{
    "uniprot_canonical_ac": "A0A0G2L7I0-1",
    "uniprot_id": [
        {
            "id": "SPRTN_DANRE",
            "url": "https://www.uniprot.org/uniprot/SPRTN_DANRE",
            "type": "external"
        }
    ],
    "mass": 70224.0,
    "length": 636,
    "protein_name": "DNA-dependent metalloprotease SPRTN",
    "gene_name": "sprtn",
    "organism": "Zebrafish",
    "refseq_name": "DNA-dependent metalloprotease SPRTN",
    "refseq_ac": [
        {
            "id": "NP_001410794",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410794",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "sprtn",
    "gene_names_refseq": "sprtn",
    "protein_names_uniprotkb": "DNA-dependent metalloprotease SPRTN; 3.4.24.-; Protein with SprT-like domain at the N terminus; Spartan",
    "protein_names_refseq": "DNA-dependent metalloprotease SPRTN; spartan; protein with SprT-like domain at the N terminus",
    "tax_id": 7955,
    "disease": "Ruijs-Aalfs syndrome (Disease Ontology:DOID:0111264)",
    "pathway": " (R-DRE-110320)",
    "pathway_count": 1,
    "publication_count": 4,
    "publication_id_list": "23594743;25261934;33514542;37788708",
    "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01008169.1, GDQH01020107.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA4476733 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from GDQH01020107.1, EH546539.1 and GDQQ01008169.1. On Aug 17, 2023 this sequence version replaced XP_005173863.1., [RefSeq]; DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Catalyzes proteolytic cleavage of the hmces DNA-protein cross-link following unfolding by the brip1/fancj helicase. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4. Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs. May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis. Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage., [UniProtKB, UniProtKB, UniProtKB]; Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks in vivo., [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "3.4.24.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
            "type": "external"
        },
        {
            "id": "3.6.4.6",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding",
    "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
    "go_biological_process": "GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0016540 protein autoprocessing;GO:0106300 protein-DNA covalent cross-linking repair",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2L7I0-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}