{ "disease_id": "DOID:10933", "recommended_name": { "id": "DOID:10933", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10933", "name": "obsessive-compulsive disorder", "description": "An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions)." }, "synonyms": [ { "id": "DOID:10933", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10933", "name": "Anancastic neurosis", "description": "" }, { "id": "DOID:10933", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10933", "name": "obsessive compulsive disorder", "description": "" }, { "id": "MONDO:0008114", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008114", "name": "obsessive-compulsive disorder", "description": "A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety." }, { "id": "MONDO:0008114", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008114", "name": "Anancastic neurosis", "description": "" }, { "id": "MONDO:0008114", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008114", "name": "obsessive compulsive disorder", "description": "" }, { "id": "MONDO:0008114", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008114", "name": "obsessive-compulsive disorder", "description": "" }, { "id": "MONDO:0008114", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008114", "name": "obsessive-compulsive disorder, susceptibility to", "description": "" }, { "id": "MONDO:0008114", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008114", "name": "OCD", "description": "" } ], "children": [], "id_list": [ "DOID:10933" ], "unlinked_id_list": [], "crossref": [ { "id": "DOID:10933", "database": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10933", "categories": [] }, { "id": "MONDO:0008114", "database": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008114", "categories": [] } ], "proteins": [ { "uniprot_canonical_ac": "A0A0B4KFU6-1", "uniprot_ac": "A0A0B4KFU6", "uniprot_id": "A0A0B4KFU6_DROME", "refseq_ac": "NP_001262373", "glycoprotein": "yes", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "protein_names": [ { "name": "5-hydroxytryptamine (Serotonin) receptor 2B, isoform E", "resource": "UniProtKB", "type": "synonym" }, { "name": "5-hydroxytryptamine (serotonin) receptor 2B, isoform E", "resource": "RefSeq", "type": "synonym" }, { "name": "CG42796-PE; 5-HT2B-PE", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "5-HT2B", "resource": "UniProtKB", "type": "recommended" }, { "name": "5-HT-2b; 5-HT[[2B]]; 5HT1b; 5HT2b; 5HT2B; anon-WO0170980.94; anon-WO0170980.95; anon-WO0170980.97; anon-WO0170980.98; CG42796; CG7994; CG8007; d5-HT2B; Dm5-ht2b; Dm5-HT2B; Dm5-HT[[2B]]; Dmel\\CG42796", "resource": "RefSeq", "type": "synonym" }, { "name": "5-HT-2b", "resource": "UniProtKB", "type": "synonym" }, { "name": "5-HT2B", "resource": "RefSeq", "type": "synonym" }, { "name": "5-HT[[2B]]", "resource": "UniProtKB", "type": "synonym" }, { "name": "5HT1b", "resource": "UniProtKB", "type": "synonym" }, { "name": "5HT2B", "resource": "UniProtKB", "type": "synonym" }, { "name": "5HT2b", "resource": "UniProtKB", "type": "synonym" }, { "name": "CG42796", "resource": "UniProtKB", "type": "synonym" }, { "name": "CG7994", "resource": "UniProtKB", "type": "synonym" }, { "name": "CG8007", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dm5-HT2B", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dm5-HT[[2B]]", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dm5-ht2b", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel\\CG42796", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel_CG42796", "resource": "UniProtKB", "type": "synonym" }, { "name": "anon-WO0170980.94", "resource": "UniProtKB", "type": "synonym" }, { "name": "anon-WO0170980.95", "resource": "UniProtKB", "type": "synonym" }, { "name": "anon-WO0170980.97", "resource": "UniProtKB", "type": "synonym" }, { "name": "anon-WO0170980.98", "resource": "UniProtKB", "type": "synonym" }, { "name": "d5-HT2B", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "P08646-1", "uniprot_ac": "P08646", "uniprot_id": "RAS1_DROME", "refseq_ac": "NP_476699", "glycoprotein": "no", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "protein_names": [ { "name": "Ras-like protein 1", "resource": "UniProtKB", "type": "recommended" }, { "name": "3.6.5.2", "resource": "UniProtKB", "type": "synonym" }, { "name": "CG9375-PA; Ras85D-PA; Ras GTPase; enhancer of faf; Ras1; Ras oncogene at 85B", "resource": "RefSeq", "type": "synonym" }, { "name": "Dmras85D", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dras1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Ras oncogene at 85D", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "Ras85D", "resource": "UniProtKB", "type": "recommended" }, { "name": "C-ras1; CG9375; D-Ras; D-ras-1; D-ras1; D-Ras1; Dm Ras1; Dmel\\CG9375; Dmras85D; dRas; Dras; DRas; dras1; dRas1; dRAS1; Dras1; DRAS1; dRas85D; Dras85D; DRas85D/Ras; E(faf); E(sev)3C; EC3-3; EK3-4; fs(3)05703; l(3)06677; l(3)s1747; P08646; p21[Ras1]; ras; Ras; RAS; ras 1; Ras 85D; Ras-1; Ras.85D; ras1; Ras1; RAS1; Ras1/RAs85D; Ras185D; Ras85; ras85B; ras85D; Ras85d; RAS85D; Ras85DNt; RasI; Rasv12; RasV12; ras[V12]; Ras[V12]; RTK; S35097; Su(tor)3-2", "resource": "RefSeq", "type": "synonym" }, { "name": "CG9375", "resource": "UniProtKB", "type": "synonym" }, { "name": "Ras1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Ras85D", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "P51905-1", "uniprot_ac": "P51905", "uniprot_id": "SC6A4_DROME", "refseq_ac": "NP_001286839", "glycoprotein": "yes", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "protein_names": [ { "name": "Sodium-dependent serotonin transporter", "resource": "UniProtKB", "type": "recommended" }, { "name": "5HT transporter", "resource": "UniProtKB", "type": "synonym" }, { "name": "5HTT", "resource": "UniProtKB", "type": "synonym" }, { "name": "CG4545-PB; SerT-PB; drosophila serotonin transporter; cocaine-sensitive serotonin transporter", "resource": "RefSeq", "type": "synonym" }, { "name": "Cocaine-sensitive serotonin transporter", "resource": "UniProtKB", "type": "synonym" }, { "name": "dSERT1", "resource": "UniProtKB", "type": "synonym" }, { "name": "serotonin transporter, isoform B", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "SerT", "resource": "UniProtKB", "type": "recommended" }, { "name": "CG4545; Dmel\\CG4545; dmSERT; DmSerT; DmSERT; dsert; dSert; dSerT; dSERT; dSERT1; serT; Sert; SERT", "resource": "RefSeq", "type": "synonym" }, { "name": "CG4545", "resource": "UniProtKB", "type": "synonym" }, { "name": "DmSERT", "resource": "UniProtKB", "type": "synonym" }, { "name": "DmSerT", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel\\CG4545", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel_CG4545", "resource": "UniProtKB", "type": "synonym" }, { "name": "SERT", "resource": "UniProtKB", "type": "synonym" }, { "name": "SerT", "resource": "RefSeq", "type": "synonym" }, { "name": "Sert", "resource": "UniProtKB", "type": "synonym" }, { "name": "dSERT1", "resource": "UniProtKB", "type": "synonym" }, { "name": "dSERT", "resource": "UniProtKB", "type": "synonym" }, { "name": "dSerT", "resource": "UniProtKB", "type": "synonym" }, { "name": "dSert", "resource": "UniProtKB", "type": "synonym" }, { "name": "dmSERT", "resource": "UniProtKB", "type": "synonym" }, { "name": "dsert", "resource": "UniProtKB", "type": "synonym" }, { "name": "serT", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "Q9VWW0-1", "uniprot_ac": "Q9VWW0", "uniprot_id": "CREBB_DROME", "refseq_ac": "NP_001097016", "glycoprotein": "yes", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "protein_names": [ { "name": "Cyclic AMP response element-binding protein B", "resource": "UniProtKB", "type": "recommended" }, { "name": "CG6103-PP; CrebB-PP; cyclic AMP response element binding protein; cAMP-response element-binding protein; lethal(1)17Af; Cyclic-AMP response element binding protein B at 17A; CREB; cAMP-response element binding protein; cAMP-regulated enhancer-binding protein; dCREB2; cAMP response element binding; cAMP response-element binding protein; blocker; cAMP response element-binding protein; activator; Cyclic-AMP response element binding protein B at 17B", "resource": "RefSeq", "type": "synonym" }, { "name": "Cyclic-AMP response element binding protein B, isoform P", "resource": "RefSeq", "type": "synonym" }, { "name": "cAMP response element-binding protein B", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB-B", "resource": "UniProtKB", "type": "synonym" } ], "gene_names": [ { "name": "CrebB", "resource": "UniProtKB", "type": "recommended" }, { "name": "CG6103; CRE-BP; Creb; CREB; Creb B 17A; Creb-B; CREB-b; CREB-B; Creb17A; creb2; Creb2; CREB2; Creb2-b; CREB2-b; Creb2.b; CREB2a; Creb2b; CREB2b; crebB; CrebB-17A; CrebB-17B; CrebB17-A; dCbz; dCREB; dCREB-2; dCREB-2a; dCREB-B; dCreb2; dCREB2; dCREB2-a; dcreb2-b; dCreb2-b; dCREB2-b; dCREB2a; dCreb2b; dCREB2b; dCrebB2; DM9; Dmel\\CG6103; FBgn0014467; l(1)17Af; S162", "resource": "RefSeq", "type": "synonym" }, { "name": "CG6103", "resource": "UniProtKB", "type": "synonym" }, { "name": "CRE-BP", "resource": "UniProtKB", "type": "synonym" }, { "name": "CREB-B", "resource": "UniProtKB", "type": "synonym" }, { "name": "CREB-b", "resource": "UniProtKB", "type": "synonym" }, { "name": "CREB2-b", "resource": "UniProtKB", "type": "synonym" }, { "name": "CREB2a", "resource": "UniProtKB", "type": "synonym" }, { "name": "CREB2b", "resource": "UniProtKB", "type": "synonym" }, { "name": "CREB2", "resource": "UniProtKB", "type": "synonym" }, { "name": "CREB", "resource": "UniProtKB", "type": "synonym" }, { "name": "Creb B 17A", "resource": "UniProtKB", "type": "synonym" }, { "name": "Creb-B", "resource": "UniProtKB", "type": "synonym" }, { "name": "Creb17A", "resource": "UniProtKB", "type": "synonym" }, { "name": "Creb2-b", "resource": "UniProtKB", "type": "synonym" }, { "name": "Creb2.b", "resource": "UniProtKB", "type": "synonym" }, { "name": "Creb2b", "resource": "UniProtKB", "type": "synonym" }, { "name": "Creb2", "resource": "UniProtKB", "type": "synonym" }, { "name": "CrebB-17A-RF", "resource": "UniProtKB", "type": "synonym" }, { "name": "CrebB-17A", "resource": "UniProtKB", "type": "synonym" }, { "name": "CrebB-17B", "resource": "UniProtKB", "type": "synonym" }, { "name": "CrebB17-A", "resource": "UniProtKB", "type": "synonym" }, { "name": "CrebB", "resource": "RefSeq", "type": "synonym" }, { "name": "Creb", "resource": "UniProtKB", "type": "synonym" }, { "name": "DM9", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel\\CG6103", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel_CG6103", "resource": "UniProtKB", "type": "synonym" }, { "name": "FBgn0014467", "resource": "UniProtKB", "type": "synonym" }, { "name": "S162", "resource": "UniProtKB", "type": "synonym" }, { "name": "creb2", "resource": "UniProtKB", "type": "synonym" }, { "name": "crebB", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB-2a", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB-2", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB-B", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB2-a", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB2-b", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB2a", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB2b", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB2", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCREB", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCbz", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCreb2-b", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCreb2b", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCreb2", "resource": "UniProtKB", "type": "synonym" }, { "name": "dCrebB2", "resource": "UniProtKB", "type": "synonym" }, { "name": "dcreb2-b", "resource": "UniProtKB", "type": "synonym" }, { "name": "l(1)17Af", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "P21237-1", "uniprot_ac": "P21237", "uniprot_id": "BDNF_MOUSE", "refseq_ac": "NP_001041604", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Neurotrophic factor BDNF precursor form", "resource": "UniProtKB", "type": "recommended" }, { "name": "Brain-derived neurotrophic factor", "resource": "UniProtKB", "type": "synonym" }, { "name": "neurotrophic factor BDNF precursor form isoform 2 preproprotein", "resource": "RefSeq", "type": "synonym" }, { "name": "proBDNF; neurotrophic factor BDNF precursor form", "resource": "RefSeq", "type": "synonym" }, { "name": "proBDNF", "resource": "UniProtKB", "type": "synonym" } ], "gene_names": [ { "name": "Bdnf", "resource": "UniProtKB", "type": "recommended" }, { "name": "Bdnf", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "O88587-1", "uniprot_ac": "O88587", "uniprot_id": "COMT_MOUSE", "refseq_ac": "NP_001104532", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Catechol O-methyltransferase", "resource": "UniProtKB", "type": "recommended" }, { "name": "2.1.1.6", "resource": "UniProtKB", "type": "synonym" }, { "name": "catechol O-methyltransferase", "resource": "RefSeq", "type": "synonym" }, { "name": "catechol-O-methyltransferase 1", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "Comt", "resource": "UniProtKB", "type": "recommended" }, { "name": "Comt1; D16Wsu103e; D330014B15Rik", "resource": "RefSeq", "type": "synonym" }, { "name": "Comt1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Comt", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "P35363-1", "uniprot_ac": "P35363", "uniprot_id": "5HT2A_MOUSE", "refseq_ac": "NP_766400", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "5-hydroxytryptamine receptor 2A", "resource": "UniProtKB", "type": "recommended" }, { "name": "5-HT-2A", "resource": "UniProtKB", "type": "synonym" }, { "name": "5-HT-2", "resource": "UniProtKB", "type": "synonym" }, { "name": "5-hydroxytryptamine 2 receptor; 5-HT2A receptor", "resource": "RefSeq", "type": "synonym" }, { "name": "5-hydroxytryptamine receptor 2A", "resource": "RefSeq", "type": "synonym" }, { "name": "Serotonin receptor 2A", "resource": "UniProtKB", "type": "synonym" } ], "gene_names": [ { "name": "Htr2a", "resource": "UniProtKB", "type": "recommended" }, { "name": "5-HT-2; 5-HT-2A; E030013E04; Htr-2; Htr2", "resource": "RefSeq", "type": "synonym" }, { "name": "Htr2a", "resource": "RefSeq", "type": "synonym" }, { "name": "Htr2", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "Q61411-1", "uniprot_ac": "Q61411", "uniprot_id": "RASH_MOUSE", "refseq_ac": "NP_001123915", "glycoprotein": "no", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "GTPase HRas", "resource": "UniProtKB", "type": "recommended" }, { "name": "3.6.5.2", "resource": "UniProtKB", "type": "synonym" }, { "name": "GTPase HRas isoform 1", "resource": "RefSeq", "type": "synonym" }, { "name": "GTPase HRas; H-ras 1 protein; transforming protein P21; c-Ha-ras transgene; c-Ha-ras p21 protein; p21ras; H-Ras-1; Harvey rat sarcoma virus oncogene 1", "resource": "RefSeq", "type": "synonym" }, { "name": "H-Ras-1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Transforming protein p21", "resource": "UniProtKB", "type": "synonym" }, { "name": "c-H-ras", "resource": "UniProtKB", "type": "synonym" }, { "name": "p21ras", "resource": "UniProtKB", "type": "synonym" } ], "gene_names": [ { "name": "Hras", "resource": "UniProtKB", "type": "recommended" }, { "name": "Hras1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Hras", "resource": "RefSeq", "type": "synonym" }, { "name": "c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; Hras-1; Hras1; Kras2; ras", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "10933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10933" } ] }, { "uniprot_canonical_ac": "Q60857-1", "uniprot_ac": "Q60857", "uniprot_id": "SC6A4_MOUSE", "refseq_ac": "NP_034614", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Sodium-dependent serotonin transporter", "resource": "UniProtKB", "type": "recommended" }, { "name": "5HT transporter", "resource": "UniProtKB", "type": "synonym" }, { "name": "5HTT", "resource": "UniProtKB", "type": "synonym" }, { "name": "SERT", "resource": "UniProtKB", "type": "synonym" }, { "name": "Solute carrier family 6 member 4", "resource": "UniProtKB", "type": "synonym" }, { "name": "sodium-dependent serotonin transporter", "resource": "RefSeq", "type": "synonym" }, { "name": "solute carrier family 6 member 4; 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