{
    "disease_id": "DOID:0050175",
    "recommended_name": {
        "id": "DOID:0050175",
        "resource": "Disease Ontology",
        "url": "http://disease-ontology.org/term/DOID:0050175",
        "name": "tick-borne encephalitis",
        "description": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus (Orthoflavivirus encephalitidis), which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis."
    },
    "synonyms": [
        {
            "id": "DOID:0050175",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "name": "Central European encephalitis",
            "description": ""
        },
        {
            "id": "DOID:0050175",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "name": "Far Eastern TBE",
            "description": ""
        },
        {
            "id": "DOID:0050175",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "name": "Russian spring-summer encephalitis",
            "description": ""
        },
        {
            "id": "DOID:0050175",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "name": "Siberian tick-borne encephalitis",
            "description": ""
        },
        {
            "id": "DOID:0050175",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "name": "Taiga encephalitis",
            "description": ""
        },
        {
            "id": "DOID:0050175",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "name": "Western European tick-borne encephalitis",
            "description": ""
        },
        {
            "id": "DOID:0050175",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "name": "west-Siberian encephalitis",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050175"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050175",
            "database": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050175",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P27512-1",
            "uniprot_ac": "P27512",
            "uniprot_id": "TNR5_MOUSE",
            "refseq_ac": "NP_035741",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tumor necrosis factor receptor superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "B-cell surface antigen CD40",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Bp50",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CD40L receptor",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5 isoform 1 precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5; CD40L receptor; B-cell surface antigen CD40; T-cell differentiation antigen",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cd40",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Bp50; GP39; HIGM1; IGM; IMD3; p50; T-BAM; Tnfrsf5; TRAP",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Tnfrsf5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P27548-1",
            "uniprot_ac": "P27548",
            "uniprot_id": "CD40L_MOUSE",
            "refseq_ac": "NP_035746",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "CD40 ligand",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CD40 ligand",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40-L",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand superfamily member 5; tumor necrosis factor ligand 8b",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "T-cell antigen Gp39",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TNF-related activation protein",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TRAP",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tumor necrosis factor ligand superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cd40lg",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CD154; CD40-L; Cd40l; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40lg",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40l",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tnfsf5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P29965-1",
            "uniprot_ac": "P29965",
            "uniprot_id": "CD40L_HUMAN",
            "refseq_ac": "NP_000065",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "CD40 ligand",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CD40 ligand",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40-L",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "T-cell antigen Gp39",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TNF-related activation protein",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TRAP",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tumor necrosis factor ligand superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor (ligand) superfamily member 5; CD40 antigen ligand; T-B cell-activating molecule; TNF-related activation protein; CD40-L; T-cell antigen Gp39",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CD40LG",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CD154; CD40L; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40LG",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40L",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TNFSF5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TRAP",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P25942-1",
            "uniprot_ac": "P25942",
            "uniprot_id": "TNR5_HUMAN",
            "refseq_ac": "NP_001241",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tumor necrosis factor receptor superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "B-cell surface antigen CD40",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Bp50",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CD40L receptor; B cell-associated molecule; B cell surface antigen CD40; tumor necrosis factor receptor superfamily member 5; CD40 molecule, TNF receptor superfamily member 5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40L receptor",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CDw40",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5 isoform 1 precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CD40",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Bp50; CDW40; p50; TNFRSF5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "TNFRSF5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "hCG_40016",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "B8X730-1",
            "uniprot_ac": "B8X730",
            "uniprot_id": "B8X730_DANRE",
            "refseq_ac": "NP_001138718",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "CD40 molecule, TNF receptor superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TNFR superfamily member 5; CD40 antigen",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "TNFR superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tumor necrosis factor receptor superfamily member 5 precursor",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5 precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "cd40",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "cd40",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "si:ch211-231h20.3; tnfsrf5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "si:ch211-231h20.3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tnfsrf5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "B8YI05-1",
            "uniprot_ac": "B8YI05",
            "uniprot_id": "B8YI05_DANRE",
            "refseq_ac": "NP_001138281",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "CD154; TNFSF5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD154",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CD40 ligand",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40 ligand",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "cd40lg",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "cd40lg",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8I6AHI1-1",
            "uniprot_ac": "A0A8I6AHI1",
            "uniprot_id": "A0A8I6AHI1_RAT",
            "refseq_ac": "NP_001418429",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tumor necrosis factor receptor superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "B-cell surface antigen CD40",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CD40 antigen, TNF receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5; CD40 molecule, TNF receptor superfamily member 5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40L receptor",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5 isoform 1 precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cd40",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Cd40",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Tnfrsf5",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9Z2V2-1",
            "uniprot_ac": "Q9Z2V2",
            "uniprot_id": "CD40L_RAT",
            "refseq_ac": "NP_445805",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "CD40 ligand",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CD40 ligand CD154; CD40-L; tumor necrosis factor ligand superfamily member 5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40 ligand",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40-L",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tumor necrosis factor ligand superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cd40lg",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Cd40l; Tnfsf5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40lg",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40l",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tnfsf5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050175",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050175"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050175"
}