{
    "uniprot_canonical_ac": "A0A0R4IMY7-1",
    "uniprot_id": [
        {
            "id": "TRPM2_DANRE",
            "url": "https://www.uniprot.org/uniprot/TRPM2_DANRE",
            "type": "external"
        }
    ],
    "mass": 167987.0,
    "length": 1470,
    "protein_name": "Transient receptor potential cation channel subfamily M member 2",
    "gene_name": "trpm2",
    "organism": "Zebrafish",
    "refseq_name": "transient receptor potential cation channel subfamily M member 2",
    "refseq_ac": [
        {
            "id": "NP_001275746",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275746",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "trpm2; si:ch73-263b18.1",
    "gene_names_refseq": "si:ch73-263b18.1; trpm2",
    "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 2",
    "protein_names_refseq": "transient receptor potential cation channel subfamily M member 2; transient receptor potential melastatin 2",
    "tax_id": 7955,
    "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)",
    "pathway": " (dre:799412);  (R-DRE-3295583);  (R-DRE-6798695)",
    "pathway_count": 3,
    "publication_count": 4,
    "publication_id_list": "23594743;23908157;30250252;33924946",
    "function": "##Evidence-Data-START## Transcript exon combination :: KF305307.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from KF305307.1. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress (PubMed:30250252). Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:30250252)., [UniProtKB, PubMed]; Species-Specific Regulation of TRPM2 by PI(4,5)P2 via the Membrane Interfacial Cavity. Publication Status: Online-Only, [RefSeq, PubMed]",
    "predicted_glycosites": 2,
    "predicted_n_glycosites": 1,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 1,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 8,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 2,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "2.7.11.1",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005216 monoatomic ion channel activity;GO:0005509 calcium ion binding;GO:0072570 ADP-D-ribose binding;GO:0099604 ligand-gated calcium channel activity",
    "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system",
    "go_biological_process": "GO:0051289 protein homotetramerization;GO:0070588 calcium ion transmembrane transport",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IMY7-1",
    "record_type": "protein",
    "filter_code": "0000000.0100111.010000.0000000000000001.00110.001"
}