318 - - NEUTRAL .49978 Confirmed somatic variant 646 NS primary 71 ENSP00000413937.2:p.Leu138= ENST00000421807.6:c.414T>G 17:g.1509318A>C INPP5K ENST00000421807.6 1347 33882 DA16008 2635113 2495509 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV57440471 COSM6437186 124164264 c.963G>A p.E321= Substitution - coding silent 38 17:1497936-1497936 - - PATHOGENIC .98858 Confirmed somatic variant 677 NS primary 62 ENSP00000413937.2:p.Glu321= ENST00000421807.6:c.963G>A 17:g.1497936C>T INPP5K ENST00000421807.6 1347 33882 HCC2157 1235084 1146870 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV57443001 COSM33344 124163054 c.944C>T p.S315F Substitution - Missense het 38 17:1497955-1497955 - - .65418 Confirmed somatic variant 16959974 cell-line primary 48 ENSP00000413937.2:p.Ser315Phe ENST00000421807.6:c.944C>T 17:g.1497955G>A INPP5K ENST00000421807.6 1347 33882 CRC-27T 2456797 2319634 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440751 COSN19718001 124164149 c.554+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 646 NS primary 69 ENST00000421807.6:c.554+396G>C 17:g.1508782C>G INPP5K ENST00000421807.6 1347 33882 ESOSCC162T 1860018 1750959 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440993 COSM1172380 124163436 c.350C>T p.S117F Substitution - Missense 38 17:1509711-1509711 - - PATHOGENIC .81311 Confirmed somatic variant 22877736 fresh/frozen - NOS primary 82 ENSP00000413937.2:p.Ser117Phe ENST00000421807.6:c.350C>T 17:g.1509711G>A INPP5K ENST00000421807.6 1347 33882 TCGA-D9-A4Z6-01 2121566 1995802 skin NS NS NS malignant_melanoma NS NS NS y COSV57442416 COSM3514457 124162641 c.210C>T p.D70= Substitution - coding silent 38 17:1513504-1513504 - - PATHOGENIC .8518 Confirmed somatic variant 540 NS NS 54 ENSP00000413937.2:p.Asp70= ENST00000421807.6:c.210C>T 17:g.1513504G>A INPP5K ENST00000421807.6 1347 33882 PCSI_0476_Pa_P_526 2385500 2248332 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57440553 COSN17208512 124165367 c.777-3101C>A p.? Unknown 38 17:1501223-1501223 - - NEUTRAL .00218 Confirmed somatic variant 382 NS primary 43 ENST00000421807.6:c.777-3101C>A 17:g.1501223G>T INPP5K ENST00000421807.6 1347 33882 TCGA-EB-A44O-01 2121602 1995838 skin NS NS NS malignant_melanoma NS NS NS y COSV100233745 COSM8129799 124164527 c.1067C>T p.P356L Substitution - Missense 38 17:1496700-1496700 - - NEUTRAL .39106 Confirmed somatic variant 540 NS NS 69 ENSP00000413937.2:p.Pro356Leu ENST00000421807.6:c.1067C>T 17:g.1496700G>A INPP5K ENST00000421807.6 1347 33882 TCGA-EB-A44O-01 2121602 1995838 skin NS NS NS malignant_melanoma NS NS NS y COSV100233746 COSM8129790 124164539 c.1066C>A p.P356T Substitution - Missense 38 17:1496701-1496701 - - PATHOGENIC .85982 Confirmed somatic variant 540 NS NS 69 ENSP00000413937.2:p.Pro356Thr ENST00000421807.6:c.1066C>A 17:g.1496701G>T INPP5K ENST00000421807.6 1347 33882 275 2748247 2606950 stomach NS NS NS carcinoma NS NS NS y COSV100233669 COSN30566516 124164315 c.776+96del p.? Unknown 38 17:1506890-1506890 - - Confirmed somatic variant 683 NS primary ENST00000421807.6:c.776+96del 17:g.1506890del INPP5K ENST00000421807.6 1347 33882 ICGC_GBM85_tumor 2634877 2495273 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV57439887 COSN23285747 124162929 c.777-3738_777-3737del p.? Unknown 38 17:1501882-1501883 - - Confirmed somatic variant 379 NS primary ENST00000421807.6:c.777-3738_777-3737del 17:g.1501882_1501883del INPP5K ENST00000421807.6 1347 33882 WGC067123 2549396 2410851 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440057 COSM975648 124162677 c.1258C>T p.R420C Substitution - Missense 38 17:1496092-1496092 - - NEUTRAL .09246 Confirmed somatic variant 646 NS primary 73 ENSP00000413937.2:p.Arg420Cys ENST00000421807.6:c.1258C>T 17:g.1496092G>A INPP5K ENST00000421807.6 1347 33882 WGC067123 2549396 2410851 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440072 COSN28860754 124162755 c.667-117G>A p.? Unknown 38 17:1507206-1507206 - - NEUTRAL .06517 Confirmed somatic variant 646 NS primary 73 ENST00000421807.6:c.667-117G>A 17:g.1507206C>T INPP5K ENST00000421807.6 1347 33882 CPCG_0184_Pr_P_P2 2121453 1995689 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440490 COSN4905499 124163949 c.45-1030G>T p.? Unknown 38 17:1515009-1515009 - - NEUTRAL .0047 Confirmed somatic variant 537 NS NS ENST00000421807.6:c.45-1030G>T 17:g.1515009C>A INPP5K ENST00000421807.6 1347 33882 HCC2157 749715 668686 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57443014 COSM30714 124163071 c.879C>T p.F293= Substitution - coding silent het 38 17:1498020-1498020 - - PATHOGENIC .83995 Confirmed somatic variant 678 cell-line primary 48 ENSP00000413937.2:p.Phe293= ENST00000421807.6:c.879C>T 17:g.1498020G>A INPP5K ENST00000421807.6 1347 33882 T112 2658324 2518483 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441957 COSM6686173 124163600 c.918C>T p.Y306= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000413937.2:p.Tyr306= ENST00000421807.6:c.918C>T 17:g.1497981G>A INPP5K ENST00000421807.6 1347 33882 345973 2144505 2013723 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441128 COSN5852672 124164884 c.963+12G>A p.? Unknown 38 17:1497924-1497924 - - NEUTRAL .00646 Confirmed somatic variant 22696596 NS NS 52 ENST00000421807.6:c.963+12G>A 17:g.1497924C>T INPP5K ENST00000421807.6 1347 33882 PCSI_0161_Pa_P_526 2339921 2204904 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441186 COSN16098920 124165198 c.666+186G>C p.? Unknown 38 17:1507929-1507929 - - NEUTRAL .00946 Confirmed somatic variant 382 NS primary 81 ENST00000421807.6:c.666+186G>C 17:g.1507929C>G INPP5K ENST00000421807.6 1347 33882 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV100233793 COSM8151450 124162848 c.356C>A p.P119H Substitution - Missense 38 17:1509705-1509705 - - PATHOGENIC .88297 Confirmed somatic variant 540 NS NS 37 ENSP00000413937.2:p.Pro119His ENST00000421807.6:c.356C>A 17:g.1509705G>T INPP5K ENST00000421807.6 1347 33882 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV100233872 COSM8146683 124164173 c.1067C>A p.P356H Substitution - Missense 38 17:1496700-1496700 - - PATHOGENIC .73316 Confirmed somatic variant 540 NS NS 37 ENSP00000413937.2:p.Pro356His ENST00000421807.6:c.1067C>A 17:g.1496700G>T INPP5K ENST00000421807.6 1347 33882 LP6007546-DNA_A01 2549449 2410904 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442857 COSN23559361 124163592 c.262-1679C>G p.? Unknown 38 17:1511478-1511478 - - NEUTRAL .04212 Confirmed somatic variant 535 NS primary ENST00000421807.6:c.262-1679C>G 17:g.1511478G>C INPP5K ENST00000421807.6 1347 33882 2014_Lung_sq_66_T 2744937 2603640 lung NS NS NS carcinoma NS NS NS y COSV57440812 COSN13701328 124162604 c.262-25G>A p.? Unknown 38 17:1509824-1509824 - - NEUTRAL .16185 Confirmed somatic variant 583 NS primary 53 ENST00000421807.6:c.262-25G>A 17:g.1509824C>T INPP5K ENST00000421807.6 1347 33882 LP6007438-DNA_A01 2263456 2130440 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442932 COSN14857961 124163153 c.777-3471C>T p.? Unknown 38 17:1501593-1501593 - - NEUTRAL .01431 Confirmed somatic variant 535 NS primary ENST00000421807.6:c.777-3471C>T 17:g.1501593G>A INPP5K ENST00000421807.6 1347 33882 TCGA-XK-AAIW-01 2339713 2204696 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 124162698 c.809G>A p.R270H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 435 NS primary 78 ENSP00000413937.2:p.Arg270His ENST00000421807.6:c.809G>A 17:g.1498090C>T INPP5K ENST00000421807.6 1347 33882 CHG-12-09247T 2634292 2494688 liver NS NS NS other neoplasm NS NS y COSV57441538 COSN30040156 124164870 c.777-34C>T p.? Unknown 38 17:1498156-1498156 - - NEUTRAL .02254 Confirmed somatic variant 660 NS primary 48 ENST00000421807.6:c.777-34C>T 17:g.1498156G>A INPP5K ENST00000421807.6 1347 33882 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV57440757 COSM6399895 124163275 c.1277G>T p.S426I Substitution - Missense 38 17:1496073-1496073 - - PATHOGENIC .91364 Confirmed somatic variant 676 NS primary 40 ENSP00000413937.2:p.Ser426Ile ENST00000421807.6:c.1277G>T 17:g.1496073C>A INPP5K ENST00000421807.6 1347 33882 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV57440779 COSM6398503 124163283 c.676G>A p.A226T Substitution - Missense 38 17:1507080-1507080 - - .61456 Confirmed somatic variant 676 NS primary 40 ENSP00000413937.2:p.Ala226Thr ENST00000421807.6:c.676G>A 17:g.1507080C>T INPP5K ENST00000421807.6 1347 33882 TCGA-D1-A16N-01 1783513 1687512 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57439815 COSM975660 124163116 c.275G>A p.R92H Substitution - Missense 38 17:1509786-1509786 - - PATHOGENIC .95481 Confirmed somatic variant 419 fresh/frozen - NOS primary 51 ENSP00000413937.2:p.Arg92His ENST00000421807.6:c.275G>A 17:g.1509786C>T INPP5K ENST00000421807.6 1347 33882 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV57442068 COSM5364464 124163791 c.788G>A p.R263H Substitution - Missense het 38 17:1498111-1498111 - - PATHOGENIC .97388 Confirmed somatic variant 25957691 NS NS 81 ENSP00000413937.2:p.Arg263His ENST00000421807.6:c.788G>A 17:g.1498111C>T INPP5K ENST00000421807.6 1347 33882 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV57442083 COSM5364466 124163800 c.78A>G p.A26= Substitution - coding silent het 38 17:1513946-1513946 - - NEUTRAL .29067 Confirmed somatic variant 25957691 NS NS 81 ENSP00000413937.2:p.Ala26= ENST00000421807.6:c.78A>G 17:g.1513946T>C INPP5K ENST00000421807.6 1347 33882 551 2478463 2341233 adrenal_gland adrenal_gland NS NS adrenal_cortical_adenoma NS NS NS y COSV57442792 COSM5613049 124162980 c.300C>G p.V100= Substitution - coding silent 38 17:1509761-1509761 - - PATHOGENIC .8448 Confirmed somatic variant 25490274 fixed - NOS primary 68 ENSP00000413937.2:p.Val100= ENST00000421807.6:c.300C>G 17:g.1509761G>C INPP5K ENST00000421807.6 1347 33882 TCGA-ER-A42K-06 2340113 2205096 skin NS NS NS malignant_melanoma NS NS NS y COSV57443110 COSM4894813 124163222 c.881C>T p.S294F Substitution - Missense 38 17:1498018-1498018 - - NEUTRAL .04612 Confirmed somatic variant 540 NS NS 40 ENSP00000413937.2:p.Ser294Phe ENST00000421807.6:c.881C>T 17:g.1498018G>A INPP5K ENST00000421807.6 1347 33882 YUPAER 2439354 2302195 skin NS NS NS malignant_melanoma NS NS NS y COSV57440177 COSM5385733 124164838 c.579G>A p.M193I Substitution - Missense het 38 17:1508202-1508202 - - PATHOGENIC .75407 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 70 ENSP00000413937.2:p.Met193Ile ENST00000421807.6:c.579G>A 17:g.1508202C>T INPP5K ENST00000421807.6 1347 33882 TCGA-GM-A2DH-01 2187734 2056012 breast NS NS NS carcinoma NS NS NS y COSV100233735 COSM7700391 124163575 c.966G>A p.L322= Substitution - coding silent 38 17:1496801-1496801 - - PATHOGENIC .83189 Confirmed somatic variant 414 NS NS 58 ENSP00000413937.2:p.Leu322= ENST00000421807.6:c.966G>A 17:g.1496801C>T INPP5K ENST00000421807.6 1347 33882 MSU2-c 2809979 2666641 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 124163172 c.616C>T p.R206W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000413937.2:p.Arg206Trp ENST00000421807.6:c.616C>T 17:g.1508165G>A INPP5K ENST00000421807.6 1347 33882 T2932 2296135 2161738 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441581 COSM4692622 124162515 c.916T>C p.Y306H Substitution - Missense 38 17:1497983-1497983 - - PATHOGENIC .9847 Confirmed somatic variant 25344691 NS NS 78.08 ENSP00000413937.2:p.Tyr306His ENST00000421807.6:c.916T>C 17:g.1497983A>G INPP5K ENST00000421807.6 1347 33882 MSU2-c 2809979 2666641 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV100233979 COSM9174724 124163161 c.1006G>A p.E336K Substitution - Missense 38 17:1496761-1496761 - - PATHOGENIC .96769 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000413937.2:p.Glu336Lys ENST00000421807.6:c.1006G>A 17:g.1496761C>T INPP5K ENST00000421807.6 1347 33882 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV57439956 COSM5851848 124164296 c.1253G>A p.S418N Substitution - Missense 38 17:1496097-1496097 - - NEUTRAL .01037 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000413937.2:p.Ser418Asn ENST00000421807.6:c.1253G>A 17:g.1496097C>T INPP5K ENST00000421807.6 1347 33882 TCGA-A5-A2K7-01 2198265 2066543 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233685 COSN31545877 124165157 c.*288C>A p.? Unknown 38 17:1495535-1495535 - - NEUTRAL .03426 Confirmed somatic variant 419 NS NS 41 ENST00000421807.6:c.*288C>A 17:g.1495535G>T INPP5K ENST00000421807.6 1347 33882 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV57439973 COSM5851852 124164307 c.619G>A p.E207K Substitution - Missense 38 17:1508162-1508162 - - .54001 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000413937.2:p.Glu207Lys ENST00000421807.6:c.619G>A 17:g.1508162C>T INPP5K ENST00000421807.6 1347 33882 2857095 2857095 2712395 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105203823 COSM9525077 124165499 c.1058C>T p.S353L Substitution - Missense 38 17:1496709-1496709 - - PATHOGENIC .74004 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000413937.2:p.Ser353Leu ENST00000421807.6:c.1058C>T 17:g.1496709G>A INPP5K ENST00000421807.6 1347 33882 TCGA-D9-A6EC-06 2262880 2129864 skin NS NS NS malignant_melanoma NS NS NS y COSV100233657 COSM8115635 124162616 c.623C>T p.S208F Substitution - Missense 38 17:1508158-1508158 - - PATHOGENIC .94511 Confirmed somatic variant 540 NS NS 56 ENSP00000413937.2:p.Ser208Phe ENST00000421807.6:c.623C>T 17:g.1508158G>A INPP5K ENST00000421807.6 1347 33882 H2347 2776270 2634406 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99052641 COSM7372284 124163104 c.513G>C p.Q171H Substitution - Missense 38 17:1509219-1509219 - - PATHOGENIC .91716 Confirmed somatic variant 29681454 NS NS 54 ENSP00000413937.2:p.Gln171His ENST00000421807.6:c.513G>C 17:g.1509219C>G INPP5K ENST00000421807.6 1347 33882 CPCG0211-F1 2340573 2205556 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57442127 COSN29616394 124163772 c.963+465_963+466dup p.? Unknown 38 17:1497485-1497486 - - Confirmed somatic variant 537 NS primary ENST00000421807.6:c.963+465_963+466dup 17:g.1497484_1497485dup INPP5K ENST00000421807.6 1347 33882 CN-AML-NR-08-Dx 2456284 2319121 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 124162507 c.555-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 blood-bone marrow primary ENST00000421807.6:c.555-77G>A 17:g.1508303C>T INPP5K ENST00000421807.6 1347 33882 PD9000a 1613700 1532748 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441286 COSN22701850 124165428 c.261+1485C>G p.? Unknown 38 17:1511968-1511968 - - .68966 Confirmed somatic variant 652 NS NS ENST00000421807.6:c.261+1485C>G 17:g.1511968G>C INPP5K ENST00000421807.6 1347 33882 TCGA-06-2566-01 2178226 2046524 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233679 COSM7489154 124163903 c.16C>A p.L6M Substitution - Missense 38 17:1516484-1516484 - - NEUTRAL .13026 Confirmed somatic variant 329 NS NS 23 ENSP00000413937.2:p.Leu6Met ENST00000421807.6:c.16C>A 17:g.1516484G>T INPP5K ENST00000421807.6 1347 33882 PCSI_0048_Pa_P 1653156 1567943 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441452 COSN8240383 124162564 c.262-230A>G p.? Unknown 38 17:1510029-1510029 - - NEUTRAL .04077 Confirmed somatic variant 382 fresh/frozen - NOS primary ENST00000421807.6:c.262-230A>G 17:g.1510029T>C INPP5K ENST00000421807.6 1347 33882 T2932 2658347 2518506 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441581 COSM4692622 124162515 c.916T>C p.Y306H Substitution - Missense 38 17:1497983-1497983 - - PATHOGENIC .9847 Confirmed somatic variant 27149842 NS NS 78.08 ENSP00000413937.2:p.Tyr306His ENST00000421807.6:c.916T>C 17:g.1497983A>G INPP5K ENST00000421807.6 1347 33882 HCC139T 1919194 1806515 liver NS NS NS carcinoma NS NS NS y COSV57440912 COSN6414831 124165807 c.554+146T>C p.? Unknown 38 17:1509032-1509032 - - NEUTRAL .00699 Confirmed somatic variant 323 fresh/frozen - NOS primary ENST00000421807.6:c.554+146T>C 17:g.1509032A>G INPP5K ENST00000421807.6 1347 33882 HCC139T 1919194 1806515 liver NS NS NS carcinoma NS NS NS y COSV57440917 COSN6414832 124165813 c.554+144T>C p.? Unknown 38 17:1509034-1509034 - - NEUTRAL .00818 Confirmed somatic variant 323 fresh/frozen - NOS primary ENST00000421807.6:c.554+144T>C 17:g.1509034A>G INPP5K ENST00000421807.6 1347 33882 TCGA-85-A4CL-01 2195132 2063410 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233961 COSM8679772 124163955 c.1344C>G p.I448M Substitution - Missense 38 17:1495826-1495826 - - PATHOGENIC .73673 Confirmed somatic variant 418 NS NS 65 ENSP00000413937.2:p.Ile448Met ENST00000421807.6:c.1344C>G 17:g.1495826G>C INPP5K ENST00000421807.6 1347 33882 2843839 2843839 2699247 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS y COSV105883442 COSM9973989 124164202 c.1277del p.S426Tfs*11 Deletion - Frameshift 38 17:1496073-1496073 - - Confirmed somatic variant 27655895 blood-bone marrow recurrent 6 ENSP00000413937.2:p.Ser426ThrfsTer11 ENST00000421807.6:c.1277del 17:g.1496073del INPP5K ENST00000421807.6 1347 33882 CSCC-27-T 2292469 2158533 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441071 COSM4488765 124163457 c.337C>T p.L113= Substitution - coding silent het 38 17:1509724-1509724 - - PATHOGENIC .75042 Confirmed somatic variant 25303977 surgery fresh/frozen primary 72 ENSP00000413937.2:p.Leu113= ENST00000421807.6:c.337C>T 17:g.1509724G>A INPP5K ENST00000421807.6 1347 33882 T1222 2658242 2518401 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 124163172 c.616C>T p.R206W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 71.91 ENSP00000413937.2:p.Arg206Trp ENST00000421807.6:c.616C>T 17:g.1508165G>A INPP5K ENST00000421807.6 1347 33882 T691 2658541 2518700 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 124163172 c.616C>T p.R206W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 65.58 ENSP00000413937.2:p.Arg206Trp ENST00000421807.6:c.616C>T 17:g.1508165G>A INPP5K ENST00000421807.6 1347 33882 CPCG0217-F1 2340498 2205481 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440046 COSN16288830 124164552 c.776+2259T>A p.? Unknown 38 17:1504721-1504721 - - NEUTRAL .03225 Confirmed somatic variant 537 NS primary ENST00000421807.6:c.776+2259T>A 17:g.1504721A>T INPP5K ENST00000421807.6 1347 33882 EOPC-139_tumor_01 2549437 2410892 prostate NS NS NS carcinoma NS NS NS y COSV57440751 COSN19718001 124164149 c.554+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 534 NS primary 47 ENST00000421807.6:c.554+396G>C 17:g.1508782C>G INPP5K ENST00000421807.6 1347 33882 HUB-02-B2-006 2607081 2466795 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442265 COSM6053586 124162772 c.1315G>C p.D439H Substitution - Missense 38 17:1495855-1495855 - - NEUTRAL .0652 Confirmed somatic variant 670 organoid culture NS ENSP00000413937.2:p.Asp439His ENST00000421807.6:c.1315G>C 17:g.1495855C>G INPP5K ENST00000421807.6 1347 33882 8058339 2121213 1995449 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441419 COSN7160500 124164394 c.44+989T>G p.? Unknown 38 17:1515467-1515467 - - NEUTRAL .0841 Confirmed somatic variant 328 NS NS ENST00000421807.6:c.44+989T>G 17:g.1515467A>C INPP5K ENST00000421807.6 1347 33882 PCSI_0048_Pa_P_526 2197258 2065536 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441452 COSN8240383 124162564 c.262-230A>G p.? Unknown 38 17:1510029-1510029 - - NEUTRAL .04077 Confirmed somatic variant 382 NS NS ENST00000421807.6:c.262-230A>G 17:g.1510029T>C INPP5K ENST00000421807.6 1347 33882 TCGA-D9-A6EC-06 2262880 2129864 skin NS NS NS malignant_melanoma NS NS NS y COSV100233656 COSM8115268 124162609 c.624C>T p.S208= Substitution - coding silent 38 17:1508157-1508157 - - PATHOGENIC .89222 Confirmed somatic variant 540 NS NS 56 ENSP00000413937.2:p.Ser208= ENST00000421807.6:c.624C>T 17:g.1508157G>A INPP5K ENST00000421807.6 1347 33882 LICA-CN-HCC_WGS_016T 2634223 2494619 liver NS NS NS other neoplasm NS NS y COSV57440981 COSN26616313 124162860 c.45-173C>T p.? Unknown 38 17:1514152-1514152 - - NEUTRAL .00383 Confirmed somatic variant 660 NS primary 48 ENST00000421807.6:c.45-173C>T 17:g.1514152G>A INPP5K ENST00000421807.6 1347 33882 364 2131821 2005885 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441008 COSM3722171 124163131 c.523G>A p.G175R Substitution - Missense 38 17:1509209-1509209 - - NEUTRAL .07332 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 74 ENSP00000413937.2:p.Gly175Arg ENST00000421807.6:c.523G>A 17:g.1509209C>T INPP5K ENST00000421807.6 1347 33882 TCGA-DA-A960-01 2380407 2243239 skin NS NS NS malignant_melanoma NS NS NS y COSV100233581 COSM8029324 124163234 c.152+1dup p.? Unknown 38 17:1513873-1513874 - - Confirmed somatic variant 540 NS primary 73 ENST00000421807.6:c.152+1dup 17:g.1513873dup INPP5K ENST00000421807.6 1347 33882 TCGA-LP-A4AX-01 2193354 2061632 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441157 COSM4829770 124162997 c.199G>A p.A67T Substitution - Missense 38 17:1513515-1513515 - - PATHOGENIC .84408 Confirmed somatic variant 415 NS NS 45 ENSP00000413937.2:p.Ala67Thr ENST00000421807.6:c.199G>A 17:g.1513515C>T INPP5K ENST00000421807.6 1347 33882 4-2 2746099 2604802 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441758 COSN28835429 124163018 c.777-85G>A p.? Unknown 38 17:1498207-1498207 - - NEUTRAL .00964 Confirmed somatic variant 646 NS primary 46 ENST00000421807.6:c.777-85G>A 17:g.1498207C>T INPP5K ENST00000421807.6 1347 33882 61 2497169 2359521 small_intestine duodenum NS NS adenoma NS NS NS y COSV57441337 COSM5740783 124162633 c.104T>C p.L35P Substitution - Missense 38 17:1513920-1513920 - - PATHOGENIC .99507 Confirmed somatic variant 26806338 fresh/frozen - NOS primary ENSP00000413937.2:p.Leu35Pro ENST00000421807.6:c.104T>C 17:g.1513920A>G INPP5K ENST00000421807.6 1347 33882 PD_01 2688657 2547639 skin shoulder NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440218 COSM6867459 124165145 c.735C>A p.P245= Substitution - coding silent het 38 17:1507021-1507021 - - .63631 Confirmed somatic variant 24662767 surgery fresh/frozen NS 71 ENSP00000413937.2:p.Pro245= ENST00000421807.6:c.735C>A 17:g.1507021G>T INPP5K ENST00000421807.6 1347 33882 38T 2745883 2604586 liver NS NS NS other neoplasm NS NS y COSV57442315 COSN29975831 124163326 c.45-927dup p.? Unknown 38 17:1514924-1514925 - - Confirmed somatic variant 660 NS primary 62 ENST00000421807.6:c.45-927dup 17:g.1514924dup INPP5K ENST00000421807.6 1347 33882 TCGA-AP-A1DM-01 2198333 2066611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233687 COSM8955248 124165163 c.947G>A p.G316D Substitution - Missense 38 17:1497952-1497952 - - NEUTRAL .35784 Confirmed somatic variant 419 NS NS 60 ENSP00000413937.2:p.Gly316Asp ENST00000421807.6:c.947G>A 17:g.1497952C>T INPP5K ENST00000421807.6 1347 33882 19 2747991 2606694 stomach NS NS NS carcinoma NS NS NS y COSV100233839 COSN30565011 124163964 c.1290+74G>T p.? Unknown 38 17:1495986-1495986 - - NEUTRAL .01269 Confirmed somatic variant 683 NS primary ENST00000421807.6:c.1290+74G>T 17:g.1495986C>A INPP5K ENST00000421807.6 1347 33882 T_CCA_SG_4 2688136 2547118 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57442188 COSN27227981 124164363 c.776+1837dup p.? Unknown 38 17:1505153-1505154 - - Confirmed somatic variant 653 NS primary 61 ENST00000421807.6:c.776+1837dup 17:g.1505153dup INPP5K ENST00000421807.6 1347 33882 I2L-P24Tb-Tumor-Biopsy 2433484 2296365 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV57441627 COSM5364256 124162420 c.955G>A p.D319N Substitution - Missense het 38 17:1497944-1497944 - - PATHOGENIC .70948 Confirmed somatic variant 25957691 NS NS 60 ENSP00000413937.2:p.Asp319Asn ENST00000421807.6:c.955G>A 17:g.1497944C>T INPP5K ENST00000421807.6 1347 33882 T189255 2658275 2518434 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57443168 COSM6686179 124163518 c.902G>A p.S301N Substitution - Missense 38 17:1497997-1497997 - - NEUTRAL .02559 Confirmed somatic variant 27149842 NS NS 77.16 ENSP00000413937.2:p.Ser301Asn ENST00000421807.6:c.902G>A 17:g.1497997C>T INPP5K ENST00000421807.6 1347 33882 TCGA-F1-6177-01 2198156 2066434 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233696 COSN30497832 124164830 c.-22C>T p.? Unknown 38 17:1516521-1516521 - - NEUTRAL .14094 Confirmed somatic variant 541 NS NS 90 ENST00000421807.6:c.-22C>T 17:g.1516521G>A INPP5K ENST00000421807.6 1347 33882 2785969 2785969 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 124163600 c.918C>T p.Y306= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000413937.2:p.Tyr306= ENST00000421807.6:c.918C>T 17:g.1497981G>A INPP5K ENST00000421807.6 1347 33882 2275_T 2194907 2063185 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441332 COSN8602376 124163143 c.262-25G>T p.? Unknown 38 17:1509824-1509824 - - NEUTRAL .2918 Confirmed somatic variant 583 NS NS ENST00000421807.6:c.262-25G>T 17:g.1509824C>A INPP5K ENST00000421807.6 1347 33882 TCGA-D1-A1NS-01 2198290 2066568 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233692 COSM8852950 124165832 c.835C>T p.P279S Substitution - Missense 38 17:1498064-1498064 - - NEUTRAL .10371 Confirmed somatic variant 419 NS NS 53 ENSP00000413937.2:p.Pro279Ser ENST00000421807.6:c.835C>T 17:g.1498064G>A INPP5K ENST00000421807.6 1347 33882 2785971 2785971 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 124163600 c.918C>T p.Y306= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000413937.2:p.Tyr306= ENST00000421807.6:c.918C>T 17:g.1497981G>A INPP5K ENST00000421807.6 1347 33882 TCGA-GN-A8LK-06 2340243 2205226 skin NS NS NS malignant_melanoma NS NS NS y COSV100233562 COSM7958046 124165326 c.507G>A p.E169= Substitution - coding silent 38 17:1509225-1509225 - - PATHOGENIC .7441 Confirmed somatic variant 540 NS NS 70 ENSP00000413937.2:p.Glu169= ENST00000421807.6:c.507G>A 17:g.1509225C>T INPP5K ENST00000421807.6 1347 33882 EOPC-171_tumor_01 2633752 2494148 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 124163381 c.554+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 50 ENST00000421807.6:c.554+22C>T 17:g.1509156G>A INPP5K ENST00000421807.6 1347 33882 CSCC-20-T 2292468 2158532 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441169 COSM4508387 124164751 c.773C>T p.T258I Substitution - Missense het 38 17:1506983-1506983 - - PATHOGENIC .87428 Confirmed somatic variant 25303977 surgery fresh/frozen primary 93 ENSP00000413937.2:p.Thr258Ile ENST00000421807.6:c.773C>T 17:g.1506983G>A INPP5K ENST00000421807.6 1347 33882 LP6005500-DNA_A01 2262738 2129722 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57441040 COSN17309196 124162819 c.555-355C>T p.? Unknown 38 17:1508581-1508581 - - NEUTRAL .05546 Confirmed somatic variant 535 NS primary ENST00000421807.6:c.555-355C>T 17:g.1508581G>A INPP5K ENST00000421807.6 1347 33882 TCGA-AA-A010-01 1651109 1565896 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57439795 COSM178159 124164339 c.787C>T p.R263C Substitution - Missense 38 17:1498112-1498112 - - PATHOGENIC .91324 Confirmed somatic variant 22810696 376 NS NS 46 ENSP00000413937.2:p.Arg263Cys ENST00000421807.6:c.787C>T 17:g.1498112G>A INPP5K ENST00000421807.6 1347 33882 LICA-CN-HCC_WGS_009T 2634216 2494612 liver NS NS NS other neoplasm NS NS y COSV57440248 COSN26517209 124163648 c.261+1573A>C p.? Unknown 38 17:1511880-1511880 - - NEUTRAL .00604 Confirmed somatic variant 660 NS primary 52 ENST00000421807.6:c.261+1573A>C 17:g.1511880T>G INPP5K ENST00000421807.6 1347 33882 A001-T-S01 2757354 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV100233671 COSM7411841 124164100 c.694C>A p.L232M Substitution - Missense 38 17:1507062-1507062 - - .59764 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000413937.2:p.Leu232Met ENST00000421807.6:c.694C>A 17:g.1507062G>T INPP5K ENST00000421807.6 1347 33882 TCGA-AX-A3FT-01 2198367 2066645 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233984 COSM9040758 124164328 c.122G>A p.R41Q Substitution - Missense 38 17:1513902-1513902 - - NEUTRAL .01064 Confirmed somatic variant 419 NS NS 64 ENSP00000413937.2:p.Arg41Gln ENST00000421807.6:c.122G>A 17:g.1513902C>T INPP5K ENST00000421807.6 1347 33882 PD40845k_lo0005 2875098 2729864 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma non_papillary_transitional_cell_carcinoma_non_invasive NS y COSV105203812 COSN32152386 124163664 c.777-4279G>A p.? Unknown 38 17:1502401-1502401 - - NEUTRAL .03905 Confirmed somatic variant 33004514 surgery-fixed NS 67 ENST00000421807.6:c.777-4279G>A 17:g.1502401C>T INPP5K ENST00000421807.6 1347 33882 TCGA-EC-A24G-01 2198318 2066596 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233972 COSM8814445 124164979 c.552C>T p.H184= Substitution - coding silent 38 17:1509180-1509180 - - .56858 Confirmed somatic variant 419 NS NS 57 ENSP00000413937.2:p.His184= ENST00000421807.6:c.552C>T 17:g.1509180G>A INPP5K ENST00000421807.6 1347 33882 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 124163806 c.554+388_554+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 60 ENST00000421807.6:c.554+388_554+389insC 17:g.1508789_1508790insG INPP5K ENST00000421807.6 1347 33882 TCGA-19-1787-01 2178217 2046515 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233576 COSM7466631 124162581 c.849C>T p.P283= Substitution - coding silent 38 17:1498050-1498050 - - NEUTRAL .06315 Confirmed somatic variant 329 NS NS 48 ENSP00000413937.2:p.Pro283= ENST00000421807.6:c.849C>T 17:g.1498050G>A INPP5K ENST00000421807.6 1347 33882 T1224 2658634 2518793 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440352 COSM5642741 124162647 c.863C>T p.P288L Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .00382 Confirmed somatic variant 27149842 NS NS 57.75 ENSP00000413937.2:p.Pro288Leu ENST00000421807.6:c.863C>T 17:g.1498036G>A INPP5K ENST00000421807.6 1347 33882 0129_CRUK_PC_0129_T1_DNA 2634968 2495364 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440086 COSN26093849 124162924 c.777-617G>A p.? Unknown 38 17:1498739-1498739 - - NEUTRAL .0021 Confirmed somatic variant 538 NS primary 55 ENST00000421807.6:c.777-617G>A 17:g.1498739C>T INPP5K ENST00000421807.6 1347 33882 GCTK_16444_T 2747525 2606228 stomach NS NS NS carcinoma NS NS NS y COSV100233973 COSM8588882 124162463 c.555-7del p.? Unknown 38 17:1508239-1508239 - - Confirmed somatic variant 683 NS primary ENST00000421807.6:c.555-7del 17:g.1508239del INPP5K ENST00000421807.6 1347 33882 LP6005500-DNA_C01 2549483 2410938 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442243 COSN23565574 124165056 c.776+3134G>A p.? Unknown 38 17:1503846-1503846 - - NEUTRAL .0167 Confirmed somatic variant 535 NS primary ENST00000421807.6:c.776+3134G>A 17:g.1503846C>T INPP5K ENST00000421807.6 1347 33882 AOCS-139-12-5 2185820 2054117 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441924 COSM3983266 124163765 c.191C>G p.S64C Substitution - Missense 38 17:1513523-1513523 - - PATHOGENIC .9676 Confirmed somatic variant 585 NS NS ENSP00000413937.2:p.Ser64Cys ENST00000421807.6:c.191C>G 17:g.1513523G>C INPP5K ENST00000421807.6 1347 33882 RK298_C01 2120999 1995235 liver NS NS NS carcinoma NS NS NS y COSV57441742 COSM3701153 124163012 c.1143G>T p.W381C Substitution - Missense 38 17:1496361-1496361 - - PATHOGENIC .95169 Confirmed somatic variant 322 NS NS ENSP00000413937.2:p.Trp381Cys ENST00000421807.6:c.1143G>T 17:g.1496361C>A INPP5K ENST00000421807.6 1347 33882 cSCCP2 1604870 1524189 skin hand NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440547 COSM137654 124163028 c.106C>T p.L36F Substitution - Missense 38 17:1513918-1513918 - - PATHOGENIC .98532 Confirmed somatic variant 21984974 surgery - NOS primary 84 ENSP00000413937.2:p.Leu36Phe ENST00000421807.6:c.106C>T 17:g.1513918G>A INPP5K ENST00000421807.6 1347 33882 4-2 2746099 2604802 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441742 COSM3701153 124163012 c.1143G>T p.W381C Substitution - Missense 38 17:1496361-1496361 - - PATHOGENIC .95169 Confirmed somatic variant 646 NS primary 46 ENSP00000413937.2:p.Trp381Cys ENST00000421807.6:c.1143G>T 17:g.1496361C>A INPP5K ENST00000421807.6 1347 33882 A001-T-S02 2757355 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV100233671 COSM7411841 124164100 c.694C>A p.L232M Substitution - Missense 38 17:1507062-1507062 - - .59764 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000413937.2:p.Leu232Met ENST00000421807.6:c.694C>A 17:g.1507062G>T INPP5K ENST00000421807.6 1347 33882 T306558 2658252 2518411 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441669 COSM6686185 124163405 c.1037T>C p.M346T Substitution - Missense 38 17:1496730-1496730 - - .64209 Confirmed somatic variant 27149842 NS NS 80.41 ENSP00000413937.2:p.Met346Thr ENST00000421807.6:c.1037T>C 17:g.1496730A>G INPP5K ENST00000421807.6 1347 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442916 COSN26437000 124164572 c.667-87G>A p.? Unknown 38 17:1507176-1507176 - - NEUTRAL .11296 Confirmed somatic variant 646 NS primary 45 ENST00000421807.6:c.667-87G>A 17:g.1507176C>T INPP5K ENST00000421807.6 1347 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442897 COSM6225141 124164563 c.986C>T p.P329L Substitution - Missense 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 646 NS primary 45 ENSP00000413937.2:p.Pro329Leu ENST00000421807.6:c.986C>T 17:g.1496781G>A INPP5K ENST00000421807.6 1347 33882 12 2747984 2606687 stomach NS NS NS carcinoma NS NS NS y COSV57440057 COSM975648 124162677 c.1258C>T p.R420C Substitution - Missense 38 17:1496092-1496092 - - NEUTRAL .09246 Confirmed somatic variant 683 NS primary ENSP00000413937.2:p.Arg420Cys ENST00000421807.6:c.1258C>T 17:g.1496092G>A INPP5K ENST00000421807.6 1347 33882 TCGA-D1-A2G0-01 2198422 2066700 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233799 COSM8816674 124163994 c.1291-1G>A p.? Unknown 38 17:1495880-1495880 - - PATHOGENIC .91507 Confirmed somatic variant 419 NS NS 70 ENST00000421807.6:c.1291-1G>A 17:g.1495880C>T INPP5K ENST00000421807.6 1347 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233827 COSM7468116 124164910 c.805G>A p.D269N Substitution - Missense 38 17:1498094-1498094 - - PATHOGENIC .97388 Confirmed somatic variant 329 NS NS 53 ENSP00000413937.2:p.Asp269Asn ENST00000421807.6:c.805G>A 17:g.1498094C>T INPP5K ENST00000421807.6 1347 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233829 COSM7472155 124164921 c.162A>C p.E54D Substitution - Missense 38 17:1513552-1513552 - - PATHOGENIC .93138 Confirmed somatic variant 329 NS NS 53 ENSP00000413937.2:p.Glu54Asp ENST00000421807.6:c.162A>C 17:g.1513552T>G INPP5K ENST00000421807.6 1347 33882 tumor_4144951 2385475 2248307 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57439887 COSN23285747 124162929 c.777-3738_777-3737del p.? Unknown 38 17:1501882-1501883 - - Confirmed somatic variant 440 NS primary 62 ENST00000421807.6:c.777-3738_777-3737del 17:g.1501882_1501883del INPP5K ENST00000421807.6 1347 33882 TCGA-3M-AB46-01 2457336 2320173 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233619 COSM8193053 124165671 c.1296G>A p.P432= Substitution - coding silent 38 17:1495874-1495874 - - NEUTRAL .00578 Confirmed somatic variant 541 NS primary 70 ENSP00000413937.2:p.Pro432= ENST00000421807.6:c.1296G>A 17:g.1495874C>T INPP5K ENST00000421807.6 1347 33882 tumor_4176133 2121030 1995266 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441778 COSN4768428 124164256 c.379-151G>A p.? Unknown 38 17:1509504-1509504 - - NEUTRAL .16975 Confirmed somatic variant 440 NS NS ENST00000421807.6:c.379-151G>A 17:g.1509504C>T INPP5K ENST00000421807.6 1347 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233824 COSM7469318 124164901 c.879C>A p.F293L Substitution - Missense 38 17:1498020-1498020 - - PATHOGENIC .9186 Confirmed somatic variant 329 NS NS 53 ENSP00000413937.2:p.Phe293Leu ENST00000421807.6:c.879C>A 17:g.1498020G>T INPP5K ENST00000421807.6 1347 33882 T3611 2658318 2518477 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442475 COSM6686187 124162667 c.631A>C p.N211H Substitution - Missense 38 17:1508150-1508150 - - PATHOGENIC .81961 Confirmed somatic variant 27149842 NS NS 69.08 ENSP00000413937.2:p.Asn211His ENST00000421807.6:c.631A>C 17:g.1508150T>G INPP5K ENST00000421807.6 1347 33882 8068611 2197319 2065597 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57439861 COSN9222116 124164594 c.777-2531G>A p.? Unknown 38 17:1500653-1500653 - - NEUTRAL .00011 Confirmed somatic variant 586 NS NS ENST00000421807.6:c.777-2531G>A 17:g.1500653C>T INPP5K ENST00000421807.6 1347 33882 TCGA-VQ-A8P2-01 2339964 2204947 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233726 COSM8162258 124162901 c.969G>T p.K323N Substitution - Missense 38 17:1496798-1496798 - - PATHOGENIC .91255 Confirmed somatic variant 541 NS primary 68 ENSP00000413937.2:p.Lys323Asn ENST00000421807.6:c.969G>T 17:g.1496798C>A INPP5K ENST00000421807.6 1347 33882 TCGA-AA-3672-01 1651015 1565802 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57440002 COSM266711 124162895 c.1259G>A p.R420H Substitution - Missense 38 17:1496091-1496091 - - NEUTRAL .0033 Confirmed somatic variant 22810696 376 NS NS 90 ENSP00000413937.2:p.Arg420His ENST00000421807.6:c.1259G>A 17:g.1496091C>T INPP5K ENST00000421807.6 1347 33882 8016470 1842414 1735679 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441913 COSN7160484 124164163 c.776+327G>C p.? Unknown 38 17:1506653-1506653 - - NEUTRAL .03287 Confirmed somatic variant 328 cell-line NS ENST00000421807.6:c.776+327G>C 17:g.1506653C>G INPP5K ENST00000421807.6 1347 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442923 COSN26436233 124164580 c.555-162T>C p.? Unknown 38 17:1508388-1508388 - - NEUTRAL .06716 Confirmed somatic variant 646 NS primary 45 ENST00000421807.6:c.555-162T>C 17:g.1508388A>G INPP5K ENST00000421807.6 1347 33882 0198_CRUK_PC_0198_T1_DNA 2634978 2495374 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57442458 COSN26174651 124162452 c.776+1435G>C p.? Unknown 38 17:1505545-1505545 - - NEUTRAL .02245 Confirmed somatic variant 538 NS primary 57 ENST00000421807.6:c.776+1435G>C 17:g.1505545C>G INPP5K ENST00000421807.6 1347 33882 2014_Lung_sq_23_T 2744894 2603597 lung NS NS NS carcinoma NS NS NS y COSV57441227 COSN28674085 124163192 c.667-74C>G p.? Unknown 38 17:1507163-1507163 - - NEUTRAL .08275 Confirmed somatic variant 583 NS primary 74 ENST00000421807.6:c.667-74C>G 17:g.1507163G>C INPP5K ENST00000421807.6 1347 33882 GCYC_414_T 2747633 2606336 stomach NS NS NS carcinoma NS NS NS y COSV57442897 COSM6225141 124164563 c.986C>T p.P329L Substitution - Missense 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 683 NS primary ENSP00000413937.2:p.Pro329Leu ENST00000421807.6:c.986C>T 17:g.1496781G>A INPP5K ENST00000421807.6 1347 33882 PASLZM 2367612 2230450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV57442156 COSM5006193 124162410 c.1021G>A p.V341M Substitution - Missense 38 17:1496746-1496746 - - NEUTRAL .01467 Confirmed somatic variant 25790293 NS NS ENSP00000413937.2:p.Val341Met ENST00000421807.6:c.1021G>A 17:g.1496746C>T INPP5K ENST00000421807.6 1347 33882 PASLZM 2367612 2230450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV57442137 COSM5006535 124162401 c.1288C>T p.Q430* Substitution - Nonsense 38 17:1496062-1496062 - - PATHOGENIC .82826 Confirmed somatic variant 25790293 NS NS ENSP00000413937.2:p.Gln430Ter ENST00000421807.6:c.1288C>T 17:g.1496062G>A INPP5K ENST00000421807.6 1347 33882 TCGA-D9-A4Z6-06 2263151 2130135 skin NS NS NS malignant_melanoma NS NS NS y COSV57442416 COSM3514457 124162641 c.210C>T p.D70= Substitution - coding silent 38 17:1513504-1513504 - - PATHOGENIC .8518 Confirmed somatic variant 540 NS NS 54 ENSP00000413937.2:p.Asp70= ENST00000421807.6:c.210C>T 17:g.1513504G>A INPP5K ENST00000421807.6 1347 33882 TCGA-HU-A4GN-01 2198035 2066313 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440664 COSM4064059 124162370 c.689A>G p.D230G Substitution - Missense 38 17:1507067-1507067 - - PATHOGENIC .86353 Confirmed somatic variant 541 NS NS 61 ENSP00000413937.2:p.Asp230Gly ENST00000421807.6:c.689A>G 17:g.1507067T>C INPP5K ENST00000421807.6 1347 33882 EXTERN_MELA_20140526_033 2839346 2695112 skin trunk NS NS malignant_melanoma NS NS NS y COSV57441603 COSM3514448 124162945 c.1294C>T p.P432S Substitution - Missense 38 17:1495876-1495876 - - NEUTRAL .15283 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000413937.2:p.Pro432Ser ENST00000421807.6:c.1294C>T 17:g.1495876G>A INPP5K ENST00000421807.6 1347 33882 8016470 1842414 1735679 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441905 COSN7160476 124164159 c.776+4086A>T p.? Unknown 38 17:1502894-1502894 - - NEUTRAL .00239 Confirmed somatic variant 328 cell-line NS ENST00000421807.6:c.776+4086A>T 17:g.1502894T>A INPP5K ENST00000421807.6 1347 33882 SDC5 2564866 2426260 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV57439731 COSM5987990 124164287 c.1236_1237del p.C413Lfs*30 Deletion - Frameshift 38 17:1496115-1496116 - - Confirmed somatic variant 27103403 surgery fresh/frozen NS ENSP00000413937.2:p.Cys413LeufsTer30 ENST00000421807.6:c.1236_1237del 17:g.1496115_1496116del INPP5K ENST00000421807.6 1347 33882 TCGA-C5-A3HF-01 2193301 2061579 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233649 COSM8649284 124164556 c.247C>T p.L83= Substitution - coding silent 38 17:1513467-1513467 - - PATHOGENIC .80721 Confirmed somatic variant 415 NS NS 24 ENSP00000413937.2:p.Leu83= ENST00000421807.6:c.247C>T 17:g.1513467G>A INPP5K ENST00000421807.6 1347 33882 TCGA-CG-4442-01 2198151 2066429 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233635 COSM7691643 124162380 c.914C>T p.T305M Substitution - Missense 38 17:1497985-1497985 - - NEUTRAL .00988 Confirmed somatic variant 541 NS NS 85 ENSP00000413937.2:p.Thr305Met ENST00000421807.6:c.914C>T 17:g.1497985G>A INPP5K ENST00000421807.6 1347 33882 WGC002974 2785035 2645151 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV100233732 COSM7425448 124165615 c.854C>G p.T285S Substitution - Missense 38 17:1498045-1498045 - - NEUTRAL .0814 Confirmed somatic variant 25526346 surgery fresh/frozen primary 45 ENSP00000413937.2:p.Thr285Ser ENST00000421807.6:c.854C>G 17:g.1498045G>C INPP5K ENST00000421807.6 1347 33882 T_CCA_SG_20 2688092 2547074 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 124163806 c.554+388_554+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 56 ENST00000421807.6:c.554+388_554+389insC 17:g.1508789_1508790insG INPP5K ENST00000421807.6 1347 33882 J31_T 2194998 2063276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441106 COSN8602377 124164467 c.153-24A>T p.? Unknown 38 17:1513585-1513585 - - NEUTRAL .01819 Confirmed somatic variant 583 NS NS ENST00000421807.6:c.153-24A>T 17:g.1513585T>A INPP5K ENST00000421807.6 1347 33882 CHG-2015-31289T 2634363 2494759 liver NS NS NS other neoplasm NS NS y COSV57440322 COSM6237841 124162559 c.133C>A p.L45I Substitution - Missense 38 17:1513891-1513891 - - NEUTRAL .148 Confirmed somatic variant 660 NS primary 45 ENSP00000413937.2:p.Leu45Ile ENST00000421807.6:c.133C>A 17:g.1513891G>T INPP5K ENST00000421807.6 1347 33882 T207 2658316 2518475 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442201 COSM4692620 124163741 c.1033A>G p.M345V Substitution - Missense 38 17:1496734-1496734 - - NEUTRAL .14185 Confirmed somatic variant 27149842 NS NS 72.83 ENSP00000413937.2:p.Met345Val ENST00000421807.6:c.1033A>G 17:g.1496734T>C INPP5K ENST00000421807.6 1347 33882 Patient_1 2443644 2306483 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV57442180 COSN18837027 124163493 c.777-1426G>T p.? Unknown 38 17:1499548-1499548 - - NEUTRAL .03782 Confirmed somatic variant 26082451 surgery fresh/frozen NS 70 ENST00000421807.6:c.777-1426G>T 17:g.1499548C>A INPP5K ENST00000421807.6 1347 33882 ccRCC-55 1980791 1867037 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV57440030 COSN2470106 124163310 c.262-1705C>A p.? Unknown 38 17:1511504-1511504 - - PATHOGENIC .79646 Confirmed somatic variant 23797736 NS NS ENST00000421807.6:c.262-1705C>A 17:g.1511504G>T INPP5K ENST00000421807.6 1347 33882 SS6003320 2193473 2061751 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442833 COSN8674007 124163344 c.44+287G>C p.? Unknown 38 17:1516169-1516169 - - NEUTRAL .09524 Confirmed somatic variant 535 NS NS ENST00000421807.6:c.44+287G>C 17:g.1516169C>G INPP5K ENST00000421807.6 1347 33882 C91 2293724 2159788 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439873 COSM4444568 124163213 c.590T>C p.I197T Substitution - Missense het 38 17:1508191-1508191 - - PATHOGENIC .99126 Confirmed somatic variant 24211491 NS NS ENSP00000413937.2:p.Ile197Thr ENST00000421807.6:c.590T>C 17:g.1508191A>G INPP5K ENST00000421807.6 1347 33882 S00827_1 2480817 2343562 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV57441520 COSM312000 124163333 c.352A>T p.T118S Substitution - Missense 38 17:1509709-1509709 - - PATHOGENIC .95918 Confirmed somatic variant 26168399 surgery fresh/frozen primary 73 ENSP00000413937.2:p.Thr118Ser ENST00000421807.6:c.352A>T 17:g.1509709T>A INPP5K ENST00000421807.6 1347 33882 2014_Lung_sq_22_T 2744893 2603596 lung NS NS NS carcinoma NS NS NS y COSV57441227 COSN28674085 124163192 c.667-74C>G p.? Unknown 38 17:1507163-1507163 - - NEUTRAL .08275 Confirmed somatic variant 583 NS primary 69 ENST00000421807.6:c.667-74C>G 17:g.1507163G>C INPP5K ENST00000421807.6 1347 33882 APGI-AMP-3734 2866052 2721129 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105203794 COSM9623940 124162500 c.587G>A p.R196Q Substitution - Missense 38 17:1508194-1508194 - - PATHOGENIC .98657 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000413937.2:p.Arg196Gln ENST00000421807.6:c.587G>A 17:g.1508194C>T INPP5K ENST00000421807.6 1347 33882 CHC197T 1652970 1567757 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442094 COSN19368247 124165222 c.777-2837del p.? Unknown 38 17:1500978-1500978 - - Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.777-2837del 17:g.1500978del INPP5K ENST00000421807.6 1347 33882 1323-01-02TD 2456400 2319237 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV57440745 COSN19146962 124164666 c.667-287G>C p.? Unknown 38 17:1507376-1507376 - - NEUTRAL .1053 Confirmed somatic variant 340 blood primary 63 ENST00000421807.6:c.667-287G>C 17:g.1507376C>G INPP5K ENST00000421807.6 1347 33882 LP6007520-DNA_A01 2263452 2130436 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57440165 COSN15262548 124165568 c.777-3161C>T p.? Unknown 38 17:1501283-1501283 - - NEUTRAL .00032 Confirmed somatic variant 535 NS primary ENST00000421807.6:c.777-3161C>T 17:g.1501283G>A INPP5K ENST00000421807.6 1347 33882 RK042_C 2120949 1995185 liver NS NS NS carcinoma NS NS NS y COSV57441768 COSN1714035 124162575 c.777-4023C>G p.? Unknown 38 17:1502145-1502145 - - NEUTRAL .00026 Confirmed somatic variant 322 NS NS ENST00000421807.6:c.777-4023C>G 17:g.1502145G>C INPP5K ENST00000421807.6 1347 33882 CHCOSK001 2779625 2637645 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV100233753 COSM9103745 124164928 c.1091G>T p.G364V Substitution - Missense 38 17:1496676-1496676 - - PATHOGENIC .99025 Confirmed somatic variant 27267998 surgery-fixed NS 40 ENSP00000413937.2:p.Gly364Val ENST00000421807.6:c.1091G>T 17:g.1496676C>A INPP5K ENST00000421807.6 1347 33882 TCG-Testes_DFCI_24-Tumor-SM-4PDEI 2806613 2663330 testis NS NS NS germ_cell_tumour non_seminoma NS NS y COSV100233840 COSM9116897 124164077 c.1056C>T p.T352= Substitution - coding silent het 38 17:1496711-1496711 - - NEUTRAL .02659 Confirmed somatic variant 27905446 fixed - NOS primary ENSP00000413937.2:p.Thr352= ENST00000421807.6:c.1056C>T 17:g.1496711G>A INPP5K ENST00000421807.6 1347 33882 T2448 2658241 2518400 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442156 COSM5006193 124162410 c.1021G>A p.V341M Substitution - Missense 38 17:1496746-1496746 - - NEUTRAL .01467 Confirmed somatic variant 27149842 NS NS 68.58 ENSP00000413937.2:p.Val341Met ENST00000421807.6:c.1021G>A 17:g.1496746C>T INPP5K ENST00000421807.6 1347 33882 BD49T 2459910 2322747 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57441395 COSN20046519 124165608 c.*115G>A p.? Unknown 38 17:1495708-1495708 - - NEUTRAL .07967 Confirmed somatic variant 658 NS primary 50 ENST00000421807.6:c.*115G>A 17:g.1495708C>T INPP5K ENST00000421807.6 1347 33882 77 2748049 2606752 stomach NS NS NS carcinoma NS NS NS y COSV100233990 COSM8575061 124162433 c.777-8C>G p.? Unknown 38 17:1498130-1498130 - - NEUTRAL .09199 Confirmed somatic variant 683 NS primary ENST00000421807.6:c.777-8C>G 17:g.1498130G>C INPP5K ENST00000421807.6 1347 33882 SJDOSTEOS005 2502772 2365122 bone NS NS NS osteosarcoma NS NS NS y COSV57440930 COSN1193209 124163697 c.554+56_554+65del p.? Unknown 38 17:1509124-1509133 - - Confirmed somatic variant 25512523 NS NS ENST00000421807.6:c.554+56_554+65del 17:g.1509124_1509133del INPP5K ENST00000421807.6 1347 33882 PT33 2521290 2383633 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV57443040 COSM5909589 124162546 c.1186-7C>T p.? Unknown 38 17:1496171-1496171 - - NEUTRAL .07984 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENST00000421807.6:c.1186-7C>T 17:g.1496171G>A INPP5K ENST00000421807.6 1347 33882 tumor_4179894 2634671 2495067 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441100 COSN25650645 124165072 c.777-4412T>G p.? Unknown 38 17:1502534-1502534 - - NEUTRAL .01333 Confirmed somatic variant 440 NS primary 72 ENST00000421807.6:c.777-4412T>G 17:g.1502534A>C INPP5K ENST00000421807.6 1347 33882 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233889 COSM8978199 124164237 c.777-1G>A p.? Unknown 38 17:1498123-1498123 - - PATHOGENIC .97388 Confirmed somatic variant 419 NS NS 59 ENST00000421807.6:c.777-1G>A 17:g.1498123C>T INPP5K ENST00000421807.6 1347 33882 FFPE-13 2818008 2674307 pancreas NS NS NS carcinoma acinar_carcinoma NS NS y COSV57442897 COSM6225141 124164563 c.986C>T p.P329L Substitution - Missense het 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 29109526 surgery-fixed primary ENSP00000413937.2:p.Pro329Leu ENST00000421807.6:c.986C>T 17:g.1496781G>A INPP5K ENST00000421807.6 1347 33882 tumor_4170844 2634759 2495155 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57442780 COSN25365884 124162448 c.45-376G>A p.? Unknown 38 17:1514355-1514355 - - NEUTRAL .01295 Confirmed somatic variant 440 NS primary 5 ENST00000421807.6:c.45-376G>A 17:g.1514355C>T INPP5K ENST00000421807.6 1347 33882 5-VS034-T1 2869858 2724855 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV57443110 COSM4894813 124163222 c.881C>T p.S294F Substitution - Missense 38 17:1498018-1498018 - - NEUTRAL .04612 Confirmed somatic variant 26950094 surgery fresh/frozen NS 75 ENSP00000413937.2:p.Ser294Phe ENST00000421807.6:c.881C>T 17:g.1498018G>A INPP5K ENST00000421807.6 1347 33882 T368 2296243 2161846 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441404 COSM4692626 124164473 c.863C>A p.P288Q Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .01179 Confirmed somatic variant 25344691 NS NS 63.75 ENSP00000413937.2:p.Pro288Gln ENST00000421807.6:c.863C>A 17:g.1498036G>T INPP5K ENST00000421807.6 1347 33882 T368 2658284 2518443 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441404 COSM4692626 124164473 c.863C>A p.P288Q Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .01179 Confirmed somatic variant 27149842 NS NS 63.75 ENSP00000413937.2:p.Pro288Gln ENST00000421807.6:c.863C>A 17:g.1498036G>T INPP5K ENST00000421807.6 1347 33882 tumor_4179894 2634671 2495067 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57440372 COSN6651475 124164004 c.*817G>T p.? Unknown 38 17:1495006-1495006 - - NEUTRAL .01546 Confirmed somatic variant 440 NS primary 72 ENST00000421807.6:c.*817G>T 17:g.1495006C>A INPP5K ENST00000421807.6 1347 33882 C0021T 2197771 2066049 kidney NS NS NS NS NS NS NS y COSV57443321 COSN9655907 124164653 c.776+341C>G p.? Unknown 38 17:1506639-1506639 - - NEUTRAL .04687 Confirmed somatic variant 588 NS NS ENST00000421807.6:c.776+341C>G 17:g.1506639G>C INPP5K ENST00000421807.6 1347 33882 TCGA-AA-3877-01 1651067 1565854 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441118 COSM178164 124163247 c.81G>A p.A27= Substitution - coding silent 38 17:1513943-1513943 - - NEUTRAL .06284 Confirmed somatic variant 376 NS NS 83 ENSP00000413937.2:p.Ala27= ENST00000421807.6:c.81G>A 17:g.1513943C>T INPP5K ENST00000421807.6 1347 33882 BN06 2120643 1994879 liver NS NS NS carcinoma NS NS NS y COSV57442850 COSN1193203 124163615 c.963+37T>A p.? Unknown 38 17:1497899-1497899 - - NEUTRAL .02871 Confirmed somatic variant 323 NS NS ENST00000421807.6:c.963+37T>A 17:g.1497899A>T INPP5K ENST00000421807.6 1347 33882 C0021T 2197771 2066049 kidney NS NS NS NS NS NS NS y COSV57443329 COSN9655913 124164660 c.262-508G>T p.? Unknown 38 17:1510307-1510307 - - NEUTRAL .01852 Confirmed somatic variant 588 NS NS ENST00000421807.6:c.262-508G>T 17:g.1510307C>A INPP5K ENST00000421807.6 1347 33882 TCGA-AF-6672-01 1651524 1566311 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV57441061 COSM1563397 124165575 c.112C>A p.L38M Substitution - Missense 38 17:1513912-1513912 - - PATHOGENIC .9876 Confirmed somatic variant 375 NS primary 43 ENSP00000413937.2:p.Leu38Met ENST00000421807.6:c.112C>A 17:g.1513912G>T INPP5K ENST00000421807.6 1347 33882 EXTERN_MELA_20140924_107 2839322 2695088 skin upper_leg NS NS malignant_melanoma NS NS NS y COSV104626978 COSM9370470 124165417 c.1114G>A p.D372N Substitution - Missense 38 17:1496390-1496390 - - .58709 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000413937.2:p.Asp372Asn ENST00000421807.6:c.1114G>A 17:g.1496390C>T INPP5K ENST00000421807.6 1347 33882 TCGA-BR-8372-01 2198045 2066323 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440526 COSM4064067 124164452 c.73T>C p.S25P Substitution - Missense 38 17:1513951-1513951 - - PATHOGENIC .96702 Confirmed somatic variant 541 NS NS 63 ENSP00000413937.2:p.Ser25Pro ENST00000421807.6:c.73T>C 17:g.1513951A>G INPP5K ENST00000421807.6 1347 33882 5-VS015-T1 2869836 2724833 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV105203833 COSM9691176 124162482 c.288C>T p.I96= Substitution - coding silent 38 17:1509773-1509773 - - .56592 Confirmed somatic variant 26950094 surgery fresh/frozen NS 90 ENSP00000413937.2:p.Ile96= ENST00000421807.6:c.288C>T 17:g.1509773G>A INPP5K ENST00000421807.6 1347 33882 T2279 2658733 2518892 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441317 COSM6686181 124163837 c.804C>T p.T268= Substitution - coding silent 38 17:1498095-1498095 - - NEUTRAL .05249 Confirmed somatic variant 27149842 NS NS 65.41 ENSP00000413937.2:p.Thr268= ENST00000421807.6:c.804C>T 17:g.1498095G>A INPP5K ENST00000421807.6 1347 33882 TCGA-BR-8372-01 2198045 2066323 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440510 COSM2738170 124163314 c.950C>T p.T317M Substitution - Missense 38 17:1497949-1497949 - - PATHOGENIC .84124 Confirmed somatic variant 541 NS NS 63 ENSP00000413937.2:p.Thr317Met ENST00000421807.6:c.950C>T 17:g.1497949G>A INPP5K ENST00000421807.6 1347 33882 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV57442051 COSM3514454 124162712 c.488A>G p.H163R Substitution - Missense 38 17:1509244-1509244 - - PATHOGENIC .97324 Confirmed somatic variant 540 NS NS 30 ENSP00000413937.2:p.His163Arg ENST00000421807.6:c.488A>G 17:g.1509244T>C INPP5K ENST00000421807.6 1347 33882 FFPE-K1 2818021 2674320 pancreas NS NS NS carcinoma acinar_carcinoma NS NS y COSV104401286 COSM9274306 124165116 c.153-10G>A p.? Unknown het 38 17:1513571-1513571 - - PATHOGENIC .89312 Confirmed somatic variant 29109526 surgery-fixed primary ENST00000421807.6:c.153-10G>A 17:g.1513571C>T INPP5K ENST00000421807.6 1347 33882 2014_Lung_sq_102_T 2744869 2603572 lung NS NS NS carcinoma NS NS NS y COSV57443380 COSM7249097 124163813 c.667-10T>G p.? Unknown 38 17:1507099-1507099 - - NEUTRAL .07942 Confirmed somatic variant 583 NS primary 74 ENST00000421807.6:c.667-10T>G 17:g.1507099A>C INPP5K ENST00000421807.6 1347 33882 Thyroid-CN-WZ044T 2635105 2495501 thyroid NS NS NS carcinoma NS NS NS y COSV57440258 COSM6420326 124162867 c.760A>G p.N254D Substitution - Missense 38 17:1506996-1506996 - - NEUTRAL .40772 Confirmed somatic variant 676 NS primary 27 ENSP00000413937.2:p.Asn254Asp ENST00000421807.6:c.760A>G 17:g.1506996T>C INPP5K ENST00000421807.6 1347 33882 2014_Lung_sq_27_T 2744898 2603601 lung NS NS NS carcinoma NS NS NS y COSV57441106 COSN8602377 124164467 c.153-24A>T p.? Unknown 38 17:1513585-1513585 - - NEUTRAL .01819 Confirmed somatic variant 583 NS primary 76 ENST00000421807.6:c.153-24A>T 17:g.1513585T>A INPP5K ENST00000421807.6 1347 33882 ESCC_134 2479627 2342387 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440352 COSM5642741 124162647 c.863C>T p.P288L Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .00382 Confirmed somatic variant 26873401 NS NS 68 ENSP00000413937.2:p.Pro288Leu ENST00000421807.6:c.863C>T 17:g.1498036G>A INPP5K ENST00000421807.6 1347 33882 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233845 COSM9192841 124163974 c.80C>T p.A27V Substitution - Missense 38 17:1513944-1513944 - - PATHOGENIC .79904 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000413937.2:p.Ala27Val ENST00000421807.6:c.80C>T 17:g.1513944G>A INPP5K ENST00000421807.6 1347 33882 LP6008141-DNA_H01 2789459 2646682 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV100233580 COSN30207599 124165051 c.262-1668C>T p.? Unknown 38 17:1511467-1511467 - - NEUTRAL .48243 Confirmed somatic variant 535 NS primary 82 ENST00000421807.6:c.262-1668C>T 17:g.1511467G>A INPP5K ENST00000421807.6 1347 33882 NYZ-1200985T 2633889 2494285 stomach NS NS NS carcinoma NS NS NS y COSV57442167 COSN24444054 124164096 c.777-1313C>T p.? Unknown 38 17:1499435-1499435 - - NEUTRAL .01503 Confirmed somatic variant 371 NS primary 45 ENST00000421807.6:c.777-1313C>T 17:g.1499435G>A INPP5K ENST00000421807.6 1347 33882 TCGA-06-1801-01 2178194 2046492 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233717 COSM7481424 124162836 c.1039G>C p.V347L Substitution - Missense 38 17:1496728-1496728 - - NEUTRAL .21698 Confirmed somatic variant 329 NS NS 56 ENSP00000413937.2:p.Val347Leu ENST00000421807.6:c.1039G>C 17:g.1496728C>G INPP5K ENST00000421807.6 1347 33882 TCGA-EY-A549-01 2198465 2066743 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57442068 COSM5364464 124163791 c.788G>A p.R263H Substitution - Missense 38 17:1498111-1498111 - - PATHOGENIC .97388 Confirmed somatic variant 419 NS NS 78 ENSP00000413937.2:p.Arg263His ENST00000421807.6:c.788G>A 17:g.1498111C>T INPP5K ENST00000421807.6 1347 33882 RK042_C 2120949 1995185 liver NS NS NS carcinoma NS NS NS y COSV57441764 COSN1714034 124162570 c.777-4020G>C p.? Unknown 38 17:1502142-1502142 - - NEUTRAL .00011 Confirmed somatic variant 322 NS NS ENST00000421807.6:c.777-4020G>C 17:g.1502142C>G INPP5K ENST00000421807.6 1347 33882 SM-4B295 2262938 2129922 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442007 COSM5032397 124162724 c.1102-6T>C p.? Unknown 38 17:1496408-1496408 - - NEUTRAL .00676 Confirmed somatic variant 535 NS primary ENST00000421807.6:c.1102-6T>C 17:g.1496408A>G INPP5K ENST00000421807.6 1347 33882 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233844 COSM9192840 124163970 c.209A>G p.D70G Substitution - Missense 38 17:1513505-1513505 - - PATHOGENIC .98841 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000413937.2:p.Asp70Gly ENST00000421807.6:c.209A>G 17:g.1513505T>C INPP5K ENST00000421807.6 1347 33882 TCGA-EB-A299-01 2121587 1995823 skin NS NS NS malignant_melanoma NS NS NS y COSV100233592 COSM8129016 124163707 c.484G>T p.E162* Substitution - Nonsense 38 17:1509248-1509248 - - PATHOGENIC .96263 Confirmed somatic variant 540 NS NS 63 ENSP00000413937.2:p.Glu162Ter ENST00000421807.6:c.484G>T 17:g.1509248C>A INPP5K ENST00000421807.6 1347 33882 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440119 COSM4692618 124163534 c.1077G>A p.P359= Substitution - coding silent 38 17:1496690-1496690 - - PATHOGENIC .80915 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000413937.2:p.Pro359= ENST00000421807.6:c.1077G>A 17:g.1496690C>T INPP5K ENST00000421807.6 1347 33882 TCGA-MA-AA42-01 2386190 2249022 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233848 COSM8652710 124165335 c.870G>A p.A290= Substitution - coding silent 38 17:1498029-1498029 - - NEUTRAL .06811 Confirmed somatic variant 415 NS primary 75 ENSP00000413937.2:p.Ala290= ENST00000421807.6:c.870G>A 17:g.1498029C>T INPP5K ENST00000421807.6 1347 33882 TCGA-55-8301-01 2194837 2063115 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV100233820 COSM7743401 124165024 c.81G>T p.A27= Substitution - coding silent 38 17:1513943-1513943 - - NEUTRAL .17092 Confirmed somatic variant 417 NS NS 58 ENSP00000413937.2:p.Ala27= ENST00000421807.6:c.81G>T 17:g.1513943C>A INPP5K ENST00000421807.6 1347 33882 TCGA-CM-4746-01 1651207 1565994 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV100233908 COSM7605863 124163425 c.1080G>A p.W360* Substitution - Nonsense 38 17:1496687-1496687 - - PATHOGENIC .98938 Confirmed somatic variant 376 NS NS 61 ENSP00000413937.2:p.Trp360Ter ENST00000421807.6:c.1080G>A 17:g.1496687C>T INPP5K ENST00000421807.6 1347 33882 TCGA-A4-7288-01 2193982 2062260 kidney NS NS NS carcinoma papillary_renal_cell_carcinoma NS NS y COSV57441934 COSM3988780 124164724 c.1056C>G p.T352= Substitution - coding silent 38 17:1496711-1496711 - - NEUTRAL .06148 Confirmed somatic variant 543 NS NS 71 ENSP00000413937.2:p.Thr352= ENST00000421807.6:c.1056C>G 17:g.1496711G>C INPP5K ENST00000421807.6 1347 33882 SJBALL021373_D1 2364176 2227090 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia Ph-like NS y COSV57442939 COSN17079618 124162626 c.554+337G>A p.? Unknown 38 17:1508841-1508841 - - NEUTRAL .0859 Confirmed somatic variant 25207766 blood-bone marrow NS ENST00000421807.6:c.554+337G>A 17:g.1508841C>T INPP5K ENST00000421807.6 1347 33882 SNUH_G16_S1 2120552 1994788 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 124162507 c.555-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 NS NS ENST00000421807.6:c.555-77G>A 17:g.1508303C>T INPP5K ENST00000421807.6 1347 33882 CN-AML-08-T 2506791 2369127 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 124162507 c.555-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 blood-bone marrow primary ENST00000421807.6:c.555-77G>A 17:g.1508303C>T INPP5K ENST00000421807.6 1347 33882 LP6008336-DNA_A02 2789419 2646642 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV100234014 COSN30406679 124163849 c.776+748G>A p.? Unknown 38 17:1506232-1506232 - - NEUTRAL .01419 Confirmed somatic variant 535 NS primary 81 ENST00000421807.6:c.776+748G>A 17:g.1506232C>T INPP5K ENST00000421807.6 1347 33882 CLL129 1897564 1786248 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV57441713 COSM1290634 124165245 c.1323G>T p.L441= Substitution - coding silent 38 17:1495847-1495847 - - NEUTRAL .05649 Confirmed somatic variant 23415222 blood-bone marrow NS ENSP00000413937.2:p.Leu441= ENST00000421807.6:c.1323G>T 17:g.1495847C>A INPP5K ENST00000421807.6 1347 33882 T1762 2658285 2518444 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440363 COSM6686177 124162934 c.786dup p.R263Tfs*82 Insertion - Frameshift 38 17:1498118-1498119 - - Confirmed somatic variant 27149842 NS NS 69.58 ENSP00000413937.2:p.Arg263ThrfsTer82 ENST00000421807.6:c.786dup 17:g.1498118dup INPP5K ENST00000421807.6 1347 33882 T2441 2658483 2518642 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 124163172 c.616C>T p.R206W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 75 ENSP00000413937.2:p.Arg206Trp ENST00000421807.6:c.616C>T 17:g.1508165G>A INPP5K ENST00000421807.6 1347 33882 T207 2296102 2161705 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57442201 COSM4692620 124163741 c.1033A>G p.M345V Substitution - Missense 38 17:1496734-1496734 - - NEUTRAL .14185 Confirmed somatic variant 25344691 NS NS 72.83 ENSP00000413937.2:p.Met345Val ENST00000421807.6:c.1033A>G 17:g.1496734T>C INPP5K ENST00000421807.6 1347 33882 T2763 2658548 2518707 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441317 COSM6686181 124163837 c.804C>T p.T268= Substitution - coding silent 38 17:1498095-1498095 - - NEUTRAL .05249 Confirmed somatic variant 27149842 NS NS 57.25 ENSP00000413937.2:p.Thr268= ENST00000421807.6:c.804C>T 17:g.1498095G>A INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440380 COSN6651502 124164009 c.777-3999C>T p.? Unknown 38 17:1502121-1502121 - - NEUTRAL .00323 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.777-3999C>T 17:g.1502121G>A INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440313 COSN6651567 124162507 c.555-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.555-77G>A 17:g.1508303C>T INPP5K ENST00000421807.6 1347 33882 CHG-29T 2634259 2494655 liver NS NS NS other neoplasm NS NS y COSV57441087 COSN23438524 124163381 c.554+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 660 NS primary 48 ENST00000421807.6:c.554+22C>T 17:g.1509156G>A INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440387 COSN6651505 124164015 c.777-4117G>A p.? Unknown 38 17:1502239-1502239 - - NEUTRAL .00196 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.777-4117G>A 17:g.1502239C>T INPP5K ENST00000421807.6 1347 33882 TCGA-18-3407-01 1780257 1684256 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233793 COSM8151450 124162848 c.356C>A p.P119H Substitution - Missense 38 17:1509705-1509705 - - PATHOGENIC .88297 Confirmed somatic variant 418 fresh/frozen - NOS primary 72 ENSP00000413937.2:p.Pro119His ENST00000421807.6:c.356C>A 17:g.1509705G>T INPP5K ENST00000421807.6 1347 33882 T603 2658711 2518870 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440611 COSM6686191 124162456 c.617G>A p.R206Q Substitution - Missense 38 17:1508164-1508164 - - NEUTRAL .06264 Confirmed somatic variant 27149842 NS NS 69.75 ENSP00000413937.2:p.Arg206Gln ENST00000421807.6:c.617G>A 17:g.1508164C>T INPP5K ENST00000421807.6 1347 33882 TCGA-39-5022-01 1781520 1685519 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57442536 COSM704958 124162706 c.228C>G p.L76= Substitution - coding silent 38 17:1513486-1513486 - - PATHOGENIC .95856 Confirmed somatic variant 418 fresh/frozen - NOS primary 76 ENSP00000413937.2:p.Leu76= ENST00000421807.6:c.228C>G 17:g.1513486G>C INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440392 COSN6651506 124164023 c.777-4130C>T p.? Unknown 38 17:1502252-1502252 - - NEUTRAL .00299 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.777-4130C>T 17:g.1502252G>A INPP5K ENST00000421807.6 1347 33882 GCTK_341_T 2747450 2606153 stomach NS NS NS carcinoma NS NS NS y COSV100233887 COSN30729867 124165412 c.555-13T>G p.? Unknown 38 17:1508239-1508239 - - .60195 Confirmed somatic variant 683 NS primary ENST00000421807.6:c.555-13T>G 17:g.1508239A>C INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440401 COSN19320948 124164032 c.777-4238G>T p.? Unknown 38 17:1502360-1502360 - - NEUTRAL .00142 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.777-4238G>T 17:g.1502360C>A INPP5K ENST00000421807.6 1347 33882 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57440119 COSM4692618 124163534 c.1077G>A p.P359= Substitution - coding silent 38 17:1496690-1496690 - - PATHOGENIC .80915 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000413937.2:p.Pro359= ENST00000421807.6:c.1077G>A 17:g.1496690C>T INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440412 COSN6651553 124164042 c.776+15G>C p.? Unknown 38 17:1506965-1506965 - - NEUTRAL .01662 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.776+15G>C 17:g.1506965C>G INPP5K ENST00000421807.6 1347 33882 TCGA-33-4587-01 2195029 2063307 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233721 COSM8709016 124162887 c.262G>A p.V88I Substitution - Missense 38 17:1509799-1509799 - - PATHOGENIC .71204 Confirmed somatic variant 418 NS NS 63 ENSP00000413937.2:p.Val88Ile ENST00000421807.6:c.262G>A 17:g.1509799C>T INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440431 COSN6651564 124164051 c.666+251A>C p.? Unknown 38 17:1507864-1507864 - - NEUTRAL .00637 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.666+251A>C 17:g.1507864T>G INPP5K ENST00000421807.6 1347 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442343 COSN6651570 124163877 c.555-328T>G p.? Unknown 38 17:1508554-1508554 - - NEUTRAL .11115 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.555-328T>G 17:g.1508554A>C INPP5K ENST00000421807.6 1347 33882 PD23577a 2214453 2082577 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441999 COSN21680810 124162655 c.963+354G>C p.? Unknown 38 17:1497582-1497582 - - NEUTRAL .31399 Confirmed somatic variant 652 NS NS ENST00000421807.6:c.963+354G>C 17:g.1497582C>G INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440408 COSN6651539 124164035 c.776+1673C>T p.? Unknown 38 17:1505307-1505307 - - NEUTRAL .00583 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.776+1673C>T 17:g.1505307G>A INPP5K ENST00000421807.6 1347 33882 PD24314a 2241668 2109199 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441374 COSN21484822 124163353 c.777-2538C>T p.? Unknown 38 17:1500660-1500660 - - NEUTRAL .00082 Confirmed somatic variant 652 NS NS ENST00000421807.6:c.777-2538C>T 17:g.1500660G>A INPP5K ENST00000421807.6 1347 33882 C0037T 2197815 2066093 kidney NS NS NS NS NS NS NS y COSV57440692 COSN9655895 124164546 c.964-41G>A p.? Unknown 38 17:1496844-1496844 - - NEUTRAL .05199 Confirmed somatic variant 588 NS NS ENST00000421807.6:c.964-41G>A 17:g.1496844C>T INPP5K ENST00000421807.6 1347 33882 T4506 2658677 2518836 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441145 COSM6686189 124162525 c.484G>A p.E162K Substitution - Missense 38 17:1509248-1509248 - - PATHOGENIC .94307 Confirmed somatic variant 27149842 NS NS 81.25 ENSP00000413937.2:p.Glu162Lys ENST00000421807.6:c.484G>A 17:g.1509248C>T INPP5K ENST00000421807.6 1347 33882 T2394 2658590 2518749 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442954 COSM6686183 124165854 c.634C>T p.R212W Substitution - Missense 38 17:1508147-1508147 - - NEUTRAL .10513 Confirmed somatic variant 27149842 NS NS 71 ENSP00000413937.2:p.Arg212Trp ENST00000421807.6:c.634C>T 17:g.1508147G>A INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440372 COSN6651475 124164004 c.*817G>T p.? Unknown 38 17:1495006-1495006 - - NEUTRAL .01546 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.*817G>T 17:g.1495006C>A INPP5K ENST00000421807.6 1347 33882 TCGA-F4-6856-01 1651313 1566100 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 124162698 c.809G>A p.R270H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 376 NS NS 45 ENSP00000413937.2:p.Arg270His ENST00000421807.6:c.809G>A 17:g.1498090C>T INPP5K ENST00000421807.6 1347 33882 CHG-14-15016T 2634332 2494728 liver NS NS NS other neoplasm NS NS y COSV57442117 COSN26562181 124164070 c.1101+13C>A p.? Unknown 38 17:1496653-1496653 - - NEUTRAL .02666 Confirmed somatic variant 660 NS primary 70 ENST00000421807.6:c.1101+13C>A 17:g.1496653G>T INPP5K ENST00000421807.6 1347 33882 S00640 2864328 2719489 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS y COSV105203822 COSM9584085 124165345 c.868del p.A290Rfs*8 Deletion - Frameshift 38 17:1498032-1498032 - - Confirmed somatic variant 29535388 surgery fresh/frozen NS 53 ENSP00000413937.2:p.Ala290ArgfsTer8 ENST00000421807.6:c.868del 17:g.1498032del INPP5K ENST00000421807.6 1347 33882 TCGA-24-2030-01 1474934 1398633 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV100233576 COSM7466631 124162581 c.849C>T p.P283= Substitution - coding silent 38 17:1498050-1498050 - - NEUTRAL .06315 Confirmed somatic variant 331 NS primary 87 ENSP00000413937.2:p.Pro283= ENST00000421807.6:c.849C>T 17:g.1498050G>A INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440446 COSN6651579 124164059 c.262-1050G>A p.? Unknown 38 17:1510849-1510849 - - NEUTRAL .00457 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.262-1050G>A 17:g.1510849C>T INPP5K ENST00000421807.6 1347 33882 T_CCA_JP_6 2688122 2547104 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 124163806 c.554+388_554+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 65 ENST00000421807.6:c.554+388_554+389insC 17:g.1508789_1508790insG INPP5K ENST00000421807.6 1347 33882 2014_Lung_sq_41_T 2744912 2603615 lung NS NS NS carcinoma NS NS NS y COSV57440751 COSN19718001 124164149 c.554+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 583 NS primary 63 ENST00000421807.6:c.554+396G>C 17:g.1508782C>G INPP5K ENST00000421807.6 1347 33882 273 2748245 2606948 stomach NS NS NS carcinoma NS NS NS y COSV100233936 COSN30549824 124162827 c.1102-32C>A p.? Unknown 38 17:1496434-1496434 - - NEUTRAL .04855 Confirmed somatic variant 683 NS primary ENST00000421807.6:c.1102-32C>A 17:g.1496434G>T INPP5K ENST00000421807.6 1347 33882 TCGA-39-5037-01 1781591 1685590 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440018 COSM704961 124164434 c.1227G>A p.E409= Substitution - coding silent 38 17:1496123-1496123 - - .64376 Confirmed somatic variant 418 fresh/frozen - NOS primary 65 ENSP00000413937.2:p.Glu409= ENST00000421807.6:c.1227G>A 17:g.1496123C>T INPP5K ENST00000421807.6 1347 33882 TCGA-E7-A7DV-01 2193219 2061497 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57441614 COSM7110439 124163634 c.616C>A p.R206= Substitution - coding silent 38 17:1508165-1508165 - - NEUTRAL .16927 Confirmed somatic variant 413 NS NS 44 ENSP00000413937.2:p.Arg206= ENST00000421807.6:c.616C>A 17:g.1508165G>T INPP5K ENST00000421807.6 1347 33882 sysucc-882T 2456760 2319597 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442228 COSN19666228 124164879 c.777-92G>T p.? Unknown 38 17:1498214-1498214 - - NEUTRAL .11173 Confirmed somatic variant 646 NS primary 61 ENST00000421807.6:c.777-92G>T 17:g.1498214C>A INPP5K ENST00000421807.6 1347 33882 T2769 2296131 2161734 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57442024 COSM4692628 124165266 c.731C>T p.P244L Substitution - Missense 38 17:1507025-1507025 - - .61387 Confirmed somatic variant 25344691 NS NS 67.41 ENSP00000413937.2:p.Pro244Leu ENST00000421807.6:c.731C>T 17:g.1507025G>A INPP5K ENST00000421807.6 1347 33882 T604 2658649 2518808 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 124163172 c.616C>T p.R206W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000413937.2:p.Arg206Trp ENST00000421807.6:c.616C>T 17:g.1508165G>A INPP5K ENST00000421807.6 1347 33882 TCGA-AZ-4315-01 1651162 1565949 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57440687 COSM1380994 124164225 c.212C>T p.S71L Substitution - Missense 38 17:1513502-1513502 - - PATHOGENIC .93935 Confirmed somatic variant 376 NS NS 61 ENSP00000413937.2:p.Ser71Leu ENST00000421807.6:c.212C>T 17:g.1513502G>A INPP5K ENST00000421807.6 1347 33882 HX27T 2120921 1995157 liver NS NS NS carcinoma NS NS NS y COSV57442880 COSN5838392 124163128 c.44+684G>A p.? Unknown 38 17:1515772-1515772 - - NEUTRAL .25514 Confirmed somatic variant 323 NS NS ENST00000421807.6:c.44+684G>A 17:g.1515772C>T INPP5K ENST00000421807.6 1347 33882 EOPC-133_tumor_01 2549444 2410899 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 124163381 c.554+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 49 ENST00000421807.6:c.554+22C>T 17:g.1509156G>A INPP5K ENST00000421807.6 1347 33882 GCYC_051_T 2747641 2606344 stomach NS NS NS carcinoma NS NS NS y COSV100233803 COSN30697867 124164632 c.555-76C>T p.? Unknown 38 17:1508302-1508302 - - NEUTRAL .12541 Confirmed somatic variant 683 NS primary ENST00000421807.6:c.555-76C>T 17:g.1508302G>A INPP5K ENST00000421807.6 1347 33882 p6low 2812886 2669300 large_intestine colon left NS adenoma tubular NS NS y COSV104411988 COSN31779190 124163298 c.*238G>A p.? Unknown 38 17:1495585-1495585 - - NEUTRAL .03835 Confirmed somatic variant 31336886 surgery-fixed NS 64 ENST00000421807.6:c.*238G>A 17:g.1495585C>T INPP5K ENST00000421807.6 1347 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440420 COSN6651554 124164045 c.667-58G>A p.? Unknown 38 17:1507147-1507147 - - NEUTRAL .06908 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.667-58G>A 17:g.1507147C>T INPP5K ENST00000421807.6 1347 33882 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441432 COSM4692624 124164519 c.868G>A p.A290T Substitution - Missense 38 17:1498031-1498031 - - NEUTRAL .0531 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000413937.2:p.Ala290Thr ENST00000421807.6:c.868G>A 17:g.1498031C>T INPP5K ENST00000421807.6 1347 33882 AML_14y_08_DX 2549541 2410996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440211 COSN23974391 124162786 c.554+117C>G p.? Unknown 38 17:1509061-1509061 - - NEUTRAL .00587 Confirmed somatic variant 544 blood-bone marrow primary 32 ENST00000421807.6:c.554+117C>G 17:g.1509061G>C INPP5K ENST00000421807.6 1347 33882 AOCS-139-19-0 2186425 2054722 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441562 COSM3983264 124164989 c.693G>T p.P231= Substitution - coding silent 38 17:1507063-1507063 - - NEUTRAL .03466 Confirmed somatic variant 585 NS NS ENSP00000413937.2:p.Pro231= ENST00000421807.6:c.693G>T 17:g.1507063C>A INPP5K ENST00000421807.6 1347 33882 W30T 2745054 2603757 thyroid NS NS NS carcinoma NS NS NS y COSV57440258 COSM6420326 124162867 c.760A>G p.N254D Substitution - Missense 38 17:1506996-1506996 - - NEUTRAL .40772 Confirmed somatic variant 676 NS primary 27 ENSP00000413937.2:p.Asn254Asp ENST00000421807.6:c.760A>G 17:g.1506996T>C INPP5K ENST00000421807.6 1347 33882 T3046 2658722 2518881 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 124162698 c.809G>A p.R270H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 27149842 NS NS 60.16 ENSP00000413937.2:p.Arg270His ENST00000421807.6:c.809G>A 17:g.1498090C>T INPP5K ENST00000421807.6 1347 33882 HUB-02-B2-087 2607141 2466853 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440866 COSN24393345 124165795 c.555-474G>A p.? Unknown 38 17:1508700-1508700 - - NEUTRAL .00908 Confirmed somatic variant 670 organoid culture NS ENST00000421807.6:c.555-474G>A 17:g.1508700C>T INPP5K ENST00000421807.6 1347 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442373 COSN6651596 124163894 c.261+289C>T p.? Unknown 38 17:1513164-1513164 - - NEUTRAL .00811 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.261+289C>T 17:g.1513164G>A INPP5K ENST00000421807.6 1347 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442334 COSN6651504 124163869 c.777-4045C>T p.? Unknown 38 17:1502167-1502167 - - NEUTRAL .00319 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.777-4045C>T 17:g.1502167G>A INPP5K ENST00000421807.6 1347 33882 OSCC-GB_01060111 2341032 2206015 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV57441385 COSM4882615 124163358 c.1043G>A p.S348N Substitution - Missense 38 17:1496724-1496724 - - PATHOGENIC .77196 Confirmed somatic variant 539 NS primary 60 ENSP00000413937.2:p.Ser348Asn ENST00000421807.6:c.1043G>A 17:g.1496724C>T INPP5K ENST00000421807.6 1347 33882 TCGA-EL-A3CY-01 2121967 1996203 thyroid NS NS NS carcinoma NS NS NS y COSV57442823 COSM3370619 124162804 c.1005C>G p.P335= Substitution - coding silent 38 17:1496762-1496762 - - NEUTRAL .02304 Confirmed somatic variant 542 NS NS 28 ENSP00000413937.2:p.Pro335= ENST00000421807.6:c.1005C>G 17:g.1496762G>C INPP5K ENST00000421807.6 1347 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442362 COSN6651584 124163888 c.262-1497G>C p.? Unknown 38 17:1511296-1511296 - - NEUTRAL .05338 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.262-1497G>C 17:g.1511296C>G INPP5K ENST00000421807.6 1347 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442352 COSN6651577 124163882 c.262-449C>T p.? Unknown 38 17:1510248-1510248 - - NEUTRAL .00134 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.262-449C>T 17:g.1510248G>A INPP5K ENST00000421807.6 1347 33882 TCGA-26-5134 2108058 1985919 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57441362 COSM2157002 124164190 c.27G>C p.P9= Substitution - coding silent 38 17:1516473-1516473 - - NEUTRAL .15234 Confirmed somatic variant 23917401 NS NS ENSP00000413937.2:p.Pro9= ENST00000421807.6:c.27G>C 17:g.1516473C>G INPP5K ENST00000421807.6 1347 33882 TCGA-FD-A6TC-01 2262697 2129681 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57441022 COSM7120771 124164679 c.1287C>T p.F429= Substitution - coding silent 38 17:1496063-1496063 - - PATHOGENIC .823 Confirmed somatic variant 413 NS primary 79 ENSP00000413937.2:p.Phe429= ENST00000421807.6:c.1287C>T 17:g.1496063G>A INPP5K ENST00000421807.6 1347 33882 PET124T 2507124 2369460 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57441198 COSN22982472 124163000 c.777-3324G>T p.? Unknown 38 17:1501446-1501446 - - NEUTRAL .18617 Confirmed somatic variant 661 NS primary 46 ENST00000421807.6:c.777-3324G>T 17:g.1501446C>A INPP5K ENST00000421807.6 1347 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442328 COSN6651503 124163862 c.777-4043A>G p.? Unknown 38 17:1502165-1502165 - - NEUTRAL .00034 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000421807.6:c.777-4043A>G 17:g.1502165T>C INPP5K ENST00000421807.6 1347 33882 ESCC_156 2479644 2342404 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441047 COSM5645997 124164351 c.1308G>C p.L436F Substitution - Missense 38 17:1495862-1495862 - - NEUTRAL .09067 Confirmed somatic variant 26873401 NS NS 84 ENSP00000413937.2:p.Leu436Phe ENST00000421807.6:c.1308G>C 17:g.1495862C>G INPP5K ENST00000421807.6 1347 33882 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57443185 COSM4795479 124164122 c.961G>A p.E321K Substitution - Missense 38 17:1497938-1497938 - - PATHOGENIC .91208 Confirmed somatic variant 381 NS primary 72 ENSP00000413937.2:p.Glu321Lys ENST00000421807.6:c.961G>A 17:g.1497938C>T INPP5K ENST00000421807.6 1347 33882 J32_T 2195006 2063284 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441017 COSN20301572 124165175 c.667-469C>A p.? Unknown 38 17:1507558-1507558 - - NEUTRAL .01033 Confirmed somatic variant 583 NS NS ENST00000421807.6:c.667-469C>A 17:g.1507558G>T INPP5K ENST00000421807.6 1347 33882 TCGA-CD-A486-01 2198066 2066344 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57443071 COSM4064063 124162874 c.586C>T p.R196W Substitution - Missense 38 17:1508195-1508195 - - PATHOGENIC .99184 Confirmed somatic variant 541 NS NS 68 ENSP00000413937.2:p.Arg196Trp ENST00000421807.6:c.586C>T 17:g.1508195G>A INPP5K ENST00000421807.6 1347 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441875 COSN25827061 124164849 c.777-3653C>A p.? Unknown 38 17:1501775-1501775 - - NEUTRAL .0002 Confirmed somatic variant 534 NS primary 44 ENST00000421807.6:c.777-3653C>A 17:g.1501775G>T INPP5K ENST00000421807.6 1347 33882 TCGA-26-5134-01 2120324 1994560 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57441362 COSM2157002 124164190 c.27G>C p.P9= Substitution - coding silent 38 17:1516473-1516473 - - NEUTRAL .15234 Confirmed somatic variant 329 NS NS 74 ENSP00000413937.2:p.Pro9= ENST00000421807.6:c.27G>C 17:g.1516473C>G INPP5K ENST00000421807.6 1347 33882 AOCS-119-3-9 2186509 2054806 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441447 COSN8831797 124163266 c.261+232G>A p.? Unknown 38 17:1513221-1513221 - - NEUTRAL .02029 Confirmed somatic variant 585 NS NS ENST00000421807.6:c.261+232G>A 17:g.1513221C>T INPP5K ENST00000421807.6 1347 33882 TCGA-06-0171 2107961 1985822 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 124162735 c.54C>T p.V18= Substitution - coding silent 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 23917401 NS NS ENSP00000413937.2:p.Val18= ENST00000421807.6:c.54C>T 17:g.1513970G>A INPP5K ENST00000421807.6 1347 33882 TCGA-EJ-7125-01 2121457 1995693 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440295 COSM3672354 124164601 c.617G>T p.R206L Substitution - Missense 38 17:1508164-1508164 - - NEUTRAL .18864 Confirmed somatic variant 435 NS NS 44 ENSP00000413937.2:p.Arg206Leu ENST00000421807.6:c.617G>T 17:g.1508164C>A INPP5K ENST00000421807.6 1347 33882 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV57443304 COSN6099345 124165123 c.262-239G>A p.? Unknown 38 17:1510038-1510038 - - NEUTRAL .012 Confirmed somatic variant 322 NS NS ENST00000421807.6:c.262-239G>A 17:g.1510038C>T INPP5K ENST00000421807.6 1347 33882 PET124T 2507124 2369460 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57441203 COSN22987696 124163005 c.262-153G>T p.? Unknown 38 17:1509952-1509952 - - NEUTRAL .11989 Confirmed somatic variant 661 NS primary 46 ENST00000421807.6:c.262-153G>T 17:g.1509952C>A INPP5K ENST00000421807.6 1347 33882 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV57443312 COSN6099353 124165129 c.45-118G>A p.? Unknown 38 17:1514097-1514097 - - NEUTRAL .01454 Confirmed somatic variant 322 NS NS ENST00000421807.6:c.45-118G>A 17:g.1514097C>T INPP5K ENST00000421807.6 1347 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441884 COSN25825941 124164856 c.777-3679T>C p.? Unknown 38 17:1501801-1501801 - - NEUTRAL .01231 Confirmed somatic variant 534 NS primary 44 ENST00000421807.6:c.777-3679T>C 17:g.1501801A>G INPP5K ENST00000421807.6 1347 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441890 COSN25825863 124164863 c.554+47A>G p.? Unknown 38 17:1509131-1509131 - - NEUTRAL .00149 Confirmed somatic variant 534 NS primary 44 ENST00000421807.6:c.554+47A>G 17:g.1509131T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2834138 2834138 2689922 skin mucosal female_genital_tract_(site_indeterminate) NS malignant_melanoma NS NS NS y COSV104623170 COSM9341102 103179186 c.17C>A p.P6H Substitution - Missense 38 17:1513469-1513469 - - PATHOGENIC .98931 Variant of unknown origin 28296713 surgery - NOS primary 76 ENSP00000318476.6:p.Pro6His ENST00000320345.10:c.17C>A 17:g.1513469G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK036_C01 1918829 1806150 liver NS NS NS carcinoma NS NS NS y COSV57439762 COSN1714041 103181572 c.548+1278G>A p.? Unknown het 38 17:1505702-1505702 - - NEUTRAL .0172 Variant of unknown origin 322 fresh/frozen - NOS primary ENST00000320345.10:c.548+1278G>A 17:g.1505702C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SNU-175 2302007 2167290 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441485 COSM2738174 103179079 c.601C>T p.R201W Substitution - Missense het 38 17:1498070-1498070 - - PATHOGENIC .83124 Variant of unknown origin 24755471 cell-line NS ENSP00000318476.6:p.Arg201Trp ENST00000320345.10:c.601C>T 17:g.1498070G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV57442436 COSM178157 103180230 c.691G>A p.G231S Substitution - Missense het 38 17:1497980-1497980 - - NEUTRAL .01795 Variant of unknown origin 30545397 cell-line primary ENSP00000318476.6:p.Gly231Ser ENST00000320345.10:c.691G>A 17:g.1497980C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 ESO-1096 1890882 1780251 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57439838 COSM1254855 103181523 c.-102C>T p.? Unknown 38 17:1513897-1513897 - - NEUTRAL .13365 Variant of unknown origin 23525077 surgery fresh/frozen primary 73 ENST00000320345.10:c.-102C>T 17:g.1513897G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440852 COSM975658 103181784 c.72C>T p.V24= Substitution - coding silent het 38 17:1509761-1509761 - - PATHOGENIC .80498 Variant of unknown origin 419 fresh/frozen - NOS primary 33 ENSP00000318476.6:p.Val24= ENST00000320345.10:c.72C>T 17:g.1509761G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC1438 2776294 2634430 lung NS NS NS carcinoma large_cell_carcinoma NS NS y COSV99052630 COSM7372286 103181127 c.638C>T p.P213L Substitution - Missense 38 17:1498033-1498033 - - NEUTRAL .05806 Variant of unknown origin 29681454 NS NS 43 ENSP00000318476.6:p.Pro213Leu ENST00000320345.10:c.638C>T 17:g.1498033G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LUAD-CHTN-3090346 1765232 1669552 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV57440835 COSM356825 103182297 c.467T>C p.L156P Substitution - Missense 38 17:1507061-1507061 - - PATHOGENIC .92333 Variant of unknown origin 22980975 surgery - NOS primary 78 ENSP00000318476.6:p.Leu156Pro ENST00000320345.10:c.467T>C 17:g.1507061A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57442400 COSM975652 103179414 c.636G>A p.P212= Substitution - coding silent het 38 17:1498035-1498035 - - NEUTRAL .02365 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000318476.6:p.Pro212= ENST00000320345.10:c.636G>A 17:g.1498035C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 NCI-H929 2809759 2666429 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV57441243 COSM2738184 103179544 c.502C>T p.P168S Substitution - Missense het 38 17:1507026-1507026 - - .52576 Variant of unknown origin 30545397 cell-line NS ENSP00000318476.6:p.Pro168Ser ENST00000320345.10:c.502C>T 17:g.1507026G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC123T 1919182 1806503 liver NS NS NS carcinoma NS NS NS y COSV57443268 COSN1193197 103179321 c.*787C>T p.? Unknown het 38 17:1495036-1495036 - - NEUTRAL .04496 Variant of unknown origin 323 fresh/frozen - NOS primary ENST00000320345.10:c.*787C>T 17:g.1495036G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440600 COSM975655 103181813 c.504G>A p.P168= Substitution - coding silent het 38 17:1507024-1507024 - - NEUTRAL .04613 Variant of unknown origin 419 fresh/frozen - NOS primary 53 ENSP00000318476.6:p.Pro168= ENST00000320345.10:c.504G>A 17:g.1507024C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SNU-C2B 2302010 2167293 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV57440138 COSM2738166 103181213 c.864A>G p.G288= Substitution - coding silent het 38 17:1496675-1496675 - - PATHOGENIC .72859 Variant of unknown origin 24755471 cell-line NS ENSP00000318476.6:p.Gly288= ENST00000320345.10:c.864A>G 17:g.1496675T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC1T 1566773 1488580 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS n COSV57440954 COSN1193215 103180513 c.-416+96A>G p.? Unknown het 38 17:1516360-1516360 - - NEUTRAL .01043 Variant of unknown origin 323 surgery fresh/frozen primary 55 ENST00000320345.10:c.-416+96A>G 17:g.1516360T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 H157 2776238 2634374 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99052630 COSM7372286 103181127 c.638C>T p.P213L Substitution - Missense 38 17:1498033-1498033 - - NEUTRAL .05806 Variant of unknown origin 29681454 NS NS 59 ENSP00000318476.6:p.Pro213Leu ENST00000320345.10:c.638C>T 17:g.1498033G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SW1222 2302013 2167296 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439938 COSM4654771 103182636 c.-116T>C p.? Unknown het 38 17:1513911-1513911 - - PATHOGENIC .98734 Variant of unknown origin 24755471 cell-line NS ENST00000320345.10:c.-116T>C 17:g.1513911A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GBC_22 2907868 2762051 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV57443533 COSM2738244 103180859 c.-184-5C>T p.? Unknown 38 17:1513984-1513984 - - NEUTRAL .0451 Variant of unknown origin 33563892 surgery-fixed NS 62 ENST00000320345.10:c.-184-5C>T 17:g.1513984G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SW1222 2302013 2167296 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439923 COSM4654769 103182622 c.502C>G p.P168A Substitution - Missense het 38 17:1507026-1507026 - - .59826 Variant of unknown origin 24755471 cell-line NS ENSP00000318476.6:p.Pro168Ala ENST00000320345.10:c.502C>G 17:g.1507026G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK126_C01 1918880 1806201 liver NS NS NS carcinoma NS NS NS y COSV57441297 COSN1714053 103180436 c.-238C>T p.? Unknown hom 38 17:1515941-1515941 - - NEUTRAL .02907 Variant of unknown origin 322 fresh/frozen - NOS primary ENST00000320345.10:c.-238C>T 17:g.1515941G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHEWS002 2294515 2160542 bone pelvis NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV57440707 COSM4579451 103181334 c.196T>C p.Y66H Substitution - Missense 38 17:1509308-1509308 - - PATHOGENIC .7629 Variant of unknown origin 25186949 NS NS 10 ENSP00000318476.6:p.Tyr66His ENST00000320345.10:c.196T>C 17:g.1509308A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LIM2405 2301994 2167277 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV57441800 COSM4642073 103182425 c.984T>C p.P328= Substitution - coding silent het 38 17:1496138-1496138 - - NEUTRAL .02457 Variant of unknown origin 24755471 cell-line NS ENSP00000318476.6:p.Pro328= ENST00000320345.10:c.984T>C 17:g.1496138A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 587284 1766769 1671089 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV57440902 COSM1210737 103180334 c.-184-1G>T p.? Unknown 38 17:1513980-1513980 - - PATHOGENIC .99647 Variant of unknown origin 22895193 surgery fresh/frozen primary ENST00000320345.10:c.-184-1G>T 17:g.1513980C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK042_C01 1918833 1806154 liver NS NS NS carcinoma NS NS NS y COSV57441764 COSN1714034 103179294 c.549-4020G>C p.? Unknown het 38 17:1502142-1502142 - - NEUTRAL .00011 Reported in another cancer sample as somatic 322 fresh/frozen - NOS primary ENST00000320345.10:c.549-4020G>C 17:g.1502142C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK042_C01 1918833 1806154 liver NS NS NS carcinoma NS NS NS y COSV57441768 COSN1714035 103179303 c.549-4023C>G p.? Unknown het 38 17:1502145-1502145 - - NEUTRAL .00026 Reported in another cancer sample as somatic 322 fresh/frozen - NOS primary ENST00000320345.10:c.549-4023C>G 17:g.1502145G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC142T 1919196 1806517 liver NS NS NS carcinoma NS NS NS y COSV57440930 COSN1193209 103180440 c.326+56_326+65del p.? Unknown het 38 17:1509124-1509133 - - Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000320345.10:c.326+56_326+65del 17:g.1509124_1509133del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 DLD1 2301972 2167255 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439847 COSM2150351 103179481 c.-175C>T p.? Unknown het 38 17:1513970-1513970 - - NEUTRAL .02048 Reported in another cancer sample as somatic 24755471 cell-line NS ENST00000320345.10:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440057 COSM975648 103179405 c.1030C>T p.R344C Substitution - Missense het 38 17:1496092-1496092 - - NEUTRAL .09246 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 69 ENSP00000318476.6:p.Arg344Cys ENST00000320345.10:c.1030C>T 17:g.1496092G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 BN06T 1919137 1806458 liver NS NS NS carcinoma NS NS NS y COSV57442850 COSN1193203 103180389 c.735+37T>A p.? Unknown het 38 17:1497899-1497899 - - NEUTRAL .02871 Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000320345.10:c.735+37T>A 17:g.1497899A>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 tumor_4137230 2634554 2494950 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441087 COSN23438524 103180194 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 440 NS primary 50 ENST00000320345.10:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 S00827 1759193 1663941 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV57441520 COSM312000 103180138 c.124A>T p.T42S Substitution - Missense 38 17:1509709-1509709 - - PATHOGENIC .95918 Reported in another cancer sample as somatic 22941188 fresh/frozen - NOS NS 73 ENSP00000318476.6:p.Thr42Ser ENST00000320345.10:c.124A>T 17:g.1509709T>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 22T 2745864 2604567 liver NS NS NS other neoplasm NS NS y COSV57443437 COSN29899782 103182945 c.549-2614G>A p.? Unknown 38 17:1500736-1500736 - - NEUTRAL .00211 Confirmed somatic variant 660 NS primary 67 ENST00000320345.10:c.549-2614G>A 17:g.1500736C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC361TB 2340446 2205429 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57439946 COSN25044683 103179740 c.549-2149G>A p.? Unknown 38 17:1500271-1500271 - - NEUTRAL .0428 Confirmed somatic variant 647 NS primary 67 ENST00000320345.10:c.549-2149G>A 17:g.1500271C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC132T 1919188 1806509 liver NS NS NS carcinoma NS NS NS y COSV57440930 COSN1193209 103180440 c.326+56_326+65del p.? Unknown het 38 17:1509124-1509133 - - Reported in another cancer sample as somatic 323 fresh/frozen - NOS primary ENST00000320345.10:c.326+56_326+65del 17:g.1509124_1509133del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6008269-DNA_E01 2688150 2547132 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57443507 COSN27046300 103181461 c.548+3483T>A p.? Unknown 38 17:1503497-1503497 - - NEUTRAL .00478 Confirmed somatic variant 535 NS primary 77 ENST00000320345.10:c.548+3483T>A 17:g.1503497A>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHG-15-00821T 2634340 2494736 liver NS NS NS other neoplasm NS NS y COSV57441898 COSN26577197 103182083 c.33+50C>A p.? Unknown 38 17:1513403-1513403 - - NEUTRAL .18705 Confirmed somatic variant 660 NS primary 53 ENST00000320345.10:c.33+50C>A 17:g.1513403G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2748840 2748840 2607543 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV57441547 COSM7324773 103180294 c.957+2T>C p.? Unknown 38 17:1496317-1496317 - - .53901 Confirmed somatic variant 29360550 surgery fresh/frozen NS 78 ENST00000320345.10:c.957+2T>C 17:g.1496317A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 DA16007 2635112 2495508 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV57440471 COSM6437186 103181061 c.735G>A p.E245= Substitution - coding silent 38 17:1497936-1497936 - - PATHOGENIC .98858 Confirmed somatic variant 677 NS primary 62 ENSP00000318476.6:p.Glu245= ENST00000320345.10:c.735G>A 17:g.1497936C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EE-A2GH-06 2121658 1995894 skin NS NS NS malignant_melanoma NS NS NS y COSV100233689 COSM7983353 103179771 c.1082G>T p.R361M Substitution - Missense 38 17:1495860-1495860 - - NEUTRAL .02005 Confirmed somatic variant 540 NS NS 34 ENSP00000318476.6:p.Arg361Met ENST00000320345.10:c.1082G>T 17:g.1495860C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV57439902 COSM6686175 103179982 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000318476.6:p.Arg130Trp ENST00000320345.10:c.388C>T 17:g.1508165G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV100233979 COSM9174724 103179967 c.778G>A p.E260K Substitution - Missense 38 17:1496761-1496761 - - PATHOGENIC .96769 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000318476.6:p.Glu260Lys ENST00000320345.10:c.778G>A 17:g.1496761C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-CD-8529-01 2198058 2066336 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57443033 COSM4064066 103179265 c.-29C>A p.? Unknown 38 17:1513514-1513514 - - PATHOGENIC .95385 Confirmed somatic variant 541 NS NS 65 ENST00000320345.10:c.-29C>A 17:g.1513514G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EE-A2MH-06 2121679 1995915 skin NS NS NS malignant_melanoma NS NS NS y COSV57441603 COSM3514448 103179724 c.1066C>T p.P356S Substitution - Missense 38 17:1495876-1495876 - - NEUTRAL .15283 Confirmed somatic variant 540 NS NS 66 ENSP00000318476.6:p.Pro356Ser ENST00000320345.10:c.1066C>T 17:g.1495876G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CN-AML-CR-21-Dx 2340285 2205268 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57442223 COSN19628996 103181733 c.326+113G>A p.? Unknown 38 17:1509065-1509065 - - NEUTRAL .00192 Confirmed somatic variant 544 blood-bone marrow primary 28 ENST00000320345.10:c.326+113G>A 17:g.1509065C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2785970 2785970 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 103180379 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000318476.6:p.Tyr230= ENST00000320345.10:c.690C>T 17:g.1497981G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-BK-A6W3-01 2263446 2130430 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57440002 COSM266711 103179660 c.1031G>A p.R344H Substitution - Missense 38 17:1496091-1496091 - - NEUTRAL .0033 Confirmed somatic variant 419 NS primary 34 ENSP00000318476.6:p.Arg344His ENST00000320345.10:c.1031G>A 17:g.1496091C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 C0100T 2197804 2066082 kidney NS NS NS NS NS NS NS y COSV57440805 COSN15570238 103180521 c.549-3151A>T p.? Unknown 38 17:1501273-1501273 - - NEUTRAL .14618 Confirmed somatic variant 588 NS NS ENST00000320345.10:c.549-3151A>T 17:g.1501273T>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-A5-A0VP-01 1783327 1687326 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233618 COSM8819723 103179887 c.525G>A p.R175= Substitution - coding silent 38 17:1507003-1507003 - - NEUTRAL .06188 Confirmed somatic variant 419 fresh/frozen - NOS primary 74 ENSP00000318476.6:p.Arg175= ENST00000320345.10:c.525G>A 17:g.1507003C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 DN15007 2633582 2493978 breast NS NS NS carcinoma HER-positive_carcinoma NS NS y COSV57441312 COSM6349374 103179685 c.-175C>A p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .04999 Confirmed somatic variant 668 NS primary 46 ENST00000320345.10:c.-175C>A 17:g.1513970G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC361TA 2120615 1994851 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57439946 COSN25044683 103179740 c.549-2149G>A p.? Unknown 38 17:1500271-1500271 - - NEUTRAL .0428 Confirmed somatic variant 381 NS NS ENST00000320345.10:c.549-2149G>A 17:g.1500271C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6007594 2262933 2129917 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57441794 COSN15055521 103181588 c.326+263C>T p.? Unknown 38 17:1508915-1508915 - - NEUTRAL .00143 Confirmed somatic variant 535 NS primary ENST00000320345.10:c.326+263C>T 17:g.1508915G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-06-0171-02 2120251 1994487 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 103179481 c.-175C>T p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 329 NS NS 65 ENST00000320345.10:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-06-0171-01 2339818 2204801 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 103179481 c.-175C>T p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 329 NS primary 65 ENST00000320345.10:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-W3-AA1W-06 2339958 2204941 skin NS NS NS malignant_melanoma NS NS NS y COSV100233883 COSM8026356 103180675 c.341T>A p.F114Y Substitution - Missense 38 17:1508212-1508212 - - PATHOGENIC .99149 Confirmed somatic variant 540 NS NS 64 ENSP00000318476.6:p.Phe114Tyr ENST00000320345.10:c.341T>A 17:g.1508212A>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK176_C01 2194707 2062985 liver NS NS NS carcinoma NS NS NS y COSV57442289 COSN6099335 103182078 c.548+1383G>C p.? Unknown 38 17:1505597-1505597 - - NEUTRAL .02961 Confirmed somatic variant 322 NS NS ENST00000320345.10:c.548+1383G>C 17:g.1505597C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GCTK_444_T 2747468 2606171 stomach NS NS NS carcinoma NS NS NS y COSV100233770 COSM8558056 103181893 c.489C>T p.G163= Substitution - coding silent 38 17:1507039-1507039 - - NEUTRAL .15391 Confirmed somatic variant 683 NS primary ENSP00000318476.6:p.Gly163= ENST00000320345.10:c.489C>T 17:g.1507039G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 YURUB 2013679 1896311 skin NS NS NS malignant_melanoma NS NS NS y COSV57443209 COSM1709542 103182310 c.113C>T p.S38F Substitution - Missense het 38 17:1509720-1509720 - - PATHOGENIC .74112 Confirmed somatic variant 22842228 NS NS ENSP00000318476.6:p.Ser38Phe ENST00000320345.10:c.113C>T 17:g.1509720G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2293782 2293782 2159833 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma functioning NS NS y COSV57443083 COSM4608647 103181852 c.910G>T p.A304S Substitution - Missense 38 17:1496366-1496366 - - PATHOGENIC .85582 Confirmed somatic variant 24747642 surgery-fixed NS 44.5 ENSP00000318476.6:p.Ala304Ser ENST00000320345.10:c.910G>T 17:g.1496366C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 0187_CRUK_PC_0187_T1_DNA 2634990 2495386 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57441725 COSN26361667 103180661 c.548+4050G>A p.? Unknown 38 17:1502930-1502930 - - NEUTRAL .00259 Confirmed somatic variant 538 NS primary 62 ENST00000320345.10:c.548+4050G>A 17:g.1502930C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV57440779 COSM6398503 103180080 c.448G>A p.A150T Substitution - Missense 38 17:1507080-1507080 - - .61456 Confirmed somatic variant 676 NS primary 40 ENSP00000318476.6:p.Ala150Thr ENST00000320345.10:c.448G>A 17:g.1507080C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV57440757 COSM6399895 103180071 c.1049G>T p.S350I Substitution - Missense 38 17:1496073-1496073 - - PATHOGENIC .91364 Confirmed somatic variant 676 NS primary 40 ENSP00000318476.6:p.Ser350Ile ENST00000320345.10:c.1049G>T 17:g.1496073C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 Pat_53_B 2492893 2355507 NS NS NS NS malignant_melanoma NS NS NS y COSV57440676 COSM5851850 103180470 c.718G>A p.G240S Substitution - Missense 38 17:1497953-1497953 - - NEUTRAL .10276 Confirmed somatic variant 24265153 surgery-fixed NS 53 ENSP00000318476.6:p.Gly240Ser ENST00000320345.10:c.718G>A 17:g.1497953C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-BH-A0HA-01 1899939 1788623 breast NS NS NS carcinoma NS NS NS y COSV100233635 COSM7691643 103179070 c.686C>T p.T229M Substitution - Missense 38 17:1497985-1497985 - - NEUTRAL .00988 Confirmed somatic variant 414 fresh/frozen - NOS primary 31 ENSP00000318476.6:p.Thr229Met ENST00000320345.10:c.686C>T 17:g.1497985G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 AOCS-108-1-7 2196304 2064582 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441425 COSN8831789 103181327 c.327-216C>G p.? Unknown 38 17:1508442-1508442 - - NEUTRAL .14437 Confirmed somatic variant 585 NS NS ENST00000320345.10:c.327-216C>G 17:g.1508442G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-ZF-AA4X-01 2385833 2248665 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57440964 COSM7180871 103180690 c.824C>T p.S275L Substitution - Missense 38 17:1496715-1496715 - - NEUTRAL .01467 Confirmed somatic variant 413 NS primary 56 ENSP00000318476.6:p.Ser275Leu ENST00000320345.10:c.824C>T 17:g.1496715G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHG-95T 2634277 2494673 liver NS NS NS other neoplasm NS NS y COSV57443045 COSN26671163 103181455 c.*415C>A p.? Unknown 38 17:1495408-1495408 - - PATHOGENIC .76068 Confirmed somatic variant 660 NS primary 49 ENST00000320345.10:c.*415C>A 17:g.1495408G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EOPC-014_tumor_01 2633793 2494189 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 103180194 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 45 ENST00000320345.10:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AG-3885-01 1651560 1566347 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV100233650 COSM7526312 103182120 c.-28C>T p.? Unknown 38 17:1513513-1513513 - - PATHOGENIC .75567 Confirmed somatic variant 375 NS primary 71 ENST00000320345.10:c.-28C>T 17:g.1513513G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 sysucc-1024T 2504582 2366914 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442104 COSM5763189 103180314 c.186T>G p.L62= Substitution - coding silent 38 17:1509318-1509318 - - NEUTRAL .49978 Confirmed somatic variant 646 NS primary 71 ENSP00000318476.6:p.Leu62= ENST00000320345.10:c.186T>G 17:g.1509318A>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 ML_124_T_01 2688384 2547366 skin NS NS NS carcinoma NS NS NS y COSV57441732 COSN27612453 103180596 c.34-1069A>G p.? Unknown 38 17:1510868-1510868 - - NEUTRAL .00068 Confirmed somatic variant 656 NS primary 74 ENST00000320345.10:c.34-1069A>G 17:g.1510868T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 DA16008 2635113 2495509 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV57440471 COSM6437186 103181061 c.735G>A p.E245= Substitution - coding silent 38 17:1497936-1497936 - - PATHOGENIC .98858 Confirmed somatic variant 677 NS primary 62 ENSP00000318476.6:p.Glu245= ENST00000320345.10:c.735G>A 17:g.1497936C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC2157 1235084 1146870 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV57443001 COSM33344 103179844 c.716C>T p.S239F Substitution - Missense het 38 17:1497955-1497955 - - .65418 Confirmed somatic variant 16959974 cell-line primary 48 ENSP00000318476.6:p.Ser239Phe ENST00000320345.10:c.716C>T 17:g.1497955G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 ESOSCC162T 1860018 1750959 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440993 COSM1172380 103180253 c.122C>T p.S41F Substitution - Missense 38 17:1509711-1509711 - - PATHOGENIC .81311 Confirmed somatic variant 22877736 fresh/frozen - NOS primary 82 ENSP00000318476.6:p.Ser41Phe ENST00000320345.10:c.122C>T 17:g.1509711G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CRC-27T 2456797 2319634 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440751 COSN19718001 103180919 c.326+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 646 NS primary 69 ENST00000320345.10:c.326+396G>C 17:g.1508782C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D9-A4Z6-01 2121566 1995802 skin NS NS NS malignant_melanoma NS NS NS y COSV57442416 COSM3514457 103179366 c.-19C>T p.? Unknown 38 17:1513504-1513504 - - PATHOGENIC .8518 Confirmed somatic variant 540 NS NS 54 ENST00000320345.10:c.-19C>T 17:g.1513504G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PCSI_0476_Pa_P_526 2385500 2248332 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57440553 COSN17208512 103182408 c.549-3101C>A p.? Unknown 38 17:1501223-1501223 - - NEUTRAL .00218 Confirmed somatic variant 382 NS primary 43 ENST00000320345.10:c.549-3101C>A 17:g.1501223G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EB-A44O-01 2121602 1995838 skin NS NS NS malignant_melanoma NS NS NS y COSV100233746 COSM8129790 103181365 c.838C>A p.P280T Substitution - Missense 38 17:1496701-1496701 - - PATHOGENIC .85982 Confirmed somatic variant 540 NS NS 69 ENSP00000318476.6:p.Pro280Thr ENST00000320345.10:c.838C>A 17:g.1496701G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EB-A44O-01 2121602 1995838 skin NS NS NS malignant_melanoma NS NS NS y COSV100233745 COSM8129799 103181354 c.839C>T p.P280L Substitution - Missense 38 17:1496700-1496700 - - NEUTRAL .39106 Confirmed somatic variant 540 NS NS 69 ENSP00000318476.6:p.Pro280Leu ENST00000320345.10:c.839C>T 17:g.1496700G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 275 2748247 2606950 stomach NS NS NS carcinoma NS NS NS y COSV100233669 COSN30566516 103181119 c.548+96del p.? Unknown 38 17:1506890-1506890 - - Confirmed somatic variant 683 NS primary ENST00000320345.10:c.548+96del 17:g.1506890del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 ICGC_GBM85_tumor 2634877 2495273 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV57439887 COSN23285747 103179706 c.549-3738_549-3737del p.? Unknown 38 17:1501882-1501883 - - Confirmed somatic variant 379 NS primary ENST00000320345.10:c.549-3738_549-3737del 17:g.1501882_1501883del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 WGC067123 2549396 2410851 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440057 COSM975648 103179405 c.1030C>T p.R344C Substitution - Missense 38 17:1496092-1496092 - - NEUTRAL .09246 Confirmed somatic variant 646 NS primary 73 ENSP00000318476.6:p.Arg344Cys ENST00000320345.10:c.1030C>T 17:g.1496092G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 WGC067123 2549396 2410851 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440072 COSN28860754 103179507 c.439-117G>A p.? Unknown 38 17:1507206-1507206 - - NEUTRAL .06517 Confirmed somatic variant 646 NS primary 73 ENST00000320345.10:c.439-117G>A 17:g.1507206C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CPCG_0184_Pr_P_P2 2121453 1995689 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440490 COSN4905499 103180702 c.-185+879G>T p.? Unknown 38 17:1515009-1515009 - - NEUTRAL .0047 Confirmed somatic variant 537 NS NS ENST00000320345.10:c.-185+879G>T 17:g.1515009C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC2157 749715 668686 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57443014 COSM30714 103179858 c.651C>T p.F217= Substitution - coding silent het 38 17:1498020-1498020 - - PATHOGENIC .83995 Confirmed somatic variant 678 cell-line primary 48 ENSP00000318476.6:p.Phe217= ENST00000320345.10:c.651C>T 17:g.1498020G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T112 2658324 2518483 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441957 COSM6686173 103180379 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000318476.6:p.Tyr230= ENST00000320345.10:c.690C>T 17:g.1497981G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 345973 2144505 2013723 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441128 COSN5852672 103181726 c.735+12G>A p.? Unknown 38 17:1497924-1497924 - - NEUTRAL .00646 Confirmed somatic variant 22696596 NS NS 52 ENST00000320345.10:c.735+12G>A 17:g.1497924C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PCSI_0161_Pa_P_526 2339921 2204904 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441186 COSN16098920 103182068 c.438+186G>C p.? Unknown 38 17:1507929-1507929 - - NEUTRAL .00946 Confirmed somatic variant 382 NS primary 81 ENST00000320345.10:c.438+186G>C 17:g.1507929C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV100233872 COSM8146683 103180957 c.839C>A p.P280H Substitution - Missense 38 17:1496700-1496700 - - PATHOGENIC .73316 Confirmed somatic variant 540 NS NS 37 ENSP00000318476.6:p.Pro280His ENST00000320345.10:c.839C>A 17:g.1496700G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV100233793 COSM8151450 103179600 c.128C>A p.P43H Substitution - Missense 38 17:1509705-1509705 - - PATHOGENIC .88297 Confirmed somatic variant 540 NS NS 37 ENSP00000318476.6:p.Pro43His ENST00000320345.10:c.128C>A 17:g.1509705G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6007546-DNA_A01 2549449 2410904 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442857 COSN23559361 103180376 c.34-1679C>G p.? Unknown 38 17:1511478-1511478 - - NEUTRAL .04212 Confirmed somatic variant 535 NS primary ENST00000320345.10:c.34-1679C>G 17:g.1511478G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6007438-DNA_A01 2263456 2130440 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442932 COSN14857961 103179956 c.549-3471C>T p.? Unknown 38 17:1501593-1501593 - - NEUTRAL .01431 Confirmed somatic variant 535 NS primary ENST00000320345.10:c.549-3471C>T 17:g.1501593G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2014_Lung_sq_66_T 2744937 2603640 lung NS NS NS carcinoma NS NS NS y COSV57440812 COSN13701328 103179334 c.34-25G>A p.? Unknown 38 17:1509824-1509824 - - NEUTRAL .16185 Confirmed somatic variant 583 NS primary 53 ENST00000320345.10:c.34-25G>A 17:g.1509824C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-XK-AAIW-01 2339713 2204696 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 103179426 c.581G>A p.R194H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 435 NS primary 78 ENSP00000318476.6:p.Arg194His ENST00000320345.10:c.581G>A 17:g.1498090C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHG-12-09247T 2634292 2494688 liver NS NS NS other neoplasm NS NS y COSV57441538 COSN30040156 103181712 c.549-34C>T p.? Unknown 38 17:1498156-1498156 - - NEUTRAL .02254 Confirmed somatic variant 660 NS primary 48 ENST00000320345.10:c.549-34C>T 17:g.1498156G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV57440779 COSM6398503 103180080 c.448G>A p.A150T Substitution - Missense 38 17:1507080-1507080 - - .61456 Confirmed somatic variant 676 NS primary 40 ENSP00000318476.6:p.Ala150Thr ENST00000320345.10:c.448G>A 17:g.1507080C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV57440757 COSM6399895 103180071 c.1049G>T p.S350I Substitution - Missense 38 17:1496073-1496073 - - PATHOGENIC .91364 Confirmed somatic variant 676 NS primary 40 ENSP00000318476.6:p.Ser350Ile ENST00000320345.10:c.1049G>T 17:g.1496073C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV57442068 COSM5364464 103180529 c.560G>A p.R187H Substitution - Missense het 38 17:1498111-1498111 - - PATHOGENIC .97388 Confirmed somatic variant 25957691 NS NS 81 ENSP00000318476.6:p.Arg187His ENST00000320345.10:c.560G>A 17:g.1498111C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D1-A16N-01 1783513 1687512 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57439815 COSM975660 103179913 c.47G>A p.R16H Substitution - Missense 38 17:1509786-1509786 - - PATHOGENIC .95481 Confirmed somatic variant 419 fresh/frozen - NOS primary 51 ENSP00000318476.6:p.Arg16His ENST00000320345.10:c.47G>A 17:g.1509786C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 551 2478463 2341233 adrenal_gland adrenal_gland NS NS adrenal_cortical_adenoma NS NS NS y COSV57442792 COSM5613049 103179755 c.72C>G p.V24= Substitution - coding silent 38 17:1509761-1509761 - - PATHOGENIC .8448 Confirmed somatic variant 25490274 fixed - NOS primary 68 ENSP00000318476.6:p.Val24= ENST00000320345.10:c.72C>G 17:g.1509761G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV57442083 COSM5364466 103180538 c.-151A>G p.? Unknown het 38 17:1513946-1513946 - - NEUTRAL .29067 Confirmed somatic variant 25957691 NS NS 81 ENST00000320345.10:c.-151A>G 17:g.1513946T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-ER-A42K-06 2340113 2205096 skin NS NS NS malignant_melanoma NS NS NS y COSV57443110 COSM4894813 103180027 c.653C>T p.S218F Substitution - Missense 38 17:1498018-1498018 - - NEUTRAL .04612 Confirmed somatic variant 540 NS NS 40 ENSP00000318476.6:p.Ser218Phe ENST00000320345.10:c.653C>T 17:g.1498018G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 YUPAER 2439354 2302195 skin NS NS NS malignant_melanoma NS NS NS y COSV57440177 COSM5385733 103181678 c.351G>A p.M117I Substitution - Missense het 38 17:1508202-1508202 - - PATHOGENIC .75407 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 70 ENSP00000318476.6:p.Met117Ile ENST00000320345.10:c.351G>A 17:g.1508202C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-GM-A2DH-01 2187734 2056012 breast NS NS NS carcinoma NS NS NS y COSV100233735 COSM7700391 103180367 c.738G>A p.L246= Substitution - coding silent 38 17:1496801-1496801 - - PATHOGENIC .83189 Confirmed somatic variant 414 NS NS 58 ENSP00000318476.6:p.Leu246= ENST00000320345.10:c.738G>A 17:g.1496801C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 MSU2-c 2809979 2666641 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 103179982 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000318476.6:p.Arg130Trp ENST00000320345.10:c.388C>T 17:g.1508165G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2932 2296135 2161738 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441581 COSM4692622 103179237 c.688T>C p.Y230H Substitution - Missense 38 17:1497983-1497983 - - PATHOGENIC .9847 Confirmed somatic variant 25344691 NS NS 78.08 ENSP00000318476.6:p.Tyr230His ENST00000320345.10:c.688T>C 17:g.1497983A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 MSU2-c 2809979 2666641 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV100233979 COSM9174724 103179967 c.778G>A p.E260K Substitution - Missense 38 17:1496761-1496761 - - PATHOGENIC .96769 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000318476.6:p.Glu260Lys ENST00000320345.10:c.778G>A 17:g.1496761C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV57439973 COSM5851852 103181104 c.391G>A p.E131K Substitution - Missense 38 17:1508162-1508162 - - .54001 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000318476.6:p.Glu131Lys ENST00000320345.10:c.391G>A 17:g.1508162C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-A5-A2K7-01 2198265 2066543 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233685 COSN31545877 103182032 c.*288C>A p.? Unknown 38 17:1495535-1495535 - - NEUTRAL .03426 Confirmed somatic variant 419 NS NS 41 ENST00000320345.10:c.*288C>A 17:g.1495535G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV57439956 COSM5851848 103181093 c.1025G>A p.S342N Substitution - Missense 38 17:1496097-1496097 - - NEUTRAL .01037 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000318476.6:p.Ser342Asn ENST00000320345.10:c.1025G>A 17:g.1496097C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2857095 2857095 2712395 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105203823 COSM9525077 103182563 c.830C>T p.S277L Substitution - Missense 38 17:1496709-1496709 - - PATHOGENIC .74004 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000318476.6:p.Ser277Leu ENST00000320345.10:c.830C>T 17:g.1496709G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 19 2747991 2606694 stomach NS NS NS carcinoma NS NS NS y COSV100233839 COSN30565011 103180720 c.1062+74G>T p.? Unknown 38 17:1495986-1495986 - - NEUTRAL .01269 Confirmed somatic variant 683 NS primary ENST00000320345.10:c.1062+74G>T 17:g.1495986C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 H2347 2776270 2634406 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99052641 COSM7372284 103179902 c.285G>C p.Q95H Substitution - Missense 38 17:1509219-1509219 - - PATHOGENIC .91716 Confirmed somatic variant 29681454 NS NS 54 ENSP00000318476.6:p.Gln95His ENST00000320345.10:c.285G>C 17:g.1509219C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T691 2658541 2518700 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 103179982 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 65.58 ENSP00000318476.6:p.Arg130Trp ENST00000320345.10:c.388C>T 17:g.1508165G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CPCG0211-F1 2340573 2205556 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57442127 COSN29616394 103180506 c.735+465_735+466dup p.? Unknown 38 17:1497485-1497486 - - Confirmed somatic variant 537 NS primary ENST00000320345.10:c.735+465_735+466dup 17:g.1497484_1497485dup INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D9-A6EC-06 2262880 2129864 skin NS NS NS malignant_melanoma NS NS NS y COSV100233656 COSM8115268 103179341 c.396C>T p.S132= Substitution - coding silent 38 17:1508157-1508157 - - PATHOGENIC .89222 Confirmed somatic variant 540 NS NS 56 ENSP00000318476.6:p.Ser132= ENST00000320345.10:c.396C>T 17:g.1508157G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PD9000a 1613700 1532748 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441286 COSN22701850 103182491 c.33+1485C>G p.? Unknown 38 17:1511968-1511968 - - .68966 Confirmed somatic variant 652 NS NS ENST00000320345.10:c.33+1485C>G 17:g.1511968G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-06-2566-01 2178226 2046524 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233679 COSM7489154 103180648 c.-444C>A p.? Unknown 38 17:1516484-1516484 - - NEUTRAL .13026 Confirmed somatic variant 329 NS NS 23 ENST00000320345.10:c.-444C>A 17:g.1516484G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PCSI_0048_Pa_P 1653156 1567943 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441452 COSN8240383 103179288 c.34-230A>G p.? Unknown 38 17:1510029-1510029 - - NEUTRAL .04077 Confirmed somatic variant 382 fresh/frozen - NOS primary ENST00000320345.10:c.34-230A>G 17:g.1510029T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2932 2658347 2518506 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441581 COSM4692622 103179237 c.688T>C p.Y230H Substitution - Missense 38 17:1497983-1497983 - - PATHOGENIC .9847 Confirmed somatic variant 27149842 NS NS 78.08 ENSP00000318476.6:p.Tyr230His ENST00000320345.10:c.688T>C 17:g.1497983A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC139T 1919194 1806515 liver NS NS NS carcinoma NS NS NS y COSV57440917 COSN6414832 103182910 c.326+144T>C p.? Unknown 38 17:1509034-1509034 - - NEUTRAL .00818 Confirmed somatic variant 323 fresh/frozen - NOS primary ENST00000320345.10:c.326+144T>C 17:g.1509034A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HCC139T 1919194 1806515 liver NS NS NS carcinoma NS NS NS y COSV57440912 COSN6414831 103182903 c.326+146T>C p.? Unknown 38 17:1509032-1509032 - - NEUTRAL .00699 Confirmed somatic variant 323 fresh/frozen - NOS primary ENST00000320345.10:c.326+146T>C 17:g.1509032A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-85-A4CL-01 2195132 2063410 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233961 COSM8679772 103180709 c.1116C>G p.I372M Substitution - Missense 38 17:1495826-1495826 - - PATHOGENIC .73673 Confirmed somatic variant 418 NS NS 65 ENSP00000318476.6:p.Ile372Met ENST00000320345.10:c.1116C>G 17:g.1495826G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2843839 2843839 2699247 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS y COSV105883442 COSM9973989 103180993 c.1049del p.S350Tfs*11 Deletion - Frameshift 38 17:1496073-1496073 - - Confirmed somatic variant 27655895 blood-bone marrow recurrent 6 ENSP00000318476.6:p.Ser350ThrfsTer11 ENST00000320345.10:c.1049del 17:g.1496073del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T1222 2658242 2518401 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 103179982 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 71.91 ENSP00000318476.6:p.Arg130Trp ENST00000320345.10:c.388C>T 17:g.1508165G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CSCC-27-T 2292469 2158533 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441071 COSM4488765 103180270 c.109C>T p.L37= Substitution - coding silent het 38 17:1509724-1509724 - - PATHOGENIC .75042 Confirmed somatic variant 25303977 surgery fresh/frozen primary 72 ENSP00000318476.6:p.Leu37= ENST00000320345.10:c.109C>T 17:g.1509724G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 38T 2745883 2604586 liver NS NS NS other neoplasm NS NS y COSV57442315 COSN29975831 103180132 c.-184-927dup p.? Unknown 38 17:1514924-1514925 - - Confirmed somatic variant 660 NS primary 62 ENST00000320345.10:c.-184-927dup 17:g.1514924dup INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-DA-A960-01 2380407 2243239 skin NS NS NS malignant_melanoma NS NS NS y COSV100233581 COSM8029324 103180036 c.-77+1dup p.? Unknown 38 17:1513873-1513874 - - Confirmed somatic variant 540 NS primary 73 ENST00000320345.10:c.-77+1dup 17:g.1513873dup INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PCSI_0048_Pa_P_526 2197258 2065536 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441452 COSN8240383 103179288 c.34-230A>G p.? Unknown 38 17:1510029-1510029 - - NEUTRAL .04077 Confirmed somatic variant 382 NS NS ENST00000320345.10:c.34-230A>G 17:g.1510029T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6005500-DNA_A01 2262738 2129722 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57441040 COSN17309196 103179568 c.327-355C>T p.? Unknown 38 17:1508581-1508581 - - NEUTRAL .05546 Confirmed somatic variant 535 NS primary ENST00000320345.10:c.327-355C>T 17:g.1508581G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-LP-A4AX-01 2193354 2061632 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441157 COSM4829770 103179783 c.-30G>A p.? Unknown 38 17:1513515-1513515 - - PATHOGENIC .84408 Confirmed somatic variant 415 NS NS 45 ENST00000320345.10:c.-30G>A 17:g.1513515C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 61 2497169 2359521 small_intestine duodenum NS NS adenoma NS NS NS y COSV57441337 COSM5740783 103179364 c.-125T>C p.? Unknown 38 17:1513920-1513920 - - PATHOGENIC .99507 Confirmed somatic variant 26806338 fresh/frozen - NOS primary ENST00000320345.10:c.-125T>C 17:g.1513920A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2785969 2785969 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 103180379 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000318476.6:p.Tyr230= ENST00000320345.10:c.690C>T 17:g.1497981G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PD40845k_lo0005 2875098 2729864 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma non_papillary_transitional_cell_carcinoma_non_invasive NS y COSV105203812 COSN32152386 103180418 c.549-4279G>A p.? Unknown 38 17:1502401-1502401 - - NEUTRAL .03905 Confirmed somatic variant 33004514 surgery-fixed NS 67 ENST00000320345.10:c.549-4279G>A 17:g.1502401C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2785971 2785971 2643433 stomach NS NS NS adenoma NS NS NS y COSV57441957 COSM6686173 103180379 c.690C>T p.Y230= Substitution - coding silent 38 17:1497981-1497981 - - PATHOGENIC .78424 Confirmed somatic variant 27175599 surgery fresh/frozen NS 71 ENSP00000318476.6:p.Tyr230= ENST00000320345.10:c.690C>T 17:g.1497981G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LICA-CN-HCC_WGS_016T 2634223 2494619 liver NS NS NS other neoplasm NS NS y COSV57440981 COSN26616313 103179609 c.-184-173C>T p.? Unknown 38 17:1514152-1514152 - - NEUTRAL .00383 Confirmed somatic variant 660 NS primary 48 ENST00000320345.10:c.-184-173C>T 17:g.1514152G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CPCG0217-F1 2340498 2205481 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440046 COSN16288830 103181386 c.548+2259T>A p.? Unknown 38 17:1504721-1504721 - - NEUTRAL .03225 Confirmed somatic variant 537 NS primary ENST00000320345.10:c.548+2259T>A 17:g.1504721A>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T306558 2658252 2518411 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441669 COSM6686185 103180218 c.809T>C p.M270T Substitution - Missense 38 17:1496730-1496730 - - .64209 Confirmed somatic variant 27149842 NS NS 80.41 ENSP00000318476.6:p.Met270Thr ENST00000320345.10:c.809T>C 17:g.1496730A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HUB-02-B2-006 2607081 2466795 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442265 COSM6053586 103179523 c.1087G>C p.D363H Substitution - Missense 38 17:1495855-1495855 - - NEUTRAL .0652 Confirmed somatic variant 670 organoid culture NS ENSP00000318476.6:p.Asp363His ENST00000320345.10:c.1087G>C 17:g.1495855C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 cSCCP2 1604870 1524189 skin hand NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440547 COSM137654 103179821 c.-123C>T p.? Unknown 38 17:1513918-1513918 - - PATHOGENIC .98532 Confirmed somatic variant 21984974 surgery - NOS primary 84 ENST00000320345.10:c.-123C>T 17:g.1513918G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D9-A6EC-06 2262880 2129864 skin NS NS NS malignant_melanoma NS NS NS y COSV100233657 COSM8115635 103179351 c.395C>T p.S132F Substitution - Missense 38 17:1508158-1508158 - - PATHOGENIC .94511 Confirmed somatic variant 540 NS NS 56 ENSP00000318476.6:p.Ser132Phe ENST00000320345.10:c.395C>T 17:g.1508158G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T_CCA_SG_4 2688136 2547118 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57442188 COSN27227981 103181166 c.548+1837dup p.? Unknown 38 17:1505153-1505154 - - Confirmed somatic variant 653 NS primary 61 ENST00000320345.10:c.548+1837dup 17:g.1505153dup INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 AOCS-139-12-5 2185820 2054117 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441924 COSM3983266 103180500 c.-38C>G p.? Unknown 38 17:1513523-1513523 - - PATHOGENIC .9676 Confirmed somatic variant 585 NS NS ENST00000320345.10:c.-38C>G 17:g.1513523G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 364 2131821 2005885 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441008 COSM3722171 103179935 c.295G>A p.G99R Substitution - Missense 38 17:1509209-1509209 - - NEUTRAL .07332 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 74 ENSP00000318476.6:p.Gly99Arg ENST00000320345.10:c.295G>A 17:g.1509209C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CSCC-20-T 2292468 2158532 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441169 COSM4508387 103181603 c.545C>T p.T182I Substitution - Missense het 38 17:1506983-1506983 - - PATHOGENIC .87428 Confirmed somatic variant 25303977 surgery fresh/frozen primary 93 ENSP00000318476.6:p.Thr182Ile ENST00000320345.10:c.545C>T 17:g.1506983G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 4-2 2746099 2604802 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441742 COSM3701153 103179803 c.915G>T p.W305C Substitution - Missense 38 17:1496361-1496361 - - PATHOGENIC .95169 Confirmed somatic variant 646 NS primary 46 ENSP00000318476.6:p.Trp305Cys ENST00000320345.10:c.915G>T 17:g.1496361C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK298_C01 2120999 1995235 liver NS NS NS carcinoma NS NS NS y COSV57441742 COSM3701153 103179803 c.915G>T p.W305C Substitution - Missense 38 17:1496361-1496361 - - PATHOGENIC .95169 Confirmed somatic variant 322 NS NS ENSP00000318476.6:p.Trp305Cys ENST00000320345.10:c.915G>T 17:g.1496361C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CN-AML-NR-08-Dx 2456284 2319121 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 103179230 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 blood-bone marrow primary ENST00000320345.10:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PD_01 2688657 2547639 skin shoulder NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440218 COSM6867459 103182016 c.507C>A p.P169= Substitution - coding silent het 38 17:1507021-1507021 - - .63631 Confirmed somatic variant 24662767 surgery fresh/frozen NS 71 ENSP00000318476.6:p.Pro169= ENST00000320345.10:c.507C>A 17:g.1507021G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2275_T 2194907 2063185 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441332 COSN8602376 103179949 c.34-25G>T p.? Unknown 38 17:1509824-1509824 - - NEUTRAL .2918 Confirmed somatic variant 583 NS NS ENST00000320345.10:c.34-25G>T 17:g.1509824C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 4-2 2746099 2604802 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441758 COSN28835429 103179814 c.549-85G>A p.? Unknown 38 17:1498207-1498207 - - NEUTRAL .00964 Confirmed somatic variant 646 NS primary 46 ENST00000320345.10:c.549-85G>A 17:g.1498207C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-GN-A8LK-06 2340243 2205226 skin NS NS NS malignant_melanoma NS NS NS y COSV100233562 COSM7958046 103182357 c.279G>A p.E93= Substitution - coding silent 38 17:1509225-1509225 - - PATHOGENIC .7441 Confirmed somatic variant 540 NS NS 70 ENSP00000318476.6:p.Glu93= ENST00000320345.10:c.279G>A 17:g.1509225C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 A001-T-S01 2757354 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV100233671 COSM7411841 103180873 c.466C>A p.L156M Substitution - Missense 38 17:1507062-1507062 - - .59764 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000318476.6:p.Leu156Met ENST00000320345.10:c.466C>A 17:g.1507062G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T1224 2658634 2518793 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440352 COSM5642741 103179373 c.635C>T p.P212L Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .00382 Confirmed somatic variant 27149842 NS NS 57.75 ENSP00000318476.6:p.Pro212Leu ENST00000320345.10:c.635C>T 17:g.1498036G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EOPC-139_tumor_01 2549437 2410892 prostate NS NS NS carcinoma NS NS NS y COSV57440751 COSN19718001 103180919 c.326+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 534 NS primary 47 ENST00000320345.10:c.326+396G>C 17:g.1508782C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 I2L-P24Tb-Tumor-Biopsy 2433484 2296365 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV57441627 COSM5364256 103179108 c.727G>A p.D243N Substitution - Missense het 38 17:1497944-1497944 - - PATHOGENIC .70948 Confirmed somatic variant 25957691 NS NS 60 ENSP00000318476.6:p.Asp243Asn ENST00000320345.10:c.727G>A 17:g.1497944C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AP-A1DM-01 2198333 2066611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233687 COSM8955248 103182041 c.719G>A p.G240D Substitution - Missense 38 17:1497952-1497952 - - NEUTRAL .35784 Confirmed somatic variant 419 NS NS 60 ENSP00000318476.6:p.Gly240Asp ENST00000320345.10:c.719G>A 17:g.1497952C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6005500-DNA_C01 2549483 2410938 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442243 COSN23565574 103181915 c.548+3134G>A p.? Unknown 38 17:1503846-1503846 - - NEUTRAL .0167 Confirmed somatic variant 535 NS primary ENST00000320345.10:c.548+3134G>A 17:g.1503846C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D1-A1NS-01 2198290 2066568 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233692 COSM8852950 103182930 c.607C>T p.P203S Substitution - Missense 38 17:1498064-1498064 - - NEUTRAL .10371 Confirmed somatic variant 419 NS NS 53 ENSP00000318476.6:p.Pro203Ser ENST00000320345.10:c.607C>T 17:g.1498064G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 12 2747984 2606687 stomach NS NS NS carcinoma NS NS NS y COSV57440057 COSM975648 103179405 c.1030C>T p.R344C Substitution - Missense 38 17:1496092-1496092 - - NEUTRAL .09246 Confirmed somatic variant 683 NS primary ENSP00000318476.6:p.Arg344Cys ENST00000320345.10:c.1030C>T 17:g.1496092G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AA-A010-01 1651109 1565896 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57439795 COSM178159 103181143 c.559C>T p.R187C Substitution - Missense 38 17:1498112-1498112 - - PATHOGENIC .91324 Confirmed somatic variant 22810696 376 NS NS 46 ENSP00000318476.6:p.Arg187Cys ENST00000320345.10:c.559C>T 17:g.1498112G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 A001-T-S02 2757355 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV100233671 COSM7411841 103180873 c.466C>A p.L156M Substitution - Missense 38 17:1507062-1507062 - - .59764 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000318476.6:p.Leu156Met ENST00000320345.10:c.466C>A 17:g.1507062G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 8058339 2121213 1995449 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441419 COSN7160500 103181205 c.-185+421T>G p.? Unknown 38 17:1515467-1515467 - - NEUTRAL .0841 Confirmed somatic variant 328 NS NS ENST00000320345.10:c.-185+421T>G 17:g.1515467A>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EOPC-171_tumor_01 2633752 2494148 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 103180194 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 50 ENST00000320345.10:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T3611 2658318 2518477 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442475 COSM6686187 103179395 c.403A>C p.N135H Substitution - Missense 38 17:1508150-1508150 - - PATHOGENIC .81961 Confirmed somatic variant 27149842 NS NS 69.08 ENSP00000318476.6:p.Asn135His ENST00000320345.10:c.403A>C 17:g.1508150T>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GCTK_16444_T 2747525 2606228 stomach NS NS NS carcinoma NS NS NS y COSV100233973 COSM8588882 103179169 c.327-7del p.? Unknown 38 17:1508239-1508239 - - Confirmed somatic variant 683 NS primary ENST00000320345.10:c.327-7del 17:g.1508239del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-F1-6177-01 2198156 2066434 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233696 COSN30497832 103181671 c.-481C>T p.? Unknown 38 17:1516521-1516521 - - NEUTRAL .14094 Confirmed somatic variant 541 NS NS 90 ENST00000320345.10:c.-481C>T 17:g.1516521G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 8016470 1842414 1735679 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441905 COSN7160476 103180934 c.548+4086A>T p.? Unknown 38 17:1502894-1502894 - - NEUTRAL .00239 Confirmed somatic variant 328 cell-line NS ENST00000320345.10:c.548+4086A>T 17:g.1502894T>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LICA-CN-HCC_WGS_009T 2634216 2494612 liver NS NS NS other neoplasm NS NS y COSV57440248 COSN26517209 103180407 c.33+1573A>C p.? Unknown 38 17:1511880-1511880 - - NEUTRAL .00604 Confirmed somatic variant 660 NS primary 52 ENST00000320345.10:c.33+1573A>C 17:g.1511880T>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D1-A2G0-01 2198422 2066700 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233799 COSM8816674 103180752 c.1063-1G>A p.? Unknown 38 17:1495880-1495880 - - PATHOGENIC .91507 Confirmed somatic variant 419 NS NS 70 ENST00000320345.10:c.1063-1G>A 17:g.1495880C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 103180548 c.326+388_326+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 60 ENST00000320345.10:c.326+388_326+389insC 17:g.1508789_1508790insG INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T189255 2658275 2518434 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57443168 COSM6686179 103180323 c.674G>A p.S225N Substitution - Missense 38 17:1497997-1497997 - - NEUTRAL .02559 Confirmed somatic variant 27149842 NS NS 77.16 ENSP00000318476.6:p.Ser225Asn ENST00000320345.10:c.674G>A 17:g.1497997C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442923 COSN26436233 103181418 c.327-162T>C p.? Unknown 38 17:1508388-1508388 - - NEUTRAL .06716 Confirmed somatic variant 646 NS primary 45 ENST00000320345.10:c.327-162T>C 17:g.1508388A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233827 COSM7468116 103181752 c.577G>A p.D193N Substitution - Missense 38 17:1498094-1498094 - - PATHOGENIC .97388 Confirmed somatic variant 329 NS NS 53 ENSP00000318476.6:p.Asp193Asn ENST00000320345.10:c.577G>A 17:g.1498094C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233824 COSM7469318 103181741 c.651C>A p.F217L Substitution - Missense 38 17:1498020-1498020 - - PATHOGENIC .9186 Confirmed somatic variant 329 NS NS 53 ENSP00000318476.6:p.Phe217Leu ENST00000320345.10:c.651C>A 17:g.1498020G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442916 COSN26437000 103181411 c.439-87G>A p.? Unknown 38 17:1507176-1507176 - - NEUTRAL .11296 Confirmed somatic variant 646 NS primary 45 ENST00000320345.10:c.439-87G>A 17:g.1507176C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-C5-A3HF-01 2193301 2061579 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233649 COSM8649284 103181392 c.19C>T p.L7= Substitution - coding silent 38 17:1513467-1513467 - - PATHOGENIC .80721 Confirmed somatic variant 415 NS NS 24 ENSP00000318476.6:p.Leu7= ENST00000320345.10:c.19C>T 17:g.1513467G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SS6003320 2193473 2061751 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442833 COSN8674007 103180151 c.-415-51G>C p.? Unknown 38 17:1516169-1516169 - - NEUTRAL .09524 Confirmed somatic variant 535 NS NS ENST00000320345.10:c.-415-51G>C 17:g.1516169C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 8068611 2197319 2065597 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57439861 COSN9222116 103181431 c.549-2531G>A p.? Unknown 38 17:1500653-1500653 - - NEUTRAL .00011 Confirmed somatic variant 586 NS NS ENST00000320345.10:c.549-2531G>A 17:g.1500653C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 tumor_4144951 2385475 2248307 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57439887 COSN23285747 103179706 c.549-3738_549-3737del p.? Unknown 38 17:1501882-1501883 - - Confirmed somatic variant 440 NS primary 62 ENST00000320345.10:c.549-3738_549-3737del 17:g.1501882_1501883del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 C91 2293724 2159788 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439873 COSM4444568 103180018 c.362T>C p.I121T Substitution - Missense het 38 17:1508191-1508191 - - PATHOGENIC .99126 Confirmed somatic variant 24211491 NS NS ENSP00000318476.6:p.Ile121Thr ENST00000320345.10:c.362T>C 17:g.1508191A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 8016470 1842414 1735679 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441913 COSN7160484 103180941 c.548+327G>C p.? Unknown 38 17:1506653-1506653 - - NEUTRAL .03287 Confirmed somatic variant 328 cell-line NS ENST00000320345.10:c.548+327G>C 17:g.1506653C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 tumor_4176133 2121030 1995266 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441778 COSN4768428 103181054 c.151-151G>A p.? Unknown 38 17:1509504-1509504 - - NEUTRAL .16975 Confirmed somatic variant 440 NS NS ENST00000320345.10:c.151-151G>A 17:g.1509504C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 J31_T 2194998 2063276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441106 COSN8602377 103181285 c.-76-24A>T p.? Unknown 38 17:1513585-1513585 - - NEUTRAL .01819 Confirmed somatic variant 583 NS NS ENST00000320345.10:c.-76-24A>T 17:g.1513585T>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EXTERN_MELA_20140526_033 2839346 2695112 skin trunk NS NS malignant_melanoma NS NS NS y COSV57441603 COSM3514448 103179724 c.1066C>T p.P356S Substitution - Missense 38 17:1495876-1495876 - - NEUTRAL .15283 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000318476.6:p.Pro356Ser ENST00000320345.10:c.1066C>T 17:g.1495876G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EC-A24G-01 2198318 2066596 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233972 COSM8814445 103181829 c.324C>T p.H108= Substitution - coding silent 38 17:1509180-1509180 - - .56858 Confirmed somatic variant 419 NS NS 57 ENSP00000318476.6:p.His108= ENST00000320345.10:c.324C>T 17:g.1509180G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 0129_CRUK_PC_0129_T1_DNA 2634968 2495364 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440086 COSN26093849 103179698 c.549-617G>A p.? Unknown 38 17:1498739-1498739 - - NEUTRAL .0021 Confirmed somatic variant 538 NS primary 55 ENST00000320345.10:c.549-617G>A 17:g.1498739C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AX-A3FT-01 2198367 2066645 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233984 COSM9040758 103181136 c.-107G>A p.? Unknown 38 17:1513902-1513902 - - NEUTRAL .01064 Confirmed somatic variant 419 NS NS 64 ENST00000320345.10:c.-107G>A 17:g.1513902C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 APGI-AMP-3734 2866052 2721129 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105203794 COSM9623940 103179218 c.359G>A p.R120Q Substitution - Missense 38 17:1508194-1508194 - - PATHOGENIC .98657 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000318476.6:p.Arg120Gln ENST00000320345.10:c.359G>A 17:g.1508194C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T207 2658316 2518475 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442201 COSM4692620 103180477 c.805A>G p.M269V Substitution - Missense 38 17:1496734-1496734 - - NEUTRAL .14185 Confirmed somatic variant 27149842 NS NS 72.83 ENSP00000318476.6:p.Met269Val ENST00000320345.10:c.805A>G 17:g.1496734T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 JCQ-HMCaA 2633675 2494071 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442897 COSM6225141 103181400 c.758C>T p.P253L Substitution - Missense 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 646 NS primary 45 ENSP00000318476.6:p.Pro253Leu ENST00000320345.10:c.758C>T 17:g.1496781G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PASLZM 2367612 2230450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV57442137 COSM5006535 103179086 c.1060C>T p.Q354* Substitution - Nonsense 38 17:1496062-1496062 - - PATHOGENIC .82826 Confirmed somatic variant 25790293 NS NS ENSP00000318476.6:p.Gln354Ter ENST00000320345.10:c.1060C>T 17:g.1496062G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-D9-A4Z6-06 2263151 2130135 skin NS NS NS malignant_melanoma NS NS NS y COSV57442416 COSM3514457 103179366 c.-19C>T p.? Unknown 38 17:1513504-1513504 - - PATHOGENIC .8518 Confirmed somatic variant 540 NS NS 54 ENST00000320345.10:c.-19C>T 17:g.1513504G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-VQ-A8P2-01 2339964 2204947 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233726 COSM8162258 103179672 c.741G>T p.K247N Substitution - Missense 38 17:1496798-1496798 - - PATHOGENIC .91255 Confirmed somatic variant 541 NS primary 68 ENSP00000318476.6:p.Lys247Asn ENST00000320345.10:c.741G>T 17:g.1496798C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 0198_CRUK_PC_0198_T1_DNA 2634978 2495374 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57442458 COSN26174651 103179142 c.548+1435G>C p.? Unknown 38 17:1505545-1505545 - - NEUTRAL .02245 Confirmed somatic variant 538 NS primary 57 ENST00000320345.10:c.548+1435G>C 17:g.1505545C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 BD49T 2459910 2322747 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57441395 COSN20046519 103182690 c.*115G>A p.? Unknown 38 17:1495708-1495708 - - NEUTRAL .07967 Confirmed somatic variant 658 NS primary 50 ENST00000320345.10:c.*115G>A 17:g.1495708C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 Patient_1 2443644 2306483 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV57442180 COSN18837027 103180309 c.549-1426G>T p.? Unknown 38 17:1499548-1499548 - - NEUTRAL .03782 Confirmed somatic variant 26082451 surgery fresh/frozen NS 70 ENST00000320345.10:c.549-1426G>T 17:g.1499548C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233829 COSM7472155 103181761 c.-67A>C p.? Unknown 38 17:1513552-1513552 - - PATHOGENIC .93138 Confirmed somatic variant 329 NS NS 53 ENST00000320345.10:c.-67A>C 17:g.1513552T>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-3M-AB46-01 2457336 2320173 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233619 COSM8193053 103182745 c.1068G>A p.P356= Substitution - coding silent 38 17:1495874-1495874 - - NEUTRAL .00578 Confirmed somatic variant 541 NS primary 70 ENSP00000318476.6:p.Pro356= ENST00000320345.10:c.1068G>A 17:g.1495874C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SDC5 2564866 2426260 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV57439731 COSM5987990 103181081 c.1008_1009del p.C337Lfs*30 Deletion - Frameshift 38 17:1496115-1496116 - - Confirmed somatic variant 27103403 surgery fresh/frozen NS ENSP00000318476.6:p.Cys337LeufsTer30 ENST00000320345.10:c.1008_1009del 17:g.1496115_1496116del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-HU-A4GN-01 2198035 2066313 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440664 COSM4064059 103179057 c.461A>G p.D154G Substitution - Missense 38 17:1507067-1507067 - - PATHOGENIC .86353 Confirmed somatic variant 541 NS NS 61 ENSP00000318476.6:p.Asp154Gly ENST00000320345.10:c.461A>G 17:g.1507067T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 WGC002974 2785035 2645151 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV100233732 COSM7425448 103182696 c.626C>G p.T209S Substitution - Missense 38 17:1498045-1498045 - - NEUTRAL .0814 Confirmed somatic variant 25526346 surgery fresh/frozen primary 45 ENSP00000318476.6:p.Thr209Ser ENST00000320345.10:c.626C>G 17:g.1498045G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-19-1787-01 2178217 2046515 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233576 COSM7466631 103179309 c.621C>T p.P207= Substitution - coding silent 38 17:1498050-1498050 - - NEUTRAL .06315 Confirmed somatic variant 329 NS NS 48 ENSP00000318476.6:p.Pro207= ENST00000320345.10:c.621C>T 17:g.1498050G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHG-2015-31289T 2634363 2494759 liver NS NS NS other neoplasm NS NS y COSV57440322 COSM6237841 103179281 c.-96C>A p.? Unknown 38 17:1513891-1513891 - - NEUTRAL .148 Confirmed somatic variant 660 NS primary 45 ENST00000320345.10:c.-96C>A 17:g.1513891G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AA-3672-01 1651015 1565802 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57440002 COSM266711 103179660 c.1031G>A p.R344H Substitution - Missense 38 17:1496091-1496091 - - NEUTRAL .0033 Confirmed somatic variant 22810696 376 NS NS 90 ENSP00000318476.6:p.Arg344His ENST00000320345.10:c.1031G>A 17:g.1496091C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2014_Lung_sq_23_T 2744894 2603597 lung NS NS NS carcinoma NS NS NS y COSV57441227 COSN28674085 103180003 c.439-74C>G p.? Unknown 38 17:1507163-1507163 - - NEUTRAL .08275 Confirmed somatic variant 583 NS primary 74 ENST00000320345.10:c.439-74C>G 17:g.1507163G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GCYC_414_T 2747633 2606336 stomach NS NS NS carcinoma NS NS NS y COSV57442897 COSM6225141 103181400 c.758C>T p.P253L Substitution - Missense 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 683 NS primary ENSP00000318476.6:p.Pro253Leu ENST00000320345.10:c.758C>T 17:g.1496781G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6007520-DNA_A01 2263452 2130436 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57440165 COSN15262548 103182641 c.549-3161C>T p.? Unknown 38 17:1501283-1501283 - - NEUTRAL .00032 Confirmed somatic variant 535 NS primary ENST00000320345.10:c.549-3161C>T 17:g.1501283G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 ccRCC-55 1980791 1867037 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV57440030 COSN2470106 103180111 c.34-1705C>A p.? Unknown 38 17:1511504-1511504 - - PATHOGENIC .79646 Confirmed somatic variant 23797736 NS NS ENST00000320345.10:c.34-1705C>A 17:g.1511504G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV100233889 COSM8978199 103181033 c.549-1G>A p.? Unknown 38 17:1498123-1498123 - - PATHOGENIC .97388 Confirmed somatic variant 419 NS NS 59 ENST00000320345.10:c.549-1G>A 17:g.1498123C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC197T 1652970 1567757 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442094 COSN19368247 103182101 c.549-2837del p.? Unknown 38 17:1500978-1500978 - - Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.549-2837del 17:g.1500978del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 tumor_4179894 2634671 2495067 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57441100 COSN25650645 103181934 c.549-4412T>G p.? Unknown 38 17:1502534-1502534 - - NEUTRAL .01333 Confirmed somatic variant 440 NS primary 72 ENST00000320345.10:c.549-4412T>G 17:g.1502534A>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-CG-4442-01 2198151 2066429 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV100233635 COSM7691643 103179070 c.686C>T p.T229M Substitution - Missense 38 17:1497985-1497985 - - NEUTRAL .00988 Confirmed somatic variant 541 NS NS 85 ENSP00000318476.6:p.Thr229Met ENST00000320345.10:c.686C>T 17:g.1497985G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T_CCA_SG_20 2688092 2547074 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 103180548 c.326+388_326+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 56 ENST00000320345.10:c.326+388_326+389insC 17:g.1508789_1508790insG INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PASLZM 2367612 2230450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV57442156 COSM5006193 103179096 c.793G>A p.V265M Substitution - Missense 38 17:1496746-1496746 - - NEUTRAL .01467 Confirmed somatic variant 25790293 NS NS ENSP00000318476.6:p.Val265Met ENST00000320345.10:c.793G>A 17:g.1496746C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2014_Lung_sq_27_T 2744898 2603601 lung NS NS NS carcinoma NS NS NS y COSV57441106 COSN8602377 103181285 c.-76-24A>T p.? Unknown 38 17:1513585-1513585 - - NEUTRAL .01819 Confirmed somatic variant 583 NS primary 76 ENST00000320345.10:c.-76-24A>T 17:g.1513585T>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 5-VS034-T1 2869858 2724855 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV57443110 COSM4894813 103180027 c.653C>T p.S218F Substitution - Missense 38 17:1498018-1498018 - - NEUTRAL .04612 Confirmed somatic variant 26950094 surgery fresh/frozen NS 75 ENSP00000318476.6:p.Ser218Phe ENST00000320345.10:c.653C>T 17:g.1498018G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 tumor_4170844 2634759 2495155 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57442780 COSN25365884 103179134 c.-184-376G>A p.? Unknown 38 17:1514355-1514355 - - NEUTRAL .01295 Confirmed somatic variant 440 NS primary 5 ENST00000320345.10:c.-184-376G>A 17:g.1514355C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EB-A299-01 2121587 1995823 skin NS NS NS malignant_melanoma NS NS NS y COSV100233592 COSM8129016 103180448 c.256G>T p.E86* Substitution - Nonsense 38 17:1509248-1509248 - - PATHOGENIC .96263 Confirmed somatic variant 540 NS NS 63 ENSP00000318476.6:p.Glu86Ter ENST00000320345.10:c.256G>T 17:g.1509248C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-06-1801-01 2178194 2046492 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233717 COSM7481424 103179585 c.811G>C p.V271L Substitution - Missense 38 17:1496728-1496728 - - NEUTRAL .21698 Confirmed somatic variant 329 NS NS 56 ENSP00000318476.6:p.Val271Leu ENST00000320345.10:c.811G>C 17:g.1496728C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 77 2748049 2606752 stomach NS NS NS carcinoma NS NS NS y COSV100233990 COSM8575061 103179120 c.549-8C>G p.? Unknown 38 17:1498130-1498130 - - NEUTRAL .09199 Confirmed somatic variant 683 NS primary ENST00000320345.10:c.549-8C>G 17:g.1498130G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T368 2296243 2161846 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441404 COSM4692626 103181292 c.635C>A p.P212Q Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .01179 Confirmed somatic variant 25344691 NS NS 63.75 ENSP00000318476.6:p.Pro212Gln ENST00000320345.10:c.635C>A 17:g.1498036G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2014_Lung_sq_102_T 2744869 2603572 lung NS NS NS carcinoma NS NS NS y COSV57443380 COSM7249097 103180554 c.439-10T>G p.? Unknown 38 17:1507099-1507099 - - NEUTRAL .07942 Confirmed somatic variant 583 NS primary 74 ENST00000320345.10:c.439-10T>G 17:g.1507099A>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 tumor_4179894 2634671 2495067 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm NS NS NS y COSV57440372 COSN6651475 103180764 c.*817G>T p.? Unknown 38 17:1495006-1495006 - - NEUTRAL .01546 Confirmed somatic variant 440 NS primary 72 ENST00000320345.10:c.*817G>T 17:g.1495006C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 S00827_1 2480817 2343562 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV57441520 COSM312000 103180138 c.124A>T p.T42S Substitution - Missense 38 17:1509709-1509709 - - PATHOGENIC .95918 Confirmed somatic variant 26168399 surgery fresh/frozen primary 73 ENSP00000318476.6:p.Thr42Ser ENST00000320345.10:c.124A>T 17:g.1509709T>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233845 COSM9192841 103180731 c.-149C>T p.? Unknown 38 17:1513944-1513944 - - PATHOGENIC .79904 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENST00000320345.10:c.-149C>T 17:g.1513944G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2014_Lung_sq_22_T 2744893 2603596 lung NS NS NS carcinoma NS NS NS y COSV57441227 COSN28674085 103180003 c.439-74C>G p.? Unknown 38 17:1507163-1507163 - - NEUTRAL .08275 Confirmed somatic variant 583 NS primary 69 ENST00000320345.10:c.439-74C>G 17:g.1507163G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EY-A549-01 2198465 2066743 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV57442068 COSM5364464 103180529 c.560G>A p.R187H Substitution - Missense 38 17:1498111-1498111 - - PATHOGENIC .97388 Confirmed somatic variant 419 NS NS 78 ENSP00000318476.6:p.Arg187His ENST00000320345.10:c.560G>A 17:g.1498111C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 C0021T 2197771 2066049 kidney NS NS NS NS NS NS NS y COSV57443329 COSN9655913 103181509 c.34-508G>T p.? Unknown 38 17:1510307-1510307 - - NEUTRAL .01852 Confirmed somatic variant 588 NS NS ENST00000320345.10:c.34-508G>T 17:g.1510307C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T368 2658284 2518443 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441404 COSM4692626 103181292 c.635C>A p.P212Q Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .01179 Confirmed somatic variant 27149842 NS NS 63.75 ENSP00000318476.6:p.Pro212Gln ENST00000320345.10:c.635C>A 17:g.1498036G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 5-VS015-T1 2869836 2724833 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV105203833 COSM9691176 103179197 c.60C>T p.I20= Substitution - coding silent 38 17:1509773-1509773 - - .56592 Confirmed somatic variant 26950094 surgery fresh/frozen NS 90 ENSP00000318476.6:p.Ile20= ENST00000320345.10:c.60C>T 17:g.1509773G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 NYZ-1200985T 2633889 2494285 stomach NS NS NS carcinoma NS NS NS y COSV57442167 COSN24444054 103180867 c.549-1313C>T p.? Unknown 38 17:1499435-1499435 - - NEUTRAL .01503 Confirmed somatic variant 371 NS primary 45 ENST00000320345.10:c.549-1313C>T 17:g.1499435G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T1762 2658285 2518444 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440363 COSM6686177 103179710 c.558dup p.R187Tfs*82 Insertion - Frameshift 38 17:1498118-1498119 - - Confirmed somatic variant 27149842 NS NS 69.58 ENSP00000318476.6:p.Arg187ThrfsTer82 ENST00000320345.10:c.558dup 17:g.1498118dup INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 ESCC_134 2479627 2342387 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440352 COSM5642741 103179373 c.635C>T p.P212L Substitution - Missense 38 17:1498036-1498036 - - NEUTRAL .00382 Confirmed somatic variant 26873401 NS NS 68 ENSP00000318476.6:p.Pro212Leu ENST00000320345.10:c.635C>T 17:g.1498036G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-BR-8372-01 2198045 2066323 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440526 COSM4064067 103181268 c.-156T>C p.? Unknown 38 17:1513951-1513951 - - PATHOGENIC .96702 Confirmed somatic variant 541 NS NS 63 ENST00000320345.10:c.-156T>C 17:g.1513951A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK042_C 2120949 1995185 liver NS NS NS carcinoma NS NS NS y COSV57441764 COSN1714034 103179294 c.549-4020G>C p.? Unknown 38 17:1502142-1502142 - - NEUTRAL .00011 Confirmed somatic variant 322 NS NS ENST00000320345.10:c.549-4020G>C 17:g.1502142C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-55-8301-01 2194837 2063115 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV100233820 COSM7743401 103181878 c.-148G>T p.? Unknown 38 17:1513943-1513943 - - NEUTRAL .17092 Confirmed somatic variant 417 NS NS 58 ENST00000320345.10:c.-148G>T 17:g.1513943C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CLL129 1897564 1786248 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV57441713 COSM1290634 103182130 c.1095G>T p.L365= Substitution - coding silent 38 17:1495847-1495847 - - NEUTRAL .05649 Confirmed somatic variant 23415222 blood-bone marrow NS ENSP00000318476.6:p.Leu365= ENST00000320345.10:c.1095G>T 17:g.1495847C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SJDOSTEOS005 2502772 2365122 bone NS NS NS osteosarcoma NS NS NS y COSV57440930 COSN1193209 103180440 c.326+56_326+65del p.? Unknown 38 17:1509124-1509133 - - Confirmed somatic variant 25512523 NS NS ENST00000320345.10:c.326+56_326+65del 17:g.1509124_1509133del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK042_C 2120949 1995185 liver NS NS NS carcinoma NS NS NS y COSV57441768 COSN1714035 103179303 c.549-4023C>G p.? Unknown 38 17:1502145-1502145 - - NEUTRAL .00026 Confirmed somatic variant 322 NS NS ENST00000320345.10:c.549-4023C>G 17:g.1502145G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 BN06 2120643 1994879 liver NS NS NS carcinoma NS NS NS y COSV57442850 COSN1193203 103180389 c.735+37T>A p.? Unknown 38 17:1497899-1497899 - - NEUTRAL .02871 Confirmed somatic variant 323 NS NS ENST00000320345.10:c.735+37T>A 17:g.1497899A>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PT33 2521290 2383633 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV57443040 COSM5909589 103179269 c.958-7C>T p.? Unknown 38 17:1496171-1496171 - - NEUTRAL .07984 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENST00000320345.10:c.958-7C>T 17:g.1496171G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SM-4B295 2262938 2129922 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV57442007 COSM5032397 103179463 c.874-6T>C p.? Unknown 38 17:1496408-1496408 - - NEUTRAL .00676 Confirmed somatic variant 535 NS primary ENST00000320345.10:c.874-6T>C 17:g.1496408A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SJBALL021373_D1 2364176 2227090 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia Ph-like NS y COSV57442939 COSN17079618 103179360 c.326+337G>A p.? Unknown 38 17:1508841-1508841 - - NEUTRAL .0859 Confirmed somatic variant 25207766 blood-bone marrow NS ENST00000320345.10:c.326+337G>A 17:g.1508841C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EXTERN_MELA_20140924_107 2839322 2695088 skin upper_leg NS NS malignant_melanoma NS NS NS y COSV104626978 COSM9370470 103182477 c.886G>A p.D296N Substitution - Missense 38 17:1496390-1496390 - - .58709 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000318476.6:p.Asp296Asn ENST00000320345.10:c.886G>A 17:g.1496390C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 C0021T 2197771 2066049 kidney NS NS NS NS NS NS NS y COSV57443321 COSN9655907 103181501 c.548+341C>G p.? Unknown 38 17:1506639-1506639 - - NEUTRAL .04687 Confirmed somatic variant 588 NS NS ENST00000320345.10:c.548+341C>G 17:g.1506639G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 FFPE-13 2818008 2674307 pancreas NS NS NS carcinoma acinar_carcinoma NS NS y COSV57442897 COSM6225141 103181400 c.758C>T p.P253L Substitution - Missense het 38 17:1496781-1496781 - - PATHOGENIC .98556 Confirmed somatic variant 29109526 surgery-fixed primary ENSP00000318476.6:p.Pro253Leu ENST00000320345.10:c.758C>T 17:g.1496781G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 Thyroid-CN-WZ044T 2635105 2495501 thyroid NS NS NS carcinoma NS NS NS y COSV57440258 COSM6420326 103179617 c.532A>G p.N178D Substitution - Missense 38 17:1506996-1506996 - - NEUTRAL .40772 Confirmed somatic variant 676 NS primary 27 ENSP00000318476.6:p.Asn178Asp ENST00000320345.10:c.532A>G 17:g.1506996T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T207 2296102 2161705 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57442201 COSM4692620 103180477 c.805A>G p.M269V Substitution - Missense 38 17:1496734-1496734 - - NEUTRAL .14185 Confirmed somatic variant 25344691 NS NS 72.83 ENSP00000318476.6:p.Met269Val ENST00000320345.10:c.805A>G 17:g.1496734T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AA-3877-01 1651067 1565854 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441118 COSM178164 103180051 c.-148G>A p.? Unknown 38 17:1513943-1513943 - - NEUTRAL .06284 Confirmed somatic variant 376 NS NS 83 ENST00000320345.10:c.-148G>A 17:g.1513943C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-BR-8372-01 2198045 2066323 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57440510 COSM2738170 103180121 c.722C>T p.T241M Substitution - Missense 38 17:1497949-1497949 - - PATHOGENIC .84124 Confirmed somatic variant 541 NS NS 63 ENSP00000318476.6:p.Thr241Met ENST00000320345.10:c.722C>T 17:g.1497949G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 1323-01-02TD 2456400 2319237 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV57440745 COSN19146962 103181516 c.439-287G>C p.? Unknown 38 17:1507376-1507376 - - NEUTRAL .1053 Confirmed somatic variant 340 blood primary 63 ENST00000320345.10:c.439-287G>C 17:g.1507376C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AF-6672-01 1651524 1566311 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV57441061 COSM1563397 103182650 c.-117C>A p.? Unknown 38 17:1513912-1513912 - - PATHOGENIC .9876 Confirmed somatic variant 375 NS primary 43 ENST00000320345.10:c.-117C>A 17:g.1513912G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV100233844 COSM9192840 103180726 c.-20A>G p.? Unknown 38 17:1513505-1513505 - - PATHOGENIC .98841 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENST00000320345.10:c.-20A>G 17:g.1513505T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-CM-4746-01 1651207 1565994 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV100233908 COSM7605863 103180244 c.852G>A p.W284* Substitution - Nonsense 38 17:1496687-1496687 - - PATHOGENIC .98938 Confirmed somatic variant 376 NS NS 61 ENSP00000318476.6:p.Trp284Ter ENST00000320345.10:c.852G>A 17:g.1496687C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV57442051 COSM3514454 103179445 c.260A>G p.H87R Substitution - Missense 38 17:1509244-1509244 - - PATHOGENIC .97324 Confirmed somatic variant 540 NS NS 30 ENSP00000318476.6:p.His87Arg ENST00000320345.10:c.260A>G 17:g.1509244T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-A4-7288-01 2193982 2062260 kidney NS NS NS carcinoma papillary_renal_cell_carcinoma NS NS y COSV57441934 COSM3988780 103181579 c.828C>G p.T276= Substitution - coding silent 38 17:1496711-1496711 - - NEUTRAL .06148 Confirmed somatic variant 543 NS NS 71 ENSP00000318476.6:p.Thr276= ENST00000320345.10:c.828C>G 17:g.1496711G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440119 COSM4692618 103180340 c.849G>A p.P283= Substitution - coding silent 38 17:1496690-1496690 - - PATHOGENIC .80915 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000318476.6:p.Pro283= ENST00000320345.10:c.849G>A 17:g.1496690C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2441 2658483 2518642 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 103179982 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 75 ENSP00000318476.6:p.Arg130Trp ENST00000320345.10:c.388C>T 17:g.1508165G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2279 2658733 2518892 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441317 COSM6686181 103180579 c.576C>T p.T192= Substitution - coding silent 38 17:1498095-1498095 - - NEUTRAL .05249 Confirmed somatic variant 27149842 NS NS 65.41 ENSP00000318476.6:p.Thr192= ENST00000320345.10:c.576C>T 17:g.1498095G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCG-Testes_DFCI_24-Tumor-SM-4PDEI 2806613 2663330 testis NS NS NS germ_cell_tumour non_seminoma NS NS y COSV100233840 COSM9116897 103180848 c.828C>T p.T276= Substitution - coding silent het 38 17:1496711-1496711 - - NEUTRAL .02659 Confirmed somatic variant 27905446 fixed - NOS primary ENSP00000318476.6:p.Thr276= ENST00000320345.10:c.828C>T 17:g.1496711G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2448 2658241 2518400 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442156 COSM5006193 103179096 c.793G>A p.V265M Substitution - Missense 38 17:1496746-1496746 - - NEUTRAL .01467 Confirmed somatic variant 27149842 NS NS 68.58 ENSP00000318476.6:p.Val265Met ENST00000320345.10:c.793G>A 17:g.1496746C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6008336-DNA_A02 2789419 2646642 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV100234014 COSN30406679 103180591 c.548+748G>A p.? Unknown 38 17:1506232-1506232 - - NEUTRAL .01419 Confirmed somatic variant 535 NS primary 81 ENST00000320345.10:c.548+748G>A 17:g.1506232C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 FFPE-K1 2818021 2674320 pancreas NS NS NS carcinoma acinar_carcinoma NS NS y COSV104401286 COSM9274306 103181986 c.-76-10G>A p.? Unknown het 38 17:1513571-1513571 - - PATHOGENIC .89312 Confirmed somatic variant 29109526 surgery-fixed primary ENST00000320345.10:c.-76-10G>A 17:g.1513571C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 C0037T 2197815 2066093 kidney NS NS NS NS NS NS NS y COSV57440692 COSN9655895 103181377 c.736-41G>A p.? Unknown 38 17:1496844-1496844 - - NEUTRAL .05199 Confirmed somatic variant 588 NS NS ENST00000320345.10:c.736-41G>A 17:g.1496844C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 273 2748245 2606948 stomach NS NS NS carcinoma NS NS NS y COSV100233936 COSN30549824 103179574 c.874-32C>A p.? Unknown 38 17:1496434-1496434 - - NEUTRAL .04855 Confirmed somatic variant 683 NS primary ENST00000320345.10:c.874-32C>A 17:g.1496434G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57441432 COSM4692624 103181345 c.640G>A p.A214T Substitution - Missense 38 17:1498031-1498031 - - NEUTRAL .0531 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000318476.6:p.Ala214Thr ENST00000320345.10:c.640G>A 17:g.1498031C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440420 COSN6651554 103180813 c.439-58G>A p.? Unknown 38 17:1507147-1507147 - - NEUTRAL .06908 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.439-58G>A 17:g.1507147C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 LP6008141-DNA_H01 2789459 2646682 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV100233580 COSN30207599 103181905 c.34-1668C>T p.? Unknown 38 17:1511467-1511467 - - NEUTRAL .48243 Confirmed somatic variant 535 NS primary 82 ENST00000320345.10:c.34-1668C>T 17:g.1511467G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHCOSK001 2779625 2637645 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV100233753 COSM9103745 103181766 c.863G>T p.G288V Substitution - Missense 38 17:1496676-1496676 - - PATHOGENIC .99025 Confirmed somatic variant 27267998 surgery-fixed NS 40 ENSP00000318476.6:p.Gly288Val ENST00000320345.10:c.863G>T 17:g.1496676C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PD23577a 2214453 2082577 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441999 COSN21680810 103179385 c.735+354G>C p.? Unknown 38 17:1497582-1497582 - - NEUTRAL .31399 Confirmed somatic variant 652 NS NS ENST00000320345.10:c.735+354G>C 17:g.1497582C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-MA-AA42-01 2386190 2249022 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233848 COSM8652710 103182370 c.642G>A p.A214= Substitution - coding silent 38 17:1498029-1498029 - - NEUTRAL .06811 Confirmed somatic variant 415 NS primary 75 ENSP00000318476.6:p.Ala214= ENST00000320345.10:c.642G>A 17:g.1498029C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2394 2658590 2518749 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442954 COSM6686183 103182956 c.406C>T p.R136W Substitution - Missense 38 17:1508147-1508147 - - NEUTRAL .10513 Confirmed somatic variant 27149842 NS NS 71 ENSP00000318476.6:p.Arg136Trp ENST00000320345.10:c.406C>T 17:g.1508147G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GCTK_341_T 2747450 2606153 stomach NS NS NS carcinoma NS NS NS y COSV100233887 COSN30729867 103182472 c.327-13T>G p.? Unknown 38 17:1508239-1508239 - - .60195 Confirmed somatic variant 683 NS primary ENST00000320345.10:c.327-13T>G 17:g.1508239A>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442362 COSN6651584 103180632 c.34-1497G>C p.? Unknown 38 17:1511296-1511296 - - NEUTRAL .05338 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.34-1497G>C 17:g.1511296C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442352 COSN6651577 103180626 c.34-449C>T p.? Unknown 38 17:1510248-1510248 - - NEUTRAL .00134 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.34-449C>T 17:g.1510248G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440392 COSN6651506 103180783 c.549-4130C>T p.? Unknown 38 17:1502252-1502252 - - NEUTRAL .00299 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.549-4130C>T 17:g.1502252G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442334 COSN6651504 103180612 c.549-4045C>T p.? Unknown 38 17:1502167-1502167 - - NEUTRAL .00319 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.549-4045C>T 17:g.1502167G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHG-29T 2634259 2494655 liver NS NS NS other neoplasm NS NS y COSV57441087 COSN23438524 103180194 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 660 NS primary 48 ENST00000320345.10:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440431 COSN6651564 103180818 c.438+251A>C p.? Unknown 38 17:1507864-1507864 - - NEUTRAL .00637 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.438+251A>C 17:g.1507864T>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T4506 2658677 2518836 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441145 COSM6686189 103179248 c.256G>A p.E86K Substitution - Missense 38 17:1509248-1509248 - - PATHOGENIC .94307 Confirmed somatic variant 27149842 NS NS 81.25 ENSP00000318476.6:p.Glu86Lys ENST00000320345.10:c.256G>A 17:g.1509248C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CN-AML-08-T 2506791 2369127 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 103179230 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 blood-bone marrow primary ENST00000320345.10:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PD24314a 2241668 2109199 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV57441374 COSN21484822 103180159 c.549-2538C>T p.? Unknown 38 17:1500660-1500660 - - NEUTRAL .00082 Confirmed somatic variant 652 NS NS ENST00000320345.10:c.549-2538C>T 17:g.1500660G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57440119 COSM4692618 103180340 c.849G>A p.P283= Substitution - coding silent 38 17:1496690-1496690 - - PATHOGENIC .80915 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000318476.6:p.Pro283= ENST00000320345.10:c.849G>A 17:g.1496690C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440412 COSN6651553 103180804 c.548+15G>C p.? Unknown 38 17:1506965-1506965 - - NEUTRAL .01662 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.548+15G>C 17:g.1506965C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440372 COSN6651475 103180764 c.*817G>T p.? Unknown 38 17:1495006-1495006 - - NEUTRAL .01546 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.*817G>T 17:g.1495006C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2763 2658548 2518707 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57441317 COSM6686181 103180579 c.576C>T p.T192= Substitution - coding silent 38 17:1498095-1498095 - - NEUTRAL .05249 Confirmed somatic variant 27149842 NS NS 57.25 ENSP00000318476.6:p.Thr192= ENST00000320345.10:c.576C>T 17:g.1498095G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-26-5134 2108058 1985919 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57441362 COSM2157002 103180981 c.-433G>C p.? Unknown 38 17:1516473-1516473 - - NEUTRAL .15234 Confirmed somatic variant 23917401 NS NS ENST00000320345.10:c.-433G>C 17:g.1516473C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-F4-6856-01 1651313 1566100 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 103179426 c.581G>A p.R194H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 376 NS NS 45 ENSP00000318476.6:p.Arg194His ENST00000320345.10:c.581G>A 17:g.1498090C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 SNUH_G16_S1 2120552 1994788 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440313 COSN6651567 103179230 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 544 NS NS ENST00000320345.10:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHG-14-15016T 2634332 2494728 liver NS NS NS other neoplasm NS NS y COSV57442117 COSN26562181 103180843 c.873+13C>A p.? Unknown 38 17:1496653-1496653 - - NEUTRAL .02666 Confirmed somatic variant 660 NS primary 70 ENST00000320345.10:c.873+13C>A 17:g.1496653G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-33-4587-01 2195029 2063307 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233721 COSM8709016 103179648 c.34G>A p.V12I Substitution - Missense 38 17:1509799-1509799 - - PATHOGENIC .71204 Confirmed somatic variant 418 NS NS 63 ENSP00000318476.6:p.Val12Ile ENST00000320345.10:c.34G>A 17:g.1509799C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-39-5022-01 1781520 1685519 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57442536 COSM704958 103179440 c.-1C>G p.? Unknown 38 17:1513486-1513486 - - PATHOGENIC .95856 Confirmed somatic variant 418 fresh/frozen - NOS primary 76 ENST00000320345.10:c.-1C>G 17:g.1513486G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442373 COSN6651596 103180640 c.33+289C>T p.? Unknown 38 17:1513164-1513164 - - NEUTRAL .00811 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.33+289C>T 17:g.1513164G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-18-3407-01 1780257 1684256 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV100233793 COSM8151450 103179600 c.128C>A p.P43H Substitution - Missense 38 17:1509705-1509705 - - PATHOGENIC .88297 Confirmed somatic variant 418 fresh/frozen - NOS primary 72 ENSP00000318476.6:p.Pro43His ENST00000320345.10:c.128C>A 17:g.1509705G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 AML_14y_08_DX 2549541 2410996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV57440211 COSN23974391 103179537 c.326+117C>G p.? Unknown 38 17:1509061-1509061 - - NEUTRAL .00587 Confirmed somatic variant 544 blood-bone marrow primary 32 ENST00000320345.10:c.326+117C>G 17:g.1509061G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T604 2658649 2518808 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57439902 COSM6686175 103179982 c.388C>T p.R130W Substitution - Missense 38 17:1508165-1508165 - - NEUTRAL .24897 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000318476.6:p.Arg130Trp ENST00000320345.10:c.388C>T 17:g.1508165G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 J32_T 2195006 2063284 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441017 COSN20301572 103182048 c.439-469C>A p.? Unknown 38 17:1507558-1507558 - - NEUTRAL .01033 Confirmed somatic variant 583 NS NS ENST00000320345.10:c.439-469C>A 17:g.1507558G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EL-A3CY-01 2121967 1996203 thyroid NS NS NS carcinoma NS NS NS y COSV57442823 COSM3370619 103179555 c.777C>G p.P259= Substitution - coding silent 38 17:1496762-1496762 - - NEUTRAL .02304 Confirmed somatic variant 542 NS NS 28 ENSP00000318476.6:p.Pro259= ENST00000320345.10:c.777C>G 17:g.1496762G>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T603 2658711 2518870 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440611 COSM6686191 103179151 c.389G>A p.R130Q Substitution - Missense 38 17:1508164-1508164 - - NEUTRAL .06264 Confirmed somatic variant 27149842 NS NS 69.75 ENSP00000318476.6:p.Arg130Gln ENST00000320345.10:c.389G>A 17:g.1508164C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440401 COSN19320948 103180790 c.549-4238G>T p.? Unknown 38 17:1502360-1502360 - - NEUTRAL .00142 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.549-4238G>T 17:g.1502360C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-26-5134-01 2120324 1994560 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57441362 COSM2157002 103180981 c.-433G>C p.? Unknown 38 17:1516473-1516473 - - NEUTRAL .15234 Confirmed somatic variant 329 NS NS 74 ENST00000320345.10:c.-433G>C 17:g.1516473C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 S00640 2864328 2719489 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS y COSV105203822 COSM9584085 103182384 c.640del p.A214Rfs*8 Deletion - Frameshift 38 17:1498032-1498032 - - Confirmed somatic variant 29535388 surgery fresh/frozen NS 53 ENSP00000318476.6:p.Ala214ArgfsTer8 ENST00000320345.10:c.640del 17:g.1498032del INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440387 COSN6651505 103180773 c.549-4117G>A p.? Unknown 38 17:1502239-1502239 - - NEUTRAL .00196 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.549-4117G>A 17:g.1502239C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-AZ-4315-01 1651162 1565949 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV57440687 COSM1380994 103181021 c.-17C>T p.? Unknown 38 17:1513502-1513502 - - PATHOGENIC .93935 Confirmed somatic variant 376 NS NS 61 ENST00000320345.10:c.-17C>T 17:g.1513502G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 GCYC_051_T 2747641 2606344 stomach NS NS NS carcinoma NS NS NS y COSV100233803 COSN30697867 103181476 c.327-76C>T p.? Unknown 38 17:1508302-1508302 - - NEUTRAL .12541 Confirmed somatic variant 683 NS primary ENST00000320345.10:c.327-76C>T 17:g.1508302G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T_CCA_JP_6 2688122 2547104 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV57443368 COSN27378243 103180548 c.326+388_326+389insC p.? Unknown 38 17:1508789-1508790 - - Confirmed somatic variant 653 NS primary 65 ENST00000320345.10:c.326+388_326+389insC 17:g.1508789_1508790insG INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57443185 COSM4795479 103180896 c.733G>A p.E245K Substitution - Missense 38 17:1497938-1497938 - - PATHOGENIC .91208 Confirmed somatic variant 381 NS primary 72 ENSP00000318476.6:p.Glu245Lys ENST00000320345.10:c.733G>A 17:g.1497938C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HX27T 2120921 1995157 liver NS NS NS carcinoma NS NS NS y COSV57442880 COSN5838392 103179928 c.-185+116G>A p.? Unknown 38 17:1515772-1515772 - - NEUTRAL .25514 Confirmed somatic variant 323 NS NS ENST00000320345.10:c.-185+116G>A 17:g.1515772C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442343 COSN6651570 103180620 c.327-328T>G p.? Unknown 38 17:1508554-1508554 - - NEUTRAL .11115 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.327-328T>G 17:g.1508554A>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440446 COSN6651579 103180828 c.34-1050G>A p.? Unknown 38 17:1510849-1510849 - - NEUTRAL .00457 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.34-1050G>A 17:g.1510849C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T3046 2658722 2518881 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440558 COSM1380992 103179426 c.581G>A p.R194H Substitution - Missense 38 17:1498090-1498090 - - PATHOGENIC .97388 Confirmed somatic variant 27149842 NS NS 60.16 ENSP00000318476.6:p.Arg194His ENST00000320345.10:c.581G>A 17:g.1498090C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440313 COSN6651567 103179230 c.327-77G>A p.? Unknown 38 17:1508303-1508303 - - NEUTRAL .13299 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.327-77G>A 17:g.1508303C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440380 COSN6651502 103180769 c.549-3999C>T p.? Unknown 38 17:1502121-1502121 - - NEUTRAL .00323 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.549-3999C>T 17:g.1502121G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-FD-A6TC-01 2262697 2129681 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57441022 COSM7120771 103181530 c.1059C>T p.F353= Substitution - coding silent 38 17:1496063-1496063 - - PATHOGENIC .823 Confirmed somatic variant 413 NS primary 79 ENSP00000318476.6:p.Phe353= ENST00000320345.10:c.1059C>T 17:g.1496063G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 T2769 2296131 2161734 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV57442024 COSM4692628 103182278 c.503C>T p.P168L Substitution - Missense 38 17:1507025-1507025 - - .61387 Confirmed somatic variant 25344691 NS NS 67.41 ENSP00000318476.6:p.Pro168Leu ENST00000320345.10:c.503C>T 17:g.1507025G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 OSCC-GB_01060111 2341032 2206015 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV57441385 COSM4882615 103180166 c.815G>A p.S272N Substitution - Missense 38 17:1496724-1496724 - - PATHOGENIC .77196 Confirmed somatic variant 539 NS primary 60 ENSP00000318476.6:p.Ser272Asn ENST00000320345.10:c.815G>A 17:g.1496724C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EOPC-133_tumor_01 2549444 2410899 prostate NS NS NS carcinoma NS NS NS y COSV57441087 COSN23438524 103180194 c.326+22C>T p.? Unknown 38 17:1509156-1509156 - - NEUTRAL .00106 Confirmed somatic variant 534 NS primary 49 ENST00000320345.10:c.326+22C>T 17:g.1509156G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 AOCS-119-3-9 2186509 2054806 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441447 COSN8831797 103180065 c.33+232G>A p.? Unknown 38 17:1513221-1513221 - - NEUTRAL .02029 Confirmed somatic variant 585 NS NS ENST00000320345.10:c.33+232G>A 17:g.1513221C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 W30T 2745054 2603757 thyroid NS NS NS carcinoma NS NS NS y COSV57440258 COSM6420326 103179617 c.532A>G p.N178D Substitution - Missense 38 17:1506996-1506996 - - NEUTRAL .40772 Confirmed somatic variant 676 NS primary 27 ENSP00000318476.6:p.Asn178Asp ENST00000320345.10:c.532A>G 17:g.1506996T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC205T 1652971 1567758 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57440408 COSN6651539 103180796 c.548+1673C>T p.? Unknown 38 17:1505307-1505307 - - NEUTRAL .00583 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.548+1673C>T 17:g.1505307G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 HUB-02-B2-087 2607141 2466853 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57440866 COSN24393345 103182888 c.327-474G>A p.? Unknown 38 17:1508700-1508700 - - NEUTRAL .00908 Confirmed somatic variant 670 organoid culture NS ENST00000320345.10:c.327-474G>A 17:g.1508700C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 p6low 2812886 2669300 large_intestine colon left NS adenoma tubular NS NS y COSV104411988 COSN31779190 103180090 c.*238G>A p.? Unknown 38 17:1495585-1495585 - - NEUTRAL .03835 Confirmed somatic variant 31336886 surgery-fixed NS 64 ENST00000320345.10:c.*238G>A 17:g.1495585C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PET124T 2507124 2369460 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57441198 COSN22982472 103179790 c.549-3324G>T p.? Unknown 38 17:1501446-1501446 - - NEUTRAL .18617 Confirmed somatic variant 661 NS primary 46 ENST00000320345.10:c.549-3324G>T 17:g.1501446C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 AOCS-139-19-0 2186425 2054722 ovary NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS y COSV57441562 COSM3983264 103181841 c.465G>T p.P155= Substitution - coding silent 38 17:1507063-1507063 - - NEUTRAL .03466 Confirmed somatic variant 585 NS NS ENSP00000318476.6:p.Pro155= ENST00000320345.10:c.465G>T 17:g.1507063C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 CHC433T 1652981 1567768 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV57442328 COSN6651503 103180603 c.549-4043A>G p.? Unknown 38 17:1502165-1502165 - - NEUTRAL .00034 Confirmed somatic variant 381 fresh/frozen - NOS primary ENST00000320345.10:c.549-4043A>G 17:g.1502165T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 ESCC_156 2479644 2342404 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57441047 COSM5645997 103181154 c.1080G>C p.L360F Substitution - Missense 38 17:1495862-1495862 - - NEUTRAL .09067 Confirmed somatic variant 26873401 NS NS 84 ENSP00000318476.6:p.Leu360Phe ENST00000320345.10:c.1080G>C 17:g.1495862C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 sysucc-882T 2456760 2319597 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57442228 COSN19666228 103181718 c.549-92G>T p.? Unknown 38 17:1498214-1498214 - - NEUTRAL .11173 Confirmed somatic variant 646 NS primary 61 ENST00000320345.10:c.549-92G>T 17:g.1498214C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-24-2030-01 1474934 1398633 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV100233576 COSM7466631 103179309 c.621C>T p.P207= Substitution - coding silent 38 17:1498050-1498050 - - NEUTRAL .06315 Confirmed somatic variant 331 NS primary 87 ENSP00000318476.6:p.Pro207= ENST00000320345.10:c.621C>T 17:g.1498050G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 2014_Lung_sq_41_T 2744912 2603615 lung NS NS NS carcinoma NS NS NS y COSV57440751 COSN19718001 103180919 c.326+396G>C p.? Unknown 38 17:1508782-1508782 - - NEUTRAL .00747 Confirmed somatic variant 583 NS primary 63 ENST00000320345.10:c.326+396G>C 17:g.1508782C>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-39-5037-01 1781591 1685590 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV57440018 COSM704961 103181248 c.999G>A p.E333= Substitution - coding silent 38 17:1496123-1496123 - - .64376 Confirmed somatic variant 418 fresh/frozen - NOS primary 65 ENSP00000318476.6:p.Glu333= ENST00000320345.10:c.999G>A 17:g.1496123C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-06-0171 2107961 1985822 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV57439847 COSM2150351 103179481 c.-175C>T p.? Unknown 38 17:1513970-1513970 - - NEUTRAL .02048 Confirmed somatic variant 23917401 NS NS ENST00000320345.10:c.-175C>T 17:g.1513970G>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441875 COSN25827061 103181689 c.549-3653C>A p.? Unknown 38 17:1501775-1501775 - - NEUTRAL .0002 Confirmed somatic variant 534 NS primary 44 ENST00000320345.10:c.549-3653C>A 17:g.1501775G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-EJ-7125-01 2121457 1995693 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV57440295 COSM3672354 103181442 c.389G>T p.R130L Substitution - Missense 38 17:1508164-1508164 - - NEUTRAL .18864 Confirmed somatic variant 435 NS NS 44 ENSP00000318476.6:p.Arg130Leu ENST00000320345.10:c.389G>T 17:g.1508164C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-E7-A7DV-01 2193219 2061497 urinary_tract bladder NS NS carcinoma NS NS NS y COSV57441614 COSM7110439 103180398 c.388C>A p.R130= Substitution - coding silent 38 17:1508165-1508165 - - NEUTRAL .16927 Confirmed somatic variant 413 NS NS 44 ENSP00000318476.6:p.Arg130= ENST00000320345.10:c.388C>A 17:g.1508165G>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 PET124T 2507124 2369460 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS y COSV57441203 COSN22987696 103179797 c.34-153G>T p.? Unknown 38 17:1509952-1509952 - - NEUTRAL .11989 Confirmed somatic variant 661 NS primary 46 ENST00000320345.10:c.34-153G>T 17:g.1509952C>A INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441890 COSN25825863 103181702 c.326+47A>G p.? Unknown 38 17:1509131-1509131 - - NEUTRAL .00149 Confirmed somatic variant 534 NS primary 44 ENST00000320345.10:c.326+47A>G 17:g.1509131T>C INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 EOPC-016_tumor_01 2633795 2494191 prostate NS NS NS carcinoma NS NS NS y COSV57441884 COSN25825941 103181697 c.549-3679T>C p.? Unknown 38 17:1501801-1501801 - - NEUTRAL .01231 Confirmed somatic variant 534 NS primary 44 ENST00000320345.10:c.549-3679T>C 17:g.1501801A>G INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV57443312 COSN6099353 103181999 c.-184-118G>A p.? Unknown 38 17:1514097-1514097 - - NEUTRAL .01454 Confirmed somatic variant 322 NS NS ENST00000320345.10:c.-184-118G>A 17:g.1514097C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV57443304 COSN6099345 103181994 c.34-239G>A p.? Unknown 38 17:1510038-1510038 - - NEUTRAL .012 Confirmed somatic variant 322 NS NS ENST00000320345.10:c.34-239G>A 17:g.1510038C>T INPP5K_ENST00000320345 ENST00000320345.10 1119 33882 TCGA-CD-A486-01 2198066 2066344 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV57443071 COSM4064063 103179632 c.358C>T p.R120W Substitution - Missense 38 17:1508195-1508195 - - PATHOGENIC .99184 Confirmed somatic variant 541 NS NS 68 ENSP00000318476.6:p.Arg120Trp ENST00000320345.10:c.358C>T 17:g.1508195G>A