{
    "uniprot_canonical_ac": "A0A0R4IPL1-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IPL1_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IPL1_DANRE",
            "type": "external"
        }
    ],
    "mass": 15027.0,
    "length": 140,
    "protein_name": "Profilin",
    "gene_name": "pfn2b",
    "organism": "Zebrafish",
    "refseq_name": "profilin-2 isoform X1",
    "refseq_ac": [
        {
            "id": "XP_005174113",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005174113",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "pfn2b; pfn2; wu:fb01g08; wu:fb54f09; wu:fd58f06",
    "gene_names_refseq": "pfn2; wu:fb01g08; wu:fb54f09; wu:fd58f06; pfn2b",
    "protein_names_uniprotkb": "Profilin",
    "protein_names_refseq": "profilin-2 isoform X1",
    "tax_id": 7955,
    "disease": "membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); hepatocellular carcinoma (Disease Ontology:DOID:684)",
    "pathway": " (dre:394235);  (R-DRE-4086400);  (R-DRE-5663220)",
    "pathway_count": 3,
    "publication_count": 10,
    "publication_id_list": "16109975;19240126;23594743;24271012;26469318;27235108;28252024;30948728;31142542;33945241",
    "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_000002035.6-RS_2024_08 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 08/15/2024 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007133.7) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG., [UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 2,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0003779 actin binding",
    "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton",
    "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization;GO:0030833 regulation of actin filament polymerization",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IPL1-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}