{
    "uniprot_canonical_ac": "A0A096MJE4-1",
    "uniprot_id": [
        {
            "id": "A0A096MJE4_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A096MJE4_RAT",
            "type": "external"
        }
    ],
    "mass": 24898.0,
    "length": 223,
    "protein_name": "Cytotoxic T-lymphocyte protein 4",
    "gene_name": "Ctla4",
    "organism": "Rat",
    "refseq_name": "",
    "refseq_ac": [],
    "gene_names_uniprotkb": "Ctla4",
    "gene_names_refseq": "",
    "protein_names_uniprotkb": "Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4",
    "protein_names_refseq": "",
    "tax_id": 10116,
    "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); lupus nephritis (Disease Ontology:DOID:0080162); latent autoimmune diabetes in adults (Disease Ontology:DOID:0080846); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); type 1 diabetes mellitus 12 (Disease Ontology:DOID:0110751); silicosis (Disease Ontology:DOID:10325); celiac disease (Disease Ontology:DOID:10608); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); hepatitis A (Disease Ontology:DOID:12549); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); urinary schistosomiasis (Disease Ontology:DOID:1394); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune hemolytic anemia (Disease Ontology:DOID:718); autoimmune thyroiditis (Disease Ontology:DOID:7188); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)",
    "pathway": " (R-RNO-389356);  (R-RNO-389513)",
    "pathway_count": 2,
    "publication_count": 0,
    "publication_id_list": "",
    "function": "Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28., [UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 50,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "",
    "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane;GO:0045334 clathrin-coated endocytic vesicle",
    "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0042130 negative regulation of T cell proliferation;GO:0050852 T cell receptor signaling pathway;GO:0006974 DNA damage response;GO:0002250 adaptive immune response",
    "synthesized_glycan_count": 0,
    "record_id": "A0A096MJE4-1",
    "record_type": "protein",
    "filter_code": "0000000.0000011.100000.0000000000001000.00000.000"
}