{ "uniprot_canonical_ac": "A0A087X1C5-1", "uniprot_id": [ { "id": "CP2D7_HUMAN", "url": "https://www.uniprot.org/uniprot/CP2D7_HUMAN", "type": "external" } ], "mass": 57489.0, "length": 515, "protein_name": "Putative cytochrome P450 2D7", "gene_name": "CYP2D7", "organism": "Human", "refseq_name": "putative cytochrome P450 2D7", "refseq_ac": [ { "id": "NP_001335315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335315", "type": "external" } ], "gene_names_uniprotkb": "CYP2D7", "gene_names_refseq": "CYP2D7; CYP2D; CYP2D6; CYP2D7AP; CYP2D7P; CYP2D7P1; CYP2D@; P450C2D; P450DB1; RNA40057", "protein_names_uniprotkb": "Putative cytochrome P450 2D7; 1.14.14.1", "protein_names_refseq": "cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing) cluster; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 1; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1; cytochrome P4502D6; nonfunctional cytochrome P450 family 2 subfamily D polypeptide 6; putative cytochrome P450 2D7", "tax_id": 9606, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); traumatic brain injury (Disease Ontology:DOID:0081292); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); spondylometaphyseal dysplasia corner fracture type (Disease Ontology:DOID:0112297); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); submandibular gland disease (Disease Ontology:DOID:12897); VACTERL association (Disease Ontology:DOID:14679); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (hsa:1564)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15051713;16169517;17494644;18838503;29557506;30040020;31154438;37938771;39060884", "function": "Association Between CYP2D7 and TCF20 Polymorphisms and Coronary Heart Disease., [RefSeq, PubMed]; May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503)., [UniProtKB, PubMed, PubMed]; The loss of the stop codon in CYP2D7 does not result in the generation of enzymatically active protein in human liver., [RefSeq, PubMed]; This gene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is a segregating pseudogene, where some individuals may have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. In this case, the functional allele is thought to be rare. This locus is part of a cluster of cytochrome P450 genes on chromosome 22. [provided by RefSeq, Jan 2017]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.55", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.55", "type": "external" }, { "id": "1.14.14.56", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.56", "type": "external" }, { "id": "1.14.14.73", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.73", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.51", "type": "external" }, { "id": "1.14.14.52", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.52", "type": "external" }, { "id": "1.14.14.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.53", "type": "external" }, { "id": "1.14.14.75", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.75", "type": "external" }, { "id": "1.14.14.78", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.78", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.130", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.130", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "record_id": "A0A087X1C5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.0000000001000000.00100.001" }