{
    "uniprot_canonical_ac": "A0A1D5PF49-1",
    "uniprot_id": [
        {
            "id": "A0A1D5PF49_CHICK",
            "url": "https://www.uniprot.org/uniprot/A0A1D5PF49_CHICK",
            "type": "external"
        }
    ],
    "mass": 51492.0,
    "length": 480,
    "protein_name": "Cyclic AMP-dependent transcription factor ATF-7",
    "gene_name": "ATF7",
    "organism": "Chicken",
    "refseq_name": "cyclic AMP-dependent transcription factor ATF-7",
    "refseq_ac": [
        {
            "id": "NP_001406868",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406868",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "ATF7",
    "gene_names_refseq": "ATF7",
    "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-7",
    "protein_names_refseq": "cyclic AMP-dependent transcription factor ATF-7",
    "tax_id": 9031,
    "disease": "",
    "pathway": "",
    "pathway_count": 0,
    "publication_count": 0,
    "publication_id_list": "",
    "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.136406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JAENSK010000489.1. On or before Apr 21, 2023 this sequence version replaced XP_025001216.1, XP_040549908.1., [RefSeq]; Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening., [UniProtKB, UniProtKB]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0051019 mitogen-activated protein kinase binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223 transcription coactivator binding;GO:0035497 cAMP response element binding",
    "go_cellular_component": "GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex",
    "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II",
    "synthesized_glycan_count": 0,
    "record_id": "A0A1D5PF49-1",
    "record_type": "protein",
    "filter_code": "0000000.0000000.100000.0001000000000000.00010.001"
}