{
    "uniprot_canonical_ac": "A0A0E3D804-1",
    "uniprot_id": [
        {
            "id": "A0A0E3D804_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0E3D804_DANRE",
            "type": "external"
        }
    ],
    "mass": 113199.0,
    "length": 997,
    "protein_name": "RNA helicase",
    "gene_name": "ifih1",
    "organism": "Zebrafish",
    "refseq_name": "interferon-induced helicase C domain-containing protein 1",
    "refseq_ac": [
        {
            "id": "NP_001295492",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295492",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "ifih1; MDA5a; MDA5b; si:dkey-81j5.2",
    "gene_names_refseq": "MDA5a; MDA5b; si:dkey-81j5.2; ifih1",
    "protein_names_uniprotkb": "RNA helicase; 3.6.4.13",
    "protein_names_refseq": "interferon-induced helicase C domain-containing protein 1; melanoma differentiation-associated protein 5a; melanoma differentiation-associated protein 5b; mda5",
    "tax_id": 7955,
    "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); immunodeficiency 95 (Disease Ontology:DOID:0061065); Fanconi anemia (Disease Ontology:DOID:13636); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
    "pathway": " (dre:565759);  (R-DRE-5689880)",
    "pathway_count": 2,
    "publication_count": 12,
    "publication_id_list": "19474100;20728541;23594743;24116956;24683187;25100833;25445907;35764162;35982787;36314827;36577070;38077314",
    "function": "##Evidence-Data-START## Transcript exon combination :: JX462556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476806, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JX462556.1. On May 13, 2015 this sequence version replaced XP_694124.4. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A zebrafish model of Ifih1-driven Aicardi-Goutieres syndrome reproduces the interferon signature and the exacerbated inflammation of patients. Publication Status: Online-Only, [RefSeq, PubMed]; Shorter spliced form, MDA5b when co-transfected with MDA5a or mitochondrial antiviral signalling protein (MAVS), induced a significantly higher level of interferon promoter activity, [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 4,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "3.6.4.13",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
            "type": "external"
        },
        {
            "id": "2.3.2.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
            "type": "external"
        },
        {
            "id": "2.3.2.27",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
            "type": "external"
        },
        {
            "id": "3.6.4.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
            "type": "external"
        },
        {
            "id": "2.7.4.3",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
            "type": "external"
        },
        {
            "id": "5.6.1.6",
            "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
            "type": "external"
        },
        {
            "id": "3.6.4.12",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
            "type": "external"
        },
        {
            "id": "5.6.2.4",
            "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
            "type": "external"
        },
        {
            "id": "3.6.4.6",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
            "type": "external"
        },
        {
            "id": "3.1.-.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
            "type": "external"
        },
        {
            "id": "3.6.1.5",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
            "type": "external"
        },
        {
            "id": "5.6.2.3",
            "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
            "type": "external"
        },
        {
            "id": "3.6.1.15",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
            "type": "external"
        },
        {
            "id": "5.6.2.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
            "type": "external"
        },
        {
            "id": "3.6.1.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0046982 protein heterodimerization activity",
    "go_cellular_component": "GO:0005737 cytoplasm",
    "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0039530 MDA-5 signaling pathway;GO:0140374 antiviral innate immune response",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0E3D804-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.010000.0000000000000001.00000.000"
}