{
    "uniprot_canonical_ac": "A0A286ZM90-1",
    "uniprot_id": [
        {
            "id": "A0A286ZM90_PIG",
            "url": "https://www.uniprot.org/uniprot/A0A286ZM90_PIG",
            "type": "external"
        }
    ],
    "mass": 164138.0,
    "length": 1527,
    "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-79 specific",
    "gene_name": "DOT1L",
    "organism": "Pig",
    "refseq_name": "",
    "refseq_ac": [],
    "gene_names_uniprotkb": "DOT1L",
    "gene_names_refseq": "",
    "protein_names_uniprotkb": "Histone-lysine N-methyltransferase, H3 lysine-79 specific",
    "protein_names_refseq": "",
    "tax_id": 9823,
    "disease": "",
    "pathway": " (R-SSC-3214841)",
    "pathway_count": 1,
    "publication_count": 0,
    "publication_id_list": "",
    "function": "Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone., [UniProtKB, UniProtKB]; Histone methyltransferase. Methylates 'Lys-79' of histone H3., [UniProtKB, UniProtKB]",
    "predicted_glycosites": 2,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 2,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 2,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 2,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0031151 histone H3K79 methyltransferase activity;GO:0140956 histone H3K79 trimethyltransferase activity",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0000781 chromosome, telomeric region",
    "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0031509 subtelomeric heterochromatin formation;GO:0006281 DNA repair;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032259 methylation",
    "synthesized_glycan_count": 0,
    "record_id": "A0A286ZM90-1",
    "record_type": "protein",
    "filter_code": "0000000.0000001.010000.0000000000010000.00010.001"
}