{
    "uniprot_canonical_ac": "A0A0R4IDX9-1",
    "uniprot_id": [
        {
            "id": "NINJ1_DANRE",
            "url": "https://www.uniprot.org/uniprot/NINJ1_DANRE",
            "type": "external"
        }
    ],
    "mass": 16131.0,
    "length": 146,
    "protein_name": "Ninjurin-1",
    "gene_name": "ninj1",
    "organism": "Zebrafish",
    "refseq_name": "ninjurin-1",
    "refseq_ac": [
        {
            "id": "NP_001410993",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410993",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "ninj1; si:ch1073-278o19.1",
    "gene_names_refseq": "ninj1; si:ch1073-278o19.1",
    "protein_names_uniprotkb": "Ninjurin-1; Nerve injury-induced protein 1",
    "protein_names_refseq": "nerve injury-induced protein 1; ninjurin-1",
    "tax_id": 7955,
    "disease": "",
    "pathway": "",
    "pathway_count": 0,
    "publication_count": 2,
    "publication_id_list": "23594743;31091274",
    "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01016067.1, GDQH01022841.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476750, SAMEA4476758 [ECO:0006172] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from CU914619.5 and BX248521.12. On Aug 31, 2023 this sequence version replaced XP_001919024.1., [RefSeq]; Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis) (By similarity). Oligomerizes in response to death stimuli and forms ring-like structures on the plasma membrane: acts by cutting and shedding membrane disks, like a cookie cutter, leading to membrane damage and loss that cannot be repaired by the cell (By similarity). Plasma membrane rupture leads to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Mechanistically, mediates plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane (By similarity). Induces plasma membrane rupture downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively (By similarity). Also acts as an effector of PANoptosis and ferroptosis (By similarity). Induces plasma membrane rupture in response to cell swelling caused by osmotic stress (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (By similarity). Also involved in striated muscle growth and differentiation (PubMed:31091274)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; We assessed the physiological role of ninjurin1 in zebrafish during heart and skeletal muscle development...Reduced levels of ninjurin1 impaired cardiac and skeletal muscle development in zebrafish Publication Status: Online-Only, [RefSeq, PubMed]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 1,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 1,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0098631 cell adhesion mediator activity;GO:0140912 membrane destabilizing activity",
    "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0097060 synaptic membrane",
    "go_biological_process": "GO:0007155 cell adhesion;GO:0042246 tissue regeneration;GO:0001525 angiogenesis;GO:0007507 heart development;GO:0050729 positive regulation of inflammatory response",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IDX9-1",
    "record_type": "protein",
    "filter_code": "0000000.0000100.100000.0000000000000001.00100.001"
}