{
    "uniprot_canonical_ac": "A0A096MJ11-1",
    "uniprot_id": [
        {
            "id": "A0A096MJ11_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A096MJ11_RAT",
            "type": "external"
        }
    ],
    "mass": 53213.0,
    "length": 488,
    "protein_name": "Gasdermin D",
    "gene_name": "Gsdmd",
    "organism": "Rat",
    "refseq_name": "gasdermin-D",
    "refseq_ac": [
        {
            "id": "NP_001387922",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387922",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Gsdmd",
    "gene_names_refseq": "Gsdmdc1; Gsdmd",
    "protein_names_uniprotkb": "Gasdermin D",
    "protein_names_refseq": "gasdermin domain containing 1; gasdermin-D",
    "tax_id": 10116,
    "disease": "",
    "pathway": " (R-RNO-111457);  (R-RNO-111458);  (R-RNO-111461);  (R-RNO-448706);  (R-RNO-5620971);  (R-RNO-5686938);  (R-RNO-6798695)",
    "pathway_count": 7,
    "publication_count": 7,
    "publication_id_list": "30161099;30600840;36040608;36224321;36988259;37549514;37578618",
    "function": "Authors demonstrated that the NF-kappaB-GSDMD axis functioned as a bridge between oxidative stress and NLRP3 inflammasome-mediated cardiomyocyte pyroptosis. Findings provide important insight into the mechanism of myocardial infarction-related ventricular remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Bone marrow stromal cell-derived exosomes improve oxidative stress and pyroptosis in doxorubicin-induced myocardial injury in vitro by regulating the transcription of GSDMD through the PI3K-AKT-Foxo1 pathway., [RefSeq, PubMed]; Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury., [RefSeq, PubMed]; Exosome miR-223-3p in the bone marrow-derived mesenchymal stem cells alleviates the inflammation and airway remodeling through NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway., [RefSeq, PubMed]; MTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental Sevoflurane Neurotoxicity., [RefSeq, PubMed]; Role of Transcription Factor Nrf2 in Pyroptosis in Spinal Cord Injury by Regulating GSDMD., [RefSeq, PubMed]; Study suggests that Gasdermin D may participate in caspase-1-mediated pyroptosis during cerebral ischemia and reperfusion injury both in vivo and in vitro, which could be a potential therapeutic target to reduce brain cerebral ischemia and reperfusion injury., [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0070300 phosphatidic acid binding;GO:0022829 wide pore channel activity",
    "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane",
    "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051260 protein homooligomerization;GO:0050729 positive regulation of inflammatory response;GO:0042742 defense response to bacterium",
    "synthesized_glycan_count": 0,
    "record_id": "A0A096MJ11-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.100000.0000000000001000.00000.000"
}