{
    "disease_id": "DOID:0050169",
    "recommended_name": {
        "id": "DOID:0050169",
        "resource": "Disease Ontology",
        "url": "http://disease-ontology.org/term/DOID:0050169",
        "name": "cutaneous lupus erythematosus",
        "description": "A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight."
    },
    "synonyms": [],
    "children": [
        {
            "id": "DOID:0060386",
            "label": "Chilblain lupus",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0050169",
        "DOID:0060386"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050169",
            "database": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0050169",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q9VQJ7-1",
            "uniprot_ac": "Q9VQJ7",
            "uniprot_id": "Q9VQJ7_DROME",
            "refseq_ac": "NP_001285571",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG3165-PB",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "LD40940p",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein, isoform B",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dmel\\CG3165",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CG3165",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CG3165",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG3165; TREX",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG3165",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q91XB0-1",
            "uniprot_ac": "Q91XB0",
            "uniprot_id": "TREX1_MOUSE",
            "refseq_ac": "NP_001012236",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Three-prime repair exonuclease 1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "3'-5' exonuclease TREX1",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "3.1.11.2",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "DNase III; 3'-5' exonuclease TREX1; trophoblast expressed 1; three prime exonuclease 1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "three-prime repair exonuclease 1",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Trex1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Trex1",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P27548-1",
            "uniprot_ac": "P27548",
            "uniprot_id": "CD40L_MOUSE",
            "refseq_ac": "NP_035746",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "CD40 ligand",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CD40 ligand",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40-L",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand superfamily member 5; tumor necrosis factor ligand 8b",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "T-cell antigen Gp39",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TNF-related activation protein",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "TRAP",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tumor necrosis factor ligand superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cd40lg",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CD154; CD40-L; Cd40l; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40lg",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40l",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Tnfsf5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P51678-1",
            "uniprot_ac": "P51678",
            "uniprot_id": "CCR3_MOUSE",
            "refseq_ac": "NP_034044",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Probable C-C chemokine receptor type 3",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "C-C CKR-3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CC-CKR-3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CCR-3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CCR3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CKR3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "MIP-1 alpha RL2",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Macrophage inflammatory protein 1-alpha receptor-like 2",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-C) receptor 3; CC chemokine receptor 3; CCR-3; CC-CKR-3; C-C CKR-3; MIP-1 alpha RL2; macrophage inflammatory protein 1-alpha receptor-like 2; chemokine (C-C) receptor 1,-like 2; MIP-1 alphaRL2; chemokine (C-C motif) receptor 3",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "probable C-C chemokine receptor type 3",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ccr3",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Ccr3",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cmkbr1l2",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Cmkbr3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P27512-1",
            "uniprot_ac": "P27512",
            "uniprot_id": "TNR5_MOUSE",
            "refseq_ac": "NP_035741",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tumor necrosis factor receptor superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "B-cell surface antigen CD40",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Bp50",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CD40L receptor",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5 isoform 1 precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5; CD40L receptor; B-cell surface antigen CD40; T-cell differentiation antigen",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cd40",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Bp50; GP39; HIGM1; IGM; IMD3; p50; T-BAM; Tnfrsf5; TRAP",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Cd40",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Tnfrsf5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q62386-1",
            "uniprot_ac": "Q62386",
            "uniprot_id": "IL17_MOUSE",
            "refseq_ac": "NP_034682",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-17A",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CTLA-8",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Cytotoxic T-lymphocyte-associated antigen 8",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "IL-17A",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "IL-17",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "cytotoxic T-lymphocyte-associated antigen 8",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-17A precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Il17a",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Ctla-8; Ctla8; IL-17; IL-17A; Il17",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Ctla8",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Il17a",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Il17",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NRI5-1",
            "uniprot_ac": "Q9NRI5",
            "uniprot_id": "DISC1_HUMAN",
            "refseq_ac": "NP_001012975",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Disrupted in schizophrenia 1 protein",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "disrupted in schizophrenia 1 protein isoform Lv",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "disrupted in schizophrenia 1 protein",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "DISC1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "C1orf136; SCZD9",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "DISC1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "KIAA0457",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q16552-1",
            "uniprot_ac": "Q16552",
            "uniprot_id": "IL17_HUMAN",
            "refseq_ac": "NP_002181",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-17A",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CTLA-8",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Cytotoxic T-lymphocyte-associated antigen 8",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "IL-17A",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "IL-17",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated antigen 8; interleukin-17",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-17A precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "IL17A",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "CTLA-8; CTLA8; IL-17; IL-17A; IL17; ILA17",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CTLA8",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "IL17A",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "IL17",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P51677-1",
            "uniprot_ac": "P51677",
            "uniprot_id": "CCR3_HUMAN",
            "refseq_ac": "NP_001828",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "C-C chemokine receptor type 3",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "C C CKR3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "C-C CKR-3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "C-C chemokine receptor type 3 isoform 1",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CC-CKR-3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CCR-3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CCR3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CKR 3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CKR3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Eosinophil eotaxin receptor",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "eosinophil CC chemokine receptor 3; b-chemokine receptor; eosinophil eotaxin receptor; C-C chemokine receptor type 3; CCR-3; C-C CKR-3; chemokine (C-C motif) receptor 3",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CCR3",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3; CMKBR3",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CCR3",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CMKBR3",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P25942-1",
            "uniprot_ac": "P25942",
            "uniprot_id": "TNR5_HUMAN",
            "refseq_ac": "NP_001241",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tumor necrosis factor receptor superfamily member 5",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "B-cell surface antigen CD40",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "Bp50",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CD40L receptor; B cell-associated molecule; B cell surface antigen CD40; tumor necrosis factor receptor superfamily member 5; CD40 molecule, TNF receptor superfamily member 5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40L receptor",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "CDw40",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor receptor superfamily member 5 isoform 1 precursor",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CD40",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "Bp50; CDW40; p50; TNFRSF5",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "CD40",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "TNFRSF5",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "hCG_40016",
                    "resource": "UniProtKB",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P29965-1",
            "uniprot_ac": "P29965",
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            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q5BK16-1",
            "uniprot_ac": "Q5BK16",
            "uniprot_id": "Q5BK16_RAT",
            "refseq_ac": "NP_001020160",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "exodeoxyribonuclease III",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "3.1.11.2",
                    "resource": "UniProtKB",
                    "type": "synonym"
                },
                {
                    "name": "three-prime repair exonuclease 1",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Trex1",
                    "resource": "UniProtKB",
                    "type": "recommended"
                },
                {
                    "name": "RGD1309596",
                    "resource": "RefSeq",
                    "type": "synonym"
                },
                {
                    "name": "Trex1",
                    "resource": "RefSeq",
                    "type": "synonym"
                }
            ],
            "evidence": [
                {
                    "id": "0050169",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050169"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050169"
}