{
    "uniprot_canonical_ac": "A0A0R4IBM0-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IBM0_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IBM0_DANRE",
            "type": "external"
        }
    ],
    "mass": 79740.0,
    "length": 730,
    "protein_name": "Neuregulin 1; Pro-neuregulin-1, membrane-bound isoform isoform IIb12",
    "gene_name": "nrg1",
    "organism": "Zebrafish",
    "refseq_name": "pro-neuregulin-1, membrane-bound isoform isoform IIb12",
    "refseq_ac": [
        {
            "id": "NP_001264015",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264015",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "nrg1; wu:fm70e01",
    "gene_names_refseq": "nrg1; wu:fm70e01",
    "protein_names_uniprotkb": "Neuregulin 1; Pro-neuregulin-1, membrane-bound isoform isoform IIb12",
    "protein_names_refseq": "neuregulin1; neuregulin 1 type I isoform; neuregulin 1 type III isoform; neuregulin 1 type II isoform; pro-neuregulin-1, membrane-bound isoform isoform IIb12",
    "tax_id": 7955,
    "disease": "nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); schizophrenia 6 (Disease Ontology:DOID:0070082); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); cerebral malaria (Disease Ontology:DOID:14069); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); cannabis dependence (Disease Ontology:DOID:1849); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); psychotic disorder (Disease Ontology:DOID:2468); substance abuse (Disease Ontology:DOID:302); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); cannabis abuse (Disease Ontology:DOID:9505)",
    "pathway": " (dre:796461)",
    "pathway_count": 1,
    "publication_count": 11,
    "publication_id_list": "16481353;16873582;18599505;18996920;19133254;23594743;36417527;36513650;36823429;36846912;37484916",
    "function": "##Evidence-Data-START## Transcript exon combination :: FJ593488.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX537303.10, CU459101.9, CR855879.8 and BX321906.30. Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform IIb12) is longer and has a distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Disc1 and nrg1 function in controlling development of oligodendrocytes and neurones from olig2-expressing precursor cells., [RefSeq, PubMed]; ErbB3 signaling is required for normal migration of trunk, but not cranial, neural crest cells Erratum:[Development. 2008 Sep;135(17):2993], [RefSeq, PubMed]; NRG1 and PI3K functionally interact with ErbB2 and ErbB3 during regeneration, [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 22,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0030296 protein tyrosine kinase activator activity;GO:0008083 growth factor activity;GO:0045499 chemorepellent activity",
    "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane",
    "go_biological_process": "GO:0048484 enteric nervous system development;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0007420 brain development;GO:0001755 neural crest cell migration",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IBM0-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}