{
    "uniprot_canonical_ac": "A0A0G2JTR4-1",
    "uniprot_id": [
        {
            "id": "ABR_RAT",
            "url": "https://www.uniprot.org/uniprot/ABR_RAT",
            "type": "external"
        }
    ],
    "mass": 97693.0,
    "length": 859,
    "protein_name": "Active breakpoint cluster region-related protein",
    "gene_name": "Abr",
    "organism": "Rat",
    "refseq_name": "active breakpoint cluster region-related protein",
    "refseq_ac": [
        {
            "id": "NP_001099284",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099284",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Abr",
    "gene_names_refseq": "Abr",
    "protein_names_uniprotkb": "Active breakpoint cluster region-related protein",
    "protein_names_refseq": "ABR, RhoGEF and GTPase activating protein; active BCR-related; breakpoint cluster region protein-like; active breakpoint cluster region-related protein",
    "tax_id": 10116,
    "disease": "",
    "pathway": " (rno:287537);  (R-RNO-193648);  (R-RNO-416482);  (R-RNO-8980692);  (R-RNO-9013026);  (R-RNO-9013148);  (R-RNO-9013149);  (R-RNO-9013404)",
    "pathway_count": 8,
    "publication_count": 2,
    "publication_id_list": "20962234;22673903",
    "function": "Breakpoint cluster region and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions, [RefSeq, PubMed]; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 5,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0004674 protein serine/threonine kinase activity",
    "go_cellular_component": "GO:0030424 axon;GO:0043197 dendritic spine;GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane",
    "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:1905522 negative regulation of macrophage migration;GO:0016477 cell migration;GO:0032496 response to lipopolysaccharide",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0G2JTR4-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.100000.0000000000001000.00011.001"
}