{
    "uniprot_canonical_ac": "A0A0G2JXT6-1",
    "uniprot_id": [
        {
            "id": "MTMR6_RAT",
            "url": "https://www.uniprot.org/uniprot/MTMR6_RAT",
            "type": "external"
        }
    ],
    "mass": 75577.0,
    "length": 655,
    "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6",
    "gene_name": "Mtmr6",
    "organism": "Rat",
    "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 1",
    "refseq_ac": [
        {
            "id": "NP_001381640",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381640",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Mtmr6",
    "gene_names_refseq": "Mtmr6",
    "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; 3.1.3.95; Myotubularin-related protein 6; Phosphatidylinositol-3-phosphate phosphatase",
    "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 1; phosphatidylinositol-3-phosphate phosphatase; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6",
    "tax_id": 10116,
    "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717)",
    "pathway": " (R-RNO-1660499)",
    "pathway_count": 1,
    "publication_count": 2,
    "publication_id_list": "22673903;23188820",
    "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport (PubMed:23188820). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (By similarity)., [UniProtKB, PubMed, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 4,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 3,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "3.1.3.95",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95",
            "type": "external"
        },
        {
            "id": "3.1.3.36",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
            "type": "external"
        },
        {
            "id": "3.1.3.67",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
            "type": "external"
        },
        {
            "id": "3.1.3.86",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
            "type": "external"
        },
        {
            "id": "3.1.3.64",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity",
    "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0032587 ruffle membrane",
    "go_biological_process": "GO:0006897 endocytosis;GO:0046856 phosphatidylinositol dephosphorylation;GO:0006629 lipid metabolic process",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2JXT6-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000001000.00001.000"
}