{
    "uniprot_canonical_ac": "A0A1B0GRG8-1",
    "uniprot_id": [
        {
            "id": "A0A1B0GRG8_MOUSE",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GRG8_MOUSE",
            "type": "external"
        }
    ],
    "mass": 30674.0,
    "length": 277,
    "protein_name": "Carbonyl reductase (NADPH)",
    "gene_name": "Cbr1b",
    "organism": "Mouse",
    "refseq_name": "",
    "refseq_ac": [],
    "gene_names_uniprotkb": "Cbr1b; Gm5678",
    "gene_names_refseq": "",
    "protein_names_uniprotkb": "Carbonyl reductase (NADPH); 1.1.1.184",
    "protein_names_refseq": "",
    "tax_id": 10090,
    "disease": "chronic kidney disease (Disease Ontology:DOID:784)",
    "pathway": "",
    "pathway_count": 0,
    "publication_count": 1,
    "publication_id_list": "21750661",
    "function": "NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue., [UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "1.1.1.184",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184",
            "type": "external"
        },
        {
            "id": "1.1.1.189",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189",
            "type": "external"
        },
        {
            "id": "1.1.1.197",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197",
            "type": "external"
        },
        {
            "id": "1.1.1.196",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196",
            "type": "external"
        },
        {
            "id": "1.1.1.71",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71",
            "type": "external"
        },
        {
            "id": "1.1.1.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-",
            "type": "external"
        },
        {
            "id": "1.6.5.10",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10",
            "type": "external"
        },
        {
            "id": "1.1.1.300",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0004090 carbonyl reductase (NADPH) activity",
    "go_cellular_component": "GO:0005737 cytoplasm",
    "go_biological_process": "GO:0006629 lipid metabolic process",
    "synthesized_glycan_count": 0,
    "record_id": "A0A1B0GRG8-1",
    "record_type": "protein",
    "filter_code": "0000000.0000110.100000.0000000000100000.00000.000"
}