{ "disease_id": "DOID:0050161", "recommended_name": { "id": "DOID:0050161", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050161", "name": "lower respiratory tract disease", "description": "A respiratory system disease which involves the lower respiratory tract." }, "synonyms": [], "children": [ { "id": "DOID:1176", "label": "bronchial disease", "link_status": false, "children": [ { "id": "DOID:1325", "label": "bronchus cancer", "link_status": false, "children": [ { "id": "DOID:3904", "label": "bronchus carcinoma", "link_status": true, "children": [] } ] }, { "id": "DOID:2841", "label": "asthma", "link_status": true, "children": [ { "id": "DOID:0080809", "label": "chronic asthma", "link_status": true, "children": [ { "id": "DOID:9360", "label": "intrinsic asthma", "link_status": false, "children": [ { "id": "DOID:0080822", "label": "aspirin-induced respiratory disease", "link_status": true, "children": [] }, { "id": "DOID:0080821", "label": "exercise-induced bronchoconstriction", "link_status": true, "children": [] }, { "id": "DOID:0080819", "label": "environmental induced asthma", "link_status": false, "children": [ { "id": "DOID:0080820", "label": "occupational asthma", "link_status": true, "children": [] } ] } ] }, { "id": "DOID:0080811", "label": "extrinsic asthma", "link_status": false, "children": [ { "id": "DOID:9415", "label": "allergic asthma", "link_status": true, "children": [] } ] }, { "id": "DOID:0080815", "label": "childhood-onset asthma", "link_status": true, "children": [] } ] }, { "id": "DOID:0080810", "label": "acute asthma", "link_status": true, "children": [ { "id": "DOID:9362", "label": "status asthmaticus", "link_status": true, "children": [] } ] } ] }, { "id": "DOID:9563", "label": "bronchiectasis", "link_status": true, "children": [ { "id": "DOID:0080527", "label": "bronchiectasis 2", "link_status": true, "children": [] }, { "id": "DOID:0080528", "label": "bronchiectasis 3", "link_status": true, "children": [] }, { "id": "DOID:0080526", "label": "bronchiectasis 1", "link_status": true, "children": [] } ] }, { "id": "DOID:6132", "label": "bronchitis", "link_status": true, "children": [] }, { "id": "DOID:2799", "label": "bronchiolitis obliterans", "link_status": true, "children": [] }, { "id": "DOID:2942", "label": "bronchiolitis", "link_status": true, "children": [] } ] }, { "id": "DOID:850", "label": "lung disease", "link_status": true, "children": [ { "id": "DOID:1324", "label": "lung cancer", "link_status": true, "children": [ { "id": "DOID:4765", "label": "pulmonary blastoma", "link_status": false, "children": [ { "id": "DOID:4769", "label": "pleuropulmonary blastoma", "link_status": true, "children": [] } ] }, { "id": "DOID:0080899", "label": "lung pleomorphic carcinoma", "link_status": true, "children": [] }, { "id": "DOID:3905", "label": "lung carcinoma", "link_status": true, "children": [ { "id": "DOID:3908", "label": "lung non-small cell carcinoma", "link_status": true, "children": [ { "id": "DOID:3907", "label": "lung squamous cell carcinoma", "link_status": true, "children": [] }, { "id": "DOID:4556", "label": "lung large cell carcinoma", "link_status": true, "children": [ { "id": "DOID:0050872", "label": "large cell neuroendocrine carcinoma", "link_status": true, "children": [] } ] }, { "id": "DOID:3910", "label": "lung adenocarcinoma", "link_status": true, "children": [ { "id": "DOID:4926", "label": "bronchiolo-alveolar adenocarcinoma", "link_status": true, "children": [] } ] }, { "id": "DOID:0080521", "label": "lung non-squamous non-small cell carcinoma", "link_status": true, "children": [] } ] }, { "id": "DOID:7596", "label": "asbestos-related lung carcinoma", "link_status": true, "children": [] }, { "id": "DOID:5409", "label": "lung small cell carcinoma", "link_status": true, "children": [] } ] }, { "id": "DOID:5410", "label": "pulmonary neuroendocrine tumor", "link_status": true, "children": [] } ] }, { "id": "DOID:11049", "label": "meconium aspiration syndrome", "link_status": true, "children": [] }, { "id": "DOID:2320", "label": "obstructive lung disease", "link_status": true, "children": [ { "id": "DOID:3083", "label": "chronic obstructive pulmonary disease", "link_status": true, "children": [ { "id": "DOID:9675", "label": "pulmonary emphysema", "link_status": true, "children": [] } ] } ] }, { "id": "DOID:0050153", "label": "pulmonary aspergilloma", "link_status": true, "children": [] }, { "id": "DOID:9808", "label": "Goodpasture syndrome", "link_status": false, "children": [ { "id": "DOID:4780", "label": "anti-basement membrane glomerulonephritis", "link_status": true, "children": [] } ] }, { "id": "DOID:11162", "label": "respiratory failure", "link_status": true, "children": [ { "id": "DOID:12716", "label": "newborn respiratory distress syndrome", "link_status": true, "children": [] }, { "id": "DOID:11394", "label": "adult respiratory distress syndrome", "link_status": true, "children": [] }, { "id": "DOID:11396", "label": "pulmonary edema", "link_status": true, "children": [] } ] }, { "id": "DOID:12148", "label": "alveolar echinococcosis", "link_status": true, "children": [] }, { "id": "DOID:1584", "label": "acute chest syndrome", "link_status": true, "children": [] }, { "id": "DOID:3683", "label": "lung benign neoplasm", "link_status": false, "children": [ { "id": "DOID:5386", "label": "lung adenoma", "link_status": true, "children": [] } ] }, { "id": "DOID:12120", "label": "pulmonary alveolar proteinosis", "link_status": true, "children": [] }, { "id": "DOID:9790", "label": "toxocariasis", "link_status": true, "children": [] }, { "id": "DOID:1495", "label": "cystic echinococcosis", "link_status": true, "children": [] }, { "id": "DOID:3082", "label": "interstitial lung disease", "link_status": true, "children": [ { "id": "DOID:0060971", "label": "interstitial lung disease 2", "link_status": true, "children": [] }, { "id": "DOID:10316", "label": "pneumoconiosis", "link_status": true, "children": [ { "id": "DOID:10322", "label": "berylliosis", "link_status": true, "children": [] }, { "id": "DOID:10320", "label": "asbestosis", "link_status": true, "children": [] }, { "id": "DOID:10325", "label": "silicosis", "link_status": true, "children": [] } ] }, { "id": "DOID:841", "label": "extrinsic allergic alveolitis", "link_status": true, "children": [ { "id": "DOID:13891", "label": "bird fancier's lung", "link_status": true, "children": [] }, { "id": "DOID:14453", "label": "farmer's lung", "link_status": true, "children": [] } ] }, { "id": "DOID:3770", "label": "pulmonary fibrosis", "link_status": true, "children": [ { "id": "DOID:0050156", "label": "idiopathic pulmonary fibrosis", "link_status": true, "children": [] } ] }, { "id": "DOID:0060941", "label": "interstitial lung disease 1", "link_status": true, "children": [] }, { "id": "DOID:2799", "label": "bronchiolitis obliterans", "link_status": true, "children": [] } ] }, { "id": "DOID:0061076", "label": "immunodeficiency 107", "link_status": true, "children": [] }, { "id": "DOID:0061070", "label": "immunodeficiency 100", "link_status": true, "children": [] }, { "id": "DOID:11339", "label": "pneumocystosis", "link_status": true, "children": [] }, { "id": "DOID:60001", "label": "pulmonary artery disease", "link_status": false, "children": [ { "id": "DOID:9477", "label": "pulmonary embolism", "link_status": true, "children": [] } ] }, { "id": "DOID:0050073", "label": "invasive aspergillosis", "link_status": true, "children": [] }, { "id": "DOID:2957", "label": "pulmonary tuberculosis", "link_status": true, "children": [] }, { "id": "DOID:2810", "label": "middle lobe syndrome", "link_status": true, "children": [] }, { "id": "DOID:3319", "label": "lymphangioleiomyomatosis", "link_status": true, "children": [] }, { "id": "DOID:12117", "label": "pulmonary alveolar microlithiasis", "link_status": true, "children": [] }, { "id": "DOID:13406", "label": "pulmonary sarcoidosis", "link_status": true, "children": [] }, { "id": "DOID:12132", "label": "granulomatosis with polyangiitis", "link_status": true, "children": [] }, { "id": "DOID:2942", "label": "bronchiolitis", "link_status": true, "children": [] }, { "id": "DOID:552", "label": "pneumonia", "link_status": true, "children": [ { "id": "DOID:2797", "label": "idiopathic interstitial pneumonia", "link_status": true, "children": [ { "id": "DOID:0050157", "label": "cryptogenic organizing pneumonia", "link_status": true, "children": [] }, { "id": "DOID:0050158", "label": "desquamative interstitial pneumonia", "link_status": true, "children": [] } ] }, { "id": "DOID:10533", "label": "viral pneumonia", "link_status": true, "children": [] }, { "id": "DOID:12375", "label": "bronchopneumonia", "link_status": true, "children": [] }, { "id": "DOID:874", "label": "bacterial pneumonia", "link_status": true, "children": [ { "id": "DOID:13276", "label": "Mycoplasma pneumoniae pneumonia", "link_status": true, "children": [] }, { "id": "DOID:0050152", "label": "aspiration pneumonia", "link_status": true, "children": [] } ] } ] }, { "id": "DOID:11650", "label": "bronchopulmonary dysplasia", "link_status": true, "children": [] } ] }, { "id": "DOID:1532", "label": "pleural disease", "link_status": true, "children": [ { "id": "DOID:3798", "label": "pleural empyema", "link_status": true, "children": [] }, { "id": "DOID:106", "label": "pleural tuberculosis", "link_status": true, "children": [] }, { "id": "DOID:4765", "label": "pulmonary blastoma", "link_status": false, "children": [ { "id": "DOID:4769", "label": "pleuropulmonary blastoma", "link_status": true, "children": [] } ] }, { "id": "DOID:0060646", "label": "congenital chylothorax", "link_status": true, "children": [] }, { "id": "DOID:7474", "label": "malignant pleural mesothelioma", "link_status": true, "children": [] }, { "id": "DOID:1673", "label": "pneumothorax", "link_status": true, "children": [ { "id": "DOID:0080218", "label": "primary spontaneous pneumothorax", "link_status": true, "children": [] } ] }, { "id": "DOID:10247", "label": "pleurisy", "link_status": true, "children": [] } ] } ], "id_list": [ "DOID:3683", "DOID:9563", "DOID:552", "DOID:4926", "DOID:1532", "DOID:0080521", "DOID:0050872", "DOID:11339", "DOID:13891", "DOID:2797", "DOID:0050158", "DOID:13276", "DOID:3908", "DOID:13406", "DOID:1325", "DOID:11049", "DOID:0080527", "DOID:0061076", "DOID:12132", "DOID:0080899", "DOID:1673", "DOID:2841", "DOID:7596", "DOID:5409", "DOID:9790", "DOID:0080811", "DOID:874", "DOID:60001", "DOID:4556", "DOID:0080526", "DOID:12716", "DOID:1495", "DOID:11162", "DOID:9360", "DOID:2799", "DOID:5410", "DOID:12375", "DOID:0080810", "DOID:0050156", "DOID:3083", "DOID:0080815", "DOID:0080809", "DOID:3082", "DOID:0060646", "DOID:6132", "DOID:4769", "DOID:3770", "DOID:10325", "DOID:9675", "DOID:2942", "DOID:2957", "DOID:2320", "DOID:10316", "DOID:12148", "DOID:9477", "DOID:2810", "DOID:0050152", "DOID:5386", "DOID:3798", "DOID:106", "DOID:0080822", "DOID:850", "DOID:3319", "DOID:14453", "DOID:10322", "DOID:3907", "DOID:0060971", "DOID:0050161", "DOID:0080528", "DOID:9415", "DOID:10320", "DOID:841", "DOID:4765", "DOID:0050073", "DOID:1176", "DOID:3910", "DOID:9808", "DOID:0080820", "DOID:3904", "DOID:0080821", "DOID:4780", "DOID:10247", "DOID:11394", "DOID:0050153", "DOID:0080218", "DOID:12120", "DOID:7474", "DOID:0060941", "DOID:1584", "DOID:10533", "DOID:0080819", "DOID:9362", "DOID:1324", "DOID:0050157", "DOID:3905", "DOID:11650", "DOID:12117", "DOID:0061070", "DOID:11396" ], "unlinked_id_list": [ "DOID:0080819", "DOID:3683", "DOID:0080811", "DOID:9360", "DOID:4765", "DOID:1325", "DOID:1176", "DOID:60001", "DOID:9808" ], "crossref": [ { "id": "DOID:0050161", "database": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050161", "categories": [] } ], "proteins": [ { "uniprot_canonical_ac": "Q9GNK5-1", "uniprot_ac": "Q9GNK5", "uniprot_id": "PGPLC_DROME", "refseq_ac": "NP_001163396", "glycoprotein": "yes", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "protein_names": [ { "name": "Peptidoglycan-recognition protein LC", "resource": "UniProtKB", "type": "recommended" }, { "name": "CG4432-PD; PGRP-LC-PD; PG recognition receptor-LC; peptidoglycan recognition protein-LC; peptidoglycan recognition protein LC; immune response deficient 7; Peptidoglycan-recognition protein-LC; totem", "resource": "RefSeq", "type": "synonym" }, { "name": "Immune response deficient 7 protein", "resource": "UniProtKB", "type": "synonym" }, { "name": "peptidoglycan recognition protein LC, isoform D", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "PGRP-LC", "resource": "UniProtKB", "type": "recommended" }, { "name": "(PGRP)-LC; CG4432; Dm PGRP-LC; Dmel\\CG4432; ird7; pgrp; pgrp lc; pgrp-lc; Pgrp-LC; PGRP-LCa; PGRP-LCd; PGRP-LCx; PGRPLC; tot", "resource": "RefSeq", "type": "synonym" }, { "name": "(PGRP)-LC", "resource": "UniProtKB", "type": "synonym" }, { "name": "CG4432", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dm PGRP-LC", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel\\CG4432", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel_CG4432", "resource": "UniProtKB", "type": "synonym" }, { "name": "PGRP-LCa", "resource": "UniProtKB", "type": "synonym" }, { "name": "PGRP-LCd", "resource": "UniProtKB", "type": "synonym" }, { "name": "PGRP-LCx", "resource": "UniProtKB", "type": "synonym" }, { "name": "PGRP-LC", "resource": "RefSeq", "type": "synonym" }, { "name": "PGRPLC", "resource": "UniProtKB", "type": "synonym" }, { "name": "Pgrp-LC", "resource": "UniProtKB", "type": "synonym" }, { "name": "ird7", "resource": "UniProtKB", "type": "synonym" }, { "name": "pgrp lc", "resource": "UniProtKB", "type": "synonym" }, { "name": "pgrp-lc", "resource": "UniProtKB", "type": "synonym" }, { "name": "pgrp", "resource": "UniProtKB", "type": "synonym" }, { "name": "tot", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "0050161", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050161" } ] }, { "uniprot_canonical_ac": "Q9VXN9-1", "uniprot_ac": "Q9VXN9", "uniprot_id": "PGPLE_DROME", "refseq_ac": "NP_001245695", "glycoprotein": "yes", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "protein_names": [ { "name": "Peptidoglycan-recognition protein LE", "resource": "UniProtKB", "type": "recommended" }, { "name": "CG8995-PB; PGRP-LE-PB; peptidoglycan recognition protein-LE", "resource": "RefSeq", "type": "synonym" }, { "name": "peptidoglycan recognition protein LE, isoform B", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "PGRP-LE", "resource": "UniProtKB", "type": "recommended" }, { "name": "CG8995", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel\\CG8995", "resource": "UniProtKB", "type": "synonym" }, { "name": "Dmel_CG8995", "resource": "UniProtKB", "type": "synonym" }, { "name": "PGRP-LE", "resource": "RefSeq", "type": "synonym" }, { "name": "PGRP", "resource": "UniProtKB", "type": "synonym" }, { "name": "anon-WO0153538.66; CG8995; Dmel\\CG8995; PGRP; pgrp le; pgrp-le", "resource": "RefSeq", "type": "synonym" }, { "name": "anon-WO0153538.66", "resource": "UniProtKB", "type": "synonym" }, { "name": "pgrp le", "resource": "UniProtKB", "type": "synonym" }, { "name": "pgrp-le", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "0050161", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050161" } ] } ], "glycans": [], "biomarkers": [], "association_flag": "1000", "record_id": "doid.0050161" }