{
    "uniprot_canonical_ac": "A0A0G2K736-1",
    "uniprot_id": [
        {
            "id": "A0A0G2K736_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K736_RAT",
            "type": "external"
        }
    ],
    "mass": 94964.0,
    "length": 876,
    "protein_name": "Lysine-specific histone demethylase",
    "gene_name": "Kdm1a",
    "organism": "Rat",
    "refseq_name": "",
    "refseq_ac": [],
    "gene_names_uniprotkb": "Kdm1a; Aof2; Kdm1",
    "gene_names_refseq": "",
    "protein_names_uniprotkb": "Lysine-specific histone demethylase; 1.14.99.66",
    "protein_names_refseq": "",
    "tax_id": 10116,
    "disease": "breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); alopecia areata (Disease Ontology:DOID:986)",
    "pathway": " (rno:500569);  (R-RNO-3214815);  (R-RNO-3214842);  (R-RNO-5625886);  (R-RNO-9018519);  (R-RNO-983231)",
    "pathway_count": 6,
    "publication_count": 3,
    "publication_id_list": "21124846;22673903;29393594",
    "function": "Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 3,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 3,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 3,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 3,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 6,
    "glyco_site_count": 3,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "1.14.99.66",
            "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66",
            "type": "external"
        },
        {
            "id": "3.6.4.12",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
            "type": "external"
        },
        {
            "id": "3.5.1.98",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98",
            "type": "external"
        },
        {
            "id": "3.5.1.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
            "type": "external"
        },
        {
            "id": "2.7.11.13",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0032453 histone H3K4 demethylase activity;GO:0061752 telomeric repeat-containing RNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex;GO:1990391 DNA repair complex",
    "go_biological_process": "GO:0036211 protein modification process;GO:0030851 granulocyte differentiation;GO:2000648 positive regulation of stem cell proliferation;GO:0046098 guanine metabolic process;GO:0010725 regulation of primitive erythrocyte differentiation",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2K736-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000001000.00011.001"
}