{
    "uniprot_canonical_ac": "A0A0G2K7T0-1",
    "uniprot_id": [
        {
            "id": "A0A0G2K7T0_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K7T0_RAT",
            "type": "external"
        }
    ],
    "mass": 43502.0,
    "length": 409,
    "protein_name": "Runt-related transcription factor",
    "gene_name": "Runx3",
    "organism": "Rat",
    "refseq_name": "runt-related transcription factor 3 isoform 1",
    "refseq_ac": [
        {
            "id": "NP_569109",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569109",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Runx3",
    "gene_names_refseq": "Runx3",
    "protein_names_uniprotkb": "Runt-related transcription factor",
    "protein_names_refseq": "Runt related transcription factor 3; runt-related transcription factor 3; runt-related transcription factor 3 isoform 1",
    "tax_id": 10116,
    "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); developmental disorder of mental health (Disease Ontology:DOID:0060037); idiopathic scoliosis (Disease Ontology:DOID:0060250); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); in situ carcinoma (Disease Ontology:DOID:8719)",
    "pathway": " (R-RNO-8941855);  (R-RNO-8941856);  (R-RNO-8941858);  (R-RNO-8951430);  (R-RNO-8951671);  (R-RNO-8951936)",
    "pathway_count": 6,
    "publication_count": 4,
    "publication_id_list": "31298391;31603252;32681471;36690210",
    "function": "Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX., [UniProtKB, UniProtKB]; RUNX3 protects against acute lung injury by inhibiting the JAK2/STAT3 pathway in rats with severe acute pancreatitis., [RefSeq, PubMed]; RUNX3-dependent oxidative epithelial-to-mesenchymal transition in methamphetamine-induced chronic lung injury., [RefSeq, PubMed]; Runt-related transcription factor 3, mediated by DNA-methyltransferase 1, regulated Schwann cell proliferation and myelination during peripheral nerve regeneration via JAK/STAT signaling pathway., [RefSeq, PubMed]; Sphingosine-1-phosphate receptor 2 modulates pain sensitivity by suppressing the ROS-RUNX3 pathway in a rat model of neuropathy., [RefSeq, PubMed]",
    "predicted_glycosites": 3,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 3,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 3,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 18,
    "glyco_site_count": 3,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
    "go_biological_process": "GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0071559 response to transforming growth factor beta;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0031175 neuron projection development",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2K7T0-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000001000.00010.001"
}