{ "uniprot_canonical_ac": "A0A0R4IN14-1", "uniprot_id": [ { "id": "A0A0R4IN14_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IN14_DANRE", "type": "external" } ], "mass": 72355.0, "length": 643, "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "raf1a", "organism": "Zebrafish", "refseq_name": "Raf-1 proto-oncogene, serine/threonine kinase a", "refseq_ac": [ { "id": "NP_571514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571514", "type": "external" } ], "gene_names_uniprotkb": "raf1a; c-raf; craf; raf1", "gene_names_refseq": "c-raf; craf; raf1; raf1a", "protein_names_uniprotkb": "RAF proto-oncogene serine/threonine-protein kinase; 2.7.11.1; Raf-1", "protein_names_refseq": "Raf-1 proto-oncogene, serine/threonine kinase a; serine/threonine protein kinase RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene homolog 1a", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); Noonan syndrome 5 (Disease Ontology:DOID:0060583); Noonan syndrome with multiple lentigines 2 (Disease Ontology:DOID:0080549); dilated cardiomyopathy 1NN (Disease Ontology:DOID:0110432); prostate cancer (Disease Ontology:DOID:10283); prostate adenocarcinoma (Disease Ontology:DOID:2526); Noonan syndrome (Disease Ontology:DOID:3490); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (dre:30716)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10207156;12925535;16109975;17397257;17603482;23594743;27356472;27895053;28791256;31263281;33279959", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01032163.1, AB098700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476745, SAMEA4476812 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU571070.6, CABZ01046288.1, CABZ01066947.1, FO818741.2 and CU468010.12. On Jun 26, 2015 this sequence version replaced NP_571514.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0035402 histone H3T11 kinase activity;GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development;GO:0000165 MAPK cascade;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "record_id": "A0A0R4IN14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.0000000000000001.00010.001" }