{
    "uniprot_canonical_ac": "A0A1W2Q672-1",
    "uniprot_id": [
        {
            "id": "A0A1W2Q672_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A1W2Q672_RAT",
            "type": "external"
        }
    ],
    "mass": 40157.0,
    "length": 348,
    "protein_name": "Bis(monoacylglycero)phosphate synthase CLN5",
    "gene_name": "Cln5",
    "organism": "Rat",
    "refseq_name": "ceroid-lipofuscinosis neuronal protein 5 isoform X1",
    "refseq_ac": [
        {
            "id": "XP_038949328",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038949328",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Cln5; AABR07019209.2",
    "gene_names_refseq": "Cln5",
    "protein_names_uniprotkb": "Bis(monoacylglycero)phosphate synthase CLN5; 3.1.2.22; Ceroid-lipofuscinosis neuronal protein 5; Palmitoyl protein thioesterase CLN5; S-depalmitoylase CLN5",
    "protein_names_refseq": "ceroid-lipofuscinosis neuronal protein 5 isoform X1",
    "tax_id": 10116,
    "disease": "neuronal ceroid lipofuscinosis 5 (Disease Ontology:DOID:0110728)",
    "pathway": "",
    "pathway_count": 0,
    "publication_count": 0,
    "publication_id_list": "",
    "function": "Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane., [UniProtKB, UniProtKB, UniProtKB]; Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation., [UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "3.1.2.22",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
            "type": "external"
        },
        {
            "id": "3.1.2.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
            "type": "external"
        },
        {
            "id": "3.4.-.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
            "type": "external"
        },
        {
            "id": "3.1.1.93",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93",
            "type": "external"
        },
        {
            "id": "3.4.19.12",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0005537 D-mannose binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0160121 bis(monoacylglycero)phosphate synthase activity",
    "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm",
    "go_biological_process": "GO:0007420 brain development;GO:0007601 visual perception;GO:0007040 lysosome organization;GO:0042147 retrograde transport, endosome to Golgi;GO:0022008 neurogenesis",
    "synthesized_glycan_count": 0,
    "record_id": "A0A1W2Q672-1",
    "record_type": "protein",
    "filter_code": "0000000.0000010.100000.0000000000001000.00010.001"
}