{
    "disease_id": "DOID:1035",
    "recommended_name": {
        "id": "DOID:1035",
        "resource": "Disease Ontology",
        "url": "http://disease-ontology.org/term/DOID:1035",
        "name": "aggressive NK-cell leukemia",
        "description": "A leukemia that is characterized by the systemic proliferation of NK cells closely associated with Epstein-Barr virus and that is located_in the peripheral blood, bone marrow, liver, and spleen."
    },
    "synonyms": [
        {
            "id": "DOID:1035",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:1035",
            "name": "aggressive NK-cell leukaemia",
            "description": ""
        },
        {
            "id": "DOID:1035",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:1035",
            "name": "large granular Lymphocyte Leukemia, NK-cell type",
            "description": ""
        },
        {
            "id": "DOID:1035",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:1035",
            "name": "natural killer cell leukaemia",
            "description": ""
        },
        {
            "id": "DOID:1035",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:1035",
            "name": "natural killer cell leukemia",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:1035"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:1035",
            "database": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:1035",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q8IMZ4-1",
            "uniprot_ac": "Q8IMZ4",
            "uniprot_id": "Q8IMZ4_DROME",
            "refseq_ac": "NP_996267",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG33336-PB; p53-PB; p53-like regulator of apoptosis and cell cycle; protein 53; Dmp53; drosophila p53",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "P53, isoform B",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "p53 protein long form variant 1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "p53, isoform B",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "p53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CG10873; CG31325; CG33336; D-p53; Dm-P53; Dmel\\CG33336; dmp53; dmP53; Dmp53; DmP53; DMP53; dp53; Dp53; P53; prac",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CG10873",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CG31325",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CG33336",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "D-p53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "DMP53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dm-P53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "DmP53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG33336",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG33336",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dmp53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dp53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "P53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "dmP53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "dmp53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "dp53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "p53",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "prac",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "1035",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1035"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P02340-1",
            "uniprot_ac": "P02340",
            "uniprot_id": "P53_MOUSE",
            "refseq_ac": "NP_001120705",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cellular tumor antigen p53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Tumor suppressor p53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "cellular tumor antigen p53 isoform b",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "cellular tumor antigen p53; p53 cellular tumor antigen; tumor supressor p53; tumor suppressor p53; mutant p53; ME-delta123p53",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tp53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Trp53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "P53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "RP23-56I20.1-001",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "RP23-56I20.1-002",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Trp53",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Trp53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "bbl; bfy; bhy; p44; p53; Tp53",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "1035",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1035"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P04637-1",
            "uniprot_ac": "P04637",
            "uniprot_id": "P53_HUMAN",
            "refseq_ac": "NP_000537",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cellular tumor antigen p53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Antigen NY-CO-13",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Phosphoprotein p53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tumor suppressor p53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "cellular tumor antigen p53 isoform a",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tumor protein 53; mutant tumor protein 53; cellular tumor antigen p53; phosphoprotein p53; transformation-related protein 53; antigen NY-CO-13; tumor supressor p53",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TP53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "BCC7; BMFS5; LFS1; P53; TRP53",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "P53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TP53",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "1035",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1035"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P79734-1",
            "uniprot_ac": "P79734",
            "uniprot_id": "P53_DANRE",
            "refseq_ac": "NP_571402",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cellular tumor antigen p53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Tumor suppressor p53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "cellular tumor antigen p53 isoform 2",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tumor suppressor p53; cellular tumor antigen p53; delta113 p53",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "tp53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "brp53; drp53; etID22686.5; fb40d06; p53; wu:fb40d06; zgc:111919",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "brp53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "drp53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "etID22686.5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "fb40d06",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "p53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tp53",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb40d06",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "zgc:111919",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "1035",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1035"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P10361-1",
            "uniprot_ac": "P10361",
            "uniprot_id": "P53_RAT",
            "refseq_ac": "NP_112251",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cellular tumor antigen p53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Tumor suppressor p53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "cellular tumor antigen p53 isoform a",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "cellular tumor antigen p53; tumor suppressor p53; transformation related protein 53; tumor protein p53 (Li-Fraumeni syndrome)",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tp53",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "P53",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tp53",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "p53; Trp53",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "1035",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1035"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.1035"
}