{
    "uniprot_canonical_ac": "A0A0R4IWH7-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IWH7_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IWH7_DANRE",
            "type": "external"
        }
    ],
    "mass": 301092.0,
    "length": 2754,
    "protein_name": "APC regulator of WNT-signaling pathway; Adenomatous polyposis coli protein",
    "gene_name": "apc",
    "organism": "Zebrafish",
    "refseq_name": "adenomatous polyposis coli protein",
    "refseq_ac": [
        {
            "id": "NP_001137312",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137312",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "apc; cb965; im:7150932; im:7152872",
    "gene_names_refseq": "apc; cb965; im:7150932; im:7152872",
    "protein_names_uniprotkb": "APC regulator of WNT-signaling pathway; Adenomatous polyposis coli protein",
    "protein_names_refseq": "adenomatosis polyposis coli; adenomatous polyposis coli; adenomatous polyposis coli protein",
    "tax_id": 7955,
    "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); medulloblastoma (Disease Ontology:DOID:0050902); familial adenomatous polyposis 1 (Disease Ontology:DOID:0080409); hereditary desmoid disease (Disease Ontology:DOID:0111349); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); adenocarcinoma (Disease Ontology:DOID:299); acinar cell carcinoma (Disease Ontology:DOID:3025); gallbladder cancer (Disease Ontology:DOID:3121); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)",
    "pathway": " (dre:386762)",
    "pathway_count": 1,
    "publication_count": 11,
    "publication_id_list": "14534590;15358764;15967793;16439994;16699180;23594743;31624259;32467235;35132438;37407577;37489330",
    "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505374, SAMEA3505377 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU915637.3 and CU861476.9. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; APC control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation, [RefSeq, PubMed]; APC controls the production of RA in the gut by regulating the expression of the retinol dehydrogenase, rdh1l, [RefSeq, PubMed]; Mutations in the APC gene resultt in impaired retinoic acid biosynthesis and upegulation of cyclooxygenase-2., [RefSeq, PubMed]; Zebrafish that are heterozygous for a truncating denomatous polyposis coli mutation spontaneously develop intestinal, hepatic and pancreatic neoplasias [Adenomatous polyposis coli], [RefSeq, PubMed]",
    "predicted_glycosites": 2,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 2,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 2,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 21,
    "glyco_site_count": 2,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0008017 microtubule binding;GO:0008013 beta-catenin binding;GO:0045295 gamma-catenin binding",
    "go_cellular_component": "GO:0005737 cytoplasm;GO:0043231 intracellular membrane-bounded organelle;GO:0016342 catenin complex;GO:0030877 beta-catenin destruction complex",
    "go_biological_process": "GO:0001708 cell fate specification;GO:0003170 heart valve development;GO:0061031 endodermal digestive tract morphogenesis;GO:0001889 liver development;GO:0007399 nervous system development",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IWH7-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.001000.0000000000000001.00010.001"
}