{
    "uniprot_canonical_ac": "A0A087WPF7-1",
    "uniprot_id": [
        {
            "id": "AUTS2_MOUSE",
            "url": "https://www.uniprot.org/uniprot/AUTS2_MOUSE",
            "type": "external"
        }
    ],
    "mass": 138920.0,
    "length": 1261,
    "protein_name": "Autism susceptibility gene 2 protein homolog",
    "gene_name": "Auts2",
    "organism": "Mouse",
    "refseq_name": "autism susceptibility gene 2 protein homolog",
    "refseq_ac": [
        {
            "id": "NP_796021",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796021",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Auts2; Kiaa0442",
    "gene_names_refseq": "2700063G02Rik; A730011F23Rik; D830032G16Rik; Auts2",
    "protein_names_uniprotkb": "Autism susceptibility gene 2 protein homolog",
    "protein_names_refseq": "autism susceptibility gene 2 protein homolog",
    "tax_id": 10090,
    "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autosomal dominant intellectual developmental disorder (Disease Ontology:DOID:0060307); autosomal dominant intellectual developmental disorder 26 (Disease Ontology:DOID:0070056); microcephaly (Disease Ontology:DOID:10907); alcohol use disorder (Disease Ontology:DOID:1574)",
    "pathway": " (R-MMU-8939243)",
    "pathway_count": 1,
    "publication_count": 7,
    "publication_id_list": "10.1101/2023.09.13.557529;19948250;21750661;25519132;25533347;34203471;34428180",
    "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation (By similarity). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (PubMed:25533347)., [UniProtKB, UniProtKB, PubMed]",
    "predicted_glycosites": 3,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 3,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 2,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 2,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 2,
    "total_o_glycosites": 3,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 15,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 1,
    "reported_interactions": 0,
    "missing_score": 9803,
    "biomarker_type": "",
    "glycan_count": 2,
    "disease_count": 5,
    "glyco_site_count": 5,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0003682 chromatin binding",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030426 growth cone",
    "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration;GO:0030036 actin cytoskeleton organization;GO:0060013 righting reflex;GO:0035022 positive regulation of Rac protein signal transduction",
    "synthesized_glycan_count": 0,
    "record_id": "A0A087WPF7-1",
    "record_type": "protein",
    "filter_code": "0000000.1000111.010000.0000000000100000.10011.001"
}