{
    "uniprot_canonical_ac": "A0A0G2K0H3-1",
    "uniprot_id": [
        {
            "id": "A0A0G2K0H3_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K0H3_RAT",
            "type": "external"
        }
    ],
    "mass": 180344.0,
    "length": 1613,
    "protein_name": "Low-density lipoprotein receptor-related protein",
    "gene_name": "Lrp6",
    "organism": "Rat",
    "refseq_name": "low-density lipoprotein receptor-related protein 6 isoform 2",
    "refseq_ac": [
        {
            "id": "NP_001388749",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388749",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Lrp6",
    "gene_names_refseq": "Lrp6",
    "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein",
    "protein_names_refseq": "low-density lipoprotein receptor-related protein 6 isoform 2; low-density lipoprotein receptor-related protein 6",
    "tax_id": 10116,
    "disease": "tooth agenesis (Disease Ontology:DOID:0050591); neural tube defect (Disease Ontology:DOID:0080074); steatotic liver disease (Disease Ontology:DOID:9452)",
    "pathway": " (R-RNO-3772470);  (R-RNO-4641262);  (R-RNO-4641263)",
    "pathway_count": 3,
    "publication_count": 5,
    "publication_id_list": "27250245;29864925;30070011;35347917;36913109",
    "function": "Changes of LRP6/beta-catenin pathway in adipose tissue of rats with intrauterine growth restriction with catch-up growth., [RefSeq, PubMed]; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes., [UniProtKB, UniProtKB]; Knockdown of LRP6 inhibited the cell viability by activation of Drp1 in glucose deprived-cardiomyocytes., [RefSeq, PubMed]; LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR., [RefSeq, PubMed]; LRP6 acts as a scaffold protein in cardiac gap junction assembly and intracellular protein trafficking. Publication Status: Online-Only, [RefSeq, PubMed]; LRP6 regulates alternative pre-mRNA splicing., [RefSeq, PubMed]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 3,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0015026 coreceptor activity;GO:0034185 apolipoprotein binding;GO:0042802 identical protein binding",
    "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane",
    "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:2000648 positive regulation of stem cell proliferation;GO:0050678 regulation of epithelial cell proliferation;GO:0060042 retina morphogenesis in camera-type eye",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2K0H3-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.010000.0000000000001000.00010.001"
}