{ "uniprot_canonical_ac": "A0A0R4IXF6-1", "uniprot_id": [ { "id": "KAT2A_DANRE", "url": "https://www.uniprot.org/uniprot/KAT2A_DANRE", "type": "external" } ], "mass": 90624.0, "length": 795, "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "kat2a", "organism": "Zebrafish", "refseq_name": "histone acetyltransferase KAT2A", "refseq_ac": [ { "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703", "type": "external" } ], "gene_names_uniprotkb": "kat2a; gb:dq017634; im:7156024", "gene_names_refseq": "gb:dq017634; gcn5; im:7156024; kat2a", "protein_names_uniprotkb": "Histone acetyltransferase KAT2A; 2.3.1.-; 2.3.1.48; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; Lysine acetyltransferase 2A", "protein_names_refseq": "PCAF; lysine acetyltransferase 2A; histone succinyltransferase KAT2A; histone glutaryltransferase KAT2A; histone acetyltransferase KAT2A", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-5689880)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17997606;22412924;23594743;24240475;28631837;29174768;30424580;30615915;32114246;32779569;37660921", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX005093.22 and FO818663.1. On Aug 14, 2023 this sequence version replaced XP_009297593.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Inhibition of mitochondrial fatty acid beta-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish., [RefSeq, PubMed]; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferasesucc, succinyltransferase or malonyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Also acetylates non-histone proteins, such as tbx5 (PubMed:29174768). Involved in heart and limb development by mediating acetylation of tbx5 (PubMed:29174768). Together with kat2b, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; These studies highlight the importance of KAT2A and KAT2B modulation of TBX5 and their impact on heart and limb development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0061733 peptide-lysine-N-acetyltransferase activity;GO:0043997 histone H4K12 acetyltransferase activity;GO:0106078 histone succinyltransferase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000123 histone acetyltransferase complex;GO:0140672 ATAC complex", "go_biological_process": "GO:1903010 regulation of bone development;GO:0006338 chromatin remodeling;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "record_id": "A0A0R4IXF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.0000000000000001.00010.001" }