{
    "uniprot_canonical_ac": "A0A0G2JWB6-1",
    "uniprot_id": [
        {
            "id": "A0A0G2JWB6_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWB6_RAT",
            "type": "external"
        }
    ],
    "mass": 165396.0,
    "length": 1475,
    "protein_name": "Peroxidasin",
    "gene_name": "Pxdn",
    "organism": "Rat",
    "refseq_name": "peroxidasin homolog precursor",
    "refseq_ac": [
        {
            "id": "NP_001258190",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258190",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Pxdn",
    "gene_names_refseq": "Perc64; Vpo1; Pxdn",
    "protein_names_uniprotkb": "Peroxidasin",
    "protein_names_refseq": "PE responsive protein c64; melanoma-associated antigen MG50; peroxidasin homolog; peroxidasin homolog precursor",
    "tax_id": 10116,
    "disease": "anterior segment dysgenesis 7 (Disease Ontology:DOID:0080612)",
    "pathway": " (rno:554172);  (R-RNO-2243919)",
    "pathway_count": 2,
    "publication_count": 6,
    "publication_id_list": "21292788;24021280;27651140;29186367;31216444;36029851",
    "function": "NOX/VPO1 pathway-derived reactive oxygen species promote the oxidative injury and dysfunctions of EPCs in PH, which may contribute to endothelial dysfunctions in PH, [RefSeq, PubMed]; The over-expression of VPO1 during the development of hypertension, accompanied by the endothelial dysfunction, the decreased NO levels, the elevated NOX and ROS activities, indicates a clear connection between VPO1 gene and hypertension.(VPO1), [RefSeq, PubMed]; VPO1 promotes cardiac remodeling by accelerating the Ang II-induced hypertrophy of H9c2 cell via the NOX2/VPO1/HOCl/ERK1/2 signaling pathways., [RefSeq, PubMed]; VPO1 promotes hypoxia-induced proliferation, apoptosis resistance, and migration in pulmonary artery smooth muscle cells via the NOX4/VPO1/HOCl/NF-kappaB signalling pathway., [RefSeq, PubMed]; Vascular peroxidase 1 promotes phenotypic transformation of pulmonary artery smooth muscle cells via ERK pathway in hypoxia-induced pulmonary hypertensive rats., [RefSeq, PubMed]; Vascular peroxidase 1/peroxidasin is a novel regulator of angiotensin II-induced vascular smooth muscle cell proliferation via NADPH oxidase-hydrogen peroxide pathways., [RefSeq, PubMed]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0005201 extracellular matrix structural constituent;GO:0004601 peroxidase activity",
    "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005604 basement membrane",
    "go_biological_process": "GO:0001525 angiogenesis;GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0051260 protein homooligomerization",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2JWB6-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.010000.0000000000001000.00010.001"
}