{
    "uniprot_canonical_ac": "A0A1D5PIE4-1",
    "uniprot_id": [
        {
            "id": "A0A1D5PIE4_CHICK",
            "url": "https://www.uniprot.org/uniprot/A0A1D5PIE4_CHICK",
            "type": "external"
        }
    ],
    "mass": 50010.0,
    "length": 450,
    "protein_name": "Antizyme inhibitor 1",
    "gene_name": "AZIN1",
    "organism": "Chicken",
    "refseq_name": "antizyme inhibitor 1",
    "refseq_ac": [
        {
            "id": "NP_001008729",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008729",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "AZIN1",
    "gene_names_refseq": "AZIN1; OAZIN",
    "protein_names_uniprotkb": "Antizyme inhibitor 1",
    "protein_names_refseq": "antizyme inhibitor 1; ornithine decarboxylase antizyme inhibitor",
    "tax_id": 9031,
    "disease": "",
    "pathway": " (gga:420254);  (R-GGA-350562)",
    "pathway_count": 2,
    "publication_count": 0,
    "publication_id_list": "",
    "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01001192.1, AJ720630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992533 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU463028.1, AJ720630.1, CN226049.1, DR414120.1, DR431376.1 and BU350527.1. On Jan 12, 2005 this sequence version replaced XP_418365.1. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]., [RefSeq]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0003824 catalytic activity;GO:0042978 ornithine decarboxylase activator activity;GO:0004586 ornithine decarboxylase activity",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
    "go_biological_process": "GO:0006596 polyamine biosynthetic process;GO:0042177 negative regulation of protein catabolic process;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:1902269 positive regulation of polyamine transmembrane transport",
    "synthesized_glycan_count": 0,
    "record_id": "A0A1D5PIE4-1",
    "record_type": "protein",
    "filter_code": "0000000.0000001.100000.0001000000000000.00000.000"
}