{
    "uniprot_canonical_ac": "A0A140LIF8-1",
    "uniprot_id": [
        {
            "id": "IRGM2_MOUSE",
            "url": "https://www.uniprot.org/uniprot/IRGM2_MOUSE",
            "type": "external"
        }
    ],
    "mass": 45205.0,
    "length": 395,
    "protein_name": "Immunity-related GTPase family M protein 2",
    "gene_name": "Irgm2",
    "organism": "Mouse",
    "refseq_name": "immunity-related GTPase family M protein 2 isoform 1",
    "refseq_ac": [
        {
            "id": "NP_062313",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062313",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Irgm2; Iigp2",
    "gene_names_refseq": "GTPI; Ifggd2; Iigp2; Irgm2",
    "protein_names_uniprotkb": "Immunity-related GTPase family M protein 2; 3.6.5.-; Interferon-inducible GTPase 2",
    "protein_names_refseq": "immunity-related GTPase family M protein 2 isoform 1; interferon inducible GTPase 2; interferon-g induced GTPase; interferon-gamma-inducible GTPase Ifggd2 protein; immunity-related GTPase family M protein 2",
    "tax_id": 10090,
    "disease": "inflammatory bowel disease 19 (Disease Ontology:DOID:0110890); tuberculosis (Disease Ontology:DOID:399)",
    "pathway": " (mmu:54396)",
    "pathway_count": 1,
    "publication_count": 10,
    "publication_id_list": "17641048;19144319;21750661;22892676;33124745;33124769;34078740;34338548;36629440;9862701",
    "function": "Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:17641048, PubMed:33124745, PubMed:33124769, PubMed:34078740, PubMed:34338548). Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections (PubMed:17641048, PubMed:34078740, PubMed:34338548). Acts by participating to Tgtp1/Irgb6 and Gbp1-mediated parasite killing by promoting their accumulation on the T.gondii parasitophorous vacuole membranes (PubMed:34078740). Also required for prolonged loading of ubiquitin and p62/Sqstm1 to parasitophorous vacuole membranes (PubMed:34078740). Also acts as a key negative regulator of the inflammatory response by inhibiting the non-canonical inflammasome, thereby protecting against Casp11-driven septic shock during endotoxemia (PubMed:33124745, PubMed:33124769)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii., [RefSeq, PubMed]; P47 GTPases Irgb10 and Iigp2 act together to confer differential susceptibility against murine chlamydial infection., [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 3,
    "reported_mutagensis": 8,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 2,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "3.6.5.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
            "type": "external"
        },
        {
            "id": "3.6.5.2",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
            "type": "external"
        },
        {
            "id": "3.6.5.4",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
            "type": "external"
        },
        {
            "id": "3.6.5.5",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
            "type": "external"
        },
        {
            "id": "3.6.1.5",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
            "type": "external"
        },
        {
            "id": "3.6.1.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
            "type": "external"
        },
        {
            "id": "3.6.5.3",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
            "type": "external"
        },
        {
            "id": "3.6.1.15",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
            "type": "external"
        },
        {
            "id": "2.7.11.1",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
            "type": "external"
        },
        {
            "id": "3.6.-.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016787 hydrolase activity",
    "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane;GO:0005774 vacuolar membrane;GO:0016020 membrane",
    "go_biological_process": "GO:0045087 innate immune response;GO:0009617 response to bacterium;GO:0031640 killing of cells of another organism;GO:0042832 defense response to protozoan;GO:0044395 protein targeting to vacuolar membrane",
    "synthesized_glycan_count": 0,
    "record_id": "A0A140LIF8-1",
    "record_type": "protein",
    "filter_code": "0000000.0100111.100000.0000000000100000.00001.000"
}