{
    "disease_id": "DOID:070355",
    "recommended_name": {
        "id": "DOID:070355",
        "resource": "Disease Ontology",
        "url": "http://disease-ontology.org/term/DOID:070355",
        "name": "multisystem proteinopathy",
        "description": "A motor neuron disease that has_material_basis_in some inheritance and affects muscle, bone, and the nervous system."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:070355"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:070355",
            "database": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:070355",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q9VV60-1",
            "uniprot_ac": "Q9VV60",
            "uniprot_id": "Q9VV60_DROME",
            "refseq_ac": "NP_648895",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine--tRNA ligase",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CG4561-PA; TyrRS-PA; yars",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Tyrosyl-tRNA synthetase",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Tyrosyl-tRNA synthetase",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TyrRS",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Aats-tyr; anon-EST:Posey261; CG4561; Dmel\\CG4561; dTyrRS; dYARS; dYARS1; EMAP; YARS; YRS",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Aats-tyr",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CG4561",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG4561",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG4561",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "EMAP",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TyrRS",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "YARS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "YRS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "anon-EST:Posey261",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "dTyrRS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "dYARS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "070355",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:070355"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q91WQ3-1",
            "uniprot_ac": "Q91WQ3",
            "uniprot_id": "SYYC_MOUSE",
            "refseq_ac": "NP_598912",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TyrRS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tyrosyl-tRNA synthetase",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tyrosyl-tRNA synthetase, cytoplasmic; tyrRS; tyrosyl--tRNA ligase",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Yars1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Yars1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Yars",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Yars",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "070355",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:070355"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P36421-1",
            "uniprot_ac": "P36421",
            "uniprot_id": "SYYC_YEAST",
            "refseq_ac": "NP_011701",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TyrRS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tyrosyl-tRNA synthetase",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine--tRNA ligase TYS1",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TYS1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "G7522",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "MGM104",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TTS1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "TYS1",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "070355",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:070355"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P54577-1",
            "uniprot_ac": "P54577",
            "uniprot_id": "SYYC_HUMAN",
            "refseq_ac": "NP_003671",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TyrRS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tyrosyl-tRNA synthetase",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine tRNA ligase 1, cytoplasmic; tyrosyl-tRNA synthetase, cytoplasmic; tyrosyl--tRNA ligase",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "YARS1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CMTDIC; IMNEPD2; TYRRS; YARS; YRS; YTS",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "YARS1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "YARS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "070355",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:070355"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q6TGS6-1",
            "uniprot_ac": "Q6TGS6",
            "uniprot_id": "SYYC_DANRE",
            "refseq_ac": "NP_958473",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TyrRS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tyrosyl-tRNA synthetase",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tyrosyl-tRNA synthetase, cytoplasmic; tyrRS; tyrosyl--tRNA ligase",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "yars1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "cb204; wu:fk52b08; yars",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "cb204",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "wu:fk52b08",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "yars1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "yars",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "070355",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:070355"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q4KM49-1",
            "uniprot_ac": "Q4KM49",
            "uniprot_id": "SYYC_RAT",
            "refseq_ac": "NP_001020867",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TyrRS",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tyrosyl-tRNA synthetase",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine--tRNA ligase, cytoplasmic",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tyrosyl-tRNA synthetase, cytoplasmic; tyrRS; tyrosyl--tRNA ligase",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Yars1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Yars1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Yars",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Yars",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "070355",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:070355"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.070355"
}