{
    "uniprot_canonical_ac": "A0A1D5PE01-1",
    "uniprot_id": [
        {
            "id": "A0A1D5PE01_CHICK",
            "url": "https://www.uniprot.org/uniprot/A0A1D5PE01_CHICK",
            "type": "external"
        }
    ],
    "mass": 58201.0,
    "length": 508,
    "protein_name": "Cholesterol side-chain cleavage enzyme, mitochondrial",
    "gene_name": "CYP11A1",
    "organism": "Chicken",
    "refseq_name": "cholesterol side-chain cleavage enzyme, mitochondrial",
    "refseq_ac": [
        {
            "id": "NP_001001756",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001756",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "CYP11A1",
    "gene_names_refseq": "CYP11A1",
    "protein_names_uniprotkb": "Cholesterol side-chain cleavage enzyme, mitochondrial; 1.14.15.6; Cholesterol desmolase",
    "protein_names_refseq": "cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P-450 cholesterol side-chain cleavage enzyme; cytochrome P450 11A1; cytochrome P450, family 11, subfamily A, polypeptide 1",
    "tax_id": 9031,
    "disease": "",
    "pathway": " (R-GGA-196108);  (R-GGA-211976)",
    "pathway_count": 2,
    "publication_count": 2,
    "publication_id_list": "19710202;21798688",
    "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267657.6823.1, ERR2368565.75713.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. On Oct 1, 2021 this sequence version replaced NP_001001756.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)., [UniProtKB, UniProtKB]; Testosterone (10 or 100 ng/ml) increased STAR, P450scc, and LHCGR mRNAs, when added to 3 h cultures of F1 granulosa cells., [RefSeq, PubMed]; This study showed that the effects of iodothyronines depend on follicle maturation and are associated with modulation of cAMP synthesis and STAR, CYP11A1, and HSD3B mRNA expression., [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "1.14.15.6",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.6",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity",
    "go_cellular_component": "GO:0005743 mitochondrial inner membrane",
    "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006700 C21-steroid hormone biosynthetic process;GO:0006704 glucocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0034650 cortisol metabolic process",
    "synthesized_glycan_count": 0,
    "record_id": "A0A1D5PE01-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.100000.0001000000000000.00000.000"
}