{
    "uniprot_canonical_ac": "A0A096MJN4-1",
    "uniprot_id": [
        {
            "id": "SEPT4_RAT",
            "url": "https://www.uniprot.org/uniprot/SEPT4_RAT",
            "type": "external"
        }
    ],
    "mass": 53083.0,
    "length": 459,
    "protein_name": "Septin-4",
    "gene_name": "Septin4",
    "organism": "Rat",
    "refseq_name": "septin-4 isoform 5",
    "refseq_ac": [
        {
            "id": "NP_001401264",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401264",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Septin4; Arts; Bh5; Gm11492; Pnut12; Sep4; Sept4",
    "gene_names_refseq": "EG3-1RVC; EG3RVC; hCDCREL-2; Pnutl2; Sept4; Septin4",
    "protein_names_uniprotkb": "Septin-4; Apoptosis-related protein in the TGF-beta signaling pathway; Arts; Bradeion beta; Brain protein H5; CE5B3 beta; Cell division control-related protein 2; Peanut-like protein 2; hCDCREL-2",
    "protein_names_refseq": "expression gene 3 in rat visual cortex; expression gene 3-1 in rat visual cortex; peanut-like 2; arts; CE5B3 beta; bradeion beta; brain protein H5; peanut-like protein 2; cell division control-related protein 2; apoptosis-related protein in the TGF-beta signaling pathway; septin-4 isoform 5",
    "tax_id": 10116,
    "disease": "Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330)",
    "pathway": " (R-RNO-111457);  (R-RNO-111469)",
    "pathway_count": 2,
    "publication_count": 2,
    "publication_id_list": "18938227;22673903",
    "function": "Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase. Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity)., [UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 8,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 2,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding",
    "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030424 axon",
    "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0048729 tissue morphogenesis;GO:2000647 negative regulation of stem cell proliferation;GO:0043065 positive regulation of apoptotic process;GO:0001764 neuron migration",
    "synthesized_glycan_count": 0,
    "record_id": "A0A096MJN4-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000001000.00001.000"
}