{
    "uniprot_canonical_ac": "A0A0G2K2P5-1",
    "uniprot_id": [
        {
            "id": "ZO1_RAT",
            "url": "https://www.uniprot.org/uniprot/ZO1_RAT",
            "type": "external"
        }
    ],
    "mass": 197148.0,
    "length": 1765,
    "protein_name": "Tight junction protein ZO-1",
    "gene_name": "Tjp1",
    "organism": "Rat",
    "refseq_name": "tight junction protein ZO-1 isoform 1",
    "refseq_ac": [
        {
            "id": "XP_063140420",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063140420",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Tjp1",
    "gene_names_refseq": "Tjp1; ZO-1",
    "protein_names_uniprotkb": "Tight junction protein ZO-1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1",
    "protein_names_refseq": "tight junction protein ZO-1 isoform 1; zona occludens 1; tight junction protein ZO-1; zona occludens protein 1; zonula occludens protein 1",
    "tax_id": 10116,
    "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); uveitis (Disease Ontology:DOID:13141); cholestasis (Disease Ontology:DOID:13580); peptic esophagitis (Disease Ontology:DOID:13976); brain ischemia (Disease Ontology:DOID:2316); bile duct cancer (Disease Ontology:DOID:4606); gallbladder carcinoma (Disease Ontology:DOID:4948); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); brain disease (Disease Ontology:DOID:936)",
    "pathway": " (R-RNO-191650);  (R-RNO-2028269);  (R-RNO-351906)",
    "pathway_count": 3,
    "publication_count": 4,
    "publication_id_list": "16641100;22673903;3528172;9707407",
    "function": "TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9707407). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting Cdc42bpb to the leading edge of migrating cells (By similarity). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (By similarity). With Tjp2 and Tjp3, participates in the junctional retention and stability of the transcription factor Dbpa, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 46,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 9,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0071253 connexin binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0044325 transmembrane transporter binding;GO:0050839 cell adhesion molecule binding",
    "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
    "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0150105 protein localization to cell-cell junction;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0032496 response to lipopolysaccharide",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2K2P5-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.010000.0000000000001000.00011.001"
}