{
    "uniprot_canonical_ac": "A0A0B4K692-1",
    "uniprot_id": [
        {
            "id": "NEP2_DROME",
            "url": "https://www.uniprot.org/uniprot/NEP2_DROME",
            "type": "external"
        }
    ],
    "mass": 88125.0,
    "length": 774,
    "protein_name": "Neprilysin-2",
    "gene_name": "Nep2",
    "organism": "Fruit fly",
    "refseq_name": "neprilysin 2, isoform B",
    "refseq_ac": [
        {
            "id": "NP_001246914",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Nep2; CG9761",
    "gene_names_refseq": "BcDNA:GH07643; CG9761; Dmel\\CG9761; DmNEP2; dNEP2; nep2; NEP2; Nep2",
    "protein_names_uniprotkb": "Neprilysin-2; 3.4.24.11",
    "protein_names_refseq": "CG9761-PB; Nep2-PB; neprilysin-2; neprilysin 2; neprilysin 2, isoform B",
    "tax_id": 7227,
    "disease": "Charcot-Marie-Tooth disease axonal type 2T (Disease Ontology:DOID:0110160); cerebellar ataxia type 43 (Disease Ontology:DOID:0111745); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); diarrhea (Disease Ontology:DOID:13250); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)",
    "pathway": " (dme:Dmel_CG9761);  (R-DME-2022377);  (R-DME-5578768);  (R-DME-6798695)",
    "pathway_count": 4,
    "publication_count": 7,
    "publication_id_list": "10731132;10731138;12537572;15554877;17157960;24395329;27629706",
    "function": "Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PubMed:24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PubMed:27629706)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
    "predicted_glycosites": 8,
    "predicted_n_glycosites": 8,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 8,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 10,
    "glyco_site_count": 8,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "3.4.24.11",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11",
            "type": "external"
        },
        {
            "id": "3.4.24.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
            "type": "external"
        },
        {
            "id": "3.1.3.48",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
            "type": "external"
        },
        {
            "id": "3.6.5.2",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
            "type": "external"
        },
        {
            "id": "2.4.1.244",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.244",
            "type": "external"
        },
        {
            "id": "3.4.11.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-",
            "type": "external"
        },
        {
            "id": "2.4.-.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding",
    "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane",
    "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0046692 sperm competition",
    "synthesized_glycan_count": 0,
    "record_id": "A0A0B4K692-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000100000000000.00100.001"
}