{
    "uniprot_canonical_ac": "A0A0R4IFG5-1",
    "uniprot_id": [
        {
            "id": "CFA53_DANRE",
            "url": "https://www.uniprot.org/uniprot/CFA53_DANRE",
            "type": "external"
        }
    ],
    "mass": 63183.0,
    "length": 519,
    "protein_name": "Cilia- and flagella-associated protein 53",
    "gene_name": "cfap53",
    "organism": "Zebrafish",
    "refseq_name": "cilia- and flagella-associated protein 53",
    "refseq_ac": [
        {
            "id": "NP_001038595",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038595",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "cfap53; ccdc11",
    "gene_names_refseq": "ccdc11; si:ch211-257i19.2; zgc:153145; cfap53",
    "protein_names_uniprotkb": "Cilia- and flagella-associated protein 53; Coiled-coil domain-containing protein 11",
    "protein_names_refseq": "cilia- and flagella-associated protein 53; coiled-coil domain containing 11; coiled-coil domain-containing protein 11",
    "tax_id": 7955,
    "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 6 (Disease Ontology:DOID:0051020)",
    "pathway": " (dre:567344)",
    "pathway_count": 1,
    "publication_count": 4,
    "publication_id_list": "23594743;25504577;26531781;26538025",
    "function": "##Evidence-Data-START## Transcript exon combination :: BC124260.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124260.1. On Jun 3, 2007 this sequence version replaced NP_001038595.1., [RefSeq]; Cfap53 is a conserved regulator of organ laterality in both humans and zebrafish., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (By similarity). Required for cilium motility within the spinal canal and Kuppfer's vesicle and is involved in the establishment of left-right symmetry during embryogenesis (PubMed:25504577, PubMed:26531781, PubMed:26538025)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Through functional evaluation of the zebrafish homolog of the gene, study identify a critical role for the CCDC11 protein in regulating the motility of cilia within the left-right asymmetry organizer during embryogenesis., [RefSeq, PubMed]; To determine the role of CCDC11 during vertebrate development, we generated mutant alleles in zebrafish., [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 2,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "",
    "go_cellular_component": "GO:0005576 extracellular region;GO:0005930 axoneme;GO:0005879 axonemal microtubule;GO:0097546 ciliary base",
    "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IFG5-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}