{
    "uniprot_canonical_ac": "A0A0R4IU56-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IU56_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IU56_DANRE",
            "type": "external"
        }
    ],
    "mass": 32159.0,
    "length": 288,
    "protein_name": "diphthine methyl ester synthase",
    "gene_name": "dph5",
    "organism": "Zebrafish",
    "refseq_name": "diphthine methyl ester synthase",
    "refseq_ac": [
        {
            "id": "NP_001007387",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007387",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "dph5; zgc:101823",
    "gene_names_refseq": "dph5; zgc:101823",
    "protein_names_uniprotkb": "diphthine methyl ester synthase; 2.1.1.314",
    "protein_names_refseq": "DPH5 homolog; diphthine methyl ester synthase",
    "tax_id": 7955,
    "disease": "neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties (Disease Ontology:DOID:0070479)",
    "pathway": " (dre:492514)",
    "pathway_count": 1,
    "publication_count": 2,
    "publication_id_list": "23594743;27189481",
    "function": "##Evidence-Data-START## Transcript exon combination :: BC085447.1, EE321506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505386, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX908733.16. On or before Dec 1, 2014 this sequence version replaced NP_001093555.1, NP_001007387.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis., [UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "2.1.1.314",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.314",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0141133 diphthine methyl ester synthase activity",
    "go_cellular_component": "",
    "go_biological_process": "GO:0032259 methylation;GO:0017183 protein histidyl modification to diphthamide",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IU56-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}