{
    "uniprot_canonical_ac": "A0A0G2JTZ2-1",
    "uniprot_id": [
        {
            "id": "SOX6_RAT",
            "url": "https://www.uniprot.org/uniprot/SOX6_RAT",
            "type": "external"
        }
    ],
    "mass": 91816.0,
    "length": 827,
    "protein_name": "Transcription factor SOX-6",
    "gene_name": "Sox6",
    "organism": "Rat",
    "refseq_name": "transcription factor SOX-6",
    "refseq_ac": [
        {
            "id": "NP_001019922",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Sox6; Sox-6",
    "gene_names_refseq": "Sox6",
    "protein_names_uniprotkb": "Transcription factor SOX-6",
    "protein_names_refseq": "SRY-box containing gene 6; SRY (sex determining region Y)-box 6; SRY box 6; transcription factor SOX-6",
    "tax_id": 10116,
    "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114); high grade glioma (Disease Ontology:DOID:3070)",
    "pathway": " (rno:293165);  (R-RNO-3769402)",
    "pathway_count": 2,
    "publication_count": 5,
    "publication_id_list": "12081133;26150426;26659076;31076992;32114773",
    "function": "LncRNA Gm4419 induces cell apoptosis in hepatic ischemia-reperfusion injury via regulating the miR-455-SOX6 axis., [RefSeq, PubMed]; Sox6 was specifically expressed in the neonatal brain and adult testis with Northern blotting., [RefSeq, PubMed]; The apoptosis process enhanced by overexpression of SOX6 or PDCD4, was rescued by the cardiac-abundant miR-499 in rat cardiomyocytes., [RefSeq, PubMed]; The authors proved that miR-499-5p inhibited hypoxia/reoxygenation-induced cardiomyocytes injury by targeting SOX6., [RefSeq, PubMed]; Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (By similarity). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis (By similarity). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (By similarity). Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity)., [UniProtKB, PubMed, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 7,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 3,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm",
    "go_biological_process": "GO:0030154 cell differentiation;GO:0048708 astrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006357 regulation of transcription by RNA polymerase II",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2JTZ2-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000001000.00001.000"
}