{
    "uniprot_canonical_ac": "A0A1D5PPP7-1",
    "uniprot_id": [
        {
            "id": "CASP6_CHICK",
            "url": "https://www.uniprot.org/uniprot/CASP6_CHICK",
            "type": "external"
        }
    ],
    "mass": 34476.0,
    "length": 304,
    "protein_name": "Caspase-6",
    "gene_name": "CASP6",
    "organism": "Chicken",
    "refseq_name": "caspase-6 isoform 1",
    "refseq_ac": [
        {
            "id": "NP_990057",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990057",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "CASP6",
    "gene_names_refseq": "CASP-6; caspase-6; CASP6",
    "protein_names_uniprotkb": "Caspase-6; 3.4.22.59; CASP-6",
    "protein_names_refseq": "caspase 6, apoptosis-related cysteine protease; caspase 6, apoptosis-related cysteine peptidase; caspase-6 isoform 1",
    "tax_id": 9031,
    "disease": "",
    "pathway": " (gga:395477)",
    "pathway_count": 1,
    "publication_count": 3,
    "publication_id_list": "10684799;11953316;15592404",
    "function": "##Evidence-Data-START## Transcript exon combination :: AF082329.1, SRR12888553.40519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Sep 30, 2021 this sequence version replaced NP_990057.1., [RefSeq]; CASP6 is responsible for cleaving lamin A and completion of chromosome condensation during nuclear disassembly of apoptosis, [RefSeq, PubMed]; Cysteine protease that plays essential roles in programmed cell death, development and innate immunity (PubMed:11953316). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein lamin-A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:11953316). Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (PubMed:11953316). Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity. PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
    "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030263 apoptotic chromosome condensation;GO:0043525 positive regulation of neuron apoptotic process",
    "synthesized_glycan_count": 0,
    "record_id": "A0A1D5PPP7-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.100000.0001000000000000.00000.000"
}