{
    "uniprot_canonical_ac": "A0A0S2I7K2-1",
    "uniprot_id": [
        {
            "id": "A0A0S2I7K2_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0S2I7K2_DANRE",
            "type": "external"
        }
    ],
    "mass": 116382.0,
    "length": 1066,
    "protein_name": "Vinculin",
    "gene_name": "vclb",
    "organism": "Zebrafish",
    "refseq_name": "vinculin b",
    "refseq_ac": [
        {
            "id": "NP_001304681",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304681",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "vclb; vinculin-b",
    "gene_names_refseq": "vclb; vinculin-b",
    "protein_names_uniprotkb": "Vinculin; Metavinculin",
    "protein_names_refseq": "vinculin b",
    "tax_id": 7955,
    "disease": "hypertrophic cardiomyopathy 15 (Disease Ontology:DOID:0110321); dilated cardiomyopathy 1W (Disease Ontology:DOID:0110446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)",
    "pathway": " (dre:100334859)",
    "pathway_count": 1,
    "publication_count": 11,
    "publication_id_list": "23594743;23840804;27578788;28767718;30635353;30944477;35417696;35613615;36260739;36314606;36427314",
    "function": "Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion., [UniProtKB, UniProtKB]; Study show that zebrafish contain two homologous vinculin isoforms, of which the sequence of key functional domains is conserved with several higher vertebrate. Loss of both zygotic vcla and maternal contribution of vcla did not result in notable defects, while the additional loss of zygotic vclb is lethal only after embryonic stages. These data indicate that embryonic development in zebrafish can occur without vinculin. Publication Status: Online-Only, [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 4,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding",
    "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion",
    "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0060977 coronary vasculature morphogenesis",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0S2I7K2-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.010000.0000000000000001.00000.000"
}