{
    "uniprot_canonical_ac": "A0A0R4IAH0-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IAH0_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IAH0_DANRE",
            "type": "external"
        }
    ],
    "mass": 116426.0,
    "length": 1052,
    "protein_name": "Histone deacetylase",
    "gene_name": "hdac4",
    "organism": "Zebrafish",
    "refseq_name": "histone deacetylase 4 isoform X1",
    "refseq_ac": [
        {
            "id": "XP_005172586",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005172586",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "hdac4; wu:fa96d08; wu:fc56f08; zgc:152701",
    "gene_names_refseq": "hdac4; wu:fa96d08; wu:fc56f08; zgc:152701",
    "protein_names_uniprotkb": "Histone deacetylase; 3.5.1.98",
    "protein_names_refseq": "histone deacetylase 4 isoform X1",
    "tax_id": 7955,
    "disease": "ataxia telangiectasia (Disease Ontology:DOID:12704); impotence (Disease Ontology:DOID:1875); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); eating disorder (Disease Ontology:DOID:8670); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)",
    "pathway": " (dre:568877)",
    "pathway_count": 1,
    "publication_count": 11,
    "publication_id_list": "21773810;22676467;23594743;24240475;25189256;25603810;31792261;32240749;32344037;32380281;33499374",
    "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_000002035.6-RS_2024_08 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 08/15/2024 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007120.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 10,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "3.5.1.98",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98",
            "type": "external"
        },
        {
            "id": "3.5.1.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0046872 metal ion binding;GO:0004407 histone deacetylase activity;GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism;GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism;GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism",
    "go_cellular_component": "GO:0000118 histone deacetylase complex",
    "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001755 neural crest cell migration;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0040029 epigenetic regulation of gene expression;GO:0036073 perichondral ossification",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0R4IAH0-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.010000.0000000000000001.00000.000"
}